Chronic Inflammatory Autoimmune Disorders Are a Risk Factor for Blood Group Alloimmunization in Transfused Patients

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4294-4294
Author(s):  
Alex B Ryder ◽  
Jeanne E Hendrickson ◽  
Christopher A. Tormey
Keyword(s):  
Autoimmune Disease ◽  
Blood Group ◽  
Conflicts Of Interest ◽  
Autoimmune Disorder ◽  
Autoimmune Disorders ◽  
Inflammatory Disorder ◽  
Transfusion Rate ◽  
Chi Square ◽  
Inflammatory Disorders ◽  
Chi Square Test

Abstract Background: Alloimmunization to red blood cell (RBC) antigens is a clinically-significant problem, but the mechanisms underlying antibody induction remain poorly understood. Data from murine models has suggested that inflammation can promote blood group alloimmunization. To our knowledge, only one group (Ramsey & Smietana, Transfusion 1995;35:582) has examined the influence of inflammation on RBC alloimmunization; however, study subjects were predominantly female, making it difficult to determine the contribution of inflammation towards transfusion-related alloimmunization. Thus, the aim of our study was to examine whether inflammation associated with chronic autoimmune disorders increases the risk for development of transfusion-related RBC alloantibodies in a primarily male patient cohort. Methods: The transfusion records of alloimmunized patients at a Veterans’ Affairs facility were extracted from a large database of individuals who underwent type and screen testing from 1961 through May, 2014. For alloimmunized patients, the following information was retrospectively collected: 1) demographic data including gender, 2) the number and specificity of alloantibodies reactive at 37°C and/or antihuman globulin phase, and 3) the presence of an underlying chronic inflammatory autoimmune disorder (and the specific diagnosis, as applicable). In addition, the records of 250 randomly-selected patients undergoing RBC administration were reviewed to establish the transfusion rate among individuals with chronic inflammatory autoimmune disorders. Results: Among all patients undergoing type and screen testing at our facility, 220 had one or more detectable alloantibodies. Patients with a chronic inflammatory autoimmune disorder constituted nearly 16% (35/220) of total alloimmunized individuals. These patients formed 50 total alloantibodies (1.4 antibodies per alloimmunized patient). Anti-D (n=10) and anti-K (n=10) were the two most common alloantibodies detected in this group, followed by anti-E (n=8) and anti-C (n=6). Men represented about 86% (30/35) of alloimmunized patients with an autoimmune disorder, indicating that the vast majority of detected antibodies resulted from transfusion rather than pregnancy. The most common autoimmune disorder among alloimmunized patients was psoriasis (9/33; 27%), followed by rheumatoid arthritis (6/33; 18%). Examination of the charts of randomly-selected patients who underwent RBC transfusion showed that 8.4% (21/250) had an underlying chronic inflammatory disorder. The ratio of alloimmunized patients with an autoimmune disease to those without one was significantly different than the ratio of transfused patients with an autoimmune disease to those without one (P=0.012, chi square test; P=0.018, chi square test with Yates’ correction for continuity). Conclusions: Patients with autoimmune diseases represented a substantial portion of individuals with transfusion-associated alloantibodies. Patients with chronic inflammatory disorders formed alloantibodies at nearly double the rate at which they were transfused. As such, precautionary interventions (e.g., extended phenotypic matching for K, E, and C antigens) may be warranted for patients with chronic inflammatory disorders. Disclosures No relevant conflicts of interest to declare.

scholarly journals Genotypic and Alelicas Frequencies of the ABO and Rh Systems in the State of Rio Grande Do Norte, Northeast of Brazil

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4990-4990
Author(s):  
Linduarte Varela Morais ◽  
Aldair Sousa Paiva ◽  
Valéria SF Sales ◽  
Geraldo Barroso Cavalcanti
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Conflicts Of Interest ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Blood Group Antigens ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Group B

Objective: To determine the immunophenotyping of a population of blood donors, intended to build a database for transfusion medicine. 2) To make available to patients with chronic diseases that are systematically dependent on blood transfusions as compatible as possible in ABH, Rh (DCcEe) and Kell 1 antigen systems. Method: A cross-sectional study was carried out on 11,664 blood donors for the ABH system typing and of these, 1255 blood donors were selected randomly for the determination of blood group antigens of the Rh system and Kell antigen. Blood centrifugation methods, centrifuge hemolysis tube test and indirect Coombs test were used for blood typing. The results obtained were compared by the Chi-square test. A level of statistical significance of p ≤ 0.05 was considered. Results: Antigenic frequencies for the ABH system found: the frequency found for the blood group O 48.8%, the frequency found for the blood group A 35.4%; the frequency found for the blood group B 10.6% and the frequency found for the blood group AB 3.2%. In the Rh-Hr system the most frequent antigens found: e 94.5%, D 88.9%; c 80.6; C 56.4%; E 26.3%. For the Kell antigen, the frequency found was 6.7%. The most frequent phenotypes found were DCcee 23.3%; ddccee 18.1%, DCCee 16.7%; Dccee 11.0%; DCcEe 10.2% and DccEe 8.8%. The lowest frequency was found: DCcEE 0.64% and ddCcEe 0.08% Conclusion: The antigenic and phenotypic frequencies found show the great importance and necessity of the immunophenotyping of these antigens of blood groups in order to transfuse them, making them as compatible as possible, thus reducing the risk of alloimmunization. Due to the great miscegenation of our population, we find different frequencies in each region, making initiatives in this regard more relevant. Disclosures No relevant conflicts of interest to declare.

scholarly journals Increased prevalence of autoimmune disease in patients with unilateral compared with bilateral moyamoya disease

2016 ◽  
Vol 124 (5) ◽  
pp. 1215-1220 ◽  
Author(s):  
Jian-Bin Chen ◽  
Yi Liu ◽  
Liang-Xue Zhou ◽  
Hong Sun ◽  
Min He ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Moyamoya Disease ◽  
Multiple Logistic Regression Analysis ◽  
Disease Prevalence ◽  
Prevalence Rates ◽  
Chi Square ◽  
Autoimmune Thyroid ◽  
Chi Square Test ◽  
Moyamoya Vessel

OBJECT This study explored whether there were differences between the autoimmune disease prevalence rates in unilateral and bilateral moyamoya disease (MMD). METHODS The authors performed a retrospective review of data obtained from the medical records of their hospital, analyzing and comparing the clinical characteristics and prevalence rates of all autoimmune diseases that were associated with unilateral and bilateral MMD in their hospital from January 1995 to October 2014. RESULTS Three hundred sixteen patients with bilateral MMD and 68 with unilateral MMD were identified. The results indicated that patients with unilateral MMD were more likely to be female than were patients with bilateral MMD (67.6% vs 51.3%, p = 0.014, odds ratio [OR] 1.99). Overall, non-autoimmune comorbidities tended to be more prevalent in the unilateral MMD cases than in the bilateral MMD cases (17.6% vs 9.8%, p = 0.063, OR 1.97, chi-square test). Autoimmune thyroid disease and other autoimmune diseases also tended to be more prevalent in the unilateral MMD cases than in the bilateral MMD cases (19.1% vs 10.8%, p = 0.056, OR 1.96 and 8.8% vs 3.5%, p = 0.092, OR 2.77, respectively, chi-square test). The overall autoimmune disease prevalence in the unilateral MMD cases was significantly higher than in the bilateral MMD cases (26.5% vs 13.6%, p = 0.008, OR 2.29, 95% CI 1.22–4.28, chi-square test). Multiple logistic regression analysis showed that autoimmune disease was more likely to be associated with unilateral than with bilateral MMD (p = 0.039, OR 10.91, 95% CI 1.13–105.25). CONCLUSIONS This study indicated a higher overall autoimmune disease prevalence in unilateral than in bilateral MMD. Unilateral MMD may be more associated with autoimmune disease than bilateral MMD. Different pathogenetic mechanisms may underlie moyamoya vessel formation in unilateral and bilateral MMD.

scholarly journals Curability of Multiple Myeloma.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 3864-3864
Author(s):  
Kay B Delasalle ◽  
Luhua Wang ◽  
Donna Weber ◽  
Sergio A. Giralt ◽  
Sheeba Thomas ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Conflicts Of Interest ◽  
Intensive Therapy ◽  
Stage I ◽  
Rank Test ◽  
Primary Therapy ◽  
Chi Square ◽  
Long Survival ◽  
Cure Fraction ◽  
Chi Square Test

Abstract Abstract 3864 Poster Board III-800 Background Among patients with multiple myeloma, superior drug combinations and the wider application of early intensive therapy (HDT) have induced more frequent partial (PR) and complete remissions (CR), with consequent longer survival. A recent multivariate analysis identified complete or partial remission status, ISS Stage I disease and HDT as independent variables for long survival and we therefore sought to examine these relationships further. Methods We updated our experience with 829 patients, aged <65, who had been treated between 1987- 2008 with various dexamethasone-based combinations (D). Results Induction therapy was followed by early HDT within first year for 53% of patients, so that the myeloma of 21% of patients was in CR within 18 months. Frequencies of CR increased serially from 16% with primary D (alone, with interferon, melphalan or VAD), to 29% with added thalidomide (T) and to 42% with added T and bortezomib (or lenalidomide) (p<.01). Survival and complete remission times were evaluated after landmark of 18 months, thus excluding 128 patients who had died (NR 59%, PR 38%, CR 3%). Only when CR duration exceeded 2 years (106 patients) was survival (median 12.9 years) longer than those of patients with CR < 2 years (median 3.8 years), or with PR (median 4.1 years) (p<.01), supporting findings by Barlogie et al on the importance of sustained CR for long survival. Survival of 24 patients with CR achieved after primary therapy alone (median 12.9 years) was similar to that of 35 patients with added HDT for consolidation of CR (median 15.1 years), but slightly longer than that of 102 patients with conversion to CR after HDT for PR or NR (median 8.2 years, p=.12 ). In order to define favorable features associated with very long CR, we identified 11 patients with duration of CR >10 years who had been treated with primary D between 1987 -1997. Using the log rank test, the median age was less (46 vs 54, p=.04), while the chi-square test showed ISS Stage I more common (64 vs 40%, p=.11), and early HDT more frequent (73 vs 26%, p.<01), than the features of 366 other patients treated during this period without such long CR. Among the 11 patients, the myeloma of 7 patients was in CR after primary therapy of whom 4 patients also received HDT; disease in the remaining 4 patients reached CR status only after HDT for PR (3) or NR (1). The myeloma has relapsed in 2 patients (CR duration 11.3 and 11.9 years), while CR has been sustained in 9 patients without maintenance for >10-19 years (median 16.2 years). Thus, prolonged CR was more frequent with younger age, stage I disease, and early HDT. Conclusions Assuming that prolonged CR for more than 10 years translates into potential cure, we calculated a “cure fraction” of 2% for patients treated between 1987 -1997. Such favorable outcome with potential cure should be more likely with current programs associated with more frequent HDT and CR. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Altered Megakaryocytes Are Associated with Development of Pulmonary Fibrosis in Mice Carrying the Hypomorphic Gata1low Mutation

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 2336-2336
Author(s):  
Barbara Bacci ◽  
Francesca Gobbo ◽  
Mariana Roccaro ◽  
Angelo Peli ◽  
Maria Zingariello ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pulmonary Fibrosis ◽  
Interstitial Pneumonia ◽  
Drug Targets ◽  
Plasma Cells ◽  
Conflicts Of Interest ◽  
Age Groups ◽  
Primary Myelofibrosis ◽  
Chi Square ◽  
Chi Square Test

Several studies indicate that abnormal megakaryocytes (MK) drive bone marrow fibrosis in primary myelofibrosis (PMF). Since the lung is a site where MK lodge to release platelets (Lefrançais, Nature 2017; 544:105), we investigated whether the MK abnormalities observed in PMF also lead to fibrosis in lung. To this aim, we used Gata1low mice that express MK abnormalities similar to those observed in PMF patients and develop myelofibrosis with age (Zingariello, Blood 2013;121:3345) and compared number/morphology of MK and extent of fibrosis in lungs from Gata1low mice or from their wild-type (WT) littermates. Two age groups were considered: adult, A (5-7 months) and old, O (>12 months). Pulmonary fibrosis was assessed by H&E and Masson's staining and graded from 0 (absent) to 3 (severe). MK were evaluated by immunohistochemistry and immunofluorescent analysis with CD42 and their number expressed per 0.144 mm2. Statistical analysis was performed with Shapiro test for normality while chi-square test and Spearman's correlation test for comparisons. Since the mutation is carried in the CD1 background that is known to develop multisite inflammation with age (Brayton, Vet Pathol 2012; 49:85), preliminary experiments compared the pro-inflammatory signature of the mice groups by ELISA determinations of the plasma levels of CXCL1 (murine equivalent of IL-8) and its inducer lipocalin2 (LCN2). WT mice expressed a pro-inflammatory signature with high levels of LCN2 (90±45ng/mL in A; 50±49 in O) and CXCL1 (44.5±11.4pg/mL in A;31.6±4.6 in O compared to 17.0 ±5.1 in O P-Selnull/Gata1low mice which do not express inflammation, p<0.01). These levels were not affected by age. Gata1low mice expressed high levels of LCN2 that increased with age (100±18 in A and 150±45 in O, p<0.05) and levels of CXCL1 significantly lower than those expressed by WT (27.9±1.3 in A and 28.8 ±9.7 in O, p<0.05) but still greater than those in negative controls. Mild and localized interstitial pneumonia characterized by infiltration with lymphocytes, plasma cells and macrophages in the alveolar septae and peribronchial-vascular spaces was observed in 66.6% of WT mice. However, mild interstitial pneumonia was detected in 84.6% of Gata1low mice where it was multi-focal to coalescent and extended from alveolar septae to subpleural interstitium. Lungs from 33% of WT mice had mild fibrosis with accumulation of collagen in alveolar septae (grade 1) while those from 70.8% Gata1low mice presented severe fibrosis (37.5% grade 1, 29.4% grade 2 and 17.6% grade 3) (Fig. 1A, 1B). The mild interstitial pneumonia associated to grade 1 fibrosis present both in Gata1low and WT littermates is considered a background lesion due to the pro-inflammatory cytokine profile of the strain investigated. By contrast, despite the severity of pneumonia was similar in Gata1low and WT littermates, grade 2 and 3 fibrosis was only present in Gata1low mice, indicating that it was not due to the baseline inflammatory milieu of their CD1 background. MK were observed intravascularly and within the perivascular interstitium of lungs from both WT and Gata1low mice, the same location where fibrosis was detected. The number of MK was significantly lower in Gata1low than in WT littermates (median=1, range 0.6-2.57 vs 1.8, range 0.4-8.3, respectively, p=0.02) (Fig 1C). The morphology of MK found in the two groups was significantly dissimilar (p<0.01): most MK (88.8%) in WT lungs contained either a round nucleus with small amount of cytoplasm or a polylobated nucleus with well developed platelet territories (Fig.1D). The morphology of most (70%) of MK in Gata1low lungs was instead characterized by large size, polylobated nuclei but poorly developed platelet territories (Fig.1E). Therefore, the significantly higher number of Gata1low mice that exhibited moderate to severe pulmonary fibrosis compared to WT controls was associated with abnormal MK suggesting that factors released by Gata1low MK in addition to CXCL1/LPN2 are involved in establishing lung fibrosis in this model. Further studies will clarify whether these factors are similar to those responsible for fibrosis in bone marrow. In conclusion, the significantly higher number of Gata1low mice that exhibited moderate to severe pulmonary fibrosis compared to WT controls establishes Gata1low mice as a potential new animal model to study human idiopathic pulmonary fibrosis and to identify possible drug targets to treat this disease. Disclosures No relevant conflicts of interest to declare.

scholarly journals A Study on Otorhinolaryngological Presentations in Covid 19 Patients in a Tertiary Health Care Center

2021 ◽  
Author(s):  
S. G. Smitha ◽  
Nikitha Pillai ◽  
Bindya Nayak ◽  
Jedhin Raveendran
Keyword(s):  
Blood Group ◽  
Rna Virus ◽  
Statistical Significance ◽  
Care Center ◽  
Chi Square ◽  
Health Care Center ◽  
Corona Virus ◽  
Chi Square Test ◽  
The Relationship ◽  
Written Informed Consent

AbstractCorona virus also known as 2019 novel corona virus, a single stranded positive sense RNA virus is the causative agent of COVID 19 disease. It mainly spreads via the respiratory route by means of aerosols. The objectives of our study were. To know the prevalence of ENT presentations in COVID 19 patients and to know the relationship between the symptoms and category of the disease as well as to know the relation between the blood group and recovery from the disease. The first 500 patients who were tested positive for COVID 19 and getting treated in our hospital were included in the study after taking written informed consent from the patients who were willing to participate in the study. A detailed history was taken from all the patients and more stress was given on the ENT symptoms with respect to its onset, duration and time taken for the relief of symptoms. The ENT symptoms were compared with the category of the disease as well as the blood group of the patients. Statistical analysis was done using Chi square test and Statistical Package for Social Sciences [SPSS] for Windows Version 22.0 Released 2013. Armonk, NY: IBM Corp., was used to perform statistical analyses. In our study 310 (62.0%) were males and 190 (38.0%) patients were females (38%), of age group ranging from 2 years to 87 years. In our study 367 (73.3%) patients were symptomatic and the rest 133 (26.6%) were asymptomatic. There were 335 (67.0%) patients in category A, 140 (28.0%) in category B and 25 (5.0%) in category C. The most common ENT presentation was headache and its prevelance was more in category C and it was of statistical significance. On comparing the blood group and the ENT symptoms occurrence of sore throat was of statistical significance and its prevelance was more among the O blood group patients. In terms of recovery from the disease the patients with blood group O had good recovery rate. Covid 19 pandemic is still an on going problem and newer strains of the virus are arising as well hence. In our study we found out that isolated ENT symptoms such as aguesia and anosmia were the only presentation of the disease. Thus they can be considered as early marker of the disease and it will be helpful in early detection and isolation of the patient as well as prevention of further spread of the disease.

Analysis of DNA Methylation and Transcription During Granulopoiesis Reveals Timed Methylation Changes in Low CpG Areas That Correlate with Changed Transcriptional Activity.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2334-2334
Author(s):  
Rönnerblad Michelle ◽  
Olofsson Tor ◽  
Iyadh Douagi ◽  
Sören Lehmann ◽  
Karl Ekwall ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Conflicts Of Interest ◽  
Cell Types ◽  
Cpg Methylation ◽  
Epigenetic Mechanism ◽  
450K Array ◽  
Chi Square ◽  
Heterochromatin Formation ◽  
Chi Square Test

Abstract Abstract 2334 Accumulating evidence demonstrates that epigenetic changes, including DNA methylation play a central role in differentiation, providing cellular memory and stabilizing lineage choice in hematopoiesis1–3. DNA methylation is an important epigenetic mechanism involved in transcriptional regulation, heterochromatin formation and the normal development of many organisms. In this study we investigated the DNA methylome and transcriptome of human cells in four separate differentiation stages in granulopoiesis, ranging from the multipotent Common Myeloid progenitor (CMP) to terminally differentiated bone marrow neutrophils (PMN). To this end we employed HumanMethylation 450 BeadChip (450K array) from Illumina with extensive genomic coverage and mRNA expression arrays (Illumina). Temporally distinct methylation changes during granulopoiesis Differential methylation between two cell stages was defined as an average difference in β value of at least 0.17 (p ≤ 0.05). We detected 12132 DMSs during granulopoiesis. Of these the majority showed decreased methylation during granulopoeisis (10771 CpGs) and a smaller set gained methylation (1658 CpGs). Strikingly, increases in methylation predominantly occur between CMP and GMP, the two least mature cell types. Some CpGs also show increased methylation in the GMP-PMC transition, while very few CpG sites increase at the final stage of differentiation from PMC to PMN. Although reduction of methylation occurs at all stages of granulopoiesis, the greatest change is between GMP and PMC. It is striking that the DNA methylation patterns preferentially change at points of lineage restriction, and that the greatest change occurs upon loss of oligopotency between GMP and PMC. DMSs within CGIs were greatly underrepresented (p<0.001 with chi-square test), while DMSs were overrepresented in shelves (p<0.001) and open sea (p<0.001). Thus, methylation appears to be more dynamic outside of CGIs during granulocytic development. For all regions the variation within enhancers was greater than outside of enhancers indicating greater methylation changes in enhancers compared to non-enhancers. In addition, CpGs in enhancer regions are significantly enriched in the list of DMSs (p<0.001, chi-square test) further supporting the observation that enhancer regions display dynamic DNA methylation changes during granulopoiesis. Changes in gene expression correlate with DNA methylation changes There was a significant overlap between genes showing decreased methylation and genes with increased expression as well as for the reverse comparison between genes with increased methylation and decreased expression. Thus, support a general anticorrelation between DNA methylation and gene expression. Azurophilic granule proteins showed increased expression peaking in PMC and a rapid decrease toward PMN. CpG methylation levels for those genes decreased concomitantly with the peak in expression. We report cell population specific changes of DNA methylation levels. The main reduction of CpG methylation coincides with the loss of oligopotency at the transition from GMP-PMC. This suggests a role of DNA methylation in regulating cell plasticity and lineage choice. Disclosures: No relevant conflicts of interest to declare.

scholarly journals ABO Blood Group. Related Investigations and Their Association with Defined Pathologies

2007 ◽  
Vol 7 ◽  
pp. 1151-1154 ◽  
Author(s):  
Ursula Jesch ◽  
P. Christian Endler ◽  
Beatrix Wulkersdorfer ◽  
Heinz Spranger
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Chi Square ◽  
Ulcus Ventriculi ◽  
Group System ◽  
Blood Group A ◽  
Chi Square Test ◽  
Group A ◽  
Group Sex

The ABO blood group system was discovered by Karl Landsteiner in 1901. Since then, scientists have speculated on an association between different pathologies and the ABO blood group system. The aim of this pilot study was to determine the significance between different blood types of the ABO blood group system and certain pathologies. We included 237 patients with known diagnosis, blood group, sex, and age in the study. As a statistical method, the Chi-square test was chosen. In some cases, a significant association between the blood groups and defined diseases could be determined. Carriers of blood group O suffered from ulcus ventriculi and gastritis (X21 = 78.629, p <0.001), colitis ulcerosa and duodenitis (X21 = 5.846, p < 0.016), whereas male patients carrying blood group A tended to contract different types of tumours. In patients with intestinal tumours, females with blood group A were more likely to develop the pathology, whereas in males, the blood group O dominated. The development of cholelithiasis was found, above all, in patients with blood group O, which differed from other research where a correlation between this pathology and blood group A was found.

scholarly journals Association of ABO Blood Group Phenotype and Allele Frequency with Chikungunya Fever

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Pairaya Rujirojindakul ◽  
Virasakdi Chongsuvivatwong ◽  
Pornprot Limprasert
Keyword(s):  
Allele Frequency ◽  
Blood Group ◽  
Rural Community ◽  
Statistical Significance ◽  
Community Survey ◽  
Abo Blood Group ◽  
Chi Square ◽  
Southern Thailand ◽  
Chi Square Test ◽  
Group Allele

Background. The objective of this study was to investigate the association of the ABO blood group phenotype and allele frequency with CHIK fever.Methods. A rural community survey in Southern Thailand was conducted in August and September 2010. A total of 506 villagers were enrolled. Cases were defined as individuals having anti-CHIK IgG by hemagglutination ≥1 : 10.Results. There were 314 cases (62.1%) with CHIK seropositivity. Females were less likely to have positive anti-CHIK IgG with odds ratio (OR) (95% CI) of 0.63 (0.43, 0.93). All samples tested were Rh positive. Distribution of CHIK seropositivity versus seronegativity (Pvalue) in A, B, AB, and O blood groups was 80 versus 46 (0.003), 80 versus 48 (0.005), 24 versus 20 (0.55), and 130 versus 78 (<0.001), respectively. However, chi-square test between ABO and CHIK infection showed no statistical significanceP=0.76. Comparison of the ABO blood group allele frequency between CHIK seropositivity and seronegativity was not statistically significant.Conclusion. This finding demonstrated no association of the ABO blood group phenotypes and allele frequencies with CHIK infection.

Acrochordons and autoimmunity: Significance of preconceptional counseling

2020 ◽  
Vol 28 (4) ◽  
pp. 335-339
Author(s):  
Burcu Beksac ◽  
Hanife Guler Donmez ◽  
Murat Cagan ◽  
Canan Unal ◽  
Erdem Fadiloglu ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Care Program ◽  
Autoimmune Disorder ◽  
Autoimmune Disorders ◽  
Control Group ◽  
Obstetric History ◽  
Skin Tags ◽  
Antibody Positivity ◽  
Preconceptional Care ◽  
Preconceptional Counseling

BACKGROUND: Acrochordons are benign hypertrophic lesions of the skin of which the pathophysiology is unclear. OBJECTIVE: This study aimed to examine the association of acrochordons with autoimmune disorders in patients with a poor obstetric history. METHODS: This retrospective cohort involved 350 female patients with poor obstetric history who were included in a preconceptional care program to investigate risk factors for obstetric complications. These patients were further investigated for the co-existence of autoimmune disorders (defined by either a diagnosis of autoimmune diseases or autoimmune antibody positivity) and acrochordons. RESULTS: An autoimmune disorder was present in 55.7% (195/350) of the patients. The rate of acrochordons was significantly higher in patients with autoimmune disorders (n= 195) compared to the control group (n= 155) (8.21% versus 2.58%, respectively) (p= 0.043). When the autoimmune disease positive (n= 58) and autoimmune antibody-positive (n= 137) groups were separately analyzed, acrochordons were found more frequently in the autoimmune disease group (p= 0.004). However, there was no statistically significant co-occurrence of autoimmune antibody positivity and the presence of skin tags (p= 0.135). CONCLUSION: There may be immune system-related biological mechanisms underlying the pathogenesis of acrochordons. Preconceptional counseling is beneficial for women with poor obstetric history and acrochordons.

scholarly journals Esophageal manometry in systemic sclerosis: findings and association with clinical manifestations

2020 ◽  
Vol 66 (1) ◽  
pp. 48-54
Author(s):  
Juliana Markus ◽  
Rogério de Melo Costa Pinto ◽  
Abadia Gilda Buso Matoso ◽  
Roberto Ranza
Keyword(s):  
Systemic Sclerosis ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Autoimmune Disorder ◽  
Cross Sectional Study ◽  
Unknown Etiology ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Diffuse Form

SUMMARY INTRODUCTION Systemic sclerosis (SSC) is an autoimmune disorder that affects several organs of unknown etiology, characterized by vascular damage and fibrosis of the skin and organs. Among the organs involved are the esophagus and the lung. OBJECTIVES To relate the profile of changes in esophageal electromanometry (EM), the profile of skin involvement, interstitial pneumopathy (ILD), and esophageal symptoms in SSC patients. METHODS This is an observational, cross-sectional study carried out at the SSC outpatient clinic of the Hospital de Clínicas of the Federal University of Uberlândia. After approval by the Ethics Committee and signed the terms of consent, 50 patients were initially enrolled, from 04/12/2014 to 06/25/2015. They were submitted to the usual investigations according to the clinical picture. The statistical analysis was descriptive in percentage, means, and standard deviation. The Chi-square test was used to evaluate the relationship between EM, high-resolution tomography, and esophageal symptoms. RESULTS 91.9% of the patients had some manometric alterations. 37.8% had involvement of the esophageal body and lower esophageal sphincter. 37.8% had ILD. 24.3% presented the diffuse form of SSC. No association was found between manometric changes and clinical manifestations (cutaneous, pulmonary, and gastrointestinal symptoms). CONCLUSION The present study confirms that esophageal motility alterations detected by EM are frequent in SSC patients, but may not be related to cutaneous extension involvement, the presence of ILD, or the gastrointestinal complaints of patients.

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