Visual Plasticity in Adulthood: Perspectives from Hebbian and Homeostatic Plasticity

2021 ◽  
pp. 107385842110376
Author(s):  
Ji Won Bang ◽  
Giles Hamilton-Fletcher ◽  
Kevin C. Chan
Keyword(s):  
Visual System ◽  
Perceptual Learning ◽  
Visual Deprivation ◽  
Homeostatic Plasticity ◽  
Cellular Mechanisms ◽  
Future Studies ◽  
Visual Perceptual Learning ◽  
Current Review ◽  
Plastic Potential ◽  
Mechanisms Of Plasticity

The visual system retains profound plastic potential in adulthood. In the current review, we summarize the evidence of preserved plasticity in the adult visual system during visual perceptual learning as well as both monocular and binocular visual deprivation. In each condition, we discuss how such evidence reflects two major cellular mechanisms of plasticity: Hebbian and homeostatic processes. We focus on how these two mechanisms work together to shape plasticity in the visual system. In addition, we discuss how these two mechanisms could be further revealed in future studies investigating cross-modal plasticity in the visual system.

Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses

2020 ◽  
Vol 17 (1) ◽  
pp. 16-28 ◽  
Author(s):  
Agnieszka Brzezińska ◽  
Julius Bourke ◽  
Rayito Rivera-Hernández ◽  
Magda Tsolaki ◽  
Joanna Woźniak ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Randomised Controlled Trials ◽  
Late Onset ◽  
Alternative Hypothesis ◽  
Controlled Trials ◽  
Major Depressive ◽  
Future Studies ◽  
Individual Vulnerability ◽  
Current Review ◽  
Randomised Controlled

The majority of research works to date suggest that Major Depressive Disorder (MDD) is a risk factor for dementia and may predispose to cognitive decline in both early and late onset variants. The presence of depression may not, however, reflect the cause, rather, an effect: it may be a response to cognitive impairment or alters the threshold at which cognitive impairment might manifest or be detected. An alternative hypothesis is that depression may be part of a prodrome to Alzheimer’s Disease (AD), suggesting a neurobiological association rather than one of psychological response alone. Genetic polymorphisms may explain some of the variances in shared phenomenology between the diagnoses, the instance, when the conditions arise comorbidly, the order in which they are detected that may depend on individual cognitive and physical reserves, as well as the medical history and individual vulnerability. This hypothesis is biologically sound but has not been systematically investigated to date. The current review highlights how genetic variations are involved in the development of both AD and MDD, and the risk conferred by these variations on the expression of these two disorders comorbidly is an important consideration for future studies of pathoaetiological mechanisms and in the stratification of study samples for randomised controlled trials.

Natural Products for Regulating Macrophages M2 Polarization

2020 ◽  
Vol 15 (7) ◽  
pp. 559-569 ◽  
Author(s):  
Zhen Chang ◽  
Youhan Wang ◽  
Chang Liu ◽  
Wanli Smith ◽  
Lingbo Kong
Keyword(s):  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Therapeutic Strategies ◽  
Research Progress ◽  
Cellular Mechanisms ◽  
Pharmacological Activities ◽  
Current Review ◽  
M2 Polarization ◽  
Macrophages Polarization ◽  
Herbal Plants

Macrophages M2 polarization have been taken as an anti-inflammatory progression during inflammation. Natural plant-derived products, with potential therapeutic and preventive activities against inflammatory diseases, have received increasing attention in recent years because of their whole regulative effects and specific pharmacological activities. However, the molecular mechanisms about how different kinds of natural compounds regulate macrophages polarization still unclear. Therefore, in the current review, we summarized the detailed research progress on the active compounds derived from herbal plants with regulating effects on macrophages, especially M2 polarization. These natural occurring compounds including flavonoids, terpenoids, glycosides, lignans, coumarins, alkaloids, polyphenols and quinones. In addition, we extensively discussed the cellular mechanisms underlying the M2 polarization for each compound, which could provide potential therapeutic strategies aiming macrophages M2 polarization.

scholarly journals Race Analysis in Competitive Swimming: A Narrative Review

2020 ◽  
Vol 18 (1) ◽  
pp. 69
Author(s):  
Tomohiro Gonjo ◽  
Bjørn Harald Olstad
Keyword(s):  
Web Of Science ◽  
Narrative Review ◽  
Limited Evidence ◽  
Long Distance ◽  
Competitive Swimming ◽  
Future Studies ◽  
Current Review ◽  
Short Course ◽  
Definition Of ◽  
Race Analysis

Researchers have quantified swimming races for several decades to provide objective information on race strategy and characteristics. The purpose of the present review was to summarize knowledge established in the literature and current issues in swimming race analysis. A systematic search of the literature for the current narrative review was conducted in September 2020 using Web of Science, SPORTDiscus (via EBSCO), and PubMed. After examining 321 studies, 22 articles were included in the current review. Most studies divided the race into the start, clean swimming, turn, and/or finish segments; however, the definition of each segment varied, especially for the turn. Ideal definitions for the start and turn-out seemed to differ depending on the stroke styles and swimmers’ level. Many studies have focused on either 100 m or 200 m events with the four strokes (butterfly, backstroke, breaststroke, and freestyle). Contrastingly, there were few or no studies for 50 m, long-distance, individual medley, and relay events. The number of studies examining races for short course, junior and Paralympic swimmers were also very limited. Future studies should focus on those with limited evidence as well as race analysis outside competitions in which detailed kinematic and physiological analyses are possible.

Visual deprivation affects serotonin levels in the visual system

1978 ◽  
Vol 30 (5) ◽  
pp. 1187-1189 ◽  
Author(s):  
H. Lai ◽  
W. L. Makous ◽  
R. M. Quock ◽  
A. Horita
Keyword(s):  
Visual System ◽  
Visual Deprivation

scholarly journals Excitotoxic Mechanisms of Apoptosis in the Mammalian Visual System Following Monocular Visual Deprivation

2002 ◽  
Vol 91 (4) ◽  
pp. 153-157 ◽  
Author(s):  
Carlo Nucci ◽  
Silvia Piccirilli ◽  
Robert Nisticò ◽  
Luciano Cerulli ◽  
Giacinto Bagetta
Keyword(s):  
Visual System ◽  
Visual Deprivation

scholarly journals Neural plasticity underlying visual perceptual learning in aging

2015 ◽  
Vol 1612 ◽  
pp. 140-151 ◽  
Author(s):  
Jyoti Mishra ◽  
Camarin Rolle ◽  
Adam Gazzaley
Keyword(s):  
Perceptual Learning ◽  
Neural Plasticity ◽  
Visual Perceptual Learning

scholarly journals Binicilik Antrenörü Gözünde Hippoterapi

2020 ◽  
Vol 8 (10) ◽  
pp. 2131-2138
Author(s):  
Ali Ekber Ün
Keyword(s):  
Review Article ◽  
Public Institutions ◽  
Team Work ◽  
Individuals With Disabilities ◽  
Future Studies ◽  
Current Review ◽  
History Of ◽  
Expert Team ◽  
The Individual ◽  
Shed Light

The purpose of this review article is to collaborate on future studies about hippotherapy to horse and riding trainers, health professionals, veterinarians, individuals in need and individuals with disabilities and their relatives and to shed light on academic studies. It has been stated in studies that hippotherapy is beneficial for patients in the world. Therefore, as a result of new private hippotherapy centers in public institutions and in Turkey, studies on hippotherapy have been started. The studies carried out in hippotherapy are increasing and widespread and continuing to contribute to the treatment of the individuals in need and individuals with disabilities with hippotherapy sessions with expert teams. However, in the studies, the sessions of the hippotherapy team with two common creatures have great duties on the equestrian coaches in order to meet the needs of the horse and the individual in need or individual with disability. For this reason, since hippotherapy is a multidisciplinary team work consisting of specialist professionals, it has been researched to contribute to the horse and rider coaches on the field and to the expert team attending the sessions, to the new experts and the families of the individuals in need and disabled individuals. In the current review, the information about the history of hippotherapy and development, information about hippotherapy institutions in Turkey, individuals in need and individuals with disabilities, benefits of hippotherapy, characteristics of the hippotherapy horse, training of the hippotherapy horse are emphasized, and especially emphasis is placed on the use of work in the field of horse and equestrian coaching.

scholarly journals The substrates and binding partners of protein kinase Cε

2010 ◽  
Vol 427 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Philip M. Newton ◽  
Robert O. Messing
Keyword(s):  
Protein Kinase ◽  
Active Drug ◽  
Major Research ◽  
Research Focus ◽  
Cellular Mechanisms ◽  
Future Studies ◽  
Kinase C ◽  
Binding Partners ◽  
Signalling Cascades ◽  
Substrate Phosphorylation

The ε isoform of protein kinase C (PKCε) has important roles in the function of the cardiac, immune and nervous systems. As a result of its diverse actions, PKCε is the target of active drug-discovery programmes. A major research focus is to identify signalling cascades that include PKCε and the substrates that PKCε regulates. In the present review, we identify and discuss those proteins that have been conclusively shown to be direct substrates of PKCε by the best currently available means. We will also describe binding partners that anchor PKCε near its substrates. We review the consequences of substrate phosphorylation and discuss cellular mechanisms by which target specificity is achieved. We begin with a brief overview of the biology of PKCε and methods for substrate identification, and proceed with a discussion of substrate categories to identify common themes that emerge and how these may be used to guide future studies.

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