Relationships Between Leptin, hCG, Cortisol, and Psychosocial Stress and Nausea and Vomiting Throughout Pregnancy

2010 ◽  
Vol 12 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Shih-Hsien Kuo ◽  
Yi-Hsin Yang ◽  
Ruey-Hsia Wang ◽  
Te-Fu Chan ◽  
Fan-Hao Chou
Keyword(s):  
Mixed Models ◽  
Psychosocial Stress ◽  
Nausea And Vomiting ◽  
Future Research ◽  
Analog Scale ◽  
Prospective Longitudinal Study ◽  
Vas Scores ◽  
Southern Taiwan ◽  
Cortisol Levels ◽  
Prospective Longitudinal

The purposes of this prospective, longitudinal study were to examine the relationships between leptin, human chorionic gonadotropin (hCG), cortisol, and psychosocial stress and nausea and vomiting (NV) in women with mild-to-moderate NV throughout pregnancy. Participants comprised 91 pregnant women recruited from prenatal clinics in southern Taiwan. Data analysis using one-way analysis of variance (ANOVA) indicated that leptin, hCG, cortisol levels, and Index of Nausea, Vomiting, and Retching (INVR) scores, but not stress (measured with the Visual Analog Scale, VAS) scores, were significantly different among the three trimesters. The average INVR score and hCG level decreased from the first to third trimesters (p < .0001 for both). The average leptin and cortisol levels increased from the first to third trimesters (p = .001 and p < .0001, respectively). Analysis using mixed models indicated that the INVR scores decreased significantly in a progressive manner through the stages of pregnancy and were significantly lower in the second and third trimesters. Findings reveal that stress/VAS and hCG may both be significantly and independently associated with INVR scores. Future research should examine psychosocial reactions in addition to exploring other biochemical markers related to NV and stress.

516 Impacts of Chronic Nausea and Vomiting on Daytime Sleepiness and Fatigue

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A203-A203
Author(s):  
Maurice Ohayon ◽  
Y J Chen ◽  
Marie-Lise Cote
Keyword(s):  
Longitudinal Study ◽  
Daytime Sleepiness ◽  
Nausea And Vomiting ◽  
Prospective Longitudinal Study ◽  
Logistic Regression Models ◽  
Related Quality ◽  
Health Related ◽  
Chronic Nausea ◽  
Prospective Longitudinal ◽  
The Impact

Abstract Introduction Chronic nausea and vomiting (CNV), common symptoms in patients with GI disorders like gastroparesis, can be a debilitating health problem with considerable impact on patients’ health-related quality of life during daytime. Yet, little is known about how CNV may impact on sleepiness and fatigue during the daytime. Our aim was to examine the impact of CNV on daytime sleepiness and fatigue based on the data from a longitudinal study. Methods Prospective longitudinal study with two waves: 12,218 subjects interviewed by phone during wave 1 (W1); 10,931 during wave 2 (W2) three years later. The sample was representative of the US general population. Analyses included subjects participating to both waves (N=10,931). CNV was defined as episodes of nausea and vomiting occurring at least twice a month for at least 1 month (outside pregnancy). Logistic regression models were employed to determine whether CNV is a predictive variable for excessive sleepiness or fatigue. Results Out of all W1 participants, 9.8% (95% CI: 9.2%-10.4%) reported nausea only while 3% (95% CI: 2.7%-3.3%) reported CNV. In W2, 7.7% (95% CI: 7.2%-8.2%) reported nausea only and 2.5% (95% CI: 2.2%-2.8%) reported having CNV. Of the subjects who participated in both W1 and W2, 25.7% of them reported CNV in W1. CNV subjects reported more frequently excessive daytime sleepiness (53.5% vs. 25.9%) and being moderately or severely fatigued (38.6% vs, 5.4%) compared with the participants without nausea or vomiting. After controlling for age, sex, BMI, health status, alcohol intake, sleep disorders and psychiatric disorders that might impact on daytime sleepiness or fatigue, it was found that subjects with CNV at both W1 and W2 had a significantly higher relative risk of reporting daytime sleepiness (RR: 2.7 (95% CI:1.9–3.9) p&lt;0.0001) and fatigue (RR: 4.9 (95% CI:3.2–7.5) p&lt;0.0001) at W2, compared with the participants without nausea or vomiting. Conclusion Many factors are likely to influence daytime sleepiness. CNV appears to be an important contributor even after controlling for several factors that can explain the sleepiness. This underlines the extent to which alertness could be disturbed and impacted by chronicity of nausea/vomiting symptoms. Support (if any) This analysis study was funded by Takeda Pharmaceutical Company

Abstract WP131: Effects Of EDAS Surgery On The Circulating Angiogenic Factors Of Patients With Moyamoya And Intracranial Atherosclerosis.

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Nestor R Gonzalez ◽  
Juan F Toscano ◽  
Raymond Liou ◽  
Neal Rao ◽  
Jason D Hinman ◽  
...  
Keyword(s):  
Mixed Models ◽  
Angiogenic Factors ◽  
Intracranial Atherosclerosis ◽  
Control Groups ◽  
Prospective Longitudinal Study ◽  
Cranial Surgery ◽  
Tumor Pathology ◽  
Vessel Maturation ◽  
And Control ◽  
Prospective Longitudinal

Objective: To evaluate the levels of circulating angiogenic factors in patients with moyamoya disease (MMD), intracranial atherosclerosis (ICAS), and controls, and the effects of EDAS in their levels. Methods: Prospective longitudinal study of angiogenic factors in 22 patients with MMD, ICAS, and controls. Patients with MMD and ICAS underwent EDAS surgery. Control cases had cranial surgery for non-vascular or tumor pathology. Angiogenic factors were measured at baseline and 7 days after surgery. Log-corrected levels were compared between groups. Multivariate analysis of variance (MANOVA) was used to examine differences within pairs and between groups. Regression mixed models were built to account for intrasubject correlation and evaluate the association of angiogenic levels with group and treatment. Results: Mean age was 41 ± 11 in MMD, 65 ± 16 in ICAS, and 51 ± 19 in controls. There were 83% females in the MMD group, 44% in ICAS, and 43% in controls. Patients with MMD had significantly higher levels of PDGFAA (568.8 pg/ml), vs ICAS (165.9pg/mL), and controls (38.4 pg/mL) p=0.007; PDGFBB (1449.7 pg/mL), vs. ICAS (141.2 pg/mL), and controls (65.2 pg/mL) p=0.03; TGFB1 (24.5 ng/mL), vs. ICAS (13.8 ng/mL), and controls (6.2 ng/mL) p=0.006; TSP1 (128.5 ng/mL), vs. ICAS (91.7 ng/mL), and controls (9 ng/mL) p=0.0007. After surgery (EDAS for MMD and ICAS vs. cranial surgery for controls) levels of PDGFAA, PDGFBB, and TGFB1 increased on the ICAS and control groups eliminating the baseline differences. EDAS, independently from etiology, affected the levels of pro-angiogenic TGFB2 (EDAS: 290 pg/mL, controls: 161 pg/mL), and BMP2 (EDAS: 153 pg/mL, controls: 109 pg/mL) p<0.02. EDAS also increased the levels of the anti-angiogenic TSP2 (EDAS: 54.5 ng/mL, controls: 29 ng/mL) p=0.02. Conclusion: Patients with MMD have baseline higher levels of pro-angiogenic factors PDGFAA, PDGFBB, and TGFB1, involved in vessel maturation. EDAS, independent from etiology, affected the levels of TGFB2, BMP2 and TSP2, cytokines involved in vessel maturation, increased vascular permeability, and modulation of cell migration, respectively.

“The beat of my heart”: the relationship between resting heart rate and psychopathy in a prospective longitudinal study

2018 ◽  
Vol 8 (4) ◽  
pp. 333-344 ◽  
Author(s):  
Henriette Bergstrøm ◽  
David P. Farrington
Keyword(s):  
Heart Rate ◽  
Longitudinal Study ◽  
Criminal Behavior ◽  
Future Research ◽  
Resting Heart Rate ◽  
Prospective Longitudinal Study ◽  
Content Type ◽  
Prospective Longitudinal ◽  
The Relationship ◽  
Negative Relationships

Purpose The purpose of this paper is to investigate the relationship between resting heart rate (RHR) and psychopathy. The literature on heart rate vs criminality (including violence) is quite clear; low RHR is associated with engaging in violent and criminal behavior. However, results are not as consistent for psychopathy. Design/methodology/approach This paper analyzes heart rate measured at ages 18 and 48, and psychopathy at age 48, in the Cambridge Study in Delinquent Development (CSDD). The CSDD is a prospective longitudinal study that has followed 411 boys from childhood to middle age, and measured social and biological factors of interest to the field of criminal psychology. Findings Interestingly, it was only heart rate at age 18 that was negatively and significantly related to psychopathy at age 48. No trends or relationships were found between heart rate at age 48 and psychopathy at age 48. The findings do, however, indicate that low heart rate at age 18 predicts psychopathy at age 48, and the strongest negative relationships are found between low heart rate (beats per minute) and impulsive and antisocial psychopathic symptoms. Originality/value This is the first ever longitudinal study showing that low RHR predicts later psychopathy. Suggestions for future research are outlined.

HPA-axis Function and Depression in Adolescence: Are they Related to Prenatal Early Life Stress?

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
B. Van den Bergh ◽  
B. Van Calster ◽  
T. Smits ◽  
S. Van Huffel ◽  
A. Simons ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Hpa Axis ◽  
Early Life ◽  
Ordinary Least Squares ◽  
Repeated Measurements ◽  
Maternal Anxiety ◽  
Future Research ◽  
Postnatal Life ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Early-life exposure to adverse environmental cues during critical windows of time in the prenatal and/or early postnatal life period could predispose the individual for somatic andmental diseases. This especially holds for stress-related disorders such as depression in which HPA-axis dysregulation plays a pathophysiological role. This is in line with the ‘fetal (or developmental) programming-hypothesis’ which has been tested in numerous preclinical experimental. We tested this hypothesis in humans in a prospective longitudinal study in which maternal emotional state was measured during each pregnancy trimester and after pregnancy. When the offspring was 14-15 years old, HPA-axis function was measured through establishing a saliva day-time cortisol profile. Severity of depressive symptoms was measured with the Children's Depression Inventory. Repeated measurements regression analysis and ordinary least-squares regression analyses indicated that maternal anxiety at 12-22 weeks of pregnancy was in female and male offspring associated with a diurnal cortisol profile that was attenuated due to elevated cortisol secretion in the evening. Moreover, in female adolescents this flattened cortisol curve was associated with depressive symptoms. Our results indicate that maternal anxiety during pregnancy enhances neurobiological vulnerability to depressive symptoms, possibly by altering (or ‘programming") foetal physiology. If our results can be replicated in future research they may lead to a re-orientation of the target of primary prevention and treatment of depressive symptoms. Preliminary results of a study on the association between prenatal exposure to maternal anxiety and cortisol stress responsivity during inoculation in the four month old will be presented.

Capturing the costs of acute hand and wrist injuries: Lessons learnt from a prospective longitudinal burden of injury study

Hand Therapy ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 119-129
Author(s):  
Luke Steven Robinson ◽  
Ted Brown ◽  
Lisa O’Brien
Keyword(s):  
Societal Perspective ◽  
Repeated Measures ◽  
Longitudinal Design ◽  
Public Health Care ◽  
Phone Call ◽  
Future Research ◽  
Wrist Injuries ◽  
Wrist Injury ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Introduction Given the high incidence of hand and wrist injuries, they are exceptionally costly to the economy. This prospective, longitudinal study aimed to establish methods for capturing the burden of acute hand and wrist injury from an individual and societal perspective. Methods A prospective longitudinal design with baseline measures of injury type and severity, and repeated measures of disability, cost, and activity limitations and participation restrictions at six weeks, three months, and six months was selected. Participants were recruited from two large urban Australian public health care services. We sought to establish methods for capturing the burden of acute hand and wrist injury from an individual and societal perspective and compare survey completion by the method of administration. Results A total of 206 patients consented to participate in this study, representing 54% of those invited to participate. The survey completion rates were 18% at six weeks, 2.4% at twelve weeks, and 0.004% at six months following injury. From the limited data collected at six weeks, it was noted that nearly half of the patients reported a decrease in usual financial income, 14% reported absenteeism, and 62% reported presenteeism. Participants who elected to have data collected via phone call had the highest survey completion rate ( n = 6/10; 30%) at six-week’s follow-up. Discussion The study findings highlight the difficulties of completing longitudinal survey research investigating individual and societal burden with this population. Future research should be carefully designed to encourage participation and retention by considering patient and public involvement in study design, the time burden placed on the participants within and across selected survey time points, providing participants with incentives to participate, and highlighting the relevance and real-world applications of the findings.

Future Research: A Prospective Longitudinal Study of Elder Self-Neglect

2008 ◽  
Vol 56 ◽  
pp. S261-S265 ◽  
Author(s):  
Carmel Bitondo Dyer ◽  
Luisa Franzini ◽  
Mary Watson ◽  
Luis Sanchez ◽  
Laura Prati ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Future Research ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

scholarly journals Cohort profile: 10K - a large-scale prospective longitudinal study in Israel

2021 ◽  
Author(s):  
Smadar Shilo ◽  
Noam Bar ◽  
Ayya Keshet ◽  
Yeela Talmor-Barkan ◽  
Hagai Rossman ◽  
...  
Keyword(s):  
Large Scale ◽  
Prediction Models ◽  
Disease Onset ◽  
Vital Signs ◽  
Glucose Monitoring ◽  
Oral Microbiome ◽  
Future Research ◽  
Apnea Test ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

AbstractThe 10K is a large-scale prospective longitudinal cohort and biobank that was established in Israel. The primary aims of the study include development of prediction models for disease onset and progression and identification of novel molecular markers with a diagnostic, prognostic and therapeutic value. The recruitment was initiated in 2018 and is expected to complete in 2021. Between 28/01/2019 and 13/12/2020, 4,629 from the expected 10,000 participants were recruited (46%). Follow-up visits are scheduled every year for a total of 25 years. The cohort includes individuals between the age of 40 and 70 years old. Predefined medical conditions were determined as exclusions. Information collected at baseline includes medical history, lifestyle and nutritional habits, vital signs, anthropometrics, blood tests results, Electrocardiography (ECG), Ankle–brachial pressure index (ABI), liver US and Dual-energy X-ray absorptiometry (DXA) tests. Molecular profiling includes transcriptome, proteome, gut and oral microbiome, metabolome and immune system profiling. Continuous measurements include glucose levels using a continuous glucose monitoring (CGM) device for 2 weeks and sleep monitoring by a home sleep apnea test (HSAT) device for 3 nights. Blood and stool samples are collected and stored at −80 °C in a storage facility for future research. Linkage is being established with national disease registries.

scholarly journals Assessing and measuring financial sustainability model of the Spanish HIV HGM BioBank

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Irene Consuegra Fernández ◽  
Isabel García Merino ◽  
María Ángeles Muñoz-Fernández
Keyword(s):  
Detection System ◽  
Clinical Investigation ◽  
Future Research ◽  
Financial Control ◽  
Economic Management ◽  
Prospective Longitudinal Study ◽  
Great Relevance ◽  
Study Type ◽  
Analytical Tools ◽  
Prospective Longitudinal

Abstract Background The Spanish HIV HGM BioBank is of great relevance for basic and clinical investigation, and for those groups trying to establish large networks focused on investigation on specific clinical problems. The collection of different types of samples from HIV-infected individuals is the beginning of the chain of translational investigation, starting in 2004 a prospective national HIV BioBank that expanded in 2009 a local node (HGM: Hospital Gregorio Marañón) for diverse pathologies and clinical networks, not only in adults but also in paediatric patients, becoming the Spanish HIV HGM BioBank. Our main objective is to find a general criteria and analytical tools to widespread its economic management to assure their sustainability and the future exploitation of the extreme high valuable biomaterial they custody. Methods The Spanish HIV HGM BioBank was created with the aim of contributing to advance understanding of different pathologies through the transfer, management, register, processing, cryopreservation and cession of biological material from patients, always for research purposes and under conditions that guarantee its usefulness in current studies and future research that may appear as knowledge evolves. In this study, we have developed a policy for financial control and recovery costs of the Spanish HIV HGM BioBank. Results Actually, Spanish HIV HGM BioBank guards 413,747 vials of 46,594 samples from 16,210 donors with various prospective longitudinal study type of samples. Interestingly, more than 7907 of these samples are now used in 28 national and international investigation projects and clinical trials. One of the objectives of this study is to develop an economic plan that you get future projects, design of acceptance or rejection keys, have internal investment limits, minimum recovery needs in short/medium term, deviation detection system and a register of capital recovery by period and type of service for the Spanish HIV HGM BioBank. Conclusion Our model can help BioBanks that do not have a costs recovery model to design it, as well as to detect improves and functional revisions to those experienced in this field.

scholarly journals Hospice Family Caregivers’ Use of Audio Diaries

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 243-244
Author(s):  
Kristin Cloyes ◽  
Eliabeth Porter ◽  
Maija Reblin ◽  
Kathi Mooney ◽  
Djin Tay ◽  
...  
Keyword(s):  
Family Caregivers ◽  
Emotional Processing ◽  
Adult Child ◽  
Well Being ◽  
Future Research ◽  
Prospective Longitudinal Study ◽  
Telephone System ◽  
Diary Writing ◽  
Potential Impact ◽  
Prospective Longitudinal

Abstract Previous work has shown that emotional processing as part of diary writing improves well-being during and after stress. The purpose of this study was to determine the feasibility of verbal/audio diaries for home hospice family caregivers (HFCGs). We also describe diary content. As part of an ongoing multi-site, prospective longitudinal study, HFCGs of cancer patients report daily fluctuations in patients’ and their own symptoms via an automated telephone system, including a recorded diary entry. HFCGs are randomly assigned instructions to either discuss additional symptoms or discuss their thoughts and feelings. Thirty-six (85.7%) participants to date have completed at least one audio diary. For this preliminary analysis, we selected the 14 longest diary recordings from each condition (n=28) to content analyze using Linguistic Inquiry and Word Count (LIWC) and NVivo 12. Participants are 78.6% female, 53 years of age on average, and most are spouse/partner (46.4%) or adult child (35.7%) caregivers. There was no difference in the overall positivity (23%) or negativity (77%) of words in either condition, but participants asked to express thoughts/feelings used significantly more anger-related terms (p=0.04) while those asked to describe symptoms used significantly more anxiety-related terms (p = 0.003). Time was the most common theme in both conditions but arose more frequently in the symptom condition (p=.08). Our findings suggest that most audio diaries are feasible for HFCGs, but varied prompts may facilitate different types of emotional expression. Future research should assess potential impact on emotional well-being and bereavement adjustment.

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