Agency for Toxic Substances and Disease Registry's 1997 priority list of hazardous substances. Latent effects—carcinogenesis, neurotoxicology, and developmental deficits in humans and animals

1999 ◽  
Vol 15 (7) ◽  
pp. 602-644 ◽  
Author(s):  
Stephanie R. Ostrowski ◽  
Sharon Wilbur ◽  
C.-H. Selene J. Chou ◽  
Hana R. Pohl ◽  
Yee-Wan Stevens ◽  
...  
2021 ◽  
Vol 22 (22) ◽  
pp. 12131
Author(s):  
Catherine R. Beamish ◽  
Tanzy M. Love ◽  
Matthew D. Rand

Mercury ranks third on the U.S. Agency of Toxic Substances and Disease Registry priority list of hazardous substances, behind only arsenic and lead. We have undertaken uncovering the mechanisms underlying the developmental toxicity of methylmercury (MeHg), inorganic mercury (HgCl2), lead acetate (Pb), and sodium arsenite (As). To probe these differences, we used the Drosophila model, taking advantage of three developmental transitions—pupariation, metamorphosis, and eclosion—to differentiate potentially unique windows of toxicity. We elaborated dose response profiles for each individual metal administered in food and accounted for internal body burden, also extending analyses to evaluate combinatorial metal mixture effects. We observed all four metals producing larval lethality and delayed pupariation, with MeHg being most potent. Compared to other metals, MeHg’s potency is caused by a higher body burden with respect to dose. MeHg uniquely caused dose-dependent failure in eclosion that was unexpectedly rescued by titrating in HgCl2. Our results highlight a unique developmental window and toxicokinetic properties where MeHg acts with specificity relative to HgCl2, Pb, and As. These findings will serve to refine future studies aimed at revealing tissue morphogenesis events and cell signaling pathways, potentially conserved in higher organisms, that selectively mediate MeHg toxicity and its antagonism by HgCl2.


2008 ◽  
Vol 2 (2) ◽  
pp. 104-113 ◽  
Author(s):  
D. Kevin Horton ◽  
Maureen Orr ◽  
Theodora Tsongas ◽  
Richard Leiker ◽  
Vikas Kapil

ABSTRACTBackground: When not managed properly, a hazardous material event can quickly extend beyond the boundaries of the initial release, creating the potential for secondary contamination of medical personnel, equipment, and facilities. Secondary contamination generally occurs when primary victims are not decontaminated or are inadequately decontaminated before receiving medical attention. This article examines the secondary contamination events reported to the Agency for Toxic Substances and Disease Registry (ATSDR) and offers suggestions for preventing such events.Methods: Data from the ATSDR Hazardous Substances Emergency Events Surveillance system were used to conduct a retrospective analysis of hazardous material events occurring in 17 states during 2003 through 2006 involving secondary contamination of medical personnel, equipment, and facilities.Results: Fifteen (0.05%) Hazardous Substances Emergency Events Surveillance events were identified in which secondary contamination occurred. At least 17 medical personnel were injured as a result of secondary contamination while they were treating contaminated victims. Of the medical personnel injured, 12 were emergency medical technicians and 5 were hospital personnel. Respiratory irritation was the most common injury sustained.Conclusions: Adequate preplanning and drills, proper decontamination procedures, good field-to-hospital communication, appropriate use of personal protective equipment, and effective training can help prevent injuries of medical personnel and contamination of transport vehicles and medical facilities. (Disaster Med Public Health Preparedness. 2008;2:104–113)


Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3985
Author(s):  
Jae Young Lee ◽  
Sajid Mushtaq ◽  
Jung Eun Park ◽  
Hee Soon Shin ◽  
So-Young Lee ◽  
...  

Concern about environmental exposure to hazardous substances has grown over the past several decades, because these substances have adverse effects on human health. Methods used to monitor the biological uptake of hazardous substances and their spatiotemporal behavior in vivo must be accurate and reliable. Recent advances in radiolabeling chemistry and radioanalytical methodologies have facilitated the quantitative analysis of toxic substances, and whole-body imaging can be achieved using nuclear imaging instruments. Herein, we review recent literature on the radioanalytical methods used to study the biological distribution, changes in the uptake and accumulation of hazardous substances, including industrial chemicals, nanomaterials, and microorganisms. We begin with an overview of the radioisotopes used to prepare radiotracers for in vivo experiments. We then summarize the results of molecular imaging studies involving radiolabeled toxins and their quantitative assessment. We conclude the review with perspectives on the use of radioanalytical methods for future environmental research.


Author(s):  
Kavitha Marapakala ◽  
A. Abdul Ajees ◽  
Jie Qin ◽  
Banumathi Sankaran ◽  
Barry P. Rosen

Arsenic is the most ubiquitous environmental toxin and carcinogen and consequently ranks first on the Environmental Protection Agency's Superfund Priority List of Hazardous Substances. It is introduced primarily from geochemical sources and is acted on biologically, creating an arsenic biogeocycle. A common biotransformation is methylation to monomethylated, dimethylated and trimethylated species. Methylation is catalyzed by the ArsM (or AS3MT) arsenic(III)S-adenosylmethionine methyltransferase, an enzyme (EC 2.1.1.137) that is found in members of every kingdom from bacteria to humans. ArsM from the thermophilic algaCyanidioschyzonsp. 5508 was expressed, purified and crystallized. Crystals were obtained by the hanging-drop vapor-diffusion method. The crystals belonged to the monoclinic space groupC2, with unit-cell parametersa= 84.85,b= 46.89,c= 100.35 Å, β = 114.25° and one molecule in the asymmetric unit. Diffraction data were collected at the Advanced Light Source and were processed to a resolution of 1.76 Å.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Veronika Holišová ◽  
Martin Urban ◽  
Zuzana Konvičková ◽  
Marek Kolenčík ◽  
Pavel Mančík ◽  
...  

AbstractHerein, Tilia sp. bract leachate was used as the reducing agent for Au nanoparticles (Au NPs) phytosynthesis. The colloidal properties of the prepared Au NPs were determined to confirm their stability over time, and the NPs were then used as active catalysts in soman nerve agent degradation. The Au NPs characterisation, reproducibility and stability studies were performed under transmission electron microscopy, ultraviolet visible spectroscopy and with ζ-potential measurements. The reaction kinetics was detected by gas chromatography coupled with mass spectrometry detector and solid-phase micro-extraction to confirm the Au NPs applicability in soman hydrolysis. The ‘green’ phytosynthetic formation of colloidal crystalline Au NPs with dominant quasi-spherical shape and 55 ± 10 nm diameter was successfully achieved, and there were no significant differences in morphology, ζ-potential or absorbance values observed during the 5-week period. This verified the prepared colloids’ long-term stability. The soman nerve agent was degraded to non-toxic substances within 24 h, with 0.2156 h−1 reaction rate constant. These results confirmed bio-nanotechnology’s great potential in preparation of stable and functional nanocatalysts for degradation of hazardous substances, including chemical warfare agents.


2019 ◽  
Vol 9 (4) ◽  
pp. 484-492
Author(s):  
V. V. Monarkh ◽  
H. V. Pantsyreva

The current condition of the former pesticide storages has been investigated and characterized. All pesticide storages of Kryzhopil region are in extremely poor condition and they contain substantial amounts of unknown mixtures of unusable pesticides, which are stored in bulk in 100% of pesticide storages being a powerful source of environmental pollution by toxicants of various chemical composition. Pesticide residues in different environment (soil, water, plant) have been determined. The research results clearly prove availability of severe local sources of contamination of agricultural lands with organochlorine pesticides. There is a risk of contamination of other environmental objects with hazardous substances and a negative impact of toxic substances on human health. Migration of pesticides from the soil into agricultural products and drinking water has been identified. It has been suggested that poor environmental conditions and consumption of pesticide-contaminated agricultural products and drinking water lead to an increase in the number of human diseases. It has been found that the population of the district has much higher morbidity rates compared to the indicators of the oblast. Step-by-step environmental risk assessment has been carried out.


PEDIATRICS ◽  
1961 ◽  
Vol 28 (3) ◽  
pp. 499-500
Author(s):  
George W. Wheatley

ABOUT 10 years ago when the Committee on Accident Prevention was created, the Academy focused national attention on accidents as the No. 1 cause of death in childhood and a major contributor to disability, disfigurement and crippling. One of the most spectacular features of this Committee's program is its efforts to prevent and treat poisoning in children, as demonstrated by the amazing growth of poison control centers. Through these community facilities, valuable data on the occurrence and frequency of childhood poisoning have been brought to light. This information has documented an impression held for a long time by many pediatricians: namely, that the creativeness of modern chemistry is both a boon and a bane, the latter all too often in the case of toddlers from about 1 to 4 years of age. Legislation has always been one of the most important means of accident prevention, including accidental poisoning. For example, an early and very effective law aimed at reducing lye burns and deaths from corrosive poisoning in children was the Federal Caustic Poisons Act of 1927, which was developed with the support of organized medicine, under the able leadership of Chevalier Jackson, Sr. But as new products and new hazards increased, new legislation was required for greater protection. The Federal Hazardous Substances Labeling Act of July 1960 grew out of the concerted efforts of organized medicine and the industries concerned. This law now adds a new dimension to health protection from a wide variety of hazardous products found in or about the home, in addition to the 12 substances formerly labeled "Poison" under the old Caustic Poisons Act. Hazardous products include those that are flammable, toxic by ingestion, inhalation or absorption, explosive, caustic, irritant or strong sensitizers. Because parents often are not aware of the danger of such products, the articles are readily available to young children for unsafe investigation. Jensen and Wilson reported, in a study of 100 cases of poisonings in children, that "in 53 cases the poison was not in its usual place, either because it was in use, because persons other than the parents had left it out, or because the parents themselves were careless." Recent mortality data reveal that there are at least 1,400 deaths at all ages from solid and liquid substances, with about 450 deaths in children under 5 years. Last year 35,000 cases of accidental poisoning were reported to the National Clearinghouse from 182 centers in 37 States. The National Health Survey has estimated that 822,000 ingestions of toxic substances occur each year. Both the householder and physician will benefit from the requirements of this new law. Information to prevent accidents from household products and to offer appropriate first aid when accidents occur must now be readily available to users and physicians. The hazardous substance must be revealed, together with such precautionary warnings and measures as are necessary for safe use and handling of such products.


Author(s):  
David Vogel

This chapter looks at American and European policies toward the risks of chemicals and hazardous substances. The 1976 Toxic Substances Control Act (TSCA) significantly strengthened American chemical regulations and contributed to the 1979 decision of the EU to both harmonize and strengthen its chemical regulations, though they remained weaker than those of the United States. While there has been no major statutory change in American chemical regulation since then, in 2006 the EU approved REACH—the Registration, Evaluation, Authorization and Restriction of Chemicals, which made European chemical regulations significantly more stringent and comprehensive than those of the United States. Meanwhile, risk assessments by the U.S. federal government do not consider the hazardous substances in electronics deposited in landfills as a threat to public health.


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