Arthropathy Secondary to Ciprofloxacin in an Adult Cystic Fibrosis Patient

1993 ◽  
Vol 27 (3) ◽  
pp. 302-303 ◽  
Author(s):  
Wayne M. Samuelson ◽  
Roy A. Pleasants ◽  
Martha S. Whitaker
Keyword(s):  
Cystic Fibrosis ◽  
Adult Patient ◽  
Cystic Fibrosis Patient ◽  
Pediatric Patients ◽  
Prior History ◽  
Case Summary ◽  
First Case ◽  
Acute Exacerbations ◽  
History Of ◽  
Possible Cause

OBJECTIVE: To report a case of possible ciprofloxacin-induced arthropathy in an adult patient with cystic fibrosis (CF). CASE SUMMARY: A 25-year-old man with CF received three separate courses of ciprofloxacin therapy at usual doses for acute pulmonary exacerbations of his disease. During the second and third courses, the patient experienced bilateral swelling of his knees between two to three weeks after initiation of each course. Both times symptoms markedly decreased after discontinuation of the drug. The patient had no prior history of arthropathy. Furthermore, during the last two acute exacerbations of his CF, he did not receive ciprofloxacin and did not experience any symptoms of arthropathy. DISCUSSION: Prior cases of quinolone-induced arthropathy involving pediatric CF patients or adult patients without CF have been reported in the literature. We report the first case of such an arthropathy in an adult patient with CF. The findings are supported by a rechallenge with the drug. CONCLUSIONS: It is likely that ciprofloxacin may produce arthropathy in adult as well as pediatric patients with CF. Quinolones should be considered as a possible cause of arthropathy in adult CF patients.

scholarly journals Cesarean Section in a Pregnant Woman with COVID-19: First Case in Portugal

2020 ◽  
Vol 33 (6) ◽  
pp. 429 ◽  
Author(s):  
Joana Lyra ◽  
Rita Valente ◽  
Marta Rosário ◽  
Mariana Guimarães
Keyword(s):  
Cesarean Section ◽  
Healthy Woman ◽  
Maternity Hospital ◽  
Prior History ◽  
Protective Equipment ◽  
Bishop Score ◽  
Term Pregnancy ◽  
First Case ◽  
History Of ◽  
Maternal And Neonatal Outcomes

We report the first cesarean delivery in a woman with COVID-19 in a level III hospital in Portugal. It refers to a healthy woman with a term pregnancy that tested positive for COVID-19 on the day of labor induction. Given a Bishop score < 4 and the prior history of a cesarean section, the team decided to perform a surgical delivery. Appropriate personal protective equipment and safety circuits were employed, as described in more detail in the case report. Both the mother and the newborn are well. With this report we aimed to share our concerns, clinical management, maternal and neonatal outcomes, and to present our current circuits and adjustments regarding the COVID-19 pandemic in our maternity hospital.

scholarly journals Sequential Mycoplasma pneumoniae pneumonia and Chromobacterium violaceum skin abscess in a pediatric patient

2017 ◽  
Vol 11 (08) ◽  
pp. 656-661 ◽  
Author(s):  
Weizhen Guo ◽  
Iris Wai Sum Li ◽  
Xi Li ◽  
Hua Xu ◽  
Dongrong Lu ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Pediatric Patients ◽  
Community Acquired Pneumonia ◽  
Chromobacterium Violaceum ◽  
Respiratory Pathogen ◽  
First Case ◽  
History Of ◽  
The Right ◽  
Super Infection ◽  
Mycoplasma Pneumoniae Pneumonia

Mycoplasma pneumoniae is a common atypical respiratory pathogen causing community-acquired pneumonia in children. Co-infection with other respiratory viruses is common in pediatric patients but super-infection with bacteria other than Streptococcus pneumoniae and Haemophilus influenzae is rare. The first case of Chromobacterium violaceum infection incubated during and manifested after pneumonia caused by Mycoplasma pneumoniae in a 12-month old girl without any known history of immunodeficiency is here reported. The patient developed fever with redness and swelling over the middle phalanx of the right hand index finger which progressed to the formation of skin abscess. Following a course of intravenous meropenem and surgical drainage of the skin abscess, the patient fully recovered and was discharged.

scholarly journals SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy?

2020 ◽  
Vol 90 (4) ◽  
Author(s):  
Maddalena Giglia ◽  
Giacomo Beci ◽  
Elena Rosselli Del Turco ◽  
Viola Guardigni ◽  
Alberto Amedeo ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Adult Patient ◽  
Clinical Improvement ◽  
Clinical Course ◽  
Effective Therapy ◽  
Total Recovery ◽  
First Case ◽  
Significant Clinical Improvement

We report the case of a man affected by cystic fibrosis who developed a severe SARS-CoV-2 related pneumonia in March 2020. In addition to lopinavir/ritonavir and hydroxychloroquine, he was treated with two doses of tocilizumab, displaying a significant clinical improvement. This is the first case described in the literature of an adult patient affected by cystic fibrosis who received tocilizumab for COVID-19, with documented total recovery, also assessed by a spirometry.

scholarly journals Homozygous Deletion of the CFTR Gene Caused by Interstitial Maternal Isodisomy in a Peruvian Child with Cystic Fibrosis

2019 ◽  
Vol 08 (03) ◽  
pp. 147-152
Author(s):  
Flor Vásquez Sotomayor ◽  
Hugo Hernán Abarca-Barriga
Keyword(s):  
Cystic Fibrosis ◽  
Pancreatic Insufficiency ◽  
Chromosomal Rearrangements ◽  
Correct Diagnosis ◽  
Homozygous Deletion ◽  
Cftr Gene ◽  
Molecular Testing ◽  
Transmembrane Conductance Regulator ◽  
First Case ◽  
History Of

AbstractWe report the first case in Peru of cystic fibrosis caused by a homozygous deletion of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. A 10-month-old child who presented with meconium ileus and pancreatic insufficiency was tested for cystic fibrosis. Both parents of the child are of Peruvian background, are nonconsanguineous, and have no personal or family history of the disease. Chromosome microarray analysis revealed a homozygous deletion of the CFTR gene on chromosome 7 (7q31.2) within a maternally derived 12.8-Mb region of loss of heterozygosity with deletion of a region that includes the CFTR gene. Parental testing confirmed this finding. This case highlights the great importance of molecular testing and the study of chromosomal rearrangements in reaching a correct diagnosis and providing proper genetic counseling to the affected families.

scholarly journals Relapse of chronic melioidosis in a paediatric cystic fibrosis patient: first case report from Malaysia

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Vanitha Mariappan ◽  
Surendran Thavagnanam ◽  
Kumutha Malar Vellasamy ◽  
Cindy Ju Shuan Teh ◽  
Nadia Atiya ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Case Report ◽  
Cystic Fibrosis Patient ◽  
First Case

scholarly journals A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 60
Author(s):  
David Lebeaux ◽  
Maia Merabishvili ◽  
Eric Caudron ◽  
Damien Lannoy ◽  
Leen Van Simaey ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Cystic Fibrosis Patient ◽  
Phage Therapy ◽  
Lung Infection ◽  
Achromobacter Xylosoxidans ◽  
Resistant Bacteria ◽  
Low Grade ◽  
First Case ◽  
Phage Receptor ◽  
Airway Colonization

Bacteriophages are a promising therapeutic strategy among cystic fibrosis and lung-transplanted patients, considering the high frequency of colonization/infection caused by pandrug-resistant bacteria. However, little clinical data are available regarding the use of phages for infections with Achromobacter xylosoxidans. A 12-year-old lung-transplanted cystic fibrosis patient received two rounds of phage therapy because of persistent lung infection with pandrug-resistant A. xylosoxidans. Clinical tolerance was perfect, but initial bronchoalveolar lavage (BAL) still grew A. xylosoxidans. The patient’s respiratory condition slowly improved and oxygen therapy was stopped. Low-grade airway colonization by A. xylosoxidans persisted for months before samples turned negative. No re-colonisation occurred more than two years after phage therapy was performed and imipenem treatment was stopped. Whole genome sequencing indicated that the eight A. xylosoxidans isolates, collected during phage therapy, belonged to four delineated strains, whereby one had a stop mutation in a gene for a phage receptor. The dynamics of lung colonisation were documented by means of strain-specific qPCRs on different BALs. We report the first case of phage therapy for A. xylosoxidans lung infection in a lung-transplanted patient. The dynamics of airway colonization was more complex than deduced from bacterial culture, involving phage susceptible as well as phage resistant strains.

scholarly journals Astounding Fibro Lipoma of Spermatic Cord: A Diagnostic Dilemma

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Gupta Rohit ◽  
Chinniahnapalaya Pandurangaiah Hariprasad ◽  
Shreekant Bharti ◽  
Anil Kumar ◽  
Shiv Shankar Paswan ◽  
...  
Keyword(s):  
Spermatic Cord ◽  
Needle Aspiration ◽  
Laparoscopic Inguinal Hernia Repair ◽  
Age Group ◽  
Diagnostic Dilemma ◽  
Complete Excision ◽  
Case Summary ◽  
First Case ◽  
Younger Age ◽  
History Of

Background. Fibro lipoma of the spermatic cord is a very rare tumor with few cases reported in literature. Atypical presentation and site of swelling mystifies the diagnosis and creates bewildering situation intraoperatively. Case Summary. A 30-year-old farmer presented with an elastic firm nonreducible, nontender swelling at inguinoscrotal region with positive cough impulse and history of laparoscopic inguinal hernia repair 3 years ago. Ultrasonography of the swelling revealed a heteroechoic lesion of size 7 × 6 centimeter with probable features of lipoma or desmoid. Fine needle aspiration drawn in consideration of the diagnostic dilemma reported a benign lipomatous swelling which on final histopathology turned out to be a fibro lipoma of size 7 × 6 × 5  cm. Conclusion. Considering the age and presentation of the patient, it was astonishing. It provided an insight to the occurrence of fibro lipoma even in younger age group which in fact is the first case of its kind as per best of our knowledge. Malignancy should be ruled out in such cases, and complete excision is the treatment of choice.

Famotidine-Induced Mixed Hepatocellular Jaundice

1994 ◽  
Vol 28 (1) ◽  
pp. 40-42 ◽  
Author(s):  
Paul W. Ament ◽  
John D. Roth ◽  
Carol J. Fox
Keyword(s):  
Liver Enzyme ◽  
Elevated Liver Enzyme ◽  
Epigastric Pain ◽  
Case Reports ◽  
Signs And Symptoms ◽  
Enzyme Concentration ◽  
Case Summary ◽  
First Case ◽  
History Of ◽  
Hepatocellular Jaundice

OBJECTIVE: To report a case of probable famotidine-induced mixed hepatocellular jaundice. CASE SUMMARY: A 55-year-old man presented with a one-month history of mid-epigastric pain. Initial physical examination and laboratory studies, including liver enzyme concentration tests, were unrevealing. A diagnosis of gastritis was made and ranitidine was prescribed. Following one week of therapy, the patient's symptoms had not improved and therapy was changed to famotidine and sucralfate. Approximately one week later the patient presented with jaundice. Liver enzyme concentrations were elevated and the patient was hospitalized for further evaluation. Five days following discontinuation of famotidine, liver enzyme concentrations were normal and jaundice had resolved. Further tests did not reveal any pathologic etiology. DISCUSSION: Hepatic changes have occurred in patients receiving histamine2-antagonists; ranitidine and cimetidine have been cited most frequently. In general, the elevations are mild, transient, and return to baseline with continued therapy. This is one of the first case reports of probable famotidine-induced mixed hepatocellular jaundice. CONCLUSIONS: There was a temporal relationship between the patient's signs and symptoms and initiation of famotidine. No identifiable factors contributed to the elevated liver enzyme concentrations and jaundice.

scholarly journals Testicular cancer in two brothers of a quadruplet: a case report and a review of literature

2017 ◽  
Vol 24 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Agnė Ulytė ◽  
Albertas Ulys ◽  
Kęstutis Sužiedėlis ◽  
Aušvydas Patašius ◽  
Giedrė Smailytė
Keyword(s):  
Risk Factors ◽  
Testicular Cancer ◽  
Rare Events ◽  
Multiple Birth ◽  
Prior History ◽  
Review Of Literature ◽  
Factors Associated ◽  
First Case ◽  
Increased Risk ◽  
History Of

Introduction. Testicular cancer and a multiple birth are both rare events, and the risk of testicular cancer is increased in twins. In Lithuania, only five quadruplets have been recorded since the middle of the 20th century. In this report, we present two rare events in one family: testicular cancer in two brothers of a quadruplet (three brothers and a sister). Case description. Both patients were diagnosed at 21 years of age and died within two years from the  diagnosis despite treatment. The  third symptomless brother did not have testicular pathology. We also review the  risk factors associated with testicular cancer, and the  proposed hypotheses how a multiple birth results in an increased risk. The most consistent risk factors for testicular cancer are cryptorchidism, prior history of testicular cancer, and a positive familial history. According to different studies, the risk of testicular cancer in twins is higher from 22% to 30%, compared to the general population. Conclusions. To our knowledge, we have presented the first case of testicular teratoblastoma in brothers of a quadruplet.

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