The influence of aripiprazole and venlafaxine on the antidepressant-like effect observed in prenatally stressed rats (animal model of depression)

2017 ◽  
Vol 37 (9) ◽  
pp. 972-982 ◽  
Author(s):  
P Ratajczak ◽  
K Kus ◽  
M Skurzyńska ◽  
E Nowakowska
Keyword(s):  
Locomotor Activity ◽  
Combined Therapy ◽  
Experimental Studies ◽  
Antidepressant Effect ◽  
Control Group ◽  
Single Administration ◽  
Pregnant Rats ◽  
Study Results ◽  
Prenatally Stressed ◽  
And Control

Depression is a nosological entity which may appear alone or concomitantly (e.g. in schizophrenia). Analysis of data from both clinical and experimental studies allows a conclusion that atypical antipsychotics, such as aripiprazole (ARI), may also be effective in treating depression in addition to antidepressants. The aim of the studies was to determine antidepressant efficacy of ARI, venlafaxine (VEN) and combined therapy using both drugs, in prenatally stressed rats (animal depression model) and control group. In addition, this article was aimed at determining the effect of these drugs on locomotor activity of these animals. The effect of chronic stress used in pregnant rats and the use of drugs such as ARI (1.5 mg/kg) and VEN (20 mg/kg) were studied in forced swimming test (FST; antidepressant effect) and locomotor activity test. Performed tests confirmed the antidepressant effect of ARI, VEN and efficacy of combined drugs in FST in both prenatally stressed rats (effect present upon single administration and after 7, 14 and 21 days of testing) and control group rats (effect present upon single administration and 7 days of testing). Moreover, upon single administration of the used drugs to prenatally stressed rats, it was found sedative effect – reduced animals’ locomotor activity. Study results have proven antidepressant and sedative efficacy of ARI, VEN and combined administration of these drugs. Due to the small amount of data on the above preparations, in particular in the context of animal depression models, further studies in this respect are recommended.

scholarly journals EFFECTIVENESS OF VAGINAL CONE THERAPY ON URINARY INCONTINENCE AMONG WOMEN IN SAVEETHA MEDICAL COLLEGE HOSPITAL, THANDALAM, CHENNAI

2019 ◽  
pp. 133-136
Author(s):  
JAGADEESWARI J ◽  
KALABARATHI S ◽  
MANGALAGOWRI P
Keyword(s):  
Urinary Incontinence ◽  
Muscle Tone ◽  
Sampling Technique ◽  
Structured Interview ◽  
Moderate Level ◽  
Control Group ◽  
College Hospital ◽  
Study Results ◽  
And Control ◽  
Experimental Group

 Objectives: The present aims to assess the level of urinary incontinence in experimental and control group, to assess the effectiveness of vaginal cone therapy on urinary incontinence in experimental group and control group and to associate the post-test level of urinary incontinence with the selected demographic variables among women in the experimental group. Methods: A quantitative quasi-experimental research design was conducted among 60 women with urinary incontinence. Convenience sampling technique was used. Semi-structured interview method was used to collect the demographical data and level of urinary incontinence among women was assessed by urinary incontinence diagnosis questionnaire. Results: Among 60 samples in experimental group 26 women had a moderate level of urinary incontinence, and 4 women had slight urinary incontinence whereas in control group 24 women had moderate level of urinary incontinence and 6 women had slight urinary incontinence. The study results show significant improvement in level of urinary incontinence among experimental group than the control group after the intervention at the level of p<0.05. This reveals that vaginal cone therapy is highly significant in the experimental group because pelvic muscle strength had improved and allows the patient to increase the physiological consciousness and promotes the muscle tone after the use of a vaginal cone. Conclusion: This study proves that vaginal cone therapy is the effective non-pharmacological method, cost-effective method and had no side effects which can be used to treat female urinary incontinence.

scholarly journals Influence of long term stress exposure on somatisation symptoms outcome

2004 ◽  
Vol 4 (4) ◽  
pp. 28-31
Author(s):  
Sabaheta Hasić ◽  
Emina Kiseljaković ◽  
Radivoj Jadrić ◽  
Belma Zečević ◽  
Nešina Avdagić ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Control Group ◽  
Stress Exposure ◽  
War Stress ◽  
Control Subjects ◽  
Study Results ◽  
Significant Difference ◽  
Student’S T ◽  
And Control

Long term stress exposure results in somatisation symptoms appearance. Cardiovascular, respiratory, gastrointestinal and muscle-bone symptoms arise because of intensified activity of autonomic nervous system caused by chronic stress. The aim of the study was to examine the relationship between long term war stress exposure and appearance of somatisation. 40 students of health-care faculties in Sarajevo, of both sexes, were included in investigation and divided in two groups-somatisation and control. Somatisation group subjects (N=20) lived in B&H under war conditions, from 1992-1995. Control subjects (N=20) spent the same period outside B&H. For evaluation of somatisation symptoms we used SCL-90-R test. The obtained data were statistically evaluated using Student’s t-test and χ2 test. Confidence level was set at ρ < 0,05. Our results showed statistically significant difference in somatisation level between somatisation and control subjects group. Different intensity of appearance of certain symptoms in male and female was established. The score of somatisation dimension between somatisation and control group showed statistically significant level (p < 0,0001). Study results confirmed correlation of chronic stress exposure (living in war environment) and somatisation symptom appearance. Individual organic systems had various level of symptom expression. The influence of sex on intensity of individual symptoms of somatisation is possible.

scholarly journals Transcranial magnetic stimulation in the correction of consequences of minor traumatic brain injury

2020 ◽  
Vol 6 (2) ◽  
pp. 36-41
Author(s):  
I. V. Litvinenko ◽  
A. A. Yurin
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Control Group ◽  
Neuropsychological Examination ◽  
General Weakness ◽  
Study Results ◽  
Minor Traumatic Brain Injury ◽  
And Control

Purpose. To evaluate therapeutic options of rhythmic transcranial magnetic stimulation (rTMS) in the treatment of consequences of minor traumatic brain injury.Materials and methods. A neuropsychological examination using standard scales for assessing cognitive functions, as well as the Beck depression inventory, the Spielberger State-Trait Anxiety Inventory, and the MFI-20 multidimensional fatigue inventory was performed on patients with traumatic brain injury (TBI) and complaints of decreased memory, attention, general weakness and fatigue. Patients were split into two groups. Active group (24 patients) received rhythmic TMS besides standard treatment (neurometabolic, nootropic) while control group (23 patients) received only standard therapy. After the treatment course, the reassessment of neuropsychological examination with the following statistic processing was performed.Study results. Comparison of treatment results in the active and control groups showed the highest efficacy of rTMS in the treatment of depression (p=0,016), anxiety (p=0,001) and in fatigue lowering (p=0,017) in patients with consequences of minor TBI.Conclusion. The data obtained from the study point the high efficacy of treatment of consequences of minor TBI by means of rTMS that displays in lowering of fatigue, anxiety, and depression severity when using.

scholarly journals Technology for obtaining an ultrathin posterior lamellar corneal graft at the Eye Tissue Bank

2020 ◽  
Vol 22 (3) ◽  
pp. 167-173
Author(s):  
A. K. Ahmedov ◽  
T. Z. Kerimov ◽  
Kh. D. Tonaeva ◽  
B. E. Malygin ◽  
S. A. Borzenok
Keyword(s):  
Experimental Studies ◽  
Tissue Bank ◽  
Corneal Graft ◽  
Control Group ◽  
Eye Banks ◽  
Preoperative Stage ◽  
Cutting Out ◽  
Stromal Collagen ◽  
And Control ◽  
Scanning Electron

Objective: to develop technologies for preoperative preparation of the posterior lamellar corneal graft based on our own formulation of the preservation medium for optimal dehydration of the donor cornea and a technique for cutting out an ultrathin flap using an optimized method at the Eye Tissue Bank. Materials methods. In a series of experimental studies, we obtained data on the hydration level of cadaveric donor corneas that were preserved in various solutions at different observation periods. Using 16 corneas, analytical weighing and pachymetry were performed via optical coherence tomography in the experimental (n = 8) and control (n = 8) groups. Morphological and functional characteristics of the corneal endothelium were then assessed. At the next stage of work, ultrathin grafts were formed from 16 corneas after hypothermic preservation in the experimental (n = 8) and control (n = 8) solutions by single-pass microkeratome, followed by microscopy of the samples using a scanning electron microscope. Results. After the first days of preservation in the proposed solution, there was dehydration of 9% cornea in the experimental group in comparison with the samples of the control group. After 4 days of preservation, there was no reliable difference found between the groups (p > 0.05) in the study of the endothelial cell viability of ultra-thin corneal grafts by immunofluorescent microscopy using the «Live and dead» marker. Scanning electron microscopy revealed that corneal stromal collagen fibers, preserved in the proposed medium, retained their integrity. Conclusion. The proposed technology can be recommended for use at eye banks for formation of an ultra-thin corneal graft at the preoperative stage.

scholarly journals Effect of Foetal Movement Counting on Prenatal Attachment and Maternal Worries among Primigravidas- A Longitudinal Study

2021 ◽  
Author(s):  
Jignya Vinodbhai Asari ◽  
Anjali Pushkar Tiwari
Keyword(s):  
Longitudinal Study ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Prenatal Attachment ◽  
Study Results ◽  
Significant Difference ◽  
The Mean ◽  
Foetal Movement ◽  
And Control

Introduction: Pregnant woman experience various physical, emotional, and hormonal changes that may cause anxiety. The anxiety and worries can be decreased by sharing information about the developing child, like foetal body movement. Aim: To assess effect of Foetal Movement Counting (FMC) on prenatal attachment and maternal worries among primigravida mothers. Materials and Methods: A longitudinal study was carried out among primigravida mothers of selected Hospitals of Central Gujarat using proforma of Cranley’s maternal foetal attachment scale and Cambridge worry scale. The study was conducted from March 2019 to July 2020. Eighty participants were recruited by convenient sampling 40 in each study group and control group. The study group were provided with foetal movement chart and the participants were asked to record foetal movements for seven consecutive days, twice a day for 20 minutes. Post assessment of prenatal attachment and maternal worries was done using tools of data collection for both study and control group. Chi- square test was used to test the significance (p-value <0.05). Results: The study results revealed that in study group mean score for prenatal attachment was 79.43 at the start and improved to 101.25 (p-value <0.001) after seven days of FMC. In control group, the mean score for prenatal attachment did not show significant difference pre-test and post-test (74.20 vs 74.85, p-value=0.077). In study group, the mean Cambridge worry scale score was 36.55 which came down to 20.28 (p-value <0.001) after seven days, while in control group it was 41.38 at the beginning and 41.30 after seven days (p-value=0.998). Conclusion: Foetal Movement Counting was found to improve maternal foetal attachment and reduce maternal worries. FMC can be routinely and effectively promoted among the pregnant population to help them achieve a positive pregnancy experience and outcome.

The effect mechanism of Ginnalin A as a homeopathic agent on various cancer cell lines

2018 ◽  
Vol 16 (1) ◽  
pp. 790-795
Author(s):  
Hasibe Vural
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Experimental Studies ◽  
Cancer Cell Lines ◽  
Control Group ◽  
Human Carcinoma ◽  
Maple Syrup ◽  
Carcinoma Cell Lines ◽  
Apoptotic Effects ◽  
And Control

AbstractEpidemiological and experimental studies have shown that natural products are beneficial for the protection against cancer. Maple syrup is a natural sweetener often consumed throughout the world. Maple syrup contains various phenolic compounds such as lignans, coumarin and Ginnalin A (GA). The aim of this study was to investigate the effects of GA shown to have cytotoxic and apoptotic effects in several human carcinoma cell lines. The effect of GA on cell viability was determined by a XTT (2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) assay as described in the manufacturer’s instruction. Total RNA was isolated from cancer cells using TRIzol Reagent and reverse transcription was performed using Script™ cDNA Synthesis Kit (Bio-Rad) according to the manufacturer’s instructions. Expressions of important genes in apoptosis including MMP-2, MMP-9, TIMP-1, TIMP-2, CDH1 and CDH2, were investigated in dose and control groups by qPCR (quantitative real time- polymerase chain reaction).When compared with the control group, qPCR results illustrated that a significant increase in gene expression was observed in the expressions of CDH1, TIMP-1 and TIMP-2 by 3.52, 5.13 and 2.67 times respectively. Research has shown that Ginnalin A can demonstrate an anti-metastatic effect by regulating the expression of important genes in metastasis on cancer cell lines. Furthermore, in this study the activation of caspase-8 in apoptotic signaling pathways and the pro-apoptotic caspases required for extrinsic apoptotic signal transduction was defined.

Effects of Spiritist “passe” (Spiritual healing) on stress hormone, pain, physiological parameters and length of stay in preterm newborns: a randomized, double-blind controlled trial

2018 ◽  
Vol 15 (4) ◽  
Author(s):  
Élida Mara Carneiro ◽  
Luana Pereira Barbosa ◽  
Ana Carolina Bittencourt ◽  
César Gómez Hernández ◽  
Rodolfo Pessato Timóteo ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Controlled Trial ◽  
Experimental Studies ◽  
Spiritual Healing ◽  
Physiological Parameters ◽  
Control Group ◽  
Stress Hormone ◽  
Double Blind ◽  
Energy Therapy ◽  
And Control

Abstract Background Among the practices of complementary medicine used to treat several diseases is the Spiritist “passe (SP).” Experimental studies have demonstrated the effectiveness of this energy therapies in reducing anxiety in adults. However, studies evaluating the effects of the “passe” energy therapy on health outcomes in newborns (NBs) are lacking. The aim of this study was to evaluate the effects of SP on stress hormone levels, pain, physiological parameters and length of stay in NBs. Methods NBs were randomly allocated into two groups: intervention (3 days SP sessions, n=13) and control (3 days sham sessions, n=12). Results In the SP group, respiratory frequency (RF) was found significantly lower (p<0.05), and reduction of heart rate and length of stay were observed, without statistical differences. While in the control, there was higher tendency of cortisol levels (p=0.05). Conclusions In this pilot study, RF reduced and prevented the elevation of the salivary cortisol concentration in preterm NBs receiving the SP compared with the control group.

scholarly journals Metabonomic Study on the Antidepressant-Like Effects of Banxia Houpu Decoction and Its Action Mechanism

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Zhanqiang Ma ◽  
Weiwei Ji ◽  
Rong Qu ◽  
Mingyan Wang ◽  
Wen Yang ◽  
...  
Keyword(s):  
Experimental Model ◽  
Antidepressant Effect ◽  
Control Group ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Model Group ◽  
Action Mechanism ◽  
Significant Difference ◽  
And Control ◽  
Endogenous Metabolites

The aim of this study was to establish an experimental model for metabonomic profiles of the rat’s brain and then to investigate the antidepressant effect of Banxia Houpu decoction (BHD) and its possible mechanisms. Behavioral research and metabonomics method based on UPLC-MS were used to assess the efficacy of different fractions of BHD on chronic unpredictable mild stress (CUMS) model of depression. There was a significant difference between the BHD group and the model group. Eight endogenous metabolites, which are contributing to the separation of the model group and control group, were detected, while BHD group regulated the perturbed metabolites showing that there is a tendency of recovery compared to control group. Therefore, we think that those potential metabolite biomarkers have some relationship with BHD’s antidepression effect. This work appraised the antidepressant effect of Banxia Houpu decoction as well as revealing a metabonomics method, a valuable parameter in the TCM research.

scholarly journals FEATURES OF PHYSICAL DEVELOPMENT AND PHYSICAL FITNESS IN BOYS WITH HEARING IMPAIRMENTS AND THEIR CORRECTION USING SPORTS GYMNASTICS

2019 ◽  
Vol 19 (3) ◽  
pp. 125-130
Author(s):  
I Novikov ◽  
V Novikov ◽  
M Novikova
Keyword(s):  
Physical Fitness ◽  
Physical Development ◽  
Control Group ◽  
Hearing Impairments ◽  
Training Course ◽  
Standard Program ◽  
Study Results ◽  
And Control ◽  
Experimental Group

Aim. The article deals with a possible correction of physical development and physical fitness in boys with hearing impairments with the help of sports gymnastics. Materials and methods. Boys aged 7–9 years were divided into two groups – experimental and control – 25 persons in each group. In the control group, the lessons were conducted following a standard program. In the experimental group, the lessons followed the program of sports gymnastics. In both groups, the training course lasted six months. Testing was conducted at the beginning and the end of the study. Results. After the experiment, the results of the experimental group exceed those of the control group. Conclusion. Regular lessons made according to a sports gymnastics program allow improving physical development and physical fitness in boys with hearing impairments aged 7–9 years.

scholarly journals Comparison of the effectiveness of feminist therapy with sex therapy Based CBT on sexual intimacy in Betrayed Women

2021 ◽  
Vol 3 (1) ◽  
pp. 01-04
Author(s):  
Bafandegan Vahid
Keyword(s):  
Experimental Studies ◽  
Sex Therapy ◽  
Control Group ◽  
Feminist Therapy ◽  
Sexual Intimacy ◽  
Control Groups ◽  
The People ◽  
Post Test ◽  
And Control ◽  
Experimental Group

The Present Study Aims to Comparison of the effectiveness of feminist therapy (FT) with sex therapy on sexual intimacy in female. This Study Was Typed of Experimental Studies with pre- test and Post-Test with Control Group. The Study Consisted of All woman Referred to the Counselling Centres in university Neyshabur City. A Sample of 36 People Was Selected Then Randomly Assigned to Two Experimental Groups and One Control Groups. The people inventory sexual intimacy Botlani (SII) Was Used for Data Collection Then Based on 12 Meetings 90 Minutes for the Experiment Groups. The Pre-Test and Post-Test Scores Were Analysed Using a Manova Test in the SPSS 20 Software. According to the Results of Showed feminist Therapy More Effect Than Other Experimental Group and Control Group (p≤0.001) so sex Therapy More Effect Than Control Group in Variable (p≤0.001). The conclusion is that the feminist therapy approach can be used to increase sexual intimacy in developing Muslim societies.

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