Anatomic Distribution of Cutaneous Melanomas and Painful Sunburns in Adults

1996 ◽  
Vol 1 (2) ◽  
pp. 81-85
Author(s):  
Qasim H. Wasti ◽  
Alfred W. Kopf ◽  
Ashfaq A. Marghoob ◽  
Catherine M. Stefanato ◽  
Judith B. Romero ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Body Surface ◽  
Causative Factor ◽  
Cutaneous Malignant Melanoma ◽  
Cooperative Group ◽  
Men And Women ◽  
Group Data ◽  
Significant Difference ◽  
High Incidence ◽  
Anatomic Distribution

Background: Data show that intermittent painful sunburns are an important causative factor for cutaneous malignant melanoma. Objective: This study was undertaken to determine whether the differences in the anatomic distribution of melanomas in men, compared to women, could be accounted for by the distribution of sunburns and whether the high incidence of melanomas on the lower extremities of women is associated with the distribution of sunburns. Methods: One hundred and fifty nonmelanoma patients, men and women aged 20 to 60 years, recalled having painful sunburns within the previous 6 months. The locations of the sunburns were indicated on body surface diagrams. The locations of 1168 melanomas as recorded in the NYU-Melanoma Cooperative Group data base were plotted on anatomic diagrams. The anatomic distribution of melanomas and of sunburns for men and women were compared. Results: There was no statistically significant difference in the distribution of sunburns on any anatomic location in men as compared to women. However, there was a disproportionately high number of melanomas on the backs of men and on the legs of women. In both men and women, there was a significant difference between the anatomic distribution of painful sunburns and melanomas. Conclusion: Since the anatomic distribution of painful sunburns is similar in men and women, whereas the anatomic distribution of melanomas differ, it would appear that factors in addition to sunburns in adults account for the differences in the anatomic distribution of melanomas in men and women.

scholarly journals The Influence of Pregnancy on the Recurrence of Cutaneous Malignant Melanoma in Women

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
M. Albersen ◽  
V. I. Westerling ◽  
P. A. M. van Leeuwen
Keyword(s):  
Malignant Melanoma ◽  
Disease Free Survival ◽  
Recurrence Risk ◽  
Cutaneous Malignant Melanoma ◽  
Stage I ◽  
Free Survival ◽  
Medical Databases ◽  
Significant Difference ◽  
History Of ◽  
Disease Free

Objective. The aim of this study was to determine whether pregnancy increases the recurrence risk of cutaneous malignant melanoma (CMM) in women with a history of stage I CMM.Methods. The electronic medical databases of Medline and Embase were explored. All 1084 obtained articles were screened on title and abstract using predetermined inclusion and exclusion criteria. A critical appraisal of relevance and validity was conducted on the remaining full text available articles.Results. Two studies were selected. Both studies revealed no significant difference in disease-free survival between women with stage I CMM and the control population.Conclusion. Pregnancy does not increase the recurrence risk of CMM in women with a history of stage I CMM.

scholarly journals A Retrospective Large Original Study of Cutaneous Melanoma

2021 ◽  
Vol 15 (6) ◽  
pp. 1995-1998
Author(s):  
Hojat Eftekhari ◽  
Shabnam Fahim ◽  
Zeinab Aryanian ◽  
Azadeh Goodarzi ◽  
Ali Sadeghinia ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Melanoma ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Cutaneous Malignant Melanoma ◽  
Original Study ◽  
Cross Sectional ◽  
Acral Lentiginous Melanoma ◽  
Melanoma Cancer ◽  
Significant Difference

Background: The incidence of cutaneous malignant melanoma (CMM) has increased continuously during recent decades among many populations of the world. Cutaneous Malignant Melanoma is a malignancy with a demographic and ethnic disparity located in the skin and mucous membranous. The objective of this study is to determine Cutaneous Melanoma (CM) characteristics in Iran. Methods: This is a retrospective cross sectional study. We used data from Razi Hospital, Tehran University Melanoma Cancer Registry. The cases included in this study met the following criteria: primary CM, in situ or invasive, diagnosed in the recent past ten years. We have evaluated prognostic factors in addition to basic demographic data. Result: A total of 193 melanomas (99 males (51.3%) and 94 females (48.7%)) were included. The mean age was 58.3±15.8years. The most frequent location for melanoma was lower extremity (75 patients, 38.9%). The most frequent subtype for melanoma based on histopathology was the Acral Lentiginous Melanoma (ALM) (74 patients, 38.3%). There was statistically significant difference between histological subtypes of melanoma and Breslow thickness (p˂ 0.00 1). Conclusion: Present study showed risk factors such as age and pre-existing nevus are important factors in CMM incidence in Iran. Early detection of melanoma is a key factor in improving patients’ survival. Keywords: Cutaneous Melanoma, Malignant Melanoma, Cancer, Epidemiology, Histopathology, Immunohistochemistry, Histology, IHC, Original study, Skin cancer

scholarly journals HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258053
Author(s):  
Ke-Jun Chen ◽  
Feng-Zeng Li ◽  
Qian Ye ◽  
Meng Jia ◽  
Sheng Fang
Keyword(s):  
Heat Shock ◽  
Malignant Melanoma ◽  
Staining Intensity ◽  
Clinicopathological Characteristics ◽  
Cutaneous Malignant Melanoma ◽  
Breslow Thickness ◽  
Human Immune System ◽  
Significant Difference ◽  
Lentigo Maligna Melanoma ◽  
Shock Proteins

Background Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many cancers, but few studies on its role in cutaneous malignant melanoma have been published. In this study, we analyzed the relationship between HSP105 expression and the clinicopathological characteristics of CMM. Methods This retrospective study included 91 patients with CMM. The clinicopathological characteristics of CMM patients, including age, lesion duration, location, pathological classification, Clark’s level, Breslow thickness, metastasis and recurrence, were collected. Immunohistochemical staining and Western blot analysis for HSP105 were performed. Pigmented nevi (n = 20) served as a control. The staining intensity and percentage of stained cells were expressed as a histochemical score (HSCORE). Results HSP105 was overexpressed in melanoma compared with nevi. Differences in the HSCORE between nevi (HSCORE = 1.05(0.15,1.50)) and CMM (HSCORE = 2.68(1.80,3.60)) were remarkable (P<0.001). Exposed site lesions, recurrent and metastatic lesions, nodular melanoma and lentigo maligna melanoma were closely associated with higher HSP105 expression (P = 0.011, P = 0.001 and P = 0.001, respectively). Moreover, no significant difference was observed in Clark’s level, Breslow thickness, or lesion duration (P>0.05). Conclusion HSP105 is overexpressed in CMM. Higher HSP105 expression in lesions is associated with different clinicopathological variables. HSP105 may be a potential target for the diagnosis, treatment and prognostic prediction of CMM.

scholarly journals Comparative Analysis of Main Clinical Features and Survival in Patients with Cutaneous Malignant Melanoma with and without Sentinel Lymph Node Biopsy

2020 ◽  
Author(s):  
Strashilov Strahil ◽  
Joana Ivanova Simeonova ◽  
Assia Andrianova Konsoulova ◽  
Mariela Borisova Vasileva-Slaveva ◽  
Angel Dancev Yordanov
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Malignant Melanoma ◽  
Lymph Node Biopsy ◽  
Cutaneous Malignant Melanoma ◽  
University Hospital ◽  
Node Biopsy ◽  
Significant Difference ◽  
Group A

Abstract Background Sentinel lymph node biopsy is fundamental in the treatment and prognosis of cutaneous malignant melanoma. The aim of this study is to identify differences in baseline clinical characteristics and survival of patients with melanoma with and without sentinel lymph node biopsy (SLNB) performed. Methods In 2018, a retrospective study of 151 patients with malignant melanoma (MM) was conducted. The patients were hospitalized at the Second Clinic of University Hospital – Pleven, for the period 2012 to 2017. The patients were divided into two groups: Group A included 58 (38.4%) patients with SLNB performed; Group B included 93 (61.6%) patients who did not undergo SLNB. A double-detection method was used while performing SLNB. Results The incidence of achromatic malignant melanoma is significantly higher in patients without SLNB performed (12 or 12.9%), than in patients with SLNB performed (2 or 3.4%) – χ2 = 3.796, df = 1, p = 0.051. Of all 151 patients in the study, 46 died, representing 30.5 per 100 patients with melanoma. Mortality rate is higher in patients without SLNB (32.3% versus 27.6% in Group A). However, the differences in the two groups are not statistically significant. Conclusions Patients with achromatic melanoma have significantly fewer SLN biopsies performed because of a late diagnosis. Most of our patients are diagnosed at a later stage when lymphatic metastases are already present which leads to a significant increase in lymph node dissections performed. There is no significant difference in mortality and survival in the SLNB and non-SLNB groups.

The Effect of Reflexology on Labor Pain and Length Among Primiparous Women: A Randomized Controlled Trial

2018 ◽  
Vol 7 ◽  
Author(s):  
Azita Kamjoo
Keyword(s):  
Controlled Trial ◽  
Intervention Group ◽  
Active Phase ◽  
Labor Pain ◽  
Control Group ◽  
Singleton Pregnancy ◽  
Group Data ◽  
Significant Difference ◽  
Labor Length ◽  
Primiparous Women

Background: Pain control is considered as the key issue in modern midwifery. Along with medical painkillers, reflexology is viewed as a non-medical and noninvasive method. Hence, we aimed to investigate the effect of reflexology on the intensity of pain and length of labor. Materials and Methods: In this clinical trial, participants included 240 Iranian primiparous women with term and singleton pregnancy. Having a 3-4 cm cervical dilatation once they visited the hospital. Through a convenient sampling method, they were selected and then randomly divided into two groups. In the intervention group, reflexology was performed, and the intensity of pain during the active phase of labor along with the length of labor in the active phase was measured by visual analog scale (VAS) and compared with the control group. Data were analyzed using descriptive statistics, t-test, and Mann-Whitney U-test. Result: Data analysis showed a statistically significant difference between the intensity of pain in the 5-7 and 8-10 cm dilatation in the two groups (P=0.01). Moreover, the labor length in the active phase was found to be significantly shorter in the intervention group (P<0.001). Conclusion: It appears that reflexology can lead to a reduction in the pain and length of labor. Therefore, through instructing this technique, a goal of midwifery, which is reducing labor pain and its length can be achieved. Keywords: Reflexology, Labor Pain, Labor Length, Primiparous Women

Rice tablet (Aluminum Phosphide) poisoning

2016 ◽  
Vol 5 (11) ◽  
pp. 5041
Author(s):  
Farkhondeh Jamshidi ◽  
Ahmad Ghorbani ◽  
Sina Darvishi*
Keyword(s):  
Medical Records ◽  
Statistical Tests ◽  
Patient Records ◽  
Demographic Information ◽  
Aluminum Phosphide ◽  
Men And Women ◽  
Significant Difference ◽  
The Mean ◽  
Aluminum Phosphide Poisoning ◽  
Commit Suicide

The abuse of some pesticides especially to suicide is one of the current problems of pesticides. Aluminum phosphide induced poisoning usually happens to suicide and sometimes it is due to accidental occupational exposure and in a few cases it has some criminal intensions. This study is conducted to evaluate patients poisoned with aluminum phosphide. In the present study the medical records of cases of poisoning with rice tablets (aluminum phosphide) hospitalized in Ahvaz Razi hospital is studied. Accordingly, a checklist is prepared that included demographic information of patients (age, gender) and information on patient records (information on poisoning) are completed using the patients’ medical records. The analysis of data is done by SPSS V22. 18 patients poisoned with rice tablet (aluminum phosphide) are studied. Results of the study show that 11 patients are male and seven are female. The mean patient age is 27.06 ±8.04 years that is 28 ±9 and 25 ±6.02 in men and women respectively. Statistical tests show no statistically significant difference in mean age in both genders (P> 0.05). Among patients, 11 subjects took aluminum phosphide to attempt suicide and 3 cases took it unintentionally and of course the reason is not mentioned in four cases. Among the patients who tried to commit suicide by taking aluminum phosphide, 6 cases are male and 5 cases are female that no statistically significant difference is observed between the genders in this respect (P> 0.05). In addition to the study of the complications caused by this poisoning and its mortality, it is recommended to responsible authorities to provide the necessary educations and treatments to prevent this type of poisoning.

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