scholarly journals Severe Para-Aminosalicylic Acid Hypersensitivity

Blood ◽  
1955 ◽  
Vol 10 (1) ◽  
pp. 62-75 ◽  
Author(s):  
W. CANNEMEYER ◽  
J. R. THOMPSON ◽  
M. R. LICHTENSTEIN
Keyword(s):  
Lymph Node ◽  
Infectious Mononucleosis ◽  
Infectious Hepatitis ◽  
Severe Form ◽  
Viral Diseases ◽  
Aminosalicylic Acid ◽  
Blood Picture ◽  
Chemical Substances ◽  
Simple Chemical ◽  
Per Se

Abstract A severe form of hypersensitivity to para-aminosalicylic acid in patients with tuberculosis was studied. The blood picture, lymph node biopsies, and imprints are described. The similarities between this hypersensitivity to a simple chemical and infectious mononucleosis and infectious hepatitis are discussed. The possibility is suggested that some of the findings in viral diseases are due to hypersensitivity to chemical substances derived from the virus rather than to infection per se.

The Blood Picture in Rubeila: Its Place in Daignosis

PEDIATRICS ◽  
1956 ◽  
Vol 18 (5) ◽  
pp. 729-729
Keyword(s):  
Pregnant Woman ◽  
Infectious Mononucleosis ◽  
Blood Cells ◽  
Plasma Cells ◽  
Correct Diagnosis ◽  
Falkland Islands ◽  
Blood Picture

Changes in the blood cells have been considered as an aid in the diagnosis of rubella hut there has been no general agreement on the differentiation of the changes seen in rubella from those seen in measles and other disorders. Observations made during an epidemic of rubella in the Falkland Islands supplemented by material from London hospitals, afforded an opportunity for further study of the blood changes in rubella. The author believes the following changes to be indicative of rubella: (1) Monocytes, Turk cells and (especially) plasma cells, abundant. (2) Lymphacytes and neutrophil leucocytes, reduced. (3) Stab-cells, little increased. (4) Metamyelocytes, scarce. (5) Degenerate forms of lymphocytes, present. These changes in the blood linger long after the attack of rubella. The distinction between the changes in rubella and those seen in measles and infectious mononucleosis is discussed. The author is of the opinion that the changes in the blood are sufficiently characteristic to be an important aid in the diagnosis of rubella, and that this is particularly advantageous when it is necessary to make a correct diagnosis in order to provide protection for an exposed pregnant woman. The characteristic changes in the blood were found in all cases of rubella examined between the first and ninth days of illness.

scholarly journals AUTOHEMAGGLUTININS AND HEMOLYSINS WITH HEMOGLOBINURIA AND ACUTE HEMOLYTIC ANEMIA, IN AN ILLNESS RESEMBLING INFECTIOUS MONONUCLEOSIS

Blood ◽  
1948 ◽  
Vol 3 (4) ◽  
pp. 419-430 ◽  
Author(s):  
LAURENCE B. ELLIS ◽  
OSCAR J. WOLLENMAN ◽  
RICHARD P. STETSON
Keyword(s):  
Hemolytic Anemia ◽  
Infectious Mononucleosis ◽  
Room Temperature ◽  
Massive Transfusion ◽  
Agglutination Test ◽  
High Dilution ◽  
Blood Picture ◽  
Transfusion Therapy ◽  
Hematologic Disorder ◽  
Initial Blood

Abstract A case is reported of a young man with acute hemolytic anemia and hemoglobinuria who presented: an initial blood picture consistent with infectious mononucleosis, associated with a heterophile agglutination test positive in high dilution; auto-hemagglutinins, active in the cold, at room temperature and at 37 Centigrade; a hemolysin active at 37 C. after chilling, requiring the presence of a thermolabile component of serum for hemolysis; a positive Donath-Landsteiner test but no evidence of syphilis. In addition there was clubbing of the digits with certain other roentgenologic changes in the bones; absence of any other etiologic factors known to be concerned with such anemia; uneventful improvement under massive transfusion therapy, with apparent recovery from his hematologic disorder when studied two years later.

Public Health and Water Quality Significance of Viral Diseases Transmitted by Drinking Water and Recreational Water

1983 ◽  
Vol 15 (5) ◽  
pp. 1-15 ◽  
Author(s):  
Victor J Cabelli
Keyword(s):  
Water Quality ◽  
Drinking Water ◽  
Municipal Wastewater ◽  
Infectious Hepatitis ◽  
Viral Diseases ◽  
Annual Number ◽  
Sampling Station ◽  
Viral Gastroenteritis ◽  
Water Quality Criteria ◽  
Recreational Water

A review of the available information from case and outbreak reports and the results of prospective and retrospective studies revealed that the potential for the spread of viral diseases by the use of fecally contaminated drinking and recreational water has only been realized for infectious hepatitis and viral gastroenteritis. These two, however, are the most serious and prevalent, respectively, of the water-related diseases. A model is described for predicting the beach specific, swimming-associated rates and annual number of cases of gastroenteritis. The inputs are the swimming-associated, gastroenteritis rate-bathing water enterococcus density regression equation developed from the USEPA prospective epidemiologic-microbiologic studies and the distribution of enterococcus density estimates and annual number of swimmers at the beach in question. In general, the gastroenteritis rates predicted from the enterococcus model were less than those from the corresponding E. coli model. Detectable rates at the 75 percentile level and rates approaching or exceeding 5/1000 swimmers at the 90 percentile level were predicted for 7 and 14, respectively, of the 87 sampling station-beach associations. All but one of the fourteen stations were potentially impacted by known municipal wastewater discharges and two of the associated beaches were posted as unsafe for swimming. The inapplicability of the model to beaches impacted with small, immediate sources of fecal wastes or stormwater run-off is noted. The limitations in the use of findings from the analysis of outbreak reports in the evaluation and establishment of water quality criteria and, hence, the need for prospective, drinking water and shellfish epidemiological studies is discussed. The need for such studies also derives from the results of the bathing beach study in that they suggest that cases of gastroenteritis are occurring with acceptable drinking and shellfish growing waters. The need for tissue culture enumerative methods for the viral gastroenteritis agents and methodology for determining the biological decay coefficients for these agents and their indicators is noted.

scholarly journals Clinical and laboratory features of infectious mononucleosis caused by the Epstein-Barr virus

2014 ◽  
Vol 95 (5) ◽  
pp. 722-725 ◽  
Author(s):  
R A Gileva ◽  
Z A Hohlova ◽  
Yu S Chechet ◽  
A S Arsenenko ◽  
L M Povolotskaya
Keyword(s):  
G Proteins ◽  
Infectious Mononucleosis ◽  
High Frequency ◽  
Epstein Barr Virus ◽  
Mononuclear Cells ◽  
Severe Form ◽  
Immunoglobulin M ◽  
Standard Laboratory ◽  
Barr Virus ◽  
Epstein Barr

Aim. To study the clinical and laboratory characteristics of patients with infectious mononucleosis caused by the Epstein-Barr virus. Methods. In infectious hospital under observation there were 108 patients aged from 11 months to 31 years with a laboratory confirmed diagnosis of «infectious mononucleosis caused by the Epstein-Barr virus». Standard laboratory tests for blood serum immunoglobulin M to the capsid protein of Epstein-Barr virus, immunoglobulin class G proteins to early Epstein-Barr virus and the index of their avidity by ELISA were carried out. Tests for other infections were conducted if it is required. Results. Patients dominated by children aged 1-7 years - 73.1%. Adult patients was 1.8% (2 patients). Only 4.6% of the patients were sent to the hospital with a diagnosis of «infectious mononucleosis» or suspected of having the disease. The typical clinical picture of infectious mononucleosis was observed in 75% of cases, atypical - in 25%. Mononuclear cells in peripheral blood were found in less than half of the patients (44.4%), in 53.1% of cases with typical and in 18.5% of cases with atypical clinic. In the remaining patients, the diagnosis of infectious mononucleosis was verified by ELISA. In 90.4% of the cases the disease was in the moderate, and in 9.6% - in the severe form. Conclusion. The high frequency of atypical course of infectious mononucleosis caused by the Epstein-Barr virus justifies the need to include it into differential diagnosis process in case of unclear infectious disease, to identify the antibodies to the Epstein-Barr virus proteins, (immunoglobulin M and G) and the index of avidity antibodies (immunoglobulin G).

scholarly journals Infectious Mononucleosis Complicated With Idiopathic Thrombocytopenic Purpura: A Case Report and Literature Review

2020 ◽  
Author(s):  
Yong Ren ◽  
Qiong Wang ◽  
Qiang Liu ◽  
Jinsheng Zhang
Keyword(s):  
T Cells ◽  
In Situ Hybridization ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Infectious Mononucleosis ◽  
Lymph Node Biopsy ◽  
Thrombocytopenic Purpura ◽  
Node Biopsy

Abstract Background: Epstein-Barr virus (EBV) is the cause of infectious mononucleosis (IM), a self-limited lymphoproliferative disorder among patients. EBV usually infects B-lymphocytes rather than T-lymphocytes. The clinicopathologic features of the idiopathic thrombocytopenic purpura (ITP) patients complicated with EBV-positive IM have been rarely described.Case presentation: We describe a case of a 19-year-old man complained with epistaxis and thrombocytopenia for one year, who was admitted to hospital for high grade fever after catching a cold. A lot of petechiae were found on the skin of both lower limbs and both hands during physical examination. Multiple enlarged lymph nodes could be touched in both sides of the neck. Ultrasound examination showed abnormal lymph nodes enlargement on both sides of the neck and supraclavicular area, and a strong echo mass was found in the liver. Serological tests for EBV revealed high level of IgM and IgG antibodies against viral capsid antigen (VCA), virus DNA quantitative<1000UI/mL. CD8-positive cytotoxic T cells accounted for up to 92.94% by flow cytometry. T cells were positive for CD38, CD57 and HLA-DR marker. Bone marrow cytology showed that the proportion of lymphocytes had increased considerably, and the rate of abnormal lymphocyte was as high as 29.5%. EBV virus encoded RNA was demonstrated in lymph node biopsy by in-situ hybridization (ISH) analysis. Immunohistochemically, there were more CD8-positive cells than CD4-positive cells in lymph node biopsy. The expression of CD7 was missing. CD99 was diffuse positive. The MIB-1/ki-67 labeling index was about 70%. EBER in situ hybridization revealed positive signals located in the nucleus. The patient was diagnosed as Infectious mononucleosis complicated with idiopathic thrombocytopenic purpura. The patient was hospitalized and discharged after recovery.Conclusions: ITP patients complicated with EBV-positive IM have been rarely reported in the literature. Comprehensive understanding of its clinicopathological features will help diagnose of this disease.

Fibrinolytic Activity of Thrombin Preparations

1964 ◽  
Vol 11 (01) ◽  
pp. 234-242 ◽  
Author(s):  
Pieter Brakman ◽  
Panpit Klug ◽  
Tage Astrup
Keyword(s):  
Protease Activity ◽  
Fibrinolytic Activity ◽  
The Other ◽  
Fibrinolytic Agents ◽  
Fibrinolytic Agent ◽  
Low Concentrations ◽  
Fibrin Plate ◽  
Simple Chemical ◽  
Per Se ◽  
High Concentrations

SummarySome thrombin samples have a slight unspecific protease activity probably caused by contaminating plasmin. All investigated samples were fibrinolytically active. This activity was caused by an activator of plasminogen. Fibrinolytic activity was apparently produced by two components of the thrombin preparations. One of these components was a contaminant with fibrinolytic activity but with no thrombin activity. This component could be separated from the thrombin by simple chemical procedures. The other fibrinolytic component appeared to be the thrombin molecule per se. It was not fibrinolytically active when used in the low concentrations required for clotting of fibrinogen, but in high concentrations, assayed on the fibrin plate, it activated plasminogen. In the accurate assay of fibrinolytic agents it is necessary to use preparations of thrombin from which the contaminating fibrinolytic agent has been removed.

scholarly journals Graft-vs.-Host Activity of Thymocytes: Relationship to the Role of Thymocytes in Hemopoiesis

Blood ◽  
1972 ◽  
Vol 39 (6) ◽  
pp. 850-861 ◽  
Author(s):  
Joan Wright Goodman ◽  
Kay T. Burch ◽  
Nancy L. Basford
Keyword(s):  
Lymph Node ◽  
F1 Hybrid ◽  
Radiation Chimeras ◽  
Lymph Node Cells ◽  
Per Se ◽  
Uptake Method ◽  
Better Than

Abstract The importance of graft-vs.-host (GVH) activity to the ability of thymocytes to augment hemopoiesis in radiation chimeras was investigated. Parental (P) lymph node cells were found by the 59Fe-uptake method not to have an analogous augmentative effect. When thymus donor, marrow donor, and irradiated recipient were chosen immunogenetically so that GVH could occur in either the presence or absence of graft-vs.-graft (GVG) activity, it was seen that GVH reactivity per se resulted in no improvement of marrow growth. However, when P thymocytes specifically tolerant to an F1 hybrid host were administered with P marrow, augmentation was three times greater than when nontolerant P thymocytes were given. It was concluded that GVH activity not only is not essential but actually is detrimental to augmentation. Ninety-day survival of chimeras given specifically tolerant P thymocytes was better than that of mice given P marrow only and very much better than those given marrow and nontolerant thymocytes.

PREVENTION OF VIRAL DISEASES

PEDIATRICS ◽  
1962 ◽  
Vol 30 (6) ◽  
pp. 862-874
Author(s):  
Robert J. Warren ◽  
Frederick C. Robbins
Keyword(s):  
Passive Immunization ◽  
Infectious Hepatitis ◽  
Active Immunization ◽  
Viral Diseases ◽  
Intimate Contact ◽  
Source Of Infection ◽  
The Family ◽  
Specific Source

Although the control of infectious hepatitis leaves much to be desired, certain measures can be taken. When a specific source of infection can be identified, such as shellfish, or the parenteral introduction of infected serum or blood, epidemiologic control can be effective in eliminating the source of infection and the use of gammaglobulin may protect those already exposed. When transmission occurs by intimate contact, such as within the family or where sanitary measures cannot be employed, passive immunization should be initiated. There are no immediate prospects for active immunization.

scholarly journals Multiorgan pathoanatomical manifestation of spontaniously ocuring intestinal yersiniosis in dogs

2020 ◽  
Vol 23 (11) ◽  
pp. 7-15
Author(s):  
Grеgory Zon ◽  
Illia Zon ◽  
Lyudmila Ivanovskaya
Keyword(s):  
Aqueous Solution ◽  
Clinical Manifestations ◽  
Infectious Hepatitis ◽  
Viral Diseases ◽  
Liver Protein ◽  
Paraffin Sections ◽  
Local Areas ◽  
Basic Protocol ◽  
Pathological Material ◽  
Small And Large Intestine

The paper presents materials on pathomorphological changes in the organs of dogs with intestinal yersiniosis, the disease which is still considered to be predominately asymptomatic. The aim of the study was to determine the main pathomorphological changes in dogs with spontaneous intestinal yersiniosis caused by Y. enterocolitica. To achieve this goal, pathological and pathomorphological studies were performed on 12 corpses of dogs aged 8-22 months between 2017-2020. The specimens had a laboratory-confirmed diagnosis of intestinal yersiniosis as a monoinfection, and three of the corpses had complications of infectious hepatitis and two corpses with complications of pseudomonosis. The material for the study was extracted during an autopsy of dogs that died due to acute and rarely chronic spontaneous intestinal yersiniosis, as well as when it was complicated by other infectious diseases. Fixation of pathological material (pieces of lungs, liver, spleen, lymph nodes, stomach, small and large intestine, kidneys) and the manufacturing of paraffin sections were performed according to generally accepted methods. The resulting sections were stained with Karatsi hematoxylin and aqueous solution of eosin. The most significant changes were found in the organs of the gastrointestinal tract (congestive catarrhal-hemorrhagic processes in the acute course and atrophic and productive in the chronic), liver (protein and fat dystrophies, local areas of necrobiosis and cytolysis of hepatocytes), spleen in the kidneys (signs of granular and hyaline-drop dystrophy of the epithelium of the tubules and dystrophic-atrophic processes in the glomeruli), characteristic of septicemia and toxemia. Based on the analysis of literature sources, the results of the study, it was found that intestinal yersiniosis of dogs is a disease that has multiorgan pathology, but due to the similarity of clinical manifestations and lack of specific diagnostic laboratories it is often disguised as other bacterial and viral diseases. The complex of pathomorphological changes in the organs of the deceased animals, taking into account the results of serological and pathological studies, can be considered a basic protocol for diagnosing intestinal yersiniosis in dogs

scholarly journals Моніторинг розповсюдження вірусів серед домашніх котів і собак у м. Дніпропетровськ

2014 ◽  
Vol 5 (1) ◽  
pp. 23-27
Author(s):  
L. V. Yashchuk ◽  
N. V. Cherevach ◽  
A. I. Vinnikov
Keyword(s):  
Viral Infections ◽  
Age Groups ◽  
Domestic Animals ◽  
Infectious Hepatitis ◽  
Urban Environments ◽  
Viral Diseases ◽  
Virus Infections ◽  
Diagnostic Measures ◽  
Respiratory Viral Infections ◽  
Near Future

Cats and dogs kept at home, as well as other animals, are susceptible to infectious diseases caused by pathogenic microorganisms, including viruses. Viral infections in urban environments are extremely common and cause severe diseases in domestic animals which often lead to death, resulting in high material and moral damages to owners of animals. Therefore, investigation of the prevalence of pathogens of viral diseases is very important in our time. The aim of this work is to define the indicators of spreading viral diseases of animals in Dnipropetrovsk, to analyze the seasonal spread of viral infections in animals, and influence of sex and breed on the frequency of disease manifestations. Materials for research were obtained on the basis of three veterinary clinics in Dnipropetrovsk. During the study, we used serological methods of diagnostics of clinical materials, namely ELISA and IHA. Immunosorbent assay was performed using the thermostatic shaker ST-3 and strip immunoassay analyzer Stat Fax 303 Plus. Also we used commercial test systems VetExpert CAV Ag and Feline VacciCheck ImmunoComb®, based on the immuno-chromatographic method. During clinical studies of 491 animals (268 cats and 223 dogs) it was found that the most common respiratory viral infections in cats were calicivirus infection and rhinotracheitis, while in dogs there were viral diseases of gastrointestinal tract, i.e. enteritis and hepatitis. Using IHA method, we revealed the antibodies to respiratory viruses in the blood of deseased cats: to calicivirus – in 95 cats, to rhinotracheitis – in 60 cats; by ELISA method we identified antigens of parvovirus, enteritis pathogen, in biological material of 61 dogs, by IHA we found antibodies to virus of infectious hepatitis in 49 individuals. Based on these data, it has been revealed that during the winter months the animals suffered mostly the respiratory viral infections (60%), and in spring there were increased occur-rence of enteritis, observed in all age groups of animals. From May, hepatitis started to appear and prevailed for all summer months, mixed with enteritis (about 50% of total number of cases). Hepatitis was recorded both in cats and dogs. By the fall, recurrence was observed for calicivirus and herpes virus infections in cats, and the cases of enteritis decreased, while hepatitis was recorded until mid-October. Such statistics is kept relatively constant. The research results can be applied in the practice of veterinary laboratories for the development of diagnostic measures and prevention of viral diseases in domestic animals, as well as in the prediction of dissemination of viral infections in animals in the near future.

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