Myocardial uptake of 68Ga-DOTATATE: correlation with cardiac disease and risk factors

2021 ◽  
pp. 028418512110541
Author(s):  
Malak Itani ◽  
Adeel Haq ◽  
Manik Amin ◽  
Joyce Mhlanga ◽  
Daniel Lenihan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Cardiac Disease ◽  
Intraclass Correlation ◽  
Standardized Uptake Value ◽  
Coronary Calcification ◽  
Blood Pool ◽  
P Value ◽  
Myocardial Uptake ◽  
Pet Ct

Background Myocardial uptake on 68Ga-DOTATATE PET/CT is often observed and its clinical relevance is poorly understood. Purpose To detect any correlation between myocardial uptake of 68Ga-DOTATATE and presence of cardiac disease or risk factors. Material and Methods In this institutional review board-approved retrospective study, we reviewed 68Ga-DOTATATE PET/CT scans in our institution between 1 May 2018 and 30 September 2018. A semi-quantitative score (MUS) for myocardial uptake of 68Ga-DOTATATE was developed by measuring mean standardized uptake value (SUV) in five myocardial regions, corrected by blood pool activity, and MUS was validated between two readers. We investigated the relationship between MUS and presence of cardiac disease or risk factors, including Framingham score and coronary calcification. Results A total of 145 scans were included (79 women; mean age = 56.9  ±  13.7 years). Inter-reader agreement was excellent with intraclass correlation coefficient (r)  =  0.964 (95% confidence interval [CI] = 0.903–0.987; P < 0.001). There was a weak but significant positive correlation between MUS and presence of coronary calcifications (Spearman rho  =  0.20; P = 0.016). MUS was higher in patients with heart disease or risk factors (n = 83, mean MUS 2.03, 95% CI = 1.85–2.21) compared to those without (n = 23, mean MUS 1.40, 95% CI = 1.17–1.62; P < 0.001), although the cardiac disease group was older with a higher percentage of men (62.0 years, 57.8% men compared to 47.6 years, 13.0% men; P value <0.0001 for both comparisons). Conclusion For patients undergoing 68Ga-DOTATATE PET/CT scan, an elevated MUS might indicate an underlying heart disease.

scholarly journals Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1421
Author(s):  
Babak Saboury ◽  
Lars Edenbrandt ◽  
Reza Piri ◽  
Oke Gerke ◽  
Tom Werner ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Cardiac Ct ◽  
Standardized Uptake Value ◽  
Coronary Calcification ◽  
High Affinity ◽  
Maximum Standardized Uptake Value ◽  
Atherosclerotic Burden ◽  
Calcification Score ◽  
Pet Ct ◽  
The Individual

Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly 18F-fluorodeoxyglucose (FDG), indicating inflammation, to applying predominantly 18F-sodium fluoride (NaF) due to its high affinity for arterial wall microcalcification and more consistent association with cardiovascular risk factors. To make NaF-PET/CT an indispensable adjunct to clinical assessment of cardiac atherosclerosis, the Alavi–Carlsen Calcification Score (ACCS) has been proposed. It constitutes a global assessment of cardiac atherosclerosis burden in the individual patient, supported by an artificial intelligence (AI)-based approach for fast observer-independent segmentation. Common measures for characterizing epicardial coronary atherosclerosis by NaF-PET/CT as the maximum standardized uptake value (SUV) or target-to-background ratio are more versatile, error prone, and less reproducible than the ACCS, which equals the average cardiac SUV. The AI-based approach ensures a quick and easy delineation of the entire heart in 3D to obtain the ACCS expressing ongoing global cardiac atherosclerosis, even before it gives rise to CT-detectable coronary calcification. The quantification of global cardiac atherosclerotic burden by the ACCS is suited for management triage and monitoring of disease progression with and without intervention.

scholarly journals High Basal Maximal Standardized Uptake Value (SUVmax) in Follicular Lymphoma Identifies Patients with a Low Risk of Long-Term Relapse

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2876
Author(s):  
Giovanni Manfredi Assanto ◽  
Giulia Ciotti ◽  
Mattia Brescini ◽  
Maria Lucia De Luca ◽  
Giorgia Annechini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Follicular Lymphoma ◽  
Standardized Uptake Value ◽  
Metabolic Tumor Volume ◽  
Late Relapse ◽  
Prognostic Role ◽  
Pet Ct ◽  
Group A ◽  
Group B

Background: Despite that the unfavorable prognostic role of a high Total Metabolic Tumor Volume (TMTV) in Follicular Lymphoma has been demonstrated, the role of SUVmax alone at baseline PET/CT could have a different prognostic role. Patients and Methods: We performed a retrospective observational monocentric cohort study. All patients affected by FL who underwent a basal PET/CT were included. Two subgroups were identified and compared in terms of PFS and OS: (A) Basal SUVmax ≤ 6; and (B) Basal SUVmax > 6. Results: Ninety-four patients were included, 34 in group A (36.2%) and 60 in group B (63.8%). The PFS at two years was comparable in the two groups (97%). The five-year PFS was 73.5% for group A and 95% for group B (p 0.005). The five-year PFS in the whole cohort was 87.5%. A clear advantage was confirmed in group A in the absence of other risk factors. Patients with SUVmax ≤ 6 and no risk factors showed a 5-year PFS of 73% against 83% for patients with SUVmax > 6 and at least two risk factors. Conclusion: A high FDG uptake favorably correlated with PFS. A low basal SUVmax reflected a higher rate of late relapse requiring a prolonged follow-up. The basal SUVmax is an approachable parameter with prognostic implications.

scholarly journals Comprehensive Study of Acute Myocardial Infarctions Triggers

2020 ◽  
Author(s):  
Kamal Khademvatani ◽  
Amin Sedokani ◽  
Sima Masudi ◽  
Parisa Nejati ◽  
Mir Hossein Seyed-Mohammadzad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Health Care Systems ◽  
Ischemic Heart ◽  
Clinical Event ◽  
P Value ◽  
Cross Sectional

AbstractAimMyocardial infarction (MI) is one of the most important cardiovascular diseases. A trigger is an external stimulus, potential to create a pathological change leading to a clinical event. In addition to classic risk factors of ischemic heart disease and myocardial infarction, MI triggers play critical roles in the incidence of acute MI.Methods and ResultsThis is a cross-sectional study of 254 patients with the first acute myocardial infarction referring to Seyedoshohada heart center of Urmia, Iran were enrolled in the study within one year of study. After 48h of hospitalization and, treatment, and cardiac caring, the patients were provided with the questionnaire to collecting the history of the disease ad triggers. In addition to laboratory and paraclinical data, the analysis of the study was performed. Out of 220 (86.4%) patients with STEMI and 34 (13.6%) patients with NSTEMI, there were significant differences (P-value <0.05) in AMI triggers with LVEF (0.03), gender (0.027), residency and living area (0.039), occupation (0.002), smoking (0.008), abnormal serum TG levels (0.018) and the season of AMI occurrence (0.013). The mean age for AMI patients was 60.4±12.97 years old with a mean BMI of 26.65±4.35 kg/m2.ConclusionIn addition to classic risk factors of ischemic heart disease and myocardial infarction, health care systems and physicians must pay more attention to triggers that may induce an acute myocardial infarction in people with predisposing factors especially in the male sex, stressful and hand working jobs, and psychological and mental tension patients.

scholarly journals HELLP SYNDROME AND HEART DISEASE (A CROSS SECTIONAL STUDY - JEDDAH- KSA)

2020 ◽  
Vol 8 (12) ◽  
pp. 1135-1140
Author(s):  
Hanyah Abdulhadi Al-Khify ◽  
◽  
Manal Abdulaziz Murad ◽  
Fatima Ibrahim Albeladi ◽  
Hoda Jehad Abousada ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Saudi Arabia ◽  
Heart Disease ◽  
Liver Function ◽  
Cardiac Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Background: HELLP is a potentially life-threatening conditions which has some similarity with preeclampsia therefore, it poses a challenging diagnostic and management issues for clinician. It is composed of H=hemolysis, EL=elevated liver enzymes and LP=low platelets. The aims of this study are to assess the prevalence of HELLP syndrome among Saudi Arabian, besides, assessing the risk factors related to it. Methodology: This is an analytical cross-sectional study conducted in kingdom of Saudi Arabia (female who previously get pregnant) from 07/08/2020 till 29/11/2020. The study was depending on using of online questionnaire assessing demographic factors including age and nationality besides disease-related information: Heart disease, Smoker patient, related risk factors of disease and DM patient. Results: We included 457 women who agreed to participate in the study and completed the questionnaire. 36.1 % of participants were aged between 25-35 years. 13.3 % of the sample had reported that they are smokers and 6.1 % as X-smokers while 16.8 % of the sample had diabetes mellitus. The prevalence of HELLP was 38.3 %. It was found that age is not a significant factor in occurrence of HELLP symptoms except in having distribution of liver function (P=0.005). Cardiac diseases are another significant risk factor in developing symptoms of HELLP especially high blood pressure where 46 % of patients with cardiac disease reported having high blood pressure during pregnancy with a risk of eight times over those with no cardiac disease (OR=8.03, 95 % CI=4.2100 to 15.3, P=0.000) however, it has no significant effect on developing disturbance in liver function. Conclusion: we had found the 38.3 % of females in Saudi Arabia had HELLP in their pregnancy, with increase the prevalence of some other conditions including smoking, diabetes mellitus, hypertension and autoimmune diseases which all found to increase the risk for developing HELLP in females. More investigation is needed to explore the same prevalence using hospital based study design.

scholarly journals The prevalence and associated cardiovascular risk factors in resistant hypertensive subjects in Eastern India

2014 ◽  
Vol 5 (4) ◽  
pp. 1-5 ◽  
Author(s):  
Pijush Kanti Mandal ◽  
Arpan Kumar Day ◽  
Subhraprakash Pramanik ◽  
Shovan Kumar Das ◽  
Sumit Khotick ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Ischemic Heart Disease ◽  
Cardiovascular Risk Factors ◽  
Resistant Hypertension ◽  
P Value ◽  
Hypertensive Patients ◽  
Co Morbidity

Background: To study the prevalence and associated cardiovascular risk factors of ‘Resistant’ hypertension (RHT) in hypertensive patients of India.Methods: A descriptive cross-sectional observational study was carried out among 300 hypertensive patients attending ‘Hypertension Clinic’ and providing informed written consent from October 2013 to December 2013 at Burdwan Medical College and hospital, Burdwan, West Bengal in India. A pre-tested interviewer-administered questionnaire was used for data collection. Results: The prevalence of Resistant hypertension was 23.33% among all hypertensives. The patients with Resistant hypertension were significantly associated with older age groups (>55 years) (77.1% vs. 38.3%, p value <0.001, OR 5.446, 95% CI 2.935 and 10.104), Obesity (BMI > 27.5 kg/m2) (67.1% vs. 45.7%, p value 0.002, OR 2.433, 95% CI 1.387 and 4.268), Diabetes mellitus (72.9% vs. 45.2%, p value <0.001, OR 3.252, 95% CI 1.808 and 5.851), Prolonged hypertension (>10 years; 74.3% vs. 43.9%, p value <0.001, OR 3.690, 95% CI 2.033 and 6.696) and co-morbidity like Ischemic Heart Disease (60% vs. 44.8%, p value 0.026, OR 1.850, 95% CI 1.073 and 3.187) as risk factors as compared to patients with non-resistant hypertension. Conclusions: Nearly one fourth of the hypertensive persons were suffering from Resistant hypertension, which was significantly associated with the presence of older age, obesity, diabetes mellitus, longer duration of hypertension and co-morbidity like Ischemic Heart Disease as risk factors. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9737 Asian Journal of Medical Sciences 2014 Vol.5(4); 1-5

Abstract TMP111: Risk Factors Associated With Watershed Stroke in Pediatric Patients Undergoing Fontan Operation

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Jay Duncan ◽  
Jo A Tilley ◽  
Mahnoor Javed ◽  
Johnbosco Umejiego ◽  
Tyler Hamby ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ventricular Function ◽  
Cardiac Disease ◽  
Fontan Operation ◽  
Significant Risk ◽  
Disease Diagnosis ◽  
P Value ◽  
Valve Regurgitation ◽  
Factors Associated ◽  
Fontan Surgery

Introduction: Cardiac disease is one of the leading causes of stroke in children. In an effort to separate pulmonary and systemic circulations, patients with single ventricle physiology undergo the Fontan surgery. Watershed strokes have been reported as a complication of Fontan surgery but literature on its prevalence and associated risk factors is lacking. Methods: Retrospective review of records of patients who underwent Fontan operation at our center from 2007 to 2018. Demographic, clinical, imaging, and outcome data were documented for all patients. Key risk factors evaluated:cardiac diagnosis, presence of significant AV-valve regurgitation, poor ventricular function, cardio-pulmonary bypass (CPB) time, Hematocrits, mean arterial pressure (Map) and significance of post-operative resuscitation measured by cardiac index and vasoactive infusion score. Univariate logistic regression was used for analyses, and a p-value of <0.05 was considered statistically significant. Results: We identified 149 patients;14 (10%) had clinical evidence and radiographic confirmation of a watershed stroke. There were no arterial ischemic strokes.From all the variables analyzed (Table 1), patients with significant A-V valve regurgitation pre- and post-operatively, depressed single ventricular function, and underlying diagnosis of hypoplastic left heart syndrome (HLHS) were at a higher risk for watershed strokes. No other risk factors were identified. (Table 1). All had no significant motor deficits at discharge. Conclusion: At our center, watershed infarcts occurred in 10% of patients undergoing Fontan surgery. Cardiac disease diagnosis and factors associated to cardiac function were significant risk factors for watershed stroke rather than surgical related variables.

scholarly journals ANALISIS FAKTOR RISIKO MODIFIKASI PENYAKIT JANTUNG KORONER DI RSU HAJI SURABAYA TAHUN 2019

2021 ◽  
Vol 10 (1) ◽  
pp. 47
Author(s):  
Citra Rachmawati ◽  
Santi Martini ◽  
Kurnia Dwi Artanti
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Smoking Behavior ◽  
World Health ◽  
P Value ◽  
Health Organization ◽  
Diabetes Melitus

ABSTRAKLatar Belakang: Pola penyakit saat ini mengalami transisi epidemiologi, salah satunya dibuktikan oleh perkembangan dari penyakit tidak menular yaitu penyakit jantung. Penyakit jantung khususnya jantung koroner ini termasuk penyakit yang menduduki tingkat nomor satu di dunia.. Diperkirakan angka kematian akibat penyakit Jantung Koroner akan mengalami peningkatan hingga 23,3 juta pada tahun 2030 (World Health Organization 2013). Penelitian ini membahas mengenai faktor risiko PJK yaitu hipertensi, diabetes melitus, aktivitas fisik, dan perilaku merokok.Tujuan: Penelitian ini bertujuan untuk menganalisis faktor risiko hipertensi, diabetes melitus, aktivitas fisik, dan perilaku merokok pada pasien penyakit jantung koroner di Rsu Haji Surabaya tahun 2019.Metode: Penelitian ini merupakan penelitian observasional dan bersifat analitik. Desain penelitian yang digunakan adalah case control.Hasil: Penelitian ini menunjukkan bahwa variabel hipertensi memiliki hubungan (p-value = 0,0 ; p<0,05) terhadap penyakit jantung koroner, variabel diabetes melitus memiliki hubungan (p-value= 0,00 ; p<0,05) terhadap penyakit jantung koroner dan variabel aktifitas fisik memiliki hubungan yang signifikan (p-value = 0,017; OR = 0,184; 95%CI =0,039-0,861) dengan kejadian penyakit jantung koroner. Sedangkan hasil yang tidak beruhubungan yaitu pada variabel perilaku merokok (p-value = 0,250; OR = 1,463; 95%CI=0,764-2,802) terhadap penyakit jantung koroner. Kesimpulan: Berdasarkan hasil dan pembahasan dapat disimpulkan bahwa hipertensi, diabetes melitus, dan aktifitas fisik memiliki hubungan dan termasuk faktor risiko kejadian penyakit jantung koroner. Sedangkan perilaku merokok tidak menunjukkan adanya hubungan yang signifikan dengan kejadian penyakit jantung koroner. Kata kunci: Penyakit jantung, jantung koroner dan faktor risiko ABSTRACTBackground: The pattern of disease is currently undergoing an epidemiological transition, one of which is evidenced by the development of non-communicable diseases, namely heart disease. Heart disease, especially coronary heart disease, is a disease that ranks number one in the world. It is estimated that the death rate due to coronary heart disease will increase to 23.3 million in 2030 (World Health Organization 2013). This study discusses the risk factors for CHD, namely hypertension, diabetes mellitus, physical activity, and smoking behavior. Purpose: The purpose of this study was to analyze the risk factors for hypertension, diabetes mellitus, physical activity, and smoking behavior in coronary heart disease patients at Rsu Haji Surabaya in 2019. Methods: This study was an observational and analytical study. The research design used was case-control. Results: The results of this study indicate that the hypertension variable has a relationship (p-value = 0.00; p <0.05) on coronary heart disease, the diabetes mellitus variable has a relationship (p-value = 0.00; p <0.05) on coronary heart disease and the activity variable physical had a significant relationship (p-value = 0.017; OR = 0.184; 95% CI=0.039-0.861) with the incidence of coronary heart disease. While the results that were not related were the smoking behavior variable (p-value = 0.250; OR = 1.463; 95% CI=0.764-2.802) on coronary heart disease.Conclusion: Based on the results and discussion, it can be concluded that hypertension, diabetes mellitus, and physical activity have a relationship and include risk factors for coronary heart disease. Meanwhile, smoking behavior does not show a significant relationship with the incidence of coronary heart disease. Keywords: Cardiovascular diseas, coronary heart and  risk factors.

Sign in / Sign up

Export Citation Format

Share Document