Nonnasopharyngeal Lymphoepitheliomas (Undifferentiated Carcinomas) of the Upper Aerodigestive Tract

1995 ◽  
Vol 104 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Douglas K. Frank ◽  
Fred Cheron ◽  
Damian DiCostanzo ◽  
Hyun Cho ◽  
Anthony P. Sclafani
Keyword(s):  
Malignant Tumors ◽  
Case Reports ◽  
Strong Association ◽  
Dna Amplification ◽  
Aerodigestive Tract ◽  
The Body ◽  
World Health ◽  
Upper Aerodigestive Tract ◽  
Barr Virus ◽  
Ebv Infection

Lymphoepitheliomas are malignant tumors of epithelial origin with various amounts of reactive lymphocytic infiltrate. Although initially described in the nasopharynx (World Health Organization type 3 nasopharyngeal carcinoma), these tumors have been identified in various locations throughout the body. A strong association with Epstein-Barr virus (EBV) infection has been established for the nasopharyngeal type. Outside the nasopharynx, lymphoepitheliomas are exceedingly rare in the upper aerodigestive tract, with only isolated case reports of tumors in the larynx, trachea, and hypopharynx. This article features a rare case of lymphoepithelioma of the pyriform sinus. Furthermore, serologic testing, as well as in situ tumor DNA amplification (using the polymerase chain reaction) and hybridization techniques, demonstrated an association of this lesion with EBV infection. The characteristic histopathologic features common to this disease entity are presented, and the literature is reviewed with regard to lymphoepitheliomas of the upper aerodigestive tract outside the nasopharynx. Association of lymphoepitheliomas with EBV infection will be discussed.

scholarly journals Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

2021 ◽  
Vol 9 (11) ◽  
pp. 3391
Author(s):  
Khadija S. Tapadar ◽  
Manoj K. Deka ◽  
R. N. Chaubey ◽  
Shah A. Sheikh ◽  
Gargi R. Choudhury ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Soft Tissue Tumors ◽  
The Body ◽  
World Health ◽  
Vascular Tumors ◽  
Benign Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Pleomorphic Sarcoma ◽  
Younger Age

Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and   lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.

Abstract 144: Lung Parenchymal Consolidation during typical Kawasaki Disease

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Seiichi Sato
Keyword(s):  
Kawasaki Disease ◽  
Lymph Nodes ◽  
Past History ◽  
Systemic Vasculitis ◽  
Case Reports ◽  
Parvovirus B19 ◽  
Severe Pneumonia ◽  
Pulmonary Involvement ◽  
The Body ◽  
Barr Virus

Introduction: Kawasaki disease (KD) is a systemic vasculitis of childhood throughout the body. We report a patient who complicated by severe pneumonia of lung parenchymal consolidation (LPC) during typical KD clinical course. Case reports: A 7-yr-old male who had a past history of KD at 3-yr-old, visited a general practitioner with fever, sore throat and neck pain. Three days later, after being treated with CTRX/TBPMPI, he was transferred to our hospital because of bilateral lymph nodes swelling and a generalized erythema and rash. On admission he was still febrile and had bilateral conjunctival injections, cervical and axillary lymphadenopathy and markedly reddened pharynx, without edema. We diagnosed him as KD and treated him with aspirin and IVIG at a dose of 2.0g/kg, but the condition worsened; he developed dyspnea and dry cough. Crackles were noted on rt-lung auscultation, along with rt-basal dullness to percussion of the thorax. Chest radiography and a subsequent computed tomography scan revealed disseminated patchy infiltrates and ground-glass alterations with massive pleural effusions on rt-lung, and enlarged axillary and mediastinal lymph nodes. Some kinds of microbiology (including Mycoplasma) and virology (Epstein-Barr virus, cytomegalovirus, parvovirus B19), from all sampled sites (pleural effusion, blood, pharyngeal swab and cerebrospinal fluid), were negative for pathogenic specimens. So we treated him as intractable KD with second-IVIG and m-PSL, which led to the quick resolution of fever and progressive amelioration of pneumonia. Echocardiography showed normal ventricular size and function without coronary artery lesion (CAL). Thereafter, he was finally afebrile. At the first follow-up visit, 1 month after discharge, he had fully recovered. Clinically, echocardiographically and radiographically, no residues were noted. Conclusion: Several manifestations of broncho-pulmonary involvement in KD have been described. But there are very few case of LPC. We should consider the possibility that LPC were secondary to pulmonary arteritis.

scholarly journals Prevalence of Malignancies in Patients With Primary Aldosteronism

2016 ◽  
Vol 101 (4) ◽  
pp. 1656-1663 ◽  
Author(s):  
K. Lang ◽  
K. Weber ◽  
M. Quinkler ◽  
A. S. Dietz ◽  
H. Wallaschofski ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Primary Aldosteronism ◽  
Renal Cell ◽  
Malignant Tumors ◽  
Single Case ◽  
Case Reports ◽  
Strong Association ◽  
Malignant Neoplasms

Abstract Context: Primary aldosteronism (PA) is the most common cause of secondary hypertension. Aldosterone excess can cause DNA damage in vitro and in vivo. Single case reports have indicated a coincidence of PA with renal cell carcinoma and other tumors. However, the prevalence of benign and malignant neoplasms in patients with PA has not yet been studied. Patients and Design: In the multicenter MEPHISTO study, the prevalence of benign and malignant tumors was investigated in 335 patients with confirmed PA. Matched hypertensive subjects from the population-based Study of Health in Pomerania cohort served as controls. Results: Of the 335 PA patients, 119 (35.5%) had been diagnosed with a tumor at any time, and 30 had two or more neoplasms. Lifetime malignancy occurrence was reported in 9.6% of PA patients compared to 6.0% of hypertensive controls (P = .08). PA patients with a history of malignancy had higher baseline aldosterone levels at diagnosis of PA (P = .009), and a strong association between aldosterone levels and the prevalence of malignancies was observed (P = .03). In total, 157 neoplasms were identified in the PA patients; they were benign in 61% and malignant in 25% of the cases (14% of unknown dignity). Renal cell carcinoma was diagnosed in five patients (13% of all malignancies) and was not reported in controls. Conclusion: Compared to hypertensive controls, the prevalence of malignancies was positively correlated with aldosterone levels, tended to be higher in PA patients, but did not differ significantly.

Low-Grade Primary Mucosa-Associated Lymphoid Tissue Lymphoma of the Nasopharynx: Clinicopathological Study

2005 ◽  
Vol 19 (4) ◽  
pp. 411-416 ◽  
Author(s):  
Omar A. El-Banhawy ◽  
Ibraheim El-Desoky
Keyword(s):  
Lymphoid Tissue ◽  
Clinical Symptoms ◽  
Malignant Tumors ◽  
Laboratory Finding ◽  
Radiological Finding ◽  
Aerodigestive Tract ◽  
Tissue Type ◽  
Primary Lymphoma ◽  
Low Grade ◽  
Upper Aerodigestive Tract

Background Malignant tumors of the nasopharynx are always a challenging problem, both from the diagnostic and from the therapeutic standpoint. Most extranodal lymphomas arise in the gastrointestinal tract, but the other mucosal organs also may be involved, especially the upper aerodigestive tract. Nasopharyngeal lymphomas are rare among lymphoma of the upper aerodigestive tract. Methods Twenty-two patients with primary lymphoma arising in mucosa-associated lymphoid tissue of the nasopharynx have been studied with reference to age, sex, clinical symptoms, laboratory finding, radiological finding, histological subtype, and immunohistochemistry. Results All patients were diagnosed histologically as low-grade lymphoma of mucosa-associated lymphoid tissue type with its characteristic lymphoepithelial lesions and follicular colonization. The tumor cells typically exhibit the following immunophenotypes: positive for CD20, CD45RA, and proliferating markers bcl-2. It was negative for T-cell markers CD45RO (UCHLI). Conclusion Ear, nose, and throat surgeons and pathologists should be aware of this type of lymphoma to avoid misinterpretation and to set up a protocol for its management.

scholarly journals Multiple Myxoid Lipomas of Supraglottic Region

2011 ◽  
Vol 1 (2) ◽  
pp. 88-90
Author(s):  
Ravinder Verma ◽  
NK Sardana ◽  
Ravneet Ravinder Verma
Keyword(s):  
Head And Neck ◽  
Case Reports ◽  
Neck Region ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Head And Neck Region

ABSTRACT Though lipomas are very common tumors occurring in the head and neck region, there are very few case reports of submucosal lipomas of the upper aerodigestive tract. A case of myxoid lipoma of the supraglottic region is reported.

scholarly journals Ganglioglioma Arising from the Septum Pellucidum

2021 ◽  
Author(s):  
Bishal Shrestha ◽  
Pritam Gurung ◽  
Sudan Dhakal ◽  
Pravesh Rajbhandari ◽  
Ranga Bahadur Basnet ◽  
...  
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Case Reports ◽  
Obstructive Hydrocephalus ◽  
Third Ventricle ◽  
Histological Finding ◽  
Septum Pellucidum ◽  
The Body ◽  
World Health ◽  
Hormone Profile ◽  
Health Organization

AbstractA 24-year-old gentleman presented to us with complaints of occasional headache for 2 years. Magnetic resonance imaging showed enhancing supra sellar mass with nonenhancing cystic components, extending superiorly up to the body of bilateral lateral ventricle, laterally displacing septum pellucidum, and compressing the third ventricle with obstructive hydrocephalus. Hormone profile depicted adrenocorticotropic hormone <5.00 pg/mL, growth hormone 1.32 ng/mL, insulin-like growth factor-1 <3.0 ng/mL. The patient underwent surgical resection. Histological finding was suggestive of ganglioglioma World Health Organization grade I. Customized immunohistochemistry panel was advised and revealed positive CD 56, NSE, and GFAP immunohistochemical stains. Gangliogliomas are less frequent neoplastic lesions confined to only a handful of case reports and studies. Accounting less than 2% of intracranial neoplasms, these lesions primarily affect those in the first 3 decades of their life. As ubiquitous it is in nature, we hereby present a case of ganglioglioma in a young adult male arising from septum pellucidum.

scholarly journals Epstein-Barr Virus Induces Expression of the LPAM-1 Integrin in B CellsIn VitroandIn Vivo

2018 ◽  
Vol 93 (5) ◽  
Author(s):  
Susanne Delecluse ◽  
Ming-Han Tsai ◽  
Anatoliy Shumilov ◽  
Maja Bencun ◽  
Sebastian Arrow ◽  
...  
Keyword(s):  
B Cells ◽  
Lymph Nodes ◽  
B Cell ◽  
Epstein Barr Virus ◽  
Digestive System ◽  
The Body ◽  
Barr Virus ◽  
Ebv Infection ◽  
Infected Cells ◽  
Epstein Barr

ABSTRACTEpstein-Barr virus (EBV) infects the oropharynx but, surprisingly, frequently induces B cell proliferation in the gut of immunosuppressed individuals. We found that EBV infectionin vitroinduces the expression of the LPAM-1 integrin on tonsillar B cells and increases it on peripheral blood cells. Similarly, LPAM-1 was induced in the tonsils of patients undergoing primary infectious mononucleosis. EBV-induced LPAM-1 bound to the MAdCAM-1 addressin, which allows B cell homing to the gastrointestinal mucosa-associated lymphoid tissue (GALT). Thus, we hypothesized that EBV-induced LPAM-1 could induce relocation of infected B cells from the tonsil to the GALT.In situhybridization with an EBER-specific probe revealed the frequent presence of EBV-infected cells in the pericolic lymph nodes of healthy individuals. Relocation of infected B cells into the GALT would expand the EBV reservoir, possibly protecting it from T cells primed in the oropharynx, and explain why EBV induces lymphoid tumors in the gut.IMPORTANCEEBV causes tumors in multiple organs, particularly in the oro- and nasopharyngeal area but also in the digestive system. This virus enters the body in the oropharynx and establishes a chronic infection in this area. The observation that the virus causes tumors in the digestive system implies that the infected cells can move to this organ. We found that EBV infection induces the expression of integrin beta 7 (ITGB7), an integrin that associates with integrin alpha 4 to form the LPAM-1 dimer. LPAM-1 is key for homing of B cells to the gastrointestinal tract, suggesting that induction of this molecule is the mechanism through which EBV-infected cells enter this organ. In favor of this hypothesis, we could also detect EBV-infected cells in the lymph nodes adjacent to the colon and in the appendix.

The Epstein-Barr Virus in Malignant Non-Hodgkinʼs Lymphoma of the Upper Aerodigestive Tract

1997 ◽  
Vol 6 (3) ◽  
pp. 134-139 ◽  
Author(s):  
German Ott ◽  
Jörg Kalla ◽  
M. Michaela Ott ◽  
Hans Konrad Müller-Hermelink
Keyword(s):  
Epstein Barr Virus ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Barr Virus ◽  
Epstein Barr
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