Targeted Drug Delivery in Cancer Therapy

Chemotherapy has been the main modality of treatment for cancer patients; however, its success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue, their intolerable toxicity, development of multi-drug resistance, and the dynamic heterogeneous biology of the growing tumors. Better understanding of tumor biology in recent years and new targeted drug delivery approaches that are being explored using different nanosystems and bioconjugates provide optimism in developing successful cancer therapy. This article reviews the possibilities and challenges for targeted drug delivery in cancer therapy.

Download Full-text

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

Current Cancer Drug Targets ◽

10.2174/1568009620666200115160805 ◽

2020 ◽

Vol 20 (4) ◽

pp. 271-287 ◽

Cited By ~ 2

Author(s):

Kuldeep Rajpoot

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Adverse Effects ◽

Targeted Drug Delivery ◽

Tumor Therapy ◽

Cancer Therapies ◽

Medication Delivery ◽

Lipid Nanocarriers ◽

Targeted Drug ◽

Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

Download Full-text

Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽

10.3390/polym13010059 ◽

2020 ◽

Vol 13 (1) ◽

pp. 59

Author(s):

Abeer M. Beagan ◽

Ahlam A. Alghamdi ◽

Shatha S. Lahmadi ◽

Majed A. Halwani ◽

Mohammed S. Almeataq ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Folic Acid ◽

Drug Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Ethyl Methacrylate ◽

Mesoporous Nanoparticles ◽

Targeted Drug ◽

Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

Download Full-text

Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy

Nanocarriers for Drug Delivery ◽

10.1016/b978-0-12-814033-8.00006-0 ◽

2019 ◽

pp. 173-204 ◽

Cited By ~ 3

Author(s):

Mahadevappa Y. Kariduraganavar ◽

Geetha B. Heggannavar ◽

Sandra Amado ◽

Geoffrey R. Mitchell

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Targeted Drug

Download Full-text

Targeted drug delivery for cancer therapy

Biomaterials for Cancer Therapeutics ◽

10.1533/9780857096760.1.31 ◽

2013 ◽

pp. 31-56 ◽

Cited By ~ 2

Author(s):

D.L. Stirland ◽

J.W. Nichols ◽

T.A. Denison ◽

Y.H. Bae

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Targeted Drug

Download Full-text

Current Therapies and Future Prospects

Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer - Advances in Medical Technologies and Clinical Practice ◽

10.4018/978-1-7998-5049-6.ch015 ◽

2021 ◽

pp. 306-318

Author(s):

Muddukrishnaiah K.

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Cancer Therapy ◽

Cancer Diagnosis ◽

Biomarker Discovery ◽

Future Prospects ◽

Cancer Treatments ◽

Therapeutic Uses ◽

Current Therapies ◽

Targeted Drug

Due to drug resistance, lack of cancer cell selectivity, and solubility, conventional cancer treatments lose their therapeutic uses, and as such, new therapeutic agents need to be developed. Nanomaterials and peptides are increasingly being used in the fields of cancer diagnosis, biomarker discovery due to their therapeutic values and novel way of targeting and curing the disease. Synergism among the peptide-conjugated nanoparticles is an exhilarating group of materials, not only sharing the benefits of conventional nanomedicine, but also possessing the unique properties of excellent biocompatibility, biodegradability, versatile sensitivity, specific biological purpose, and synthetic feasibility. These virtues inspired by the scientists and have taken advantage in the peptide-conjugated nano drugs for the accurate delivery of drugs reliably to the site of the lesion. This chapter offers a summary of emerging technologies that have recently been developed in the broad field of peptide-conjugated nanoparticles and offers guidance for targeted drug delivery and cancer therapy.

Download Full-text

ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy

International Journal of Nanomedicine ◽

10.2147/ijn.s249240 ◽

2020 ◽

Vol Volume 15 ◽

pp. 3333-3346 ◽

Cited By ~ 2

Author(s):

Srinivasan Ayyanaar ◽

Chandrasekar Balachandran ◽

Rangaswamy Chinnabba Bhaskar ◽

Mookkandi Palsamy Kesavan ◽

Shin Aoki ◽

...

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Cancer Therapy ◽

Iron Oxide Nanoparticles ◽

Targeted Drug Delivery ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Magnetic Iron Oxide ◽

Targeted Drug

Download Full-text

Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy

Chemical Communications ◽

10.1039/c9cc07831b ◽

2019 ◽

Vol 55 (100) ◽

pp. 15101-15104 ◽

Cited By ~ 4

Author(s):

Xiaoting Ji ◽

Haoyuan Lv ◽

Xinxin Sun ◽

Caifeng Ding

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Carcinoembryonic Antigen ◽

Silica Nanoparticles ◽

Targeted Drug Delivery ◽

Antigen Detection ◽

Targeted Cancer Therapy ◽

Carbon Dot ◽

Targeted Drug

Bifunctional composite nanospheres for carcinoembryonic antigen sensing and targeted drug delivery, based on carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels.

Download Full-text

Recent advances in combinatorial cancer therapy via multifunctionalized gold nanoparticles

Nanomedicine ◽

10.2217/nnm-2020-0051 ◽

2020 ◽

Vol 15 (12) ◽

pp. 1221-1237

Author(s):

Touqeer Ahmad ◽

Rizwana Sarwar ◽

Ayesha Iqbal ◽

Uzma Bashir ◽

Umar Farooq ◽

...

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Photothermal Therapy ◽

Therapeutic Implications ◽

Therapeutic Applications ◽

Diagnosis Of Cancer ◽

Targeted Drug ◽

Cancerous Cells

The diverse behavior of nanogold in the therapeutic field is related to its unique size and shape. Nanogold offers improvements in modern diagnostic and therapeutic implications, increases disease specificity and targeted drug delivery, and is relatively economical compared with other chemotherapeutic protocols. The diagnosis of cancer and photothermal therapy improve drastically with the implementation of nanotechnology. Different types of nanoparticles, that is, gold silica nanoshells, nanorods and nanospheres of diverse shapes and geometries, are used widely in the photothermal therapy of cancerous cells and nodules. Numerous reviews have been published on the therapeutic applications of gold nanoparticles, but studies on combinatorial applications of nanogold in cancer therapy are limited. This review focuses on the combinatorial cancer therapy using optical properties of nanogold with different shapes and geometries, and their therapeutic applications in cancer diagnosis, photothermal therapy, cancer imaging and targeted drug delivery.

Download Full-text