Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

Sex differences in cardiovascular disease (CVD) mortality have been attributed to differences in pathophysiology between men and women and to disparities in CVD management that disproportionately affect women compared to men. Similarly, there has been investigation of differences in the prevalence and presentation of insomnia attributable to sex. Few studies have examined how sex and insomnia interact to influence CVD outcomes, however. In this review, we summarize the literature on sex-specific differences in the prevalence and presentation of insomnia as well as existing research regarding the relationship between insomnia and CVD outcomes as it pertains to sex. Research to date indicate that women are more likely to have insomnia than men, and there appear to be differential associations in the relation between insomnia and CVD by sex. We posit potential mechanisms of the relationship between sex, insomnia and CVD, discuss gaps in the existing literature, and provide commentary on future research needed in this area. Unraveling the complex relations between sex, insomnia, and CVD may help to explain sex-specific differences in CVD, and identify sex-specific strategies for promotion of cardiovascular health. Throughout this review, terms “men” and “women” are used as they are in the source literature, which does not differentiate between sex and gender. The implications of this are also discussed.

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Body Mass Index and Mortality From Cardiovascular Disease Among Japanese Men and Women

Stroke ◽

10.1161/01.str.0000169925.57251.4e ◽

2005 ◽

Vol 36 (7) ◽

pp. 1377-1382 ◽

Cited By ~ 90

Author(s):

Renzhe Cui ◽

Hiroyasu Iso ◽

Hideaki Toyoshima ◽

Chigusa Date ◽

Akio Yamamoto ◽

...

Keyword(s):

Cardiovascular Disease ◽

Body Mass Index ◽

Body Mass ◽

Japanese Men ◽

Men And Women

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Association of Sleep Duration with Mortality from Cardiovascular Disease and Other Causes for Japanese Men and Women: the JACC Study

SLEEP ◽

10.1093/sleep/32.3.295 ◽

2009 ◽

Vol 32 (3) ◽

pp. 295-301 ◽

Cited By ~ 219

Author(s):

Satoyo Ikehara ◽

Hiroyasu Iso ◽

Chigusa Date ◽

Shogo Kikuchi ◽

Yoshiyuki Watanabe ◽

...

Keyword(s):

Cardiovascular Disease ◽

Sleep Duration ◽

Japanese Men ◽

Men And Women

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Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia

American Journal of Clinical Nutrition ◽

10.1093/ajcn/76.6.1237 ◽

2002 ◽

Vol 76 (6) ◽

pp. 1237-1243 ◽

Cited By ~ 50

Author(s):

Vikkie A Mustad ◽

Carla A Smith ◽

Peter P Ruey ◽

Neile K Edens ◽

Stephen J DeMichele

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Cardiovascular Disease Risk Factors ◽

Men And Women

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Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study

Scientific Reports ◽

10.1038/s41598-021-98835-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Tanja Zamrik ◽

Mirjam Frank ◽

Carina Emmel ◽

Lars Christian Rump ◽

Raimund Erbel ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Cystatin C ◽

Socioeconomic Position ◽

Social Inequalities ◽

Men And Women ◽

Income Quartile ◽

Age And Sex

AbstractSocial inequalities in health and disease are well studied. Less information is available on inequalities in biomarker levels indicating subclinical stages of disease such as cystatin C, an early diagnostic marker of renal dysfunction and predictor for cardiovascular disease. We evaluated the relationship between cystatin C, socioeconomic position (SEP) and established cardiovascular risk factors in a population-based study. In 4475 men and women aged 45–75 years participating in the baseline examination of the Heinz Nixdorf Recall Study cystatin C was measured from serum samples with a nephelometric assay. SEP was assessed by education and household income. Linear regression models were used to analyse the association between SEP and cystatin C as well as the impact of cardiovascular risk factors (i.e., body mass index, blood pressure, blood glucose, diabetes mellitus, blood lipids, C-reactive protein, smoking) on this association. After adjustment for age and sex cystatin C decreased by 0.019 mg/l (95% confidence interval (CI) − 0.030 to − 0.008) per five years of education. While using a categorical education variable cystatin C presented 0.039 mg/l (95% CI 0.017–0.061) higher in men and women in the lowest educational category (≤ 10 years of education) compared to the highest category (≥ 18 years). Concerning income, cystatin C decreased by 0.014 mg/l (95% CI − 0.021 to − 0.006) per 1000 € after adjustment for age and sex. For men and women in the lowest income quartile cystatin C was 0.024 mg/l (95% CI 0.009–0.038) higher compared to the highest income quartile. After adjusting for established cardiovascular risk factors the observed associations were substantially diminished. Social inequalities seem to play a role in subclinical stages of renal dysfunction, which are also related to development of cardiovascular disease. Adjustment for traditional cardiovascular risk factors showed that these risk factors largely explain the association between SEP and cystatin C.

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Reference Standards for Cardiorespiratory Fitness by Cardiovascular Disease Category and Testing Modality: Data From FRIEND

Journal of the American Heart Association ◽

10.1161/jaha.121.022336 ◽

2021 ◽

Author(s):

James E. Peterman ◽

Ross Arena ◽

Jonathan Myers ◽

Susan Marzolini ◽

Philip A. Ades ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cardiorespiratory Fitness ◽

Clinical Care ◽

Cardiopulmonary Exercise Testing ◽

Age Groups ◽

Reference Standards ◽

National Database ◽

Disease Category ◽

Men And Women ◽

The Mean

Background The importance of cardiorespiratory fitness for stratifying risk and guiding clinical decisions in patients with cardiovascular disease is well‐established. To optimize the clinical value of cardiorespiratory fitness, normative reference standards are essential. The purpose of this report is to extend previous cardiorespiratory fitness normative standards by providing updated cardiorespiratory fitness reference standards according to cardiovascular disease category and testing modality. Methods and Results The analysis included 15 045 tests (8079 treadmill, 6966 cycle) from FRIEND (Fitness Registry and the Importance of Exercise National Database). Using data from tests conducted January 1, 1974, through March 1, 2021, percentiles of directly measured peak oxygen consumption (VO 2peak ) were determined for each decade from 30 through 89 years of age for men and women with a diagnosis of coronary artery bypass surgery, myocardial infarction, percutaneous coronary intervention, or heart failure. There were significant differences between sex and age groups for VO 2peak ( P <0.001). The mean VO 2peak was 23% higher for men compared with women and VO 2peak decreased by a mean of 7% per decade for both sexes. Among each decade, the mean VO 2peak from treadmill tests was 21% higher than the VO 2peak from cycle tests. Differences in VO 2peak were observed among the age groups in both sexes according to cardiovascular disease category. Conclusions This report provides normative reference standards by cardiovascular disease category for both men and women performing cardiopulmonary exercise testing on a treadmill or cycle ergometer. These updated and enhanced reference standards can assist with patient risk stratification and guide clinical care.

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Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study

Stroke ◽

10.1161/strokeaha.120.031212 ◽

2021 ◽

Author(s):

Satoyo Ikehara ◽

Hiroyasu Iso ◽

Yoshihiro Kokubo ◽

Kazumasa Yamagishi ◽

Isao Saito ◽

...

Keyword(s):

Public Health ◽

Cardiovascular Disease ◽

Heart Disease ◽

Ischemic Stroke ◽

Ischemic Heart Disease ◽

Ischemic Heart ◽

Japanese Men ◽

Food Frequency ◽

Men And Women ◽

History Of

Background and Purpose: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. Methods: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center–based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). Results: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77–0.93, P for trend=0.002) for total stroke, 0.80 (0.71–0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79–1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80–1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80–0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. Conclusions: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

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Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S.

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2020.09.535 ◽

2020 ◽

Vol 76 (19) ◽

pp. 2181-2193 ◽

Cited By ~ 1

Author(s):

Jun Li ◽

Dong Hoon Lee ◽

Jie Hu ◽

Fred K. Tabung ◽

Yanping Li ◽

...

Keyword(s):

Cardiovascular Disease ◽

Men And Women ◽

The U.S

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Abstract 030: Dietary Inflammatory Potential is Associated with Cardiovascular Disease Risk in Two Large Prospective Cohort Studies of US Men and Women

Circulation ◽

10.1161/circ.139.suppl_1.030 ◽

2019 ◽

Vol 139 (Suppl_1) ◽

Author(s):

Jun Li ◽

Donghoon Lee ◽

Yanping Li ◽

Fred Tabung ◽

Shilpa Bhupathiraju ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Studies ◽

Prospective Cohort ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Men And Women ◽

Prospective Cohort Studies ◽

Large Prospective Cohort

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A history of smoking does not reduce long-term benefits of cardiac rehabilitation on cardiorespiratory fitness in men and women with cardiovascular disease

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2020-0349 ◽

2020 ◽

Author(s):

Kenneth Shinkichi Noguchi ◽

Michael Pryzbek ◽

Kevin Moncion ◽

Angelica McQuarrie ◽

Maureen J. MacDonald ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cardiac Rehabilitation ◽

Cardiorespiratory Fitness ◽

Smoking Behaviour ◽

Smoking History ◽

Cardiac Events ◽

Men And Women ◽

All Cause Mortality ◽

History Of

Smoking is an important risk factor for cardiovascular disease and all-cause mortality. Cardiac rehabilitation (CR) is effective for reducing the risk of recurrent cardiac events through improving cardiorespiratory fitness (CRF). Little is known about the influence of smoking on CRF throughout long-term CR. The purpose of this analysis was to compare CRF trajectories among individuals with positive and negative smoking history enrolled in long-term CR. Participants had a positive smoking history if they currently smoke or formerly smoked (Smoke+, n=55, mean age=64.9 ± 9.0 years) and had a negative history if they never smoked (Smoke–, n=34, mean age=61.4 ± 9.0 years). CRF (VO2peak) was measured at baseline and annually thereafter for 6 years. The Smoke+ group had lower CRF compared to the Smoke– group over enrollment (β=-3.29 (SE=1.40), 95% CI -6.04, -0.54, p=0.02), but there was no interaction of smoking history and enrollment (β=0.35 (SE=0.21), 95% CI -0.06, 0.77, p=0.10). Moreover, trajectories were not influenced by pack-years (β=0.01 (SE=0.01), 95% CI -0.01, 0.04, p=0.23) or time smoke-free (β=-0.002 (SE=0.01), 95% CI -0.02, 0.02, p=0.80). Although the trajectories of CRF do not appear to be affected by smoking behaviour, individuals without a history of smoking maintained higher CRF throughout enrollment. Novelty bullets: • The benefits of long-term exercise-based cardiac rehabilitation on cardiorespiratory fitness are similar between those who have smoked and those who have never smoked. • Neither the number of pack-years nor the length of time spent smoke-free influence cardiorespiratory fitness trajectories following long-term cardiac rehabilitation.

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