Multi-modality imaging evaluation of the dorsal arachnoid web

Purpose Dorsal arachnoid web (DAW) is a rare intradural abnormality which is associated with progressive myelopathy. Our objective was to review multi-modality imaging techniques demonstrating the scalpel sign appearance in evaluation of DAW. Methods We retrospectively reviewed various imaging modalities of patients found to have DAW at our institution during January 2015 to February 2020. Five patients underwent surgical decompression with pathological correlation. The remaining patients were presumptively diagnosed based on the characteristic finding of scalpel sign. Clinical data were evaluated and correlated to imaging findings. All imaging modalities demonstrated the characteristic scalpel sign. Results Sixteen patients (10 females, and six males) with multi-imaging modalities were evaluated. Their mean age was 52 year (range 23–74 years). Fifteen patients underwent conventional spine MRI. Further high-resolution MR imaging techniques, e.g. 3D T2 myelographic sequence, were utilized with two patients. MRI spine CSF flow study was performed to evaluate the flow dynamic across the arachnoid web in one patient. Eight patients were evaluated with CT myelogram. Syrinx formation was discovered in seven (44%) patients; five (71%) of them underwent surgical resection and decompression. Two patients underwent successful catheter-directed fenestration of the web with clinical improvement. We found a statically significant positive correlation between the degree of cord displacement and compression with syrinx formation (r = 0.55 and 0.65 with p-value of 0.03 and 0.009, respectively). Conclusion DAW has characteristic scalpel sign independent of imaging modality. Multi-modality imaging evaluation of DAW is helpful for evaluation and surgical planning.

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Detecting accurate tumor size across imaging modalities in breast cancer

Breast Disease ◽

10.3233/bd-201021 ◽

2021 ◽

pp. 1-6

Author(s):

Olutayo Sogunro ◽

Constance Cashen ◽

Sami Fakir ◽

Julie Stausmire ◽

Nancy Buderer

Keyword(s):

Breast Cancer ◽

Tumor Size ◽

Breast Imaging ◽

Imaging Modality ◽

Breast Cancer Diagnosis ◽

Imaging Modalities ◽

Clinical Staging ◽

P Value ◽

Pathology Report ◽

Breast Cancers

BACKGROUND: Of the most common imaging modalities for breast cancer diagnosis – mammogram (MAM), ultrasound (US), magnetic resonance imaging (MRI) – it has not been well established which of these most accurately corresponds to the histological tumor size. OBJECTIVE: To determine which imaging modality (MAM, US, MRI) is most accurate for determining the histological tumor size of breast lesions. METHODS: A retrospective study of 76 breast cancers found in 73 female patients who received MAM, US, and/or MRI was performed. 239 charts were reviewed and 73 patients met inclusion criteria. Analysis was performed using signed rank tests comparing the reported tumor size on the imaging modality to the tumor size on pathology report. RESULTS: Mammography and ultrasonography underestimated tumor size by 3.5 mm and 4 mm (p-values < 0.002), respectively. MRI tends to overestimate tumor size by 3 mm (p-value = 0.0570). Mammogram was equivalent to pathological size within 1 mm 24% of the time and within 2 mm 35% of the time. CONCLUSIONS: No one single modality is the most accurate for detecting tumor size. When interpreting the size reported on breast imaging modalities, the amount of underestimation and overestimation in tumor size should be considered for both clinical staging and surgical decision-making.

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Imaging Modalities in Gynecology

Donald School Journal of Ultrasound in Obstetrics & Gynecology ◽

10.5005/jp-journals-10009-1123 ◽

2010 ◽

Vol 4 (1) ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Raydeen M Busse

Keyword(s):

Computer Technology ◽

Imaging Technique ◽

Imaging Modality ◽

Imaging Techniques ◽

Cost Effective ◽

Imaging Modalities ◽

List Type ◽

Imaging Procedures ◽

Resonance Imaging ◽

Magnetic Resonance Imaging Mri

Abstract Although ultrasound is the primary imaging modality for most gynecologic diagnoses and conditions, knowledge of other diagnostic imaging procedures is important to gynecologists, emergency room physicians and radiologists who care for women of all ages. Since the early 1960s when ultrasound was introduced for the use in obstetrics and gynecology, other imaging techniques have rapidly come into play due to the tremendous advances in computer technology and in the field of engineering. It behooves us to become familiar and knowledgeable about the differences in these imaging techniques in order to gather the most information in the shortest amount of time to care for patients in the most efficient and cost-effective way. This review is meant for the use of most practicing physicians that are exposed to common as well as uncommon gynecologic conditions; therefore the primary imaging modalities discussed in this paper are limited to ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Objectives Understanding of the strengths and limitations of ultrasound, MRI and CT Obtaining knowledge of when to apply the most appropriate imaging technique for a certain clinical situations

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Imaging Modalities in Gynecology

Donald School Journal of Ultrasound in Obstetrics & Gynecology ◽

10.5005/dsjuog-3-2-74 ◽

2009 ◽

Vol 3 (2) ◽

pp. 74-85

Author(s):

Raydeen M Busse

Keyword(s):

Computer Technology ◽

Imaging Technique ◽

Imaging Modality ◽

Imaging Techniques ◽

Cost Effective ◽

Imaging Modalities ◽

List Type ◽

Imaging Procedures ◽

Resonance Imaging ◽

Magnetic Resonance Imaging Mri

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Advanced Imaging Techniques for Radiotherapy Planning of Gliomas

Cancers ◽

10.3390/cancers13051063 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1063

Author(s):

Antonella Castellano ◽

Michele Bailo ◽

Francesco Cicone ◽

Luciano Carideo ◽

Natale Quartuccio ◽

...

Keyword(s):

Radiation Treatment ◽

Imaging Modality ◽

Imaging Techniques ◽

Clinical Results ◽

Target Volume ◽

Radiotherapy Planning ◽

Tumor Control ◽

Current Standard ◽

Volume Delineation ◽

Hemodynamic Information

The accuracy of target delineation in radiation treatment (RT) planning of cerebral gliomas is crucial to achieve high tumor control, while minimizing treatment-related toxicity. Conventional magnetic resonance imaging (MRI), including contrast-enhanced T1-weighted and fluid-attenuated inversion recovery (FLAIR) sequences, represents the current standard imaging modality for target volume delineation of gliomas. However, conventional sequences have limited capability to discriminate treatment-related changes from viable tumors, owing to the low specificity of increased blood-brain barrier permeability and peritumoral edema. Advanced physiology-based MRI techniques, such as MR spectroscopy, diffusion MRI and perfusion MRI, have been developed for the biological characterization of gliomas and may circumvent these limitations, providing additional metabolic, structural, and hemodynamic information for treatment planning and monitoring. Radionuclide imaging techniques, such as positron emission tomography (PET) with amino acid radiopharmaceuticals, are also increasingly used in the workup of primary brain tumors, and their integration in RT planning is being evaluated in specialized centers. This review focuses on the basic principles and clinical results of advanced MRI and PET imaging techniques that have promise as a complement to RT planning of gliomas.

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Impact of the COVID-19 pandemic on the selection of chest imaging modalities and reporting systems: a survey of Italian radiologists

La radiologia medica ◽

10.1007/s11547-021-01385-1 ◽

2021 ◽

Author(s):

Andrea Borghesi ◽

Nicola Sverzellati ◽

Roberta Polverosi ◽

Maurizio Balbi ◽

Elisa Baratella ◽

...

Keyword(s):

Continuing Education ◽

Reporting System ◽

Imaging Modality ◽

Diagnostic Technique ◽

Imaging Modalities ◽

Chest Imaging ◽

Reporting Systems ◽

Imaging Approach ◽

Narrative Report ◽

Selection Of

Abstract Purpose Chest imaging modalities play a key role for the management of patient with coronavirus disease (COVID-19). Unfortunately, there is no consensus on the optimal chest imaging approach in the evaluation of patients with COVID-19 pneumonia, and radiology departments tend to use different approaches. Thus, the main objective of this survey was to assess how chest imaging modalities have been used during the different phases of the first COVID-19 wave in Italy, and which diagnostic technique and reporting system would have been preferred based on the experience gained during the pandemic. Material and Methods The questionnaire of the survey consisted of 26 questions. The link to participate in the survey was sent to all members of the Italian Society of Medical and Interventional Radiology (SIRM). Results The survey gathered responses from 716 SIRM members. The most notable result was that the most used and preferred chest imaging modality to assess/exclude/monitor COVID-19 pneumonia during the different phases of the first COVID-19 wave was computed tomography (51.8% to 77.1% of participants). Additionally, while the narrative report was the most used reporting system (55.6% of respondents), one-third of participants would have preferred to utilize structured reporting systems. Conclusion This survey shows that the participants’ responses did not properly align with the imaging guidelines for managing COVID-19 that have been made by several scientific, including SIRM. Therefore, there is a need for continuing education to keep radiologists up to date and aware of the advantages and limitations of the chest imaging modalities and reporting systems.

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In Vivo Imaging of Biodegradable Implants and Related Tissue Biomarkers

Polymers ◽

10.3390/polym13142348 ◽

2021 ◽

Vol 13 (14) ◽

pp. 2348

Author(s):

Leon Riehakainen ◽

Chiara Cavallini ◽

Paolo Armanetti ◽

Daniele Panetta ◽

Davide Caramella ◽

...

Keyword(s):

Imaging Modality ◽

Imaging Techniques ◽

Special Focus ◽

Tissue Remodelling ◽

Biodegradable Implant ◽

Advantages And Disadvantages ◽

Non Invasive ◽

Positron Emission ◽

Longitudinal Imaging

Non-invasive longitudinal imaging of osseointegration of bone implants is essential to ensure a comprehensive, physical and biochemical understanding of the processes related to a successful implant integration and its long-term clinical outcome. This study critically reviews the present imaging techniques that may play a role to assess the initial stability, bone quality and quantity, associated tissue remodelling dependent on implanted material, implantation site (surrounding tissues and placement depth), and biomarkers that may be targeted. An updated list of biodegradable implant materials that have been reported in the literature, from metal, polymer and ceramic categories, is provided with reference to the use of specific imaging modalities (computed tomography, positron emission tomography, ultrasound, photoacoustic and magnetic resonance imaging) suitable for longitudinal and non-invasive imaging in humans. The advantages and disadvantages of the single imaging modality are discussed with a special focus on preclinical imaging for biodegradable implant research. Indeed, the investigation of a new implant commonly requires histological examination, which is invasive and does not allow longitudinal studies, thus requiring a large number of animals for preclinical testing. For this reason, an update of the multimodal and multi-parametric imaging capabilities will be here presented with a specific focus on modern biomaterial research.

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The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study.

BMJ Open ◽

10.1136/bmjopen-2018-027772 ◽

2019 ◽

Vol 9 (9) ◽

pp. e027772 ◽

Cited By ~ 3

Author(s):

GAM Govaert ◽

MGG Hobbelink ◽

IHF Reininga ◽

P Bosch ◽

TC Kwee ◽

...

Keyword(s):

Cohort Study ◽

The Netherlands ◽

Diagnostic Imaging ◽

Fdg Pet ◽

Imaging Techniques ◽

Time Frame ◽

Imaging Modalities ◽

Multicenter Cohort Study ◽

Discriminative Ability ◽

Imaging Strategy

IntroductionThe optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.Methods and analysisThis study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are eligible for inclusion. Patients will undergo all three investigational imaging procedures (WBC scintigraphy, FDG-PET and MRI) within a time frame of 14 days after inclusion. The reference standard will be the result of at least five intraoperative sampled microbiology cultures, or, in case of no surgery, the clinical presence or absence of infection at 1 year follow-up. Initially, the results of all three imaging modalities will be available to the treating team as per local protocol. At a later time point, all scans will be centrally reassessed by nuclear medicine physicians and radiologists who are blinded for the identity of the patients and their clinical outcome. The discriminative ability of the imaging modalities will be quantified by several measures of diagnostic accuracy.Ethics and disseminationApproval of the study by the Institutional Review Board has been obtained prior to the start of this study. The results of this trial will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at scientific meetings and data sharing with other investigators through academically established means.Trial registration numberThe IFI trial is registered in the Netherlands Trial Register (NTR7490).

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Tracking Transplanted Stem Cells Using Magnetic Resonance Imaging and the Nanoparticle Labeling Method in Urology

BioMed Research International ◽

10.1155/2015/231805 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Jae Heon Kim ◽

Hong J. Lee ◽

Yun Seob Song

Keyword(s):

Magnetic Resonance Imaging ◽

Stem Cells ◽

Molecular Imaging ◽

Magnetic Resonance ◽

Imaging Modality ◽

Imaging Techniques ◽

Image Resolution ◽

Imaging Method ◽

Resonance Imaging

A reliablein vivoimaging method to localize transplanted cells and monitor their viability would enable a systematic investigation of cell therapy. Most stem cell transplantation studies have used immunohistological staining, which does not provide information about the migration of transplanted cellsin vivoin the same host. Molecular imaging visualizes targeted cells in a living host, which enables determining the biological processes occurring in transplanted stem cells. Molecular imaging with labeled nanoparticles provides the opportunity to monitor transplanted cells noninvasively without sacrifice and to repeatedly evaluate them. Among several molecular imaging techniques, magnetic resonance imaging (MRI) provides high resolution and sensitivity of transplanted cells. MRI is a powerful noninvasive imaging modality with excellent image resolution for studying cellular dynamics. Several types of nanoparticles including superparamagnetic iron oxide nanoparticles and magnetic nanoparticles have been used to magnetically label stem cells and monitor viability by MRI in the urologic field. This review focuses on the current role and limitations of MRI with labeled nanoparticles for tracking transplanted stem cells in urology.

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Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer

International Journal of Molecular Sciences ◽

10.3390/ijms22052757 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2757

Author(s):

Braden Miller ◽

Hunter Chalfant ◽

Alexandra Thomas ◽

Elizabeth Wellberg ◽

Christina Henson ◽

...

Keyword(s):

Breast Cancer ◽

Imaging Techniques ◽

Growth Factor Receptor ◽

Breast Cancer Diagnosis ◽

Screening Mammography ◽

Imaging Modalities ◽

Conventional Imaging ◽

Obese Women ◽

Detection Rates ◽

Therapeutic Decision Making

Obesity, diabetes, and inflammation increase the risk of breast cancer, the most common malignancy in women. One of the mainstays of breast cancer treatment and improving outcomes is early detection through imaging-based screening. There may be a role for individualized imaging strategies for patients with certain co-morbidities. Herein, we review the literature regarding the accuracy of conventional imaging modalities in obese and diabetic women, the potential role of anti-inflammatory agents to improve detection, and the novel molecular imaging techniques that may have a role for breast cancer screening in these patients. We demonstrate that with conventional imaging modalities, increased sensitivity often comes with a loss of specificity, resulting in unnecessary biopsies and overtreatment. Obese women have body size limitations that impair image quality, and diabetes increases the risk for dense breast tis-sue. Increased density is known to obscure the diagnosis of cancer on routine screening mammography. Novel molecu-lar imaging agents with targets such as estrogen receptor, human epidermal growth factor receptor 2 (HER2), pyrimi-dine analogues, and ligand-targeted receptor probes, among others, have potential to reduce false positive results. They can also improve detection rates with increased resolution and inform therapeutic decision making. These emerg-ing imaging techniques promise to improve breast cancer diagnosis in obese patients with diabetes who have dense breasts, but more work is needed to validate their clinical application.

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Abstract P381: Pre-Treatment Perfusion Mismatch Volumes in Ischemic Stroke Patients Treated With Tenecteplase or Alteplase

Stroke ◽

10.1161/str.52.suppl_1.p381 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Adrienne N Dula ◽

Ian M Alrahwan ◽

Steven J Warach

Keyword(s):

Imaging Modality ◽

Infarct Volume ◽

Volume Growth ◽

Logistic Models ◽

P Value ◽

Full Cohort ◽

Stroke Registry ◽

Discharge Disposition ◽

Chi Squared ◽

Pre Treatment

Introduction: The overall goal of this study is to evaluate the relationship of pretreatment perfusion mismatch volumes to outcomes in patients receiving alteplase (ALT) to those receiving tenecteplase (TNK). Methods: This study included patients receiving treatment with ALT (0.9 mg/kg; max, 90 mg) or TNK (0.25 mg/kg; max, 25 mg) between 09/01/2017 - 06/30/2020 identified through our local stroke registry stroke registry. Of the 505 patients meeting these criteria, 280 have been screened, including patients receiving EVT (n=94) and a sampling of n=111 from the ALT group and 75 from the TNK group. Final eligibility will be patients with a pretreatment perfusion deficit, mismatch > 15 mL, and mismatch (MM) ratio ≥ 1.2. Volumes are based on RAPID software (iSchemiaView). Using univariate (chi-squared with continuity correction or Mann-Whitney U) and adjusted logistic models, the effect of lysis type and pre-treatment imaging were assessed on the primary outcome of discharge disposition. Results: A total of 93 patients were included in our analysis, 40 receiving ALT and 53 patients receiving TNK, demographics found in Table 1. Discharge to home occurred in 48.8% (20/40) of patients treated with ALT and 30.7% (16/53) treated with TNK, odds ratio (OR), 0.47; 95% CI [0.20, 1.09], (P-value for OR=0.0766). Upon adjustment for EVT, age, sex, NIHSS on admission, imaging modality, cohort imbalances (marked by *), and MM, the relation of lysis type to discharge to home gave an OR of 0.25; 95% CI [0.06, 0.90], P= 0.0383) with age (P<0.0001) and imaging modality (P=0.0020) significantly contributing to the model. Lysis type did not significantly influence discharge to hospice or death (OR, 0.62; 95% CI [0.05, 6.86], P=0.6945) upon adjustment for baseline factors. Conclusion: In this preliminary analysis, MM volumes did not contribute to the outcome of discharged to home. Analysis of the full cohort is ongoing and final analyses will relate lytic type to infarct volume growth and clinical outcomes.

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