Obstetric antiphospholipid syndrome: current uncertainties should guide our way

Lupus ◽  
2010 ◽  
Vol 19 (4) ◽  
pp. 446-452 ◽  
Author(s):  
DW Branch ◽  
RM Silver ◽  
TF Porter
Keyword(s):  
Antiphospholipid Syndrome ◽  
Reproductive Medicine ◽  
Fetal Death ◽  
Recurrent Miscarriage ◽  
Antiphospholipid Antibody ◽  
The Us ◽  
The World ◽  
Obstetric Antiphospholipid Syndrome ◽  
The Subject ◽  
The Common

The subject of obstetric antiphospholipid syndrome (APS) has been reviewed dozens of times, and there is little doubt that the international APS community has done well in bringing APS to the attention of clinicians around the world. However, the evolution of clinical practice, at least in the US, also has convinced us that our field would benefit from further clinical study. For example, the number of women diagnosed with ‘APS’, but who do not meet the revised Sapporo criteria, seems to have increased. It is now common practice for women with recurrent miscarriage or prior fetal death to be treated with heparin, even in the presence of indeterminate or low titer antiphospholipid antibody (aPL) levels and even after only one positive test. In part, this common practice derives from confusion on the part of many clinicians and patients regarding the diagnosis of APS as well as the clinical and laboratory criteria for the syndrome. In part, this derives from the common practice of so-called ‘empiric treatment’ in US reproductive medicine, often driven as much by patients as by clinicians. This brief commentary focuses on areas of uncertainty that we see as deserving of new or renewed study for the sake of improving our understanding of APS and best patient care.

scholarly journals What’s new in obstetric antiphospholipid syndrome

Hematology ◽  
2019 ◽  
Vol 2019 (1) ◽  
pp. 421-425
Author(s):  
D. Ware Branch
Keyword(s):  
Antiphospholipid Syndrome ◽  
Pregnancy Outcomes ◽  
Fetal Death ◽  
Systemic Autoimmune Disease ◽  
Current Debate ◽  
Third Trimester ◽  
Trimester Pregnancy ◽  
Obstetric Antiphospholipid Syndrome ◽  
The Subject ◽  
Early Miscarriage

Abstract Antiphospholipid syndrome (APS) is a rare systemic autoimmune disease, the obstetric features of which include recurrent early miscarriage, fetal death at or beyond 10 weeks of gestation, and early delivery for severe preeclampsia or placental insufficiency. Controversies regarding the specificity of these obstetric clinical features, as well as the laboratory diagnostic criteria, are the subject of current debate and reanalysis. Clinical and laboratory features can be used to stratify women with APS in terms of risk of adverse second and third trimester pregnancy outcomes. Numerous “treatments” have been used in high-risk and refractory patients, but rigorously designed clinical trials are needed. APS is a rare disease that requires innovative investigative approaches to provide credible results.

scholarly journals Migrating architectures: Palladio’s legacy from Calcutta to New Delhi

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Pilar Maria Guerrieri
Keyword(s):  
Thomas Jefferson ◽  
New Delhi ◽  
Archival Material ◽  
The Us ◽  
The World ◽  
The Subject ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
The Uk ◽  
The Relationship

AbstractPalladianism, which originated in Italy, is a style of architecture which spread widely across the world and has been extensively studied. It is known that it migrated to the UK during the eighteenth century at the same time as it did to Germany through Georg Knobelsdorff, to Russia through the work of Charles Cameron and Giacomo Quarenghi, to the US through Thomas Jefferson between the eighteenth and nineteenth centuries, and was adopted in Poland, Sweden, and elsewhere. Palladianism became a tool of politicians and a status symbol for the elites to differentiate themselves from the common man. There are a few studies on the migration and adoption of Palladianism in India, primarily in relation to Calcutta’s architecture between the eighteenth and nineteenth centuries. In particular, there is specific research focusing on Lord Wellesley’s Palladian building programme, frequently highlighting the relationship between Government House, Calcutta and Kedleston Hall in Derbyshire. This essay focuses on the subject of the migration of Palladian architecture and, in particular, on its adoption by the capitals of India, Calcutta and Delhi, on the basis of primary archival material.

scholarly journals Intricate Coalescence of Nature and Philosophy in Coelho’s world: Ruminations from The Alchemist

2020 ◽  
pp. 72-79
Author(s):  
L. Monica Lilly
Keyword(s):  
Common Language ◽  
Human Species ◽  
The World ◽  
The Subject ◽  
The Common ◽  
Human Psyche ◽  
Egyptian Desert ◽  
The Universe

 In The Alchemist, Paulo Coelho projects Santiago communicating with Nature which he refers to as the common language of the world. A study of The Alchemist will reveal how Santiago, an Andalusian shepherd boy who yearns to travel in search of a bounty treasure explores the wisdom of life. His quest for the treasure buried near the Pyramids propels him to enter an unchartered territory from his homeland in Spain to the Egyptian desert. This paper aims to explore the ecological reflections mired with concepts of slants in philosophy. Ecology on one hand is considered as a branch of science but, despite providing erudition on the subject it is understood that it provides sagacity to understand the universe better. This paper rightly discusses the amalgamation of nature and literature. It is indeed a manifestation of the recurrently believed ideologies that connect human psyche and platitudes of the cosmos. The logos that interrelates the existing connection between the non human and the human species require an exceptional mastery. This paper will analyze and depict the emotions connected with nature from the spectacle of the Protagonist Santiago in The Alchemist.

scholarly journals Human as a phenomenon of unity of corporeal and spiritual in various-system languages (based on the material of euphemisms in the English and Buryat languages)

2020 ◽  
pp. 58-66
Author(s):  
Oyuna Tsydendambaeva ◽  
Olga Dorzheeva
Keyword(s):  
Scientific Discourse ◽  
The Body ◽  
Linguistic Expression ◽  
The West ◽  
The World ◽  
Key Concepts ◽  
The Subject ◽  
The Common

This article is dedicated to the examination of euphemisms in the various-system languages – English and Buryat that contain view of the world by a human, and the ways of their conceptualization. Euphemisms remain insufficiently studied. Whereupon, examination of linguistic expression of the key concepts of culture is among the paramount programs of modern linguistics, need for the linguoculturological approach towards analysis of euphemisms in the languages, viewing it in light of the current sociocultural transformations, which are refer to euphemisms and values reflected by them. The subject of this research is the euphemisms in the English and Buryat languages, representing the semiosphere “corporeal and spiritual”. The scientific novelty consists in introduction of the previously unexamined euphemism in Buryat language that comprise semiosphere “corporeal and spiritual” into the scientific discourse. The analysis of language material testifies to the fact that in various cultures the topic of intimacy and sex is euphemized differently. The lexis indicating the intimate parts of the body is vividly presented in the West, while in Buryat language – rather reserved. The author also determines the common, universal, and nationally marked components elucidating the linguistic worldview of different ethnoses and cultures.

"China's Chernobyl": COVID-19 Narratives of Collapse and Global Domination

2021 ◽  
Vol 94 (4) ◽  
pp. 683-706
Author(s):  
Barry Sautman
Keyword(s):  
Empirical Basis ◽  
Yellow Peril ◽  
Common Enemy ◽  
The Us ◽  
The World ◽  
Biological Pollution ◽  
The Common ◽  
Wish Fulfillment ◽  
Party State

In COVID-19's first months, US politicians and media forecast that a contrast between Chinese deception and incapability and Western success against the pandemic might fatally sink internal confidence in China's party-state. They also predicted that it would diminish China externally, as it came to be seen as endangering the world by spreading biological pollution. A "China's Chernobyl" prediction became the latest "China collapse" wish-fulfillment. This speculation rests on two contradictory yet co-existing Yellow Peril tropes: "deceit and incompetence" and "world domination." However, no empirical basis exists for either notion: China prevailed against the pandemic and lacks the capacity for global hegemony. "China's Chernobyl" is most relevant then as a wish that creates a belief, that China should and could collapse. That in turn bolsters the US-led mobilization to counter China as a "strong competitor" and frames China as the common enemy, thereby promoting Western transnational and US internal cohesion.

scholarly journals “Restoring the Kinship”: the Novel The Adolescent as a Prologue to the Dialogue Between Nikolay Fedorov and Fyodor Dostoevsky

2021 ◽  
pp. 58-87
Author(s):  
Anastasia G. Gacheva
Keyword(s):  
The Novel ◽  
Fyodor Dostoevsky ◽  
Main Work ◽  
Common Task ◽  
The World ◽  
The Subject ◽  
The Common

The article is an attempt to read the novel The Adolescent in the light of the spiritual and creative dialogue between the philosopher of the common task Nikolay Fedorov and Fyodor Dostoevsky. Although The Adolescent was written and published three years before Fedorov’s student N. Peterson presented his teacher’s ideas to the writer in the article “What should a people’s school be?”, the novel can be considered as a prologue to the topic that eventually became the subject of Fedorov’s main work The question of brotherhood or kinship, about the causes of the non-fraternal, unrelated, i.e. non-peaceful, state of the world, and about the means to restore kinship. The plot of the novel is interpreted in the article through the prism of Fedorov’s themes of non-kinship and the restoration of universal kinship, the idea of returning the hearts of sons to their fathers and the fathers’ ones to their children. It is shown how the theme of “family as the practical beginning of love” is expressed in the novel.

The Common fossils of the British Rocks

The Geologist ◽  
1858 ◽  
Vol 1 (6) ◽  
pp. 238-241
Author(s):  
S. J. Mackie
Keyword(s):  
Sedimentary Rocks ◽  
The Arctic ◽  
Rock Masses ◽  
Scottish Highlands ◽  
The Past ◽  
Arctic Regions ◽  
The World ◽  
The Subject ◽  
The Common ◽  
Birth Time

A Man would see but little of the reality of the world if he shut himself up in his house, and only gazed out from the same window; he would learn little more if he contented himself with alternately gazing upon the scenes passing around him, from the windows of every storey. So a geologist, in limiting himself to the study of the rock-masses of a circumscribed area, would never, by the utmost perseverance, in going continually over the same ground, attain to a perfect understanding of the subject of his study. He must go abroad, either in his own person or equivalently, by making himself acquainted with the travels and labours of others. Our knowledge of the ancient conditions and relations of the oldest rock-masses would not be complete if we limited our investigations to those isolated patches in our own country, which, however important, are still only a part of that great whole, more important traces of which are to be met in regions far away. Thus those very old—indeed, primitive sedimentary rocks, represented in the British Isles in a fragmentary manner, as by the younger or bedded gneiss of the Scottish Highlands, assume in Canada and the Arctic regions proportions of great extent, and consequently, of far greater value. Far back in the obscurity of the past, as must be placed the birth-time of these primitive land-masses, we seem, in our first investigations, plunged in interminable ignorance, like the explorers of some vast subterranean cave in impenetrable darkness.

Ut Pictura Poesis

PMLA ◽  
1909 ◽  
Vol 24 (1) ◽  
pp. 40-123 ◽  
Author(s):  
William Guild Howard
Keyword(s):  
John Dryden ◽  
English Prose ◽  
Parallel Lines ◽  
The World ◽  
English Speaking ◽  
The Subject ◽  
The Common ◽  
Ut Pictura Poesis

The Latin poem De arte graphica by Charles Alphonse du Fresnoy was edited with a translation into French prose and with notes by Roger de Piles in 1668; and in 1695 John Dryden, “to satisfy the desires of so many gentlemen who were willing to give the world this useful work,” not only translated de Piles's book into English prose but also supplied his translation with an “original preface containing a parallel between painting and poetry.” Dryden's Parallel is one of the least original, but it is not the least interesting of his literary essays: Saintsbury calls it “the first writing at any length by a very distinguished Englishman of letters on the subject of pictorial art.” Together with his translation of du Fresnoy and de Piles, it forms for us English-speaking people the handiest introduction to that long-lived esthetic theory founded upon the proposition Ut pictura poesis. Lessing seems to have seen in Dryden's preface some suggestion of a deviation of the parallel lines from the common direction; or perhaps the point at which they ought to have parted company; for he wrote, “ Falsche Übertragung des mahlerischen Ideals in die Poesie. Dort ist es ein Ideal der Körper, hier muss es ein Ideal der Handlungen seyn. Dryden in s. Vorrede zum Fresnoy.”

Obstetric antiphospholipid syndrome: still a challenge

Lupus ◽  
2010 ◽  
Vol 19 (4) ◽  
pp. 457-459 ◽  
Author(s):  
RA Levy ◽  
GRR Jesús ◽  
NR Jesús
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Antiphospholipid Syndrome ◽  
Fetal Death ◽  
Obstetric Complications ◽  
Premature Delivery ◽  
Thrombotic Risk ◽  
Recurrent Abortions ◽  
Obstetric Antiphospholipid Syndrome

Obstetric complications such as fetal death, premature delivery, preeclampsia and recurrent abortions (since chromosomal or anatomic defects have been excluded) are characteristic manifestations of antiphospholipid syndrome (APS). They can occur in patients with known APS with previous arterial or venous events in any tissue or organ, or be its first and only manifestation. Pregnancy in a patient with APS is considered high risk and the full prenatal clinical follow-up must be carried with this in mind, eliminating or minimizing concomitant thrombotic risk factors.

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