scholarly journals Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties

2012 ◽  
Vol 91 (12) ◽  
pp. 1172-1177 ◽  
Author(s):  
R. Jimbo ◽  
P.G. Coelho ◽  
M. Bryington ◽  
M. Baldassarri ◽  
N. Tovar ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Dental Implants ◽  
Tissue Quality ◽  
Implant Surface ◽  
Nanomechanical Properties ◽  
Nanoparticle Surface ◽  
Heat Treated ◽  
Coated Implant ◽  
Bone To Implant Contact ◽  
Surrounding Bone

Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.

scholarly journals Defining surfaces : Implant topography – a review (Preprint)

2018 ◽  
Author(s):  
Preeti Satheesh Kumar ◽  
Vyoma Venkatesh Grandhi ◽  
Vrinda Gupta
Keyword(s):  
Surface Roughness ◽  
Surface Topography ◽  
Dental Implants ◽  
Sol Gel ◽  
Implant Surface ◽  
Research Publications ◽  
Bone To Implant Contact ◽  
Titanium Dental Implants

BACKGROUND . A variety of claims are made regarding the effects of surface topography on implant osseointegration. The development of implant surfaces topography has been empirical, requiring numerous in vitro and in vivo tests. Most of these tests were not standardized, using different surfaces, cell populations or animal models. The exact role of surface chemistry and topography on the early events of the osseointegration of dental implants remain poorly understood. OBJECTIVE This review considers the major claims made concerning the effects of titanium implant surface topography on osseointegration. The osseointegration rate of titanium dental implants is related to their composition and surface roughness. The different methods used for increasing surface roughness or applying osteoconductive coatings to titanium dental implants are reviewed. Important findings of consensus are highlighted, and existing controversies are revealed. METHODS This review considers many of the research publications listed in MEDLINE and presented in biomedical research publications and textbooks. Surface treatments, such as titanium plasma-spraying, grit-blasting acid-etching,alkaline etching, anodization,polymer demixing ,sol gel conversion and their corresponding surface morphologies and properties are described. RESULTS Many in vitro evaluations are not predictive of or correlated with in vivo outcomes. In some culture models, increased surface topography positively affects pro-osteogenic cellular activities. Many studies reveal increase in bone-to-implant contact,with increased surface topography modifications on implant surfaces. CONCLUSIONS Increased implant surface topography improves the bone-to-implant contact and the mechanical properties of the enhanced interface.

scholarly journals Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 7076
Author(s):  
Christian Flörke ◽  
Anne-Katrin Eisenbeiß ◽  
Ulla Metz ◽  
Aydin Gülses ◽  
Yahya Acil ◽  
...  
Keyword(s):  
Bone Density ◽  
Dental Implants ◽  
Experimental Model ◽  
Bone Growth ◽  
Implant Surface ◽  
Feasible Option ◽  
Bone To Implant Contact ◽  
Mini Pigs ◽  
Titanium Dental Implants

Background and Objectives: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. Materials and Methods: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in length) was inserted into frontal bone (n: 12) and the basis of the corpus mandible (n: 24). Eighteen implants were contaminated via inoculation of Enterococcus faecalis. Six weeks after implant insertion, bone-to-implant contact (BIC) ratio, interthread bone density (ITBD), and peri-implant bone density (PIBD) were examined. In addition to that, new bone formation was assessed via fluorescence microscopy, histomorphometry, and light microscopical examinations. Results: Compared to the sterile implants, the contaminated implants showed significantly reduced BIC (p < 0.001), ITBD (p < 0.001), and PBD (p < 0.001) values. Around the sterile implants, the green and red fluorophores were overlapping and surrounding the implant without gaps, indicating healthy bone growth on the implant surface, whereas contaminated implants were surrounded by connective tissue. Conclusions: The current experimental model could be a feasible option to realize a significant alteration of dental-implant osseointegration and examine novel surface decontamination techniques without impairing local and systemic inflammatory complications.

scholarly journals Histological and Nanomechanical Properties of a New Nanometric Hydroxiapatite Implant Surface. An In Vivo Study in Diabetic Rats

Materials ◽  
2020 ◽  
Vol 13 (24) ◽  
pp. 5693
Author(s):  
Paula G. F. P. Oliveira ◽  
Paulo G. Coelho ◽  
Edmara T. P. Bergamo ◽  
Lukasz Witek ◽  
Cristine A. Borges ◽  
...  
Keyword(s):  
Bone Repair ◽  
Diabetic Rats ◽  
Missing Teeth ◽  
Implant Surface ◽  
Bone Parameters ◽  
Nanomechanical Properties ◽  
Mini Implants ◽  
Implant Therapy ◽  
Bone To Implant Contact

Implant therapy is a predictable treatment to replace missing teeth. However, the osseointegration process may be negatively influenced by systemic conditions, such as diabetes mellitus (DM). Microtopography and implant surface developments are strategies associated to better bone repair. This study aimed to evaluate, in healthy and diabetic rats, histomorphometric (bone to implant contact = %BIC; and bone area fraction occupancy = %BAFO) and nanomechanical (elastic modulus = EM; and hardness = H) bone parameters, in response to a nanometric hydroxyapatite implant surface. Mini implants (machined = MAC; double acid etched = DAE, and with addition of nano-hydroxyapatite = NANO) were installed in tibias of healthy and diabetic rats. The animals were euthanized at 7 and 30 days. NANO surface presented higher %BIC and %BAFO when compared to MAC and DAE (data evaluated as a function of implant surface). NANO surface presented higher %BIC and %BAFO, with statistically significant differences (data as a function of time and implant surface). NANO surface depicted higher EM and H values, when compared to machined and DAE surfaces (data as a function of time and implant surface). Nano-hydroxyapatite coated implants presented promising biomechanical results and could be an important tool to compensate impaired bone healing reported in diabetics.

scholarly journals Osteogenic Cell Behavior on Titanium Surfaces in Hard Tissue

2019 ◽  
Vol 8 (5) ◽  
pp. 604 ◽  
Author(s):  
Jung-Yoo Choi ◽  
Tomas Albrektsson ◽  
Young-Jun Jeon ◽  
In-Sung Luke Yeo
Keyword(s):  
Electron Microscopy ◽  
Bone Formation ◽  
Dental Implants ◽  
Electron Microscopic Level ◽  
In Vivo Model ◽  
Electron Microscopic ◽  
Implant Surface ◽  
Cell Responses ◽  
Surrounding Bone

It is challenging to remove dental implants once they have been inserted into the bone because it is hard to visualize the actual process of bone formation after implant installation, not to mention the cellular events that occur therein. During bone formation, contact osteogenesis occurs on roughened implant surfaces, while distance osteogenesis occurs on smooth implant surfaces. In the literature, there have been many in vitro model studies of bone formation on simulated dental implants using flattened titanium (Ti) discs; however, the purpose of this study was to identify the in vivo cell responses to the implant surfaces on actual, three-dimensional (3D) dental Ti implants and the surrounding bone in contact with such implants at the electron microscopic level using two different types of implant surfaces. In particular, the different parts of the implant structures were scrutinized. In this study, dental implants were installed in rabbit tibiae. The implants and bone were removed on day 10 and, subsequently, assessed using scanning electron microscopy (SEM), immunofluorescence microscopy (IF), transmission electron microscopy (TEM), focused ion-beam (FIB) system with Cs-corrected TEM (Cs-STEM), and confocal laser scanning microscopy (CLSM)—which were used to determine the implant surface characteristics and to identify the cells according to the different structural parts of the turned and roughened implants. The cell attachment pattern was revealed according to the different structural components of each implant surface and bone. Different cell responses to the implant surfaces and the surrounding bone were attained at an electron microscopic level in an in vivo model. These results shed light on cell behavioral patterns that occur during bone regeneration and could be a guide in the use of electron microscopy for 3D dental implants in an in vivo model.

The Clinical and Histologic Outcome of Dental Implant in Large Ridge Defect Regenerated With Alloplast: A Randomized Controlled Preclinical Trial

2013 ◽  
Vol 39 (2) ◽  
pp. 148-153 ◽  
Author(s):  
David M. Kim ◽  
Marc L. Nevins ◽  
Zhao Lin ◽  
Ardavan Fateh ◽  
Soo-Woo Kim ◽  
...  
Keyword(s):  
Dental Implants ◽  
Collagen Membrane ◽  
Bone Contact ◽  
Preclinical Trial ◽  
Randomized Controlled ◽  
Microscopic Evaluation ◽  
Bone To Implant Contact ◽  
The Mean ◽  
To Receive ◽  
Surrounding Bone

A basic tenant of successful osseointegration is that the implant resides in a sufficient quality and quantity of bone to ensure bone contact and thus stabilization. A prospective, randomized controlled preclinical trial was conducted to evaluate the bone-to-implant contact (BIC) when placing implants in bone regenerated by 3 different combinations of biphasic calcium phosphate (BCP). Dental implants were placed into the regenerated ridges of 6 female foxhounds; the ridges were reconstructed with different formulations of BCP in combination with an hydroxyapatite collagen membrane. They were retrieved after 3 months to perform light microscopic and histomorphometric analyses. Implants in each group appeared to be stable and osseointegrated. Light microscopic evaluation revealed tight contacts between the implant threads with the surrounding bone for all 4 groups. The mean BIC ranged from 64.7% to 73.7%. This preclinical trial provided clinical and histologic evidence to support the efficacy of all 3 formulations of BCP to treat large alveolar ridge defects to receive osseointegrated dental implants.

scholarly journals Effect of the Acid-Etching on Grit-Blasted Dental Implants to Improve Osseointegration: Histomorphometric Analysis of the Bone-Implant Contact in the Rabbit Tibia Model

Coatings ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1426
Author(s):  
Blanca Ríos-Carrasco ◽  
Bernardo Ferreira Lemos ◽  
Mariano Herrero-Climent ◽  
F. Javier Gil Mur ◽  
Jose Vicente Ríos-Santos
Keyword(s):  
Contact Angle ◽  
Dental Implants ◽  
Acid Etching ◽  
Implant Stability ◽  
Contact Ratio ◽  
Implant Surface ◽  
Significant Difference ◽  
Rabbit Tibia ◽  
Titanium Dental Implant ◽  
Bone To Implant Contact

Previous studies have shown that the most reliable way to evaluate the success of an implant is by bone-to-implant contact (BIC). Recent techniques allow modifications to the implant surface that improve mechanical and biological characteristics, and also upgrade osseointegration. Objective: The aim was to evaluate the osseointegration in rabbit tibia of two different titanium dental implant surfaces: shot-blasted with Al2O3 (SB) and the same treatment with an acid-etching by immersion for 15 s in HCl/H2SO4 (SB + AE). Material and methods: Roughness parameters (Ra, Rt, and Rz) were determined by white light interferometer microscopy. Surface wettability was evaluated with a contact angle video-based system using water, di-iodomethane, and formamide. Surface free energy was determined by means of Owens and Wendt equations. Scanning electron microscopy equipped with X-ray microanalysis was used to study the morphology and determine the chemical composition of the surfaces. Twenty-four grade 4 titanium dental implants (Essential Klockner®) were implanted in the rabbit’s tibia, 12 for each surface treatment, using six rabbits. Six weeks later the rabbits were sacrificed and the implants were sent for histologic analysis. Resonance frequency analysis (RFA) was recorded both at the time of surgery and the end of the research with each device (Osstell Mentor and Osstell ISQ). Results: The roughness measurements between the two treatments did not show statistically significant differences. However, the effect of the acid etching made the surface slightly more hydrophilic (decreasing contact angle from 74.7 for SB to 64.3 for SB + AE) and it presented a higher surface energy. The bone-to-implant contact ratio (BIC %) showed a similar tendency, with 55.18 ± 15.67 and 59.9 ± 13.15 for SB and SB + AE implants, respectively. After 6 weeks of healing, the SB + AE showed an implant stability quotient (ISQ) value of 76 ± 4.47 and the shot-blasted one an ISQ value of 75.83 ± 8.44 (no statistically significant difference). Implants with different surface properties had distinctive forms of behavior regarding osseointegration. Furthermore, the Osstell system was an invasive and reliable method to measure implant stability. Conclusion: Both surfaces of implants studied showed high osseointegration. The SB and SB + AE implants used in our study had similar behavior both in terms of BIC values and RFA. The RFA systems in Osstell Mentor and Osstell ISQ confirmed nearly perfect reproducibility and repeatability.

Photofunctionalization of Dental Implants

2016 ◽  
Vol 42 (5) ◽  
pp. 445-450 ◽  
Author(s):  
Dennis Flanagan
Keyword(s):  
Biological Activity ◽  
Dental Implants ◽  
Uv Radiation ◽  
Titanium Surface ◽  
Biological Effects ◽  
Wave Length ◽  
Implant Surface ◽  
Dental Implant Surface ◽  
Titanium Dental Implant ◽  
Bone To Implant Contact

After dental implants are manufactured there can be a loss of biological activity that may be reactivated by exposure to ultraviolet (UV) radiation, that is, photofunctionalization. The titanium surface is energy conditioned by UV radiation. This imparts a slight positive surface energy and hydrophilicity to the titanium dental implant surface. This conditioning renews biological activity lost after a shelf life of as little as 2 weeks. The UV radiation has chemical and biological effects on the osseous-implant interface. Photofunctionization for as little as 15 minutes accelerates healing and increases bone to implant contact. The most effective time exposure and UV wave length are in need of identification to produce a surface most conducive for osseointegration.

scholarly journals Macrophagic Inflammatory Response Next to Dental Implants with Different Macro- and Micro-Structure: An In Vitro Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5324
Author(s):  
Maria Menini ◽  
Francesca Delucchi ◽  
Domenico Baldi ◽  
Francesco Pera ◽  
Francesco Bagnasco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Implants ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
Optimal Outcomes ◽  
Negative Controls ◽  
Inflammatory Effect

(1) Background: Intrinsic characteristics of the implant surface and the possible presence of endotoxins may affect the bone–implant interface and cause an inflammatory response. This study aims to evaluate the possible inflammatory response induced in vitro in macrophages in contact with five different commercially available dental implants. (2) Methods: one zirconia implant NobelPearl® (Nobel Biocare) and four titanium implants, Syra® (Sweden & Martina), Prama® (Sweden & Martina), 3iT3® (Biomet 3i) and Shard® (Mech & Human), were evaluated. After 4 h of contact of murine macrophage cells J774a.1 with the implants, the total RNA was extracted, transcribed to cDNA and the gene expression of the macrophages was evaluated by quantitative PCR (qPCR) in relation to the following genes: GAPDH, YWHAZ, IL1β, IL6, TNFα, NOS2, MMP-9, MMP-8 and TIMP3. The results were statistically analyzed and compared with negative controls. (3) Results: No implant triggered a significant inflammatory response in macrophages, although 3iT3 exhibited a slight pro-inflammatory effect compared to other samples. (4) Conclusions: All the samples showed optimal outcomes without any inflammatory stimulus on the examined macrophagic cells.

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