Canine Periodontal Disease Control Using a Clindamycin Hydrochloride Gel

2011 ◽  
Vol 28 (4) ◽  
pp. 224-229 ◽  
Author(s):  
Thomas P. Johnston ◽  
Pravakar Mondal ◽  
Dhananjay Pal ◽  
Scott MacGee ◽  
Arnold J. Stromberg ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Fusobacterium Nucleatum ◽  
Positive Influence ◽  
Periodontal Pocket ◽  
Gingival Index ◽  
Pocket Depth ◽  
Cleaning Procedure ◽  
Before And After ◽  
The Matrix ◽  
Gingival Cells

Stabilizing or reducing periodontal pocket depth can have a positive influence on the retention of teeth in dogs. A topical 2 % clindamycin hydrochloride gel (CHgel) was evaluated for the treatment of periodontal disease in dogs. The CHgel formulation provides for the sustained erosion of the matrix, but also flows into the periodontal pocket as a viscous liquid, and then rapidly forms a gel that has mucoadhesive properties and also may function as a physical barrier to the introduction of bacteria. A professional teeth cleaning procedure including scaling and root planing was done in dogs with one group receiving CHgel following treatment. Periodontal health was determined before and after the procedure including measurement of periodontal pocket depth, gingival index, gingival bleeding sites, and number of suppurating sites. There was a statistically significant decrease in periodontal pocket depth (19 %), gingival index (16 %), and the number of bleeding sites (64 %) at 90-days in dogs receiving CHgel. Additionally, the number of suppurating sites was lower (93 %) at 90-days for the group receiving CHgel. The addition of CHgel effectively controlled the bacterial burden (e.g., Fusobacterium nucleatum) at both day 14 and 90. Gingival cells in culture were shown to rapidly incorporate clindamycin and attain saturation in approximately 20-minutes. In summary, a professional teeth cleaning procedure including root planning and the addition of CHgel improves the gingival index and reduces periodontal pocket depth.

A Novel Systemic Indicator of Periodontal Tissue Damage: Ischemia Modified Albumin

2018 ◽  
Vol 21 (8) ◽  
pp. 544-549 ◽  
Author(s):  
Mahmure A. Tayman ◽  
Canan Önder ◽  
Şivge Kurgan ◽  
Muhittin A. Serdar ◽  
Meral Günhan
Keyword(s):  
Periodontal Disease ◽  
Inflammatory Diseases ◽  
Periodontal Therapy ◽  
Periodontal Pocket ◽  
Oxidative Stress Marker ◽  
Pocket Depth ◽  
Ischemia Modified Albumin ◽  
Nonsurgical Periodontal Therapy ◽  
Before And After ◽  
The Impact

Background: Ischemia-modified albumin (IMA) is a systemic indicator of inflammatory diseases and is suggested as an oxidative stress marker. Objective: To determine the IMA and high-sensitivity C-reactive protein (hsCRP) serum levels for patients with chronic periodontitis (CP) and to evaluate the impact of non-surgical periodontal therapy on serum IMA and hsCRP levels. Methods: Twenty one systemically healthy patients with CP and 15 systemically and periodontally healthy controls (C) were enrolled in the study. Periodontal pocket depth (PPD), bleeding on probing (BOP) and attachment loss (AL) were recorded at the time of diagnosis and 6 weeks after the nonsurgical periodontal therapy. Blood samples were obtained before and after treatment from all groups, and serum IMA and hsCRP levels were evaluated by ELISA method. Results: All of the clinical findings were found to be elevated in the CP group in comparison to C group (p<0.05). Levels of IMA and hsCRP were higher in the CP group (p<0.05) and decreased after non-surgical periodontal therapy (p<0.05). Positive correlations were determined between PPD, BOP and hsCRP (p<0.05) as well as between PPD, AL, BOP and IMA levels (p<0.01) before treatment. A significant positive correlation was also observed between hsCRP and IMA (p<0.01) before and after treatment. Conclusion: IMA is a marker indicating systemic inflammation during periodontal disease, and is significantly reduced as a result of non-surgical periodontal therapy. Therefore, IMA might be suggested as a useful indicator of periodontal disease.

scholarly journals THE RELIABILITY OF GINGIVAL CREVICULAR BLOOD AS A DIAGNOSTIC TOOL FOR DIABETES BY USING GLUCOSE SELF-MONITORING DEVICE IN PATIENTS WITH PERIODONTAL DISEASE WITH AND WITHOUT DIABETES

2021 ◽  
Vol 71 (3) ◽  
pp. 779-82
Author(s):  
Farhan Butt ◽  
Marium Iqbal ◽  
Saima Hanif ◽  
Mohsin Ghiraj ◽  
Faisal Bhangar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Periodontal Disease ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diagnostic Tool ◽  
Periodontal Pocket ◽  
Gingival Index ◽  
Pocket Depth ◽  
Cross Sectional ◽  
Finger Stick

Objective: To assess the reliability of gingival crevicular blood as a diagnostic tool for diabetes in patients with periodontal disease with and without diabetes. Study Design: Cross sectional study. Place and Duration of Study: Department of Periodontics, Jinnah Medical and Dental College, Karachi, Pakistan, from Jul 2017 to Jul 2018. Methodology: Forty patients with diabetes and 60 patients without diabetes with mild to moderate gingivitis or periodontitis in either the upper or lower anterior region were included. Gingival crevicular blood (GCB) was collected and was assessed by glucometer. The same patient underwent finger stick blood (FSB) and intravenous blood glucose level (IV). Plaque Index (PI), Periodontal Pocket Depth (PPD) and Gingival index were also recorded. Results: A positive correlation (r) was detected between glucose levels of Gingival crevicular blood with finger stick blood with the value of coefficient correlation ‘r’=0.849. The mean values of Gingival index in patients without diabetes is 1.53 ± 0.97mm, patients with newly diagnosed diabetes is 1.87 ± 0.920mm and without diabetes is 2.13± 0.94mm. Conclusion: Blood glucose level can be assessed with the help of Gingival crevicular blood as this technique was found easy and non-invasive to the patient and it can help in diagnosing diabetes during regular periodontal treatment.

scholarly journals Efektivitas Tindakan Skeling terhadap Perawatan Gingivitis di Rumah Sakit Gigi dan Mulut Universitas Sam Ratulangi Manado

e-GIGI ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Febri Korompot ◽  
Krista V. Siagian ◽  
Damajanty H. C. Pangemanan ◽  
Johanna Khoman
Keyword(s):  
Experimental Study ◽  
Inflammatory Response ◽  
Periodontal Disease ◽  
Sampling Technique ◽  
P Value ◽  
Test Design ◽  
Gingival Index ◽  
Paired Sample ◽  
Before And After ◽  
Post Test

Abstract: The most common periodontal disease is gingivitis which is caused by biofilm accumulation on plaque around the gingival margin and inflammatory response to bacteria. Scaling is used to eliminate bacterial and calculus deposits that cause gingivitis. This study was aimed to determine the effectiveness of scaling in gingivitis treatment. This was a pre-experimental study with one group pre and post test design. Samples were obtained by using total sampling technique. There were 30 patients aged 17-45 years that had scaling performed on them at RSGM in 2019. Gingivitis was observed before and after scaling using the modified gingival index (MGI). The results showed that before scaling, there were mild gingivitis 23.30%, moderate gingivitis 70%, and severe gingivitis 6.70%. Two days after scaling, mild gingivitis and moderate gingivitis were observed 50% each. The paired sample t-test showed a p-value of 0.000. In conclusion, scaling is effective in gingivitis treatment based on the assessment using the modified gingival index.Keywords: gingivitis, scaling, modified gingival index Abstrak: Penyakit periodontal yang paling sering dijumpai yakni gingivitis (peradangan gingiva). Gingivitis disebabkan oleh akumulasi biofilm pada plak di sekitar margin gingiva dan respon peradangan terhadap bakteri. Tindakan untuk menghilangkan deposit bakteri dan kalkulus yang menyebabkan gingivitis salah satunya ialah tindakan skeling. Tujuan penelitian ini untuk mengetahui efektivitas tindakan skeling terhadap perawatan gingivitis. Jenis penelitian ialah pra eksperimental dengan one grup pre and post test design. Pengambilan sampel menggunakan teknik total sampling terhadap pasien yang berusia 17-45 tahun yang dilakukan tindakan skeling di RSGM pada tahun 2019 berjumlah 30 orang. Penelitian ini dilakukan dengan melihat gingivitis sebelum skeling dan setelah skeling melalui pengukuran keparahan gingiva menggunakan modified gingival index (MGI). Hasil penelitian menunjukkan bahwa sebelum skeling gingivitis ringan 23,30%, gingivitis sedang 70%, gingivitis berat 6,70%. Dua hari pasca skeling didapatkan gingivitis ringan dan gingivitis sedang sama besar yaitu masing-masing 50%. Hasil uji t berpasangan menunjukkan nilai p=0,000. Simpulan penelitian ialah tindakan skeling efektif terhadap perawatan gingivitis berdasarkan penilaian modified gingival index.Kata kunci: gingivitis, skeling, modified gingival index

scholarly journals Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease

2003 ◽  
Vol 17 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Sheila Cavalca Cortelli ◽  
Antonio Olavo Cardoso Jorge ◽  
José Roberto Cortelli ◽  
Shawn Francis Jordan ◽  
Violet Ibyola Haraszthy
Keyword(s):  
Periodontal Disease ◽  
Strong Association ◽  
Aggressive Periodontitis ◽  
Actinobacillus Actinomycetemcomitans ◽  
Periodontal Pocket ◽  
Chain Reaction ◽  
Chi Square ◽  
Pocket Depth ◽  
Polymerase Chain ◽  
Brazilian Cohort

This study examined the prevalence of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans in patients with periodontal disease. Pooled subgingival plaque samples from 136 patients with some form of periodontal disease were examined. Subjects were between 14 and 76 years of age. Clinical examinations included periodontal pocket depth (PD), plaque index (PI) and bleeding index (BI). The obtained plaque samples were examined for the presence of highly or minimally leukotoxic A. actinomycetemcomitans strains by the polymerase chain reaction (PCR). Chi-square and logistic regression were performed to evaluate the results. Forty-seven subjects were diagnosed with gingivitis, 70 with chronic periodontitis and 19 with aggressive periodontitis. According to chi-square there was no significant correlation detected between PD (chi2 = 0.73), PI (chi2 = 0.35), BI (chi2 = 0.09) and the presence of the highly leukotoxic A. actinomycetemcomitans. The highly leukotoxic A. actinomycetemcomitans strains were correlated with subjects that were 28 years of age and younger (chi2 = 7.41). There was a significant correlation between highly leukotoxic A. actinomycetemcomitans and aggressive periodontitis (chi2 = 22.06). This study of a Brazilian cohort confirms the strong association between highly leukotoxic A. actinomycetemcomitans strains and the presence of aggressive periodontitis.

scholarly journals The anti-inflammatory effect of the platelet-rich plasma in the periodontal pocket

2018 ◽  
Vol 12 (04) ◽  
pp. 528-531 ◽  
Author(s):  
Lubaba A. Abdul Ameer ◽  
Zainab J. Raheem ◽  
Saif Saadedeen Abdulrazaq ◽  
Basima Gh. Ali ◽  
Maysaa Mahdi Nasser ◽  
...  
Keyword(s):  
Lymphocyte Count ◽  
Platelet Rich Plasma ◽  
Periodontal Treatment ◽  
Periodontal Pocket ◽  
Treatment Modalities ◽  
Pocket Depth ◽  
Before And After ◽  
Noticeable Reduction ◽  
Anti Inflammatory ◽  
Inflammatory Effect

ABSTRACT Objective: Chronic periodontitis (CP) is a common inflammatory disease that causes destruction to the supporting tissues of the teeth. Many treatment modalities tried to stop the disease progression. Platelet-rich plasma (PRP) is one of the regenerative methods that used in adjunct to conventional periodontal treatment. The aim of this study was to evaluate the anti-inflammatory effect of PRP by monitoring the lymphocyte count before and after its application to the periodontal pocket. Materials and Methods: Twenty patients, with CP and a pocket depth equal to or deeper than 4 mm, subjected to scaling, root planing, and PRP injection into the pocket. The lymphocyte count measured before and after 1 month from PRP application. Clinical periodontal parameters were taken during two visits (1 month apart), with customized stent fabrication. Results: All clinical periodontal parameters showed a reduction in their value following 1 month of PRP application. . There was a noticeable reduction in lymphocyte count from (mean 2.47 ± 0.91) to (mean 1.94 ± 0.77). Conclusion: In addition to its traditional uses, PRP has a great role in the periodontal treatment by its anti-inflammatory effect.

scholarly journals Analysis of clinical and microbiological results of photodynamic therapy as support in non-surgical treatment of periodontitis – preliminary study

2019 ◽  
pp. 35-41
Author(s):  
Adrian Maj ◽  
Aida Kusiak ◽  
Katarzyna Garbacz ◽  
Marta Ziółkowska-Klinkosz
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Periodontal Disease ◽  
Periodontal Treatment ◽  
Periodontal Pocket ◽  
Therapeutic Effects ◽  
Before And After ◽  
Microbiological Laboratory ◽  
Pre Treatment ◽  
Non Surgical Treatment

Introduction. Photodynamic therapy is supportive method of non-surgical treatment of periodontitis. The aim of the study was the assessment of photodynamic therapy impact on periodontal disease clinical parameters with a particular emphasis on microbiological aspects during periodontal treatment. Material and methods. The research was conducted on seven healthy patients aged 26- 55 years. All the patients were treated with a non-surgical (SRP) periodontal treatment. Then, the assisted photodynamic therapy was applied in selected pockets. Samples of the material obtained from periodontal pockets before and after the treatment were cultured in a microbiological laboratory. Results. After the introduced therapy the clinical improvement of periodontal disease was observed in the majority (6/7) of patients taking part in the study. There obtained the elimination of inflammation to 85.7% of the patients. Periodontal pocket depths have deteriorated from 0.5 to 3.0 mm in comparison to the pre-treatment values. The overall number of bacteria compared to the pre-treatment value was reduced. In addition, there was noticed a decrease in the number of periopathogens. Control samples showed a vivid dominance of the physiological flora. Conclusions. The non-surgical treatment of periodontitis in combination with the supportive action of photodynamic therapy has promising therapeutic effects by reducing the inflammation and decreasing the depth of periodontal pockets. The change in the ratio of periopathogens to physiological flora may indicate the restoration and maintenance of the state balance in periodontal pockets for patients with periodontitis.

Non-Surgical Periodontal Therapy Decreases Periodontal Pocket Depth and Clinical Attachment Loss of Rheumatoid Arthritis Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3376-3377
Author(s):  
Marryam Riaz ◽  
Sohaib Shujaat ◽  
Ayesha Fahim ◽  
Shamail Zafar ◽  
Mariyah Javed ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gingival Recession ◽  
Periodontal Therapy ◽  
Periodontal Pocket ◽  
P Value ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Public And Private ◽  
Attachment Loss ◽  
Before And After

Objective: The objective of the present study was to determine the effect of non-surgical periodontal therapy on the disease severity in rheumatoid arthritis patients. Methods: Five hundred and twenty arthritis patients were included in the study, using consecutive non-probability sampling from the outpatient department of various public and private hospitals of Pakistan. Patients with periodontitis along with systemic Rheumatoid Arthritis (RA) were included in the study. Clinical parameters taken for the severity of periodontitis were the Gingival recession (GV), Periodontal Pocket Depth (PPD) and Clinical Attachment Loss (CAL). Independent sample t-test was used for significance before and after non-surgical periodontal therapy. Data was presented with mean (standard deviation). Results: The PPD and CAL of Rheumatoid Arthritis patients were found to be decreased significantly following non-surgical periodontal treatment (p value < 0.05), unlike the gingival recession, which did not decrease significantly (p value > 0.05). Conclusion: The PPD and CAL values of periodontal patients with rheumatoid arthritis were significantly reduced after giving non-surgical Periotherapy along with oral hygiene instruction. Keywords: arthritis; gingiva; periodontitis; periodontal pocket

scholarly journals Retrieval of a periodontally compromised tooth by allogeneic grafting of mesenchymal stem cells from dental pulp: A case report

2018 ◽  
Vol 46 (7) ◽  
pp. 2983-2993 ◽  
Author(s):  
Beatriz Hernández-Monjaraz ◽  
Edelmiro Santiago-Osorio ◽  
Edgar Ledesma-Martínez ◽  
Andrés Alcauter-Zavala ◽  
Víctor Manuel Mendoza-Núñez
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Periodontal Disease ◽  
Dental Pulp ◽  
Enzymatic Digestion ◽  
Periodontal Pocket ◽  
Mineral Density ◽  
Culture Dish ◽  
Pocket Depth ◽  
Lower Premolar

Objective To report a case of successful allogeneic grafting of mesenchymal dental pulp stem cells (DPSCs) as preliminary findings in a patient with periodontal disease enrolled into clinical trial ISRCTN12831118. Methods Mesenchymal stem cells from the dental pulp of a deciduous tooth from a 7-year-old donor were separated from the pulp chamber and processed via enzymatic digestion and centrifugation. DPSCs were passaged and cultured on a 35 × 13 mm culture dish in minimum essential medium-alpha, without supplementation. After reaching 80% confluency, 5 x 106 allogeneic DPSCs in 250 µl phosphate buffered saline were seeded onto a dry scaffold of lyophilized collagen-polyvinylpyrrolidone sponge placed in the left lower premolar area of a 61-year-old patient with periodontal disease. Surgical access to the lower premolar area was achieved using the flap technique. Results At 3 and 6 months following allogeneic graft, the patient showed no sign of rejection and exhibited decreases in tooth mobility, periodontal pocket depth and bone defect area. Bone mineral density had increased at the graft site. Conclusions Regenerative periodontal therapy using DPSCs of allogeneic origin may be a promising treatment for periodontal disease-induced bone defects.

scholarly journals Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

2012 ◽  
Vol 23 (4) ◽  
pp. 428-432 ◽  
Author(s):  
Bernardo Oliveira de Campos ◽  
Ricardo Guimarães Fischer ◽  
Anders Gustafsson ◽  
Carlos Marcelo da Silva Figueredo
Keyword(s):  
Surgical Treatment ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Gingival Index ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Crevicular Fluid ◽  
Attachment Level ◽  
Gingival Fluid ◽  
Non Surgical Treatment

The aim of this study was to evaluate the effectiveness of the non-surgical periodontal treatment in reducing the gingival crevicular fluid (GCF) levels of IL-18 from inflamed periodontal sites. Fourteen patients with periodontal disease were included, being 9 patients with chronic periodontitis (mean age: 48.8 SD ± 7.4 years) and 5 patients with gingivitis (mean age: 43.6 SD ± 11.8). The patients were divided in the following groups: gingivitis sites from periodontitis patients (sites GP), periodontitis sites from periodontitis patients (sites PP), and gingivitis sites from gingivitis patients (sites GG). Probing pocket depth (PPD), probing attachment level (AL), plaque index (PI) and gingival index (GI) were recorded, and gingival fluid samples were collected. The subjects received non-surgical treatment and were re-evaluated 30 days after treatment (day 30 AT). There was a significant reduction in PI in GG (1.0 ± 0.4 to 0.5 ± 0.2), GP (1.2 ± 0.3 to 0.5 ± 0.3), and in PP (1.3 ± 0.4 to 0.7 ± 0.3) 30 AT. There was also a significant reduction in the GI in GG (1.3 ± 0.3 to 0.7 ± 0.4). PPD reduced significantly in GG (2.4 ± 0.6 to 1.9 ± 0.1), and PP (6.7 ± 1.1 to 5.2 ± 0.9) 30 AT. When all the samples were analyzed together, there was a significant reduction in IL-18 (12.9 ± 7.2 to 10.0 ± 3.1). This study showed that non-surgical treatment was effective in reducing GCF levels of IL-18 from inflamed periodontal sites.

scholarly journals The Antimicrobial Treatment of Periodontal Disease: Changing the Treatment Paradigm

1999 ◽  
Vol 10 (3) ◽  
pp. 245-275 ◽  
Author(s):  
W.J. Loesche
Keyword(s):  
Periodontal Disease ◽  
Antimicrobial Agents ◽  
Disease Risk ◽  
Antimicrobial Treatment ◽  
Periodontal Pocket ◽  
Gingival Tissue ◽  
Central Feature ◽  
New Paradigm ◽  
Pocket Depth ◽  
Periodontal Infection

Over the last 100 years, methods of surgical periodontal treatment have enjoyed a history of success in improving oral health. The paradigm of care is based on the "non-specific plaque hypothesis"-that is, the overgrowth of bacterial plaques cause periodontal disease, and the suppression of this overgrowth reduces disease risk. The central feature of this approach to care is the removal of inflamed gingival tissue around the teeth to reduce periodontal pocket depth, thereby facilitating plaque removal by the dentist and by the patient at home. Over the last 30 years, with the recognition that periodontal disease(s) is caused by specific bacteria and that specific antimicrobial agents can reduce or eliminate the infection, a second paradigm has developed. This new paradigm, the "specific plaque hypothesis", focuses on reducing the specific bacteria that cause periodontal attachment loss. The contrast between the two paradigms can be succinctly stated as follows: The antimicrobial therapy reduces the cause, while the surgical therapy reduces the result of the periodontal infection. The specific plaque hypothesis has two important implications. First, with the increasing attention to evidence-based models for prevention, treatment, outcome assessment, and reimbursement of care, increasing attention and financial effort will be channeled into effective preventive and treatment methods. Second, the recent observations that periodontal infections increase the risk of specific systemic health problems, such as cardiovascular disease, argue for the prevention and elimination of these periodontal infections. This review highlights some of the evidence for the specific plaque hypothesis, and the questions that should be addressed if antimicrobial agents are to be used responsively and effectively.

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