Impact of Phase Sequence on Cycle Length Resonance

Author(s):  
Christopher M. Day ◽  
A. M. Tahsin Emtenan

The concept of resonant cycle length, that there are certain cycle lengths that may provide excellent progression owing to corridor geometry and other factors, has some currency as a potential strategy for cycle length selection. Past studies have identified resonant cycles under certain conditions and demonstrated benefits from use of the strategy as a means of selecting cycle length. The present study revisited the concept in application to flow-based models of traffic signal performance, highlighting the impact of phase sequence optimization. The phenomenon of cycle length resonance was explored for corridors with equal and randomly generated spacing between intersections, and finally for a field-calibrated corridor. Under each scenario, the performance of different cycle lengths was explored under two optimization strategies: optimization of only offsets, and optimization of both offsets and phase sequence. It was found that phase sequence has a substantial impact on the performance of coordination. Optimized phase sequences were found to yield 8% to 14% improvement in performance compared with use of the default sequence. For corridors where a resonant cycle length was evident, when phase sequences could also be adjusted, the poorer performance of non-resonant cycle lengths could be mitigated by optimizing phase sequence. Although use of a resonant cycle length is likely to yield good performance for some corridors under appropriate conditions, the use of a phase sequence optimization strategy is likely to have a strong impact on most corridors, and could be more impactful than selection of a resonant cycle length.

2014 ◽  
Vol 19 (2) ◽  
pp. 343-370 ◽  
Author(s):  
Krista E. Wiegand

This article seeks to explain factors that make mediation attempts more or less likely in territorial, maritime, and river disputes. I argue that the intensity of the dispute and the salience of disputed territory have strong influence on mediation attempts. The study further examines the impact of these factors on the type of mediation strategy (directive, procedural, or communications). Hypotheses about mediation attempts are tested with the icow data set of interstate territorial, maritime, and river disputes from 1816 to 2001. Findings indicate that intensity of the dispute and salience of disputed territory have a strong impact on the selection of mediation in the first place, and second, that salience of disputed territory makes the directive strategy more likely, while intensity of the dispute makes procedural or communications strategies more likely.


2020 ◽  
Vol 6 (30) ◽  
pp. eaay9206
Author(s):  
Gajendra W. Suryawanshi ◽  
Wannisa Khamaikawin ◽  
Jing Wen ◽  
Saki Shimizu ◽  
Hubert Arokium ◽  
...  

Despite advances in hematopoietic stem/progenitor cell (HSPC) transplant for HIV-1–infected patients, the impact of a preexisting HIV-1 infection on the engraftment and clonal repopulation of HSPCs remains poorly understood. We have developed a long terminal repeat indexing-mediated integration site sequencing (LTRi-Seq) method that provides a multiplexed clonal quantitation of both anti–HIV-1 RNAi (RNA interference) gene-modified and control vector-modified cell populations, together with HIV-1–infected cells—all within the same animal. In our HIV-1–preinfected humanized mice, both therapeutic and control HSPCs repopulated efficiently without abnormalities. Although the HIV-1–mediated selection of anti–HIV-1 RNAi-modified clones was evident in HIV-1–infected mice, the organ-to-organ and intra-organ clonal distributions in infected mice were indistinguishable from those in uninfected mice. HIV-1–infected cells showed clonal patterns distinct from those of HSPCs. Our data demonstrate that, despite the substantial impact of HIV-1 infection on CD4+ T cells, HSPC repopulation remains polyclonal, thus supporting the use of HSPC transplant for anti-HIV treatment.


Author(s):  
Burak Cesme ◽  
Peter G. Furth ◽  
Ryan Casburn ◽  
Kevin Lee

At signalized intersections, pedestrian phases can be configured as recall or pushbutton actuated. While pedestrian recall results in a moderate reduction in pedestrian delay because, with recall, a pedestrian arriving during the time nominally reserved for the Walk interval will be served immediately rather than waiting to be served in the next cycle, it can also lead to longer cycle lengths, increasing delay for all users, including pedestrians. This research explores the impact of pedestrian recall along a coordinated-actuated arterial for pedestrians crossing the mainline (i.e., crossing the coordinated phase) to provide pedestrian recall versus actuation guidelines for agencies. The guidance was developed with the aim of balancing pedestrian delay with operational efficiency for vehicles. Two criteria were considered while developing the guidance: (1) pedestrian demand; and (2) vehicular green time duration for the concurrent vehicle phase that is parallel to the pedestrian crossing. VISSIM microsimulation software was used on a real network in Fairfax County, Virginia to model the effects of pedestrian recall and actuation. Results showed that pedestrian recall should be considered when pedestrian demand is large enough that there is a pedestrian call in most cycles (pedestrian probability in a given cycle is greater than 0.6 or pedestrian volume per cycle is greater than 0.9). The guidance also suggests setting pedestrian phases on recall when the length of the vehicular green for the concurrent phase is long enough in most cycles that a pedestrian phase would fit without constraining the signal cycle length.


2016 ◽  
Vol 11 (3) ◽  
pp. 129 ◽  
Author(s):  
Sima Ghaleb Magatef ◽  
Raed Ahmad Momani

This study aims to identify the impact of internal marketing on the performance of employees in Jordanian private hospitals sector. This study was conducted on all employees of several administrative levels in this sector. The study also aims to find out the impact of independent variables namely, in-house training, incentives, rewards, internal communication, empowerment and culture of the organization, on the dependent variable, which is the performance of employees. To achieve the study objectives, data were collected through the selection of a random sample of workers in private Jordanian hospital sector from various levels. 450 copies of the designed questionnaire were distributed over the targeted sample group. However, only 333 copies of the questionnaire were recovered, and this is 74% of the total number of the distributed copies. The results show that the organization culture has strong impact on the employee’s performance. This variable came first among other variables, followed by the variables about incentives and rewards regarding the impact on the dependent variable employees. On the other hand, the rest of variables showed weak impact on the dependent variable either due to lack of employee’s interest, or the lack of their awareness regarding the importance of these variables and the need to apply them in order to improve the performance of employees and increase their efficiency and effectiveness at work.


2002 ◽  
Vol 283 (6) ◽  
pp. H2706-H2713 ◽  
Author(s):  
Zoran B. Popović ◽  
Kent A. Mowrey ◽  
Youhua Zhang ◽  
Shaowei Zhuang ◽  
Tomotsugu Tabata ◽  
...  

Atrial fibrillation (AF) is characterized by short and irregular ventricular cycle lengths (VCL). While the beneficial effects of heart rate slowing (i.e., the prolongation of VCL) in AF are well recognized, little is known about the impact of irregularity. In 10 anesthetized dogs, R-R intervals, left ventricular (LV) pressure, and aortic flow were collected for >500 beats during fast AF and when the average VCL was prolonged to 75%, 100%, and 125% of the intrinsic sinus cycle length by selective atrioventricular (AV) nodal vagal stimulation. We used the ratio of the preceding and prepreceding R-R intervals (RRp/RRpp) as an index of cycle length irregularity and assessed its effects on the maximum LV power, the minimum of the first derivative of LV pressure, and the time constant of relaxation by using nonlinear fitting with monoexponential functions. During prolongation of VCL, there was a pronounced decrease in curvature with the formation of a plateau, indicating a lesser dependence on RRp/RRpp. We conclude that prolongation of the VCL during AF reduces the sensitivity of the LV performance parameters to irregularity.


2009 ◽  
Vol 297 (5) ◽  
pp. H1940-H1948 ◽  
Author(s):  
Kenneth D. Varian ◽  
Ying Xu ◽  
Carlos A. A. Torres ◽  
Michelle M. Monasky ◽  
Paul M. L. Janssen

It is well known that the strength of cardiac contraction is dependent on the cycle length, evidenced by the force-frequency relationship (FFR) and the existence of postrest potentiation (PRP). Because the contractile strength of the steady-state FFR and force-interval relationship involve instant intrinsic responses to cycle length as well as slower acting components such as posttranslational modification-based mechanisms, it remains unclear how cycle length intrinsically affects cardiac contraction and relaxation. To dissect the impact of cycle length changes from slower acting signaling components associated with persisting changes in cycle length, we developed a novel technique/protocol to study cycle length-dependent effects on cardiac function; twitch contractions of right ventricular rabbit trabeculae at different cycle lengths were randomized around a steady-state frequency. Patterns of cycle lengths that resulted in changes in force and/or relaxation times can now be identified and analyzed. Using this novel protocol, taking under 10 min to complete, we found that the duration of the cycle length before a twitch contraction (“primary” cycle length) positively correlated with force. In sharp contrast, the cycle length one (“secondary”) or two (“tertiary”) beats before the analyzed twitch correlated negatively with force. Using this protocol, we can quantify the intrinsic effect of cycle length on contractile strength while avoiding rundown and lengthiness that are often complications of FFR and PRP assessments. The data show that the history of up to three cycle lengths before a contraction influences myocardial contractility and that primary cycle length affects cardiac twitch dynamics in the opposite direction from secondary/tertiary cycle lengths.


Methodology ◽  
2007 ◽  
Vol 3 (1) ◽  
pp. 14-23 ◽  
Author(s):  
Juan Ramon Barrada ◽  
Julio Olea ◽  
Vicente Ponsoda

Abstract. The Sympson-Hetter (1985) method provides a means of controlling maximum exposure rate of items in Computerized Adaptive Testing. Through a series of simulations, control parameters are set that mark the probability of administration of an item on being selected. This method presents two main problems: it requires a long computation time for calculating the parameters and the maximum exposure rate is slightly above the fixed limit. Van der Linden (2003) presented two alternatives which appear to solve both of the problems. The impact of these methods in the measurement accuracy has not been tested yet. We show how these methods over-restrict the exposure of some highly discriminating items and, thus, the accuracy is decreased. It also shown that, when the desired maximum exposure rate is near the minimum possible value, these methods offer an empirical maximum exposure rate clearly above the goal. A new method, based on the initial estimation of the probability of administration and the probability of selection of the items with the restricted method ( Revuelta & Ponsoda, 1998 ), is presented in this paper. It can be used with the Sympson-Hetter method and with the two van der Linden's methods. This option, when used with Sympson-Hetter, speeds the convergence of the control parameters without decreasing the accuracy.


2020 ◽  
Author(s):  
M Testori ◽  
M Kempf ◽  
RB Hoyle ◽  
Hedwig Eisenbarth

© 2019 Hogrefe Publishing. Personality traits have been long recognized to have a strong impact on human decision-making. In this study, a sample of 314 participants took part in an online game to investigate the impact of psychopathic traits on cooperative behavior in an iterated Prisoner's dilemma game. We found that disinhibition decreased the maintenance of cooperation in successive plays, but had no effect on moving toward cooperation after a previous defection or on the overall level of cooperation over rounds. Furthermore, our results underline the crucial importance of a good model selection procedure, showing how a poor choice of statistical model can provide misleading results.


10.28945/2926 ◽  
2005 ◽  
Author(s):  
James N. Morgan ◽  
Craig A. VanLengen

The divide between those who have computer and Internet access and those who do not appears to be narrowing, however overall statistics may be misleading. Measures of computer availability in schools often include cases where computers are only available for administration or are available only on a very limited basis (Gootman, 2004). Access to a computer and the Internet outside of school helps to reinforce student learning and emphasize the importance of using technology. Recent U.S. statistics indicate that ethnic background and other demographic characteristics still have substantial impact on the availability and use of computers by students outside of the classroom. This paper examines recent census data to determine the impact of the household on student computer use outside of the classroom. Encouragingly, the findings of this study suggest that use of a computer at school substantially increases the chance that a student will use a computer outside of class. Additionally, this study suggests that computer use outside of the classroom is positively and significantly impacted by being in a household with adults who either use a computer at work or work in an industry where computers are extensively used.


2020 ◽  
Vol 15 (3) ◽  
pp. 187-201 ◽  
Author(s):  
Sunil K. Dubey ◽  
Amit Alexander ◽  
Munnangi Sivaram ◽  
Mukta Agrawal ◽  
Gautam Singhvi ◽  
...  

Damaged or disabled tissue is life-threatening due to the lack of proper treatment. Many conventional transplantation methods like autograft, iso-graft and allograft are in existence for ages, but they are not sufficient to treat all types of tissue or organ damages. Stem cells, with their unique capabilities like self-renewal and differentiate into various cell types, can be a potential strategy for tissue regeneration. However, the challenges like reproducibility, uncontrolled propagation and differentiation, isolation of specific kinds of cell and tumorigenic nature made these stem cells away from clinical application. Today, various types of stem cells like embryonic, fetal or gestational tissue, mesenchymal and induced-pluripotent stem cells are under investigation for their clinical application. Tissue engineering helps in configuring the stem cells to develop into a desired viable tissue, to use them clinically as a substitute for the conventional method. The use of stem cell-derived Extracellular Vesicles (EVs) is being studied to replace the stem cells, which decreases the immunological complications associated with the direct administration of stem cells. Tissue engineering also investigates various biomaterials to use clinically, either to replace the bones or as a scaffold to support the growth of stemcells/ tissue. Depending upon the need, there are various biomaterials like bio-ceramics, natural and synthetic biodegradable polymers to support replacement or regeneration of tissue. Like the other fields of science, tissue engineering is also incorporating the nanotechnology to develop nano-scaffolds to provide and support the growth of stem cells with an environment mimicking the Extracellular matrix (ECM) of the desired tissue. Tissue engineering is also used in the modulation of the immune system by using patient-specific Mesenchymal Stem Cells (MSCs) and by modifying the physical features of scaffolds that may provoke the immune system. This review describes the use of various stem cells, biomaterials and the impact of nanotechnology in regenerative medicine.


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