scholarly journals Cesarean Section in a Pregnant Woman with COVID-19: First Case in Portugal

2020 ◽  
Vol 33 (6) ◽  
pp. 429 ◽  
Author(s):  
Joana Lyra ◽  
Rita Valente ◽  
Marta Rosário ◽  
Mariana Guimarães
Keyword(s):  
Cesarean Section ◽  
Healthy Woman ◽  
Maternity Hospital ◽  
Prior History ◽  
Protective Equipment ◽  
Bishop Score ◽  
Term Pregnancy ◽  
First Case ◽  
History Of ◽  
Maternal And Neonatal Outcomes

We report the first cesarean delivery in a woman with COVID-19 in a level III hospital in Portugal. It refers to a healthy woman with a term pregnancy that tested positive for COVID-19 on the day of labor induction. Given a Bishop score < 4 and the prior history of a cesarean section, the team decided to perform a surgical delivery. Appropriate personal protective equipment and safety circuits were employed, as described in more detail in the case report. Both the mother and the newborn are well. With this report we aimed to share our concerns, clinical management, maternal and neonatal outcomes, and to present our current circuits and adjustments regarding the COVID-19 pandemic in our maternity hospital.

scholarly journals COVID-19-associated brief psychotic disorder

2020 ◽  
Vol 13 (8) ◽  
pp. e236940 ◽  
Author(s):  
Colin M Smith ◽  
Jonathan R Komisar ◽  
Ahmad Mourad ◽  
Brian R Kincaid
Keyword(s):  
Mental Illness ◽  
Family History ◽  
Psychotic Disorder ◽  
Neuropsychiatric Symptoms ◽  
Healthy Woman ◽  
Psychotic Symptoms ◽  
First Case ◽  
Brief Psychotic Disorder ◽  
History Of ◽  
New Onset

A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals.

Arthropathy Secondary to Ciprofloxacin in an Adult Cystic Fibrosis Patient

1993 ◽  
Vol 27 (3) ◽  
pp. 302-303 ◽  
Author(s):  
Wayne M. Samuelson ◽  
Roy A. Pleasants ◽  
Martha S. Whitaker
Keyword(s):  
Cystic Fibrosis ◽  
Adult Patient ◽  
Cystic Fibrosis Patient ◽  
Pediatric Patients ◽  
Prior History ◽  
Case Summary ◽  
First Case ◽  
Acute Exacerbations ◽  
History Of ◽  
Possible Cause

OBJECTIVE: To report a case of possible ciprofloxacin-induced arthropathy in an adult patient with cystic fibrosis (CF). CASE SUMMARY: A 25-year-old man with CF received three separate courses of ciprofloxacin therapy at usual doses for acute pulmonary exacerbations of his disease. During the second and third courses, the patient experienced bilateral swelling of his knees between two to three weeks after initiation of each course. Both times symptoms markedly decreased after discontinuation of the drug. The patient had no prior history of arthropathy. Furthermore, during the last two acute exacerbations of his CF, he did not receive ciprofloxacin and did not experience any symptoms of arthropathy. DISCUSSION: Prior cases of quinolone-induced arthropathy involving pediatric CF patients or adult patients without CF have been reported in the literature. We report the first case of such an arthropathy in an adult patient with CF. The findings are supported by a rechallenge with the drug. CONCLUSIONS: It is likely that ciprofloxacin may produce arthropathy in adult as well as pediatric patients with CF. Quinolones should be considered as a possible cause of arthropathy in adult CF patients.

scholarly journals Spontaneous closure of the hymen during term pregnancy

2017 ◽  
Vol 6 (8) ◽  
pp. 3670
Author(s):  
Gomathy E. ◽  
Poonguzhali Liston ◽  
Shilpa G.
Keyword(s):  
Glycogen Content ◽  
Squamous Epithelium ◽  
Spontaneous Closure ◽  
Prior History ◽  
Gonococcal Infection ◽  
Term Pregnancy ◽  
History Of ◽  
Stratified Squamous Epithelium ◽  
Secondary Closure ◽  
In Pregnancy

The hymen is a thin fold of mucous membrane; partially closing the external vaginal opening.1It is composed mainly of elastic, collagenous connective tissue and covered on its both surfaces by stratified squamous epithelium. At pregnancy, the epithelium of hymen becomes very thick and rich in glycogen, which may lead to spontaneous closure. We aim to report a rare case of spontaneous closure of hymen in a 23-year old primigravida in labour with no prior history of menstrual problems or problems during intercourse. Two conditions can cause the secondary closure of the hymen: following previous scarring and in pregnancy. In pregnancy, it could be spontaneous closure due to increase glycogen content of the hymen or due to extensive scarring as seen in previous hymenal surgeries. Spontaneous closure of hymen during pregnancy though very rare can occur. Along with extensive scarring, prolonged abstinence and oestrogenic effect on hymen, gonococcal infection can also cause sponatenous closure of hymen during pregnancy. 

scholarly journals COVID-19 mRNA vaccine in pregnancy and newborn passive immunization: a case report

2021 ◽  
Author(s):  
Nadine El Kassis ◽  
Wael Abdallah ◽  
Rim Abou Chakra ◽  
Wissam Arab ◽  
Serge Sassine ◽  
...  
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Cesarean Section ◽  
Protective Effect ◽  
Passive Immunization ◽  
Prior History ◽  
Case Presentation ◽  
Maternal Vaccination ◽  
History Of ◽  
In Pregnancy

Aim: Evaluating the newborn passive immunization after maternal vaccination against SARS-COV-2. Case presentation: We present the case of a pregnant woman, with no prior history of COVID-19 infection, who got her second dose of mRNA vaccine against SARS-COV-2, 3 days before the start of her spontaneous labor. She was delivered by cesarean section after dynamical dystocia. Placental cord blood was retrieved immediately and sent to evaluate the titers of COVID-19 antibodies. Vaccine-generated antibodies were present in the umbilical cord with IgG spike >100 AU/ml. Conclusion: By reviewing the literature, vaccination seems to give hope about the potential protective effect of the maternal vaccination on her baby. Thus, pregnant women deserve a priority in the COVID-19 vaccination program.

scholarly journals Testicular cancer in two brothers of a quadruplet: a case report and a review of literature

2017 ◽  
Vol 24 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Agnė Ulytė ◽  
Albertas Ulys ◽  
Kęstutis Sužiedėlis ◽  
Aušvydas Patašius ◽  
Giedrė Smailytė
Keyword(s):  
Risk Factors ◽  
Testicular Cancer ◽  
Rare Events ◽  
Multiple Birth ◽  
Prior History ◽  
Review Of Literature ◽  
Factors Associated ◽  
First Case ◽  
Increased Risk ◽  
History Of

Introduction. Testicular cancer and a multiple birth are both rare events, and the risk of testicular cancer is increased in twins. In Lithuania, only five quadruplets have been recorded since the middle of the 20th century. In this report, we present two rare events in one family: testicular cancer in two brothers of a quadruplet (three brothers and a sister). Case description. Both patients were diagnosed at 21 years of age and died within two years from the  diagnosis despite treatment. The  third symptomless brother did not have testicular pathology. We also review the  risk factors associated with testicular cancer, and the  proposed hypotheses how a multiple birth results in an increased risk. The most consistent risk factors for testicular cancer are cryptorchidism, prior history of testicular cancer, and a positive familial history. According to different studies, the risk of testicular cancer in twins is higher from 22% to 30%, compared to the general population. Conclusions. To our knowledge, we have presented the first case of testicular teratoblastoma in brothers of a quadruplet.

scholarly journals Maternal Death Caused by Severe-Critical COVID-19 in Jakarta: Case Series

2021 ◽  
Vol 9 (C) ◽  
pp. 103-108
Author(s):  
Suskhan Djusad ◽  
Alfa Putri Meutia ◽  
Arresta Suastika ◽  
Gita Nurul Hidayah ◽  
Ilham Utama Surya ◽  
...  
Keyword(s):  
Septic Shock ◽  
Pregnant Women ◽  
Maternal Death ◽  
Maternal Age ◽  
Case Series ◽  
Advanced Maternal Age ◽  
Limited Information ◽  
First Case ◽  
History Of ◽  
Maternal And Neonatal Outcomes

BACKGROUND: As of January 2021, Indonesia had the 21st highest number of total COVID-19 cases and the 17th highest total deaths among all countries. COVID-19 infection in pregnant women seems to negatively affect both maternal and neonatal outcomes. CASE REPORT: We describe four cases of pregnant women confirmed with severe and critical COVID-19 that resulted in maternal death from November until December 2020. The first case was complicated with thrombocytopenia, her condition quickly deteriorated post-delivery. Pulmonary embolism was suspected as the cause of death. Second and third cases were complicated with preeclampsia, obesity, and advanced maternal age. Second case came in sepsis condition. Her SARS CoV-2 RTPCR swab test came out after her death. Third patient did not have COVID-19 symptoms at admission. She starts having symptoms on second day and was confirmed positive a day after. She falls in septic shock. Fourth patient has history of fever, cough, and dyspnea. She was confirmed positive on first day and her condition worsened, diagnosed with bacterial co-infection sepsis on day eight. All patients underwent cesarean section. CONCLUSION: Limited information and studies for COVID-19 management in pregnant women are challenging for obstetricians. Management should be individualized weighing the benefit and risks in presence of comorbidities or accompanying disease.

Incidence of cesarean delivery after induction of labour with dinoprostone gel at term in nulliparous women with unfavourable bishops score

2017 ◽  
Vol 6 (4) ◽  
pp. 1253
Author(s):  
Kalpana Mehta ◽  
Dhanesh Kumar ◽  
Dharmendra Singh Fathepuriya ◽  
Leena Verma
Keyword(s):  
Cesarean Section ◽  
Vaginal Delivery ◽  
Previous History ◽  
Fetal Distress ◽  
Induction Of Labour ◽  
Normal Vaginal Delivery ◽  
Bishop Score ◽  
Nulliparous Women ◽  
History Of ◽  
The Mean

Background: The aim of induction of labour is to achieve vaginal delivery in advance of the normal timing of parturition and to avoid operative delivery. The objective was to study the incidence of instrumental delivery and cesarean section in nulliparous women with unfavourable bishops score at term.Methods: This study was conducted on 200 patients in nulliparous women with unfavourable bishop score, cephalic presentation and no previous history of abortion.Results: The most frequent cause of induction of labour was postdatism (47.5%) followed by PIH (25.5%) and PROM (13%). 143 (71.5%) women had normal vaginal delivery whereas in 54 women (27%) cesarean section was done. 2 women (1%) had forceps application for delivery and remaining 1 women (0.5%) had ventouse delivery. Out of 200 patients 9 had maternal complication of induction of labour.Conclusions: In present study 71.5% women had normal vaginal delivery, 27% had cesarean section. Mean bishop score at induction was 3.31 which improved to 4.0 after 12 hours of gel instillation. The mean induction to delivery interval was 13.38 hrs in present study, 54.5% patients were delivered within 12 hours of gel instillation in this study. Most common indication of cesarean section was failed progress followed by fetal distress.

scholarly journals Dexamethasone Implant Migration through an Iris Coloboma

2020 ◽  
Vol 11 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Yoav Glidai ◽  
Shulamit Schwartz ◽  
Eyal Cohen
Keyword(s):  
Macular Edema ◽  
Anterior Chamber ◽  
Cystoid Macular Edema ◽  
Corneal Edema ◽  
Lens Capsule ◽  
Prior History ◽  
Dexamethasone Implant ◽  
Implant Migration ◽  
First Case ◽  
History Of

Ozurdex® 0.7 mg (dexamethasone 0.7 mg implant, Allergan, Dublin, Ireland), an intravitreal biodegradable implant, is indicated for cystoid macular edema due to various causes. One of its known and uncommon complications is implant migration to the anterior chamber, causing corneal edema that, in some cases, is irreversible. Reported risk factors for device migration are open or defective lens capsule and prior history of vitrectomy. We present a case of dexamethasone implant migration through a congenital iris coloboma in a pseudophakic patient with an intact lens capsule. The patient is a 56-year-old pseudophakic man with a history of congenital iris coloboma, myopia, retinal tears, and a branch retinal vein occlusion with subsequent cystoid macular edema resistant to anti-VEGF medications but responsive to corticosteroids. He presented with sudden painless decreased vision in his left eye, 8 weeks following dexamethasone implant (Ozurdex) injection to the same eye. Upon presentation, he was diagnosed with corneal edema caused by anterior chamber migration of the implant. He was referred for immediate surgical intervention to extract the implant, with a resolution of the corneal edema within 2 weeks postoperatively. To conclude, this is the first case that reports Ozurdex implant migration through an iris coloboma in the setting of an intact posterior capsule. In addition, we describe a novel surgical approach for implant removal from the anterior chamber that is simple and efficient.

scholarly journals Frequency and phenotype of headache in covid-19: a study of 2194 patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
David García-Azorín ◽  
Álvaro Sierra ◽  
Javier Trigo ◽  
Ana Alberdi ◽  
María Blanco ◽  
...  
Keyword(s):  
Reference Population ◽  
Prior History ◽  
Health Administration ◽  
Castilla Y Leon ◽  
First Case ◽  
Headache Onset ◽  
Severe Intensity ◽  
History Of ◽  
Systemic Symptoms ◽  
Carlos Iii

AbstractTo estimate the frequency of headache in patients with confirmed COVID-19 and characterize the phenotype of headache attributed to COVID-19, comparing patients depending on the need of hospitalization and sex, an observational study was done. We systematically screened all eligible patients from a reference population of 261,431 between March 8 (first case) and April 11, 2020. A physician administered a survey assessing demographic and clinical data and the phenotype of the headache. During the study period, 2194 patients out of the population at risk were diagnosed with COVID-19. Headache was described by 514/2194 patients (23.4%, 95% CI 21.7–25.3%), including 383/1614 (23.7%) outpatients and 131/580 (22.6%) inpatients. The headache phenotype was studied in detail in 458 patients (mean age, 51 years; 72% female; prior history of headache, 49%). Headache was the most frequent first symptom of COVID-19. Median headache onset was within 24 h, median duration was 7 days and persisted after 1 month in 13% of patients. Pain was bilateral (80%), predominantly frontal (71%), with pressing quality (75%), of severe intensity. Systemic symptoms were present in 98% of patients. Headache frequency and phenotype was similar in patients with and without need for hospitalization and when comparing male and female patients, being more intense in females.Trial registration: This study was supported by the Institute of Health Carlos III (ISCIII), code 07.04.467804.74011 and Regional Health Administration, Gerencia Regional de Salud, Castilla y Leon (GRS: 2289/A/2020).

Novel G6PC3 Mutations in patients with Congenital Neutropenia: Case reports and Review of the Literature

2021 ◽  
Vol 21 ◽  
Author(s):  
Seyed Farzad Maroufi ◽  
Zoha Shaka ◽  
Helia Mojtabavi ◽  
Mona Sadeghalvad ◽  
Elham Rayzan ◽  
...  
Keyword(s):  
Heart Defects ◽  
Case Reports ◽  
Severe Neutropenia ◽  
Prior History ◽  
Compound Heterozygous ◽  
Missense Mutations ◽  
Severe Congenital Neutropenia ◽  
Congenital Neutropenia ◽  
First Case ◽  
History Of

Background: Severe congenital neutropenia (SCN4) caused by mutations in glucose-6-phosphatase catalytic subunit 3 (G6PC3) is characterized by recurrent infections due to severe neutropenia, and it may be accompanied by other extra-hematopoietic manifestations; including structural heart defects, urogenital abnormalities, prominent superficial venous markings, growth retention, and inflammatory bowel diseases with rare incidence. The homozygous or compound heterozygous mutations of G6PC3 are responsible for most cases of autosomal recessive SCN4. Herein, we present two cases of SCN4 affected by novel mutations in the G6PC3, in addition to a summarized list of variants in G6PC3 gene that are reported as pathogenic and related to the SCN4 phenotype. Case presentation: Herein we present two cases of SCN4; the first case was a three-months old boy with severe neutropenia and prior history of hospitalization due to umbilical separation, umbilical herniation, omphalitis, and pyelonephritis; and the second case was an eight-year-old with a history of neutropenia, recurrent and severe episodes of intractable diarrhea, refractory rectovaginal and rectoperineal fistula, congenital inguinal hernia, and ASD type 2. Whole exome sequencing was performed for both cases and revealed two novel homozygous missense mutations in G6PC3 that were predicted to be deleterious; c.337G>A, p. Gly113Arg in the first case and c.479C>T; P. Ser160Leu in the second case. To our knowledge, both of these two mutations has not been reported in the G6PDC3 gene. Conclusions: In patients with severe neutropenia with varying extra hematopoietic syndrome, mutation of G6PC3 should be suspected after ruling out other mutations related to neutropenia. This study pointed toward novel G6PC3 mutations, that should be considered in order to diagnose patients with severe congenital neutropenia.

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