scholarly journals Two Cases of Hepatic Mastocytoma in Sheep

1972 ◽  
Vol 9 (2) ◽  
pp. 159-163 ◽  
Author(s):  
A. C. Johnstone
Keyword(s):  
Lymph Node ◽  
The Other ◽  
First Report ◽  
Hepatic Neoplasia

Two mastocytomas of the liver of sheep are described. The specimens were obtained during a survey of hepatic neoplasia that was conducted on abattoir-slaughtered sheep. Although tissues other than the liver were not examined, both tumours had metastasised, one to the portohepatic lymph node, and the other intrahepatically. It is believed that this is the first report of mastocytoma in this species.

Superconductive Properties of CsxRbyC60 (33K) - Isotope Effect -

1992 ◽  
Vol 247 ◽  
Author(s):  
T. W. Ebbesen ◽  
K. Tanigaki ◽  
S. Saito ◽  
J. Mizuki ◽  
J. S. Tsai ◽  
...  
Keyword(s):  
Fermi Level ◽  
Penetration Depth ◽  
Isotope Effect ◽  
Lattice Constant ◽  
Density Of States ◽  
Coherence Length ◽  
The Other ◽  
First Report ◽  
Electron Coupling

ABSTRACTThe surprisingly high Tc for the superconductivity of alkali doped C60 has spurred wide interest in understanding its mechanism [1–7]. We first report the superconductive properties of CsxRbyC60 which has a Tc as high as 33 K when x=2 and y=1 in the feed [4, 5]. SQUID measurements show that in this material the coherence length is 45 A and the penetration depth about 1, 800 A [5]. It has now been proven that the observed increase in the Tc with the size of the alkali dopant is due to the increase in the lattice constant [6]. This is most likely due to the changes in the density of states at the Fermi level. The other important parameter according to BSC theory is the phonon which mediates the electron-electron coupling. In the second part of this paper we present recent results which show that the Tc is indeed strongly influenced by this parameter [7]. The isotope effect is unexpectedly strong on the Tc.

scholarly journals MON-533 Diffuse Sclerosing Variant Papillary Thyroid Cancer: Clinical and Histopathological Features, Mutational Profile, Management and Outcome

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Abeer Abdulhadi Aljomaiah ◽  
Yosra Moria ◽  
Nora Aldaej ◽  
Meshael Alswailem ◽  
Ali Saeed Alzahrani
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Molecular Genetics ◽  
Papillary Thyroid Cancer ◽  
Distant Metastases ◽  
The Other ◽  
Papillary Thyroid ◽  
Histopathological Features ◽  
Diffuse Sclerosing Variant

Abstract Diffuse sclerosing variant (DSV) is a rare subtype of papillary thyroid cancer (PTC). Whether it represents a higher grade subtype than conventional PTC is not quite clear. Furthermore, there are limited data on its long-term outcome and its molecular genetics. In this report, we studied all cases of DSV PTC seen at our center during the last 20 years. Out of more than 6000 patients (pts) with differentiated thyroid cancer, only 37 were DSV. We reviewed the clinical and histopathological features, management and outcome of these cases. In addition, molecular genetics is partially achieved; 17 out of these 37 cases have been genotyped for BRAFV600E, TERT promotor mutations, NRAS, HRAS and KRAS mutations. The molecular profiling of the other 20 cases is being done. A total of 37 pts were studied {(12 Males:25 Females, median age 21 years (8-89)}. One pt had lobectomy and the other 36 pts (97.3%) had a total thyroidectomy. Central only (4 pts) or central/lateral lymph node dissection (29 pts) were performed. The median tumor size was 4.5 cm (1.5-8.1). The tumor was multifocal in 27 cases (73%), with extrathyroidal invasion in 27 (73%) and lymphovascular invasion in 24 pts (64.8%). A background lymphocytic thyroiditis was present in 12 pts (32.4%). Lymph node metastases were present in 34 pts (92%) and distant metastases in 13 pts (35%). The sites of metastasis are lungs in 12 pts (32.4%) and lungs and bone in 1 pt. Twenty pts (54.1%) were in TNM8 stage 1, 10 pts (27%) in stage 2, 1 (2.7%) in stage 4a, 3 (8.1%) in stage 4b and 3 unstageable. The ATA risk classification for these pts was 4 pts (10.8%) in low, 12 (32.4%) in intermediate, 19 (51.4%) in high-risk groups and 2 could not be assessed. I-131 was administered to 33 pts (89.2%). The median administered activity was 136 mCi (46-218). Fifteen pts (40.5%) received additional therapies (3 surgeries, 7 RAI, 5 surgeries, and RAI). In 17 pts (46%) which were genotyped, only 3 tumors (8.1%) had BRAFV600E mutation, 1 (2.7%) had TERT promotor C228T mutation and none had RAS mutations. At the last follow up, 15 pts (40.5%) achieved an excellent response, 9 (24%) an indeterminate response, 6 (16.2%) with a structural disease, and 7 (19%) were lost for follow up. Conclusion: DSV PTC is a rare variant, occurs mostly in adolescent and young pts, characterized by aggressive histopathological features and high rates of lymph node and distant metastases but the commonly reported mutations in PTC are rare in DSV and mortality is absent.

scholarly journals Some Peculiarities of Variable Optical Spectra of 11 Low-Redshift Quasars

1994 ◽  
Vol 159 ◽  
pp. 518-518
Author(s):  
I.I. Pronik
Keyword(s):  
Seyfert Galaxy ◽  
Optical Spectra ◽  
The Other ◽  
Bench Mark ◽  
Published Data ◽  
First Report ◽  
Ngc 1275 ◽  
Very High ◽  
Calibration Coefficients ◽  
The Continuum

The flux of narrow 5007 Å [OIII] forbidden line during last 20 years is accepted as a bench-mark for calibration of the continuum and broad-lines fluxes in AGN. But one can not get away from the problem of the forbidden lines variability in these objects. The first report were published by Bardin et al. (1967). Some of the results are revieved by V. Pronik, I. Pronik (1988, 1992). There were 4 years monitoring of [OIII] fluxes variability in the Seyfert galaxy NGC 1275 nucleus (Pronik et al., 1990). Now we reexamine the published data of W. Zheng et al. (1986, 1987, 1988), discussed earlier in supposition of forbidden lines constant in spectra of 11 low-redshifted QSOs. Maximal calibration coefficients adopted by W. Zheng et al. in supposition of [OIII] lines constant were in the interval 2.0–3.6. On the other hand the fluxes errors are about 15%. Disagreement is very high. This is one of the arguments in the forbidden lines variability Tightness.

scholarly journals Karyotype analysis with orcein and CMA in two species of Alocasia (Schott) G. Don (Araceae)

1970 ◽  
Vol 40 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Syeda Sharmeen Sultana ◽  
Hosne Ara ◽  
Sheikh Shamimul Alam
Keyword(s):  
Chromosome Number ◽  
Key Words ◽  
Karyotype Analysis ◽  
Chromosome Complement ◽  
Taxonomic Status ◽  
The Other ◽  
First Report ◽  
Total Length ◽  
Internet Information ◽  
Chromosomal Length

Alocasia fallax Schott and A. odora (Roxb.) Koch (Araceae) were investigated cytogenetically to confirm their taxonomic status. There is no report of 2n chromosome number for A. fallax in the available literature and internet information. Therefore the 2n chromosome number (2n = 28) found in this study is probably the first report for A. fallax. Alocasia odora showed exactly double 2n chromosome number (2n = 56) from A. fallax. In addition to chromosome number, the other karyotypic features of A. odora were exactly double for that of A. fallax. The centromeric formulae of A. fallax was 24 m + 4 sm whereas it is just double in A. odora. Total length of 2n chromosome complement of A. odora (62.58 μm) was almost double to A. fallax. The range of chromosomal length of the two species was almost same. Moreover, A. odora plant is much taller than A. fallax. All of these data suggests that A. odora might be an autotetraploid of A. fallax which in course of evolution had undergone some changes in GC-rich repeats. Key words: Alocasia; CMA; Karyotype analysis DOI: http://dx.doi.org/10.3329/bjb.v40i1.7998 Bangladesh J. Bot. 40(1): 53-56, 2011 (June)

scholarly journals Lymph node metastasis prediction of papillary thyroid carcinoma based on transfer learning radiomics

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinhua Yu ◽  
Yinhui Deng ◽  
Tongtong Liu ◽  
Jin Zhou ◽  
Xiaohong Jia ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Transfer Learning ◽  
Area Under The Curve ◽  
The Other ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Diagnostic Time

Abstract Non-invasive assessment of the risk of lymph node metastasis (LNM) in patients with papillary thyroid carcinoma (PTC) is of great value for the treatment option selection. The purpose of this paper is to develop a transfer learning radiomics (TLR) model for preoperative prediction of LNM in PTC patients in a multicenter, cross-machine, multi-operator scenario. Here we report the TLR model produces a stable LNM prediction. In the experiments of cross-validation and independent testing of the main cohort according to diagnostic time, machine, and operator, the TLR achieves an average area under the curve (AUC) of 0.90. In the other two independent cohorts, TLR also achieves 0.93 AUC, and this performance is statistically better than the other three methods according to Delong test. Decision curve analysis also proves that the TLR model brings more benefit to PTC patients than other methods.

scholarly journals Successful Treatment of Transient Central Diabetes Insipidus following Traumatic Brain Injury in a Dog

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Catriona Croton ◽  
Sarah Purcell ◽  
Andrea Schoep ◽  
Mark Haworth
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Diabetes Insipidus ◽  
Successful Treatment ◽  
Serum Sodium ◽  
Rapid Onset ◽  
Central Diabetes Insipidus ◽  
The Other ◽  
Clinical Progression ◽  
First Report

An 11-year-old female spayed Maltese presented comatose, half an hour after vehicular trauma, and was treated for traumatic brain injury and pulmonary contusions. The dog developed severe hypernatremia within six hours of presentation, which responded poorly to the administration of five percent dextrose in water. As central diabetes insipidus was suspected, desmopressin was trialled and resolution of hypernatremia was achieved six days later. Transient trauma-induced central diabetes insipidus has been described previously in two dogs; in the first, serum sodium concentrations were evaluated three days after injury and the other developed hypernatremia seven days after injury. To the authors’ knowledge, this is the first report of rapid onset, transient, and trauma-induced central diabetes insipidus in a dog that encompasses the complete clinical progression of the syndrome from shortly after injury through to resolution.

Squamous Cell Carcinoma of the Scrotum in a Radiation Technologist and the Use of Sentinel Lymph Node Biopsy in Recurrent Disease

2007 ◽  
Vol 73 (3) ◽  
pp. 302-303 ◽  
Author(s):  
David A. Shifrin ◽  
Marianne K. Lange ◽  
Richard J. Kahnoski ◽  
Anthony N. Avallone
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Biopsy ◽  
First Report ◽  
Node Biopsy ◽  
Uncommon Neoplasm

Squamous cell carcinoma (SCC) of the scrotum is an uncommon neoplasm. It has been described in many different occupations and is associated with a myriad of carcinogens, yet the etiology still remains a mystery. This is the first report of its occurrence in a radiation technologist. Additionally, the use of sentinel lymph node biopsy in SCC has been advocated as a safe method of limiting the morbidity associated with bilateral ilioinguinal dissections. This is the first report of its use in recurrent metastatic SCC of the scrotum.

Morfologia dei polinucleati neutrofili studiata con il metodo gemellare Nota prima: La formula di Arneth

1956 ◽  
Vol 5 (2) ◽  
pp. 125-137
Author(s):  
G. Torrioli Riggio ◽  
L. Reggiani
Keyword(s):  
The Other ◽  
First Report ◽  
Group I ◽  
Mz Twins ◽  
The Relationship ◽  
Disease Factor

SUMMARYIn this first report the Authors take into consideration only the meaning of group I of Arneth's formula, utilizing the data of the zoo findings on pairs of DZ, of healthy MZ and diseased MZ Twins. They find, in group I, a moderate influence of the disease factor.These findings are believed to be in agreement with Pappenheim's theory, according to which the relationship between the first group of Arneth's formula and the following groups would be lined more closely to a maturative factor influenced by physiopathological conditions than to a cellular constitutional, which is present, though.The genie factor dominate instead in the other four groups, as will be amply shown in the next report.

Classification of Lymph Node Metastases from Gastric Cancer: Comparison between N-Site and N-Number Systems. Our Experience and Review of the Literature

2007 ◽  
Vol 73 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Paolo Aurello ◽  
Francesco D'Angelo ◽  
Simone Rossi ◽  
Riccardo Bellagamba ◽  
Claudia Cicchini ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Value ◽  
Subtotal Gastrectomy ◽  
Tnm Staging ◽  
The Other ◽  
Tnm System ◽  
Node Metastasis ◽  
Number Systems ◽  
Node Location

The tumor, node, metastasis (TNM) system has become the principal method for assessing the extent of disease, determining prognosis in gastric cancer patients, and affecting the therapy strategies. The extent of lymph node metastasis is the most important prognostic factor. The aim of this study was to compare the N-classifications of the 4th and the 5th-6th TNM editions and to evaluate retrospectively the prognostic value of the 2002 TNM edition. We evaluated 344 patients who underwent curative total or subtotal gastrectomy. Nodal involvement was detected in 221 (64%) patients. Median follow-up period was 76 months. Thirty per cent of the old N1 patients were reclassified as pN2 (18.5%) and pN3 (11.3%). Eighty-eight per cent of the old N2 patients were reclassified as pN1 (75%) and pN3 (13.7%). In reclassifying the patients, statistically significant changes were reported between 1987 and 2002 TNM stage grouping, mainly in stage IIIB and IV. The 5-year survival rate per stage group did not statistically differ between the 4th and the 5th–6th editions, although a diminutive trend was registered in the IIIA stage. pTNM stage, nodal numerical stage, nodal topographical stage, and depth of tumor invasion resulted in significantly independent prognostic factors. Our data confirm the simplicity and easy application of the new stadiation and the better prognostic stratification of the N-stage. The pN3 group showed a worse prognosis independent of location. On the other hand, prognostic value of pN1 and pN2 stage is lower, probably depending on lymph node location. In multivariate analysis, the difference between old and new TNM staging is low. Hence, we suggest comparing lymph node location and number in larger series. In our series, in pT1 tumors, neither pN2 nor pN3 involvement was found. Hence, in our opinion, for correct N-staging, 10 lymph nodes in early gastric cancer and at least 16 in the other pT-stages seem sufficient for a real pN0 stadiation.

Cancer cells uptake porphyrinsviaheme carrier protein 1

2013 ◽  
Vol 17 (01n02) ◽  
pp. 36-43 ◽  
Author(s):  
Kazuhiro Hiyama ◽  
Hirofumi Matsui ◽  
Masato Tamura ◽  
Osamu Shimokawa ◽  
Mariko Hiyama ◽  
...  
Keyword(s):  
Laser Beam ◽  
Cancer Cells ◽  
The Other ◽  
Carrier Protein ◽  
Hematoporphyrin Derivative ◽  
Lower Intensity ◽  
First Report ◽  
Over Expression ◽  
Other Hand ◽  
Eximer Laser

Although exogenous porphyrin accumulation in cancer cells is important for the success of photodynamic therapies, the mechanism is not clear. We hypothesized that a newly reported transporter, heme carrier protein 1 (HCP1), is highly expressed in cancer cells, and transports porphyrins into the cells. We investigated the following three unknowns: whether cancer cells take up hematoporphyrin derivative via HCP1, whether HCP1 is involved in photodynamic therapies, and whether cancer cells highly express HCP1. First, when HCP1-overexpressed cells were treated with hematoporphyrin derivative and then exposed to an eximer laser beam, they emitted a significantly higher intensity of hematoporphyrin derivative fluorescence and became more susceptible to the laser beam than control. Second, when three other types of cancer cells with silenced HCP1 were treated with hematoporphyrin derivative and then exposed to the laser beam, they emitted a significantly lower intensity of hematoporphyrin derivative fluorescence. Third, non-cancer cells slightly expressed HCP1; on the other hand, the three other types of cancer cells clearly expressed HCP1. These results indicated that cancer cells uptake hematoporphyrin derivative via HCP1 and over-expression of HCP1 increases the efficacy of photodynamic therapies by increasing porphyrin accumulation in the cells. This is the first report about a transporter of porphyrin in cancer cells.

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