A censored sequential posterior odd test method in testability demonstration test planning

Author(s):  
Yong Zhang ◽  
Chao Wang ◽  
Xin Lin ◽  
Guanjun Liu ◽  
Peng Yang ◽  
...  

Testability demonstration tests can effectively verify product capabilities of fault detection and isolation; however, they suffer from insufficient samples, long cycles and high costs due to destructiveness of fault injection tests, which leads to an increasing demand for small sample tests. The sequential posterior odd test can effectively reduce sample sizes, but test results can be random and the sample size may be large. In this article, a censored sequential posterior odd test method is proposed, which can control the incremental risk caused by forced censoring within a contracted range by risk splitting. The development process of the testability demonstration test based on the censored sequential posterior odd test is designed. The number of censored tests and the calculation method of the censored threshold are presented. The case application shows that with the same prior distribution and constraint parameters, the average sample size of the proposed method is smaller than that of the sequential posterior odd test and of the classical method considering risks for both producers and consumers. The presented method can further reduce the risk of misjudgment and the number of test samples, contributing to the reduction of the test cycle and costs.

Author(s):  
Johannes Herdlevaer ◽  
Gordon Hugh Black

There has been an increasing demand for onshore testing of equipment destined for offshore operation. The justification for this requirement can be summarized as follows: 1. High cost of offshore commissioning where even minor faults detected, constitutes potentially serious problems. 2. Consequenses of delay of platform start-up are enormous. 3. Skilled experienced personel and diagnostic equipment is available onshore, and rectification of new units will benefit from the existence of previous experience. 4. Spare and renewal parts availability. This paper describes the method for string testing of a 3 unit 60 mw utility gasturbine-generator power module built for the gullfaks A platform in the Norwegian sector of the north sea. It describes the test facility and test equipment set up and also the test program which was followed. At the time of writing the paper the test program was barely initiated, and for that reason the test results will be presented in the form of an addendum to this paper during the meeting.


2011 ◽  
Vol 65 ◽  
pp. 291-294
Author(s):  
Yao Hua Wang ◽  
Liang Wang ◽  
Hai Shan Yang ◽  
Bao Guo Zhu

In order to solve the problem which generally exists in assessing high explosive ignition reliability of electro-explosive devices (EED), a new test method, based on information equivalence principle, is proposed on the condition of a relatively smaller sample size for instead. According to the definition of information principle, the method measures the reliability test information by the negative logarithm of ignition probability of EED and converts the test by GJB376-1987 at a larger amount of stimulation with a big sample size to a small one. We adopt this method to assess the ignition reliability of EED used in the emergency opening system. The result is that we just need 29 sample size on the confidence of not less than 95% and the ignition reliability greater than 0.999. Compared with the 2996 sample size in GJB376-1987, the method reduces the sample usage greatly. Tests shows that the small sample test method based on information equivalence principle for the ignition reliability test of EED is accurate, feasible and can meet the objective of experimental design


Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4102-4102
Author(s):  
Kim A. Janatpour ◽  
Robert C. Gosselin ◽  
John T. Owings ◽  
Ted Wun

Abstract -Background: Laboratory criteria for the antiphospholipid antibody syndrome (APS) include detection of the lupus anticoagulant (LA) by coagulation based tests, or detection of either anti-cardiolipin (aCL), or anti-B2-glycoprotein I (aB2GPI) antibodies by enzyme-linked immunoabsorbant assay (ELISA). Multiplex testing enables simultaneous measurement of multiple serum antibodies with small beads coated with target antigens and small sample volumes (5 μL). We compared the concordance of a prototype multiplex method to standard ELISA methods for measuring IgG and IgM antibodies directed against CL or B2GPI. Methods: Samples from patients with suspected APS were tested for IgG and IgM aCL and aB2GPI antibodies using standard ELISA methods (ELISA, Bio-Rad Laboratories, Hercules, CA) and by a prototype multiplex bead set analyzed on the BioPlex 2200 (Bio-Rad Laboratories, Hercules, CA). The multiplex method used beads coated with either CL alone, B2GPI alone, or CL-B2GPI complex. Results were normalized using ratios (obtained result/upper limit of normal). A positive result was defined as a ratio of > 1. For CL, the multiplex test is considered positive if positive results are present using beads with either the CL alone or the CL-B2GPI complex. Results: Table 1. Concordance of ELISA vs Multiplex tests for antiphospholipid antibody detection Multiplex Test Results Concordance (%) ELISA Test Results Positive Negative Positive Negative All Results aCL-IgG Positive (n=52) 30 22 58 - Negative (n=232) 32 200 - 86 82 aCL-IgM Positive (n=42) 32 10 76 - Negative (n=241) 34 207 - 85 84 aβ2GPI-IgG Positive (n=34) 20 14 59 - Negative (n=249) 17 232 - 93 89 aβ2GPI-IgM Positive (n=61) 31 30 51 - Negative (n=219) 22 197 - 90 81 Conclusions: The overall concordance of multiplex results with ELISA results was good (81–89%). Negative multiplex results showed excellent correlation with ELISA (85–93%). Positive multiplex results had variable correlation with ELISA (51–76%). Evaluation of clinically significant positive results and clinical outcome measures is needed to determine clinical sensitivity and specificity of the multiplex test. Further refinement of the multiplex platform may provide an efficient and cost-effective assay for antibodies associated with the antiphospholipid syndrome.


2020 ◽  
Vol 40 (1) ◽  
pp. 15-19
Author(s):  
Jelena Marinović ◽  
Marija Tonkić ◽  
Miroslav Barišić ◽  
Marina Radić ◽  
Ivana Goić-Barišić ◽  
...  

Background. Infections caused by multidrug-resistant organisms (MDRO) are difficult to treat and associated with poor outcomes for patients. Therefore, early identification and management of colonization are essential as first steps in infection prevention. Culture-based methods have been widely used for MDRO screening. The turnaround time (TAT) for the identification of carriers varies between 48-72 h with this method. The aim of our study was to compare the performance of the new rapid semiautomatic method for detection of MDRO (HB&L Uroquattro, Alifax) with standard cultivation on selective media. Methods. Twenty-one axillary, 20 nose and 19 rectal swabs were taken in duplicate on two selected days at the University Hospital Centre Split, Croatia. Swabs were cultivated and MDRO isolates were identified on selective media (Chromagar MRSA and Chromagar ESBL) according to the standard operating procedure. Novel Alifax method was performed according to manufacturer’s instructions. Results. TAT for the new method was significantly lower (6.5 h) in comparison to the classical method. With classical method, 10 extended spectrum ß-lactamases (ESBL) producing strains from 10 different rectal specimens were isolated on Chromagar ESBL media. Exactly the same specimens were positive for the presence of ESBL-producing bacteria by rapid Alifax method. On selective Chromagar MRSA media, 11 MDRO were isolated, while rapid method detected 11 MDRO from the same specimens. Conclusions. High concordance of positive and negative results obtained with classical and rapid method is encouraging. However, our study was performed on a small sample size and further research with larger sample size is needed.


2017 ◽  
Vol 1 (3) ◽  
pp. 85-94
Author(s):  
S. Deva Arul ◽  
K. Rebecca Jebaseeli Edna

This paper presents the derivation of operating characteristics function and associated measures of performance of mixed sampling Plans for costly or destructive items. The first stage is concerned with single sample variable inspection and in the second stage modified Chain Sampling inspection is recommended. If the first stage inspection of mixed plans does not lead to acceptance of the batch or lot then the second stage becomes more important. In the second stage of mixed plans, it is advisable to have small sample size for costly or destructive items. Therefore, in the second stage, the modified chain sampling plan which always utilizes the past lot inspection results in order to achieve very small sample size is taken into consideration. The economic or cost-effective of the sampling plans is measured through Average Sample Number which is smaller compared to any other mixed sampling plans. Designing procedure is given and tables are constructed to facilitate easy application in the production industries.


2020 ◽  
Vol 21 ◽  
Author(s):  
Roberto Gabbiadini ◽  
Eirini Zacharopoulou ◽  
Federica Furfaro ◽  
Vincenzo Craviotto ◽  
Alessandra Zilli ◽  
...  

Background: Intestinal fibrosis and subsequent strictures represent an important burden in inflammatory bowel disease (IBD). The detection and evaluation of the degree of fibrosis in stricturing Crohn’s disease (CD) is important to address the best therapeutic strategy (medical anti-inflammatory therapy, endoscopic dilation, surgery). Ultrasound elastography (USE) is a non-invasive technique that has been proposed in the field of IBD for evaluating intestinal stiffness as a biomarker of intestinal fibrosis. Objective: The aim of this review is to discuss the ability and current role of ultrasound elastography in the assessment of intestinal fibrosis. Results and Conclusion: Data on USE in IBD are provided by pilot and proof-of-concept studies with small sample size. The first type of USE investigated was strain elastography, while shear wave elastography has been introduced lately. Despite the heterogeneity of the methods of the studies, USE has been proven to be able to assess intestinal fibrosis in patients with stricturing CD. However, before introducing this technique in current practice, further studies with larger sample size and homogeneous parameters, testing reproducibility, and identification of validated cut-off values are needed.


2020 ◽  
Author(s):  
Qing Zhao ◽  
Pei Chen ◽  
Yu Zhang ◽  
Haining Liu ◽  
Xianwen Li

BACKGROUND Mobile health application has become an important tool for healthcare systems. One such tool is the delivery of assisting in people with cognitive impairment and their caregivers. OBJECTIVE This scoping review aims to explore and evaluate the existing evidence and challenges on the use of mHealth applications that assisting in people with cognitive impairment and their caregivers. METHODS Nine databases, including PubMed, EMBASE, Cochrane, PsycARTICLES, CINAHL, Web of Science, Applied Science & Technology Source, IEEE Xplore and the ACM Digital Library were searched from inception through June 2020 for the studies of mHealth applications on people with cognitive impairment and their caregivers. Two reviewers independently extracted, checked synthesized data independently. RESULTS Of the 6101 studies retrieved, 64 studies met the inclusion criteria. Three categories emerged from this scoping review. These categories are ‘application functionality’, ‘evaluation strategies’, ‘barriers and challenges’. All the included studies were categorized into 7 groups based on functionality: (1) cognitive assessment; (2) cognitive training; (3) life support; (4) caregiver support; (5) symptom management; (6) reminiscence therapy; (7) exercise intervention. The included studies were broadly categorized into four types: (1) Usability testing; (2) Pilot and feasibility studies; (3) Validation studies; and (4) Efficacy or Effectiveness design. These studies had many defects in research design such as: (1) small sample size; (2) deficiency in active control group; (3) deficiency in analyzing the effectiveness of intervention components; (4) lack of adverse reactions and economic evaluation; (5) lack of consideration about the education level, electronic health literacy and smartphone proficiency of the participants; (6) deficiency in assessment tool; (7) lack of rating the quality of mHealth application. Some progress should be improved in the design of smartphone application functionality, such as: (1) the design of cognitive measurements and training game need to be differentiated; (2) reduce the impact of the learning effect. Besides this, few studies used health behavior theory and performed with standardized reporting. CONCLUSIONS Preliminary results show that mobile technologies facilitate the assistance in people with cognitive impairment and their caregivers. The majority of mHealth application interventions incorporated usability outcome and health outcomes. However, these studies have many defects in research design that limit the extrapolation of research. The content of mHealth application is urgently improved to adapt to demonstrate the real effect. In addition, further research with strong methodological rigor and adequate sample size are needed to examine the feasibility, effectiveness, and cost-effectiveness of mHealth applications for people with cognitive impairment and their caregivers.


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