High risk HPV infection prevalence and associated cofactors: a population-based study in female ISSSTE beneficiaries attending the HPV screening and early detection of cervical cancer program

Abstract Background Cervical cancer is the second cause leading of malignancy-related death among Mexican women. The present study determined the population-based prevalence of high risk Human Papillomavirus (HR-HPV) infection and associated cofactors in female beneficiaries of the Institute of Security and Social Services for State Workers (ISSSTE) attending the Program for HPV Screening and Early Detection of Cervical Cancer and registered in the Women’s Cancer Detection System (SIDECAM). Methods In a cross-sectional study, cervical samples from 115,651 female users of the program for HPV screening and early detection of cervical cancer recruited in 23 ISSSTE care centers were analyzed for HR-HPV. Logistic regression analyses, adjusting for potential confounders, were performed to determine the association of HR-HPV infection with sexual health and behavior variables and with positivity to cervical premalignant lesions by cytology. Results The overall prevalence of HR-HPV infection among female ISSSTE beneficiaries in the 2013–2015 period was 13%. A bivariate analysis of relevant variables for HR-HPV infection showed a statistically significant association for age, number of sexual partners, use of hormonal contraceptives and smoking. A statistical association was found between infection by HR-HPV with the use of hormonal contraceptives, number of sexual partners and smoking and association of HPV 16 and other non-16/18 HR-HPV infection with number of lifetime sexual partners and tobacco use adjusted for age, history of hormonal contraception, number of sexual partners and tobacco use with the exception of exposition variable itself. Similarly, an association was found between HR-HPV infection, regardless of the virus genotype, with positivity to cervical premalignant lesions adjusted for age, number of lifetime sexual partners, history of hormonal contraception and tobacco use. Conclusions HR-HPV prevalence in female ISSSTE Women’s Cancer Program users is similar to the population-based prevalence previously reported in Mexican women without cervical alterations. The ISSSTE robust screening and early detection program, based on cytology studies and HPV co-testing, allows us to know the prevalence of HR-HPV infection among female users of the service.

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The Correlation of Papanicolaou Smears and Clinical Features to Identify the Common Risk Factors for Cervical Cancer: a Retrospective and Descriptive Study From a Tertiary Care Hospital in Trinidad

10.21203/rs.3.rs-1189806/v1 ◽

2022 ◽

Author(s):

Srikanth Umakanthan ◽

Saudah Ghany ◽

La Donna Gay ◽

Tia Gilkes ◽

Jamila Freeman ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

Clinical Findings ◽

Sexual Partners ◽

Cervical Cytology ◽

Premalignant Lesions ◽

Abnormal Cervical Cytology ◽

Number Of Sexual Partners ◽

Common Risk Factors ◽

The Common

Abstract Background: Cervical cancer, the fourth most frequent cancer in women, is associated with the human papilloma virus (HPV). This study focuses on identifying any risk factors and clinical findings for abnormal cervical cytology and histopathology in relation to the Trinidad and Tobago population. Some risk factors include early age of first coitus, high number of sexual partners, high parity, smoking, and use of certain medications such as oral contraception. This study is aimed to identify the significance of Papanicolaou (pap) smears and to identify the common risk factors that contribute to the development of premalignant and malignant cervical lesions. Method: A three-year retrospective, descriptive study of cervical cancer was conducted at the Eric Williams Medical Sciences Complex to assess the risk factors and clinical findings using cervical cytology and histopathology data of patients with premalignant lesions. The subject population included 215 female patients aged 18 years and older who had the following documented abnormal cervical cytology: (ASCUS), ASC-H, LSIL, HSIL, Atypical Glandular cells, HPV, Adenocarcinoma, Invasive Squamous Cell Carcinoma. Histopathology records were analysed for thirty-three of these patients. Patients’ information were recorded on data collection sheets adapted from the North Central Regional Health Authority’s cytology laboratory standardised reporting format request form (Appendix I). Results and findings: The data were analysed via Statistical Package for Social Sciences (SPSS) software edition 23 using frequency tables and descriptive analysis. The sample mean age of the population was 36.7 years, first age of coitus was 18.1 years, number of sexual partners was 3.8 and number of live births was 2. LSIL was the most popular abnormal finding, 32.6 %, followed by HSIL, 28.8% and ASCUS, 27.4%. Most histopathological reports resulted in CIN I and II.Conclusion: The major risk factors observed for cytology abnormalities and premalignant lesions were early age of coitus, high number of sexual partners, and no use of contraception.Patients mostly presented as asymptomatic despite obtaining abnormal cytology results. Hence, regular pap smear screening should continue to be highly encouraged.

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Distribution of human papillomavirus types, cervical cancer screening history, and risk factors for infection in Manitoba

Chronic Diseases and Injuries in Canada ◽

10.24095/hpcdp.32.4.01 ◽

2012 ◽

Vol 32 (4) ◽

pp. 177-185 ◽

Cited By ~ 1

Author(s):

A.A. Demers ◽

B. Shearer ◽

A. Severini ◽

R. Lotocki ◽

E.V. Kliewer ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

Human Papillomavirus ◽

Cancer Screening ◽

Pap Test ◽

Hpv Infection ◽

Sexual Partners ◽

Hpv Typing ◽

Number Of Sexual Partners ◽

Screening History

Objectives We conducted a study to investigate the prevalence of human papillomavirus (HPV) infections in an opportunistic sample of women in Manitoba, Canada. We inquired about risk factors associated with HPV infections and linked the HPV typing results with the cervical cancer screening history of the participants. Methods The study population included 592 women attending Papanicolaou (Pap) test clinics. After signing a consent form, participants were given a self-administered questionnaire on risk factors and received a conventional Pap test. Residual cells from the Pap tests were collected and sent for HPV typing. Results The mean age of the population was 43 years. A total of 115 participants (19.4%) had an HPV infection, 89 of whom had a normal Pap test. Of those who were HPV-positive, 61 (10.3%) had high-risk (Group 1) HPV. HPV-16 was the most prevalent type (15/115: 13.0% of infections). The most consistent risk factors for HPV infection were young age, Aboriginal ethnicity, higher lifetime number of sexual partners and higher number of sexual partners in the previous year. Conclusion The prevalence of HPV types in Manitoba is consistent with the distributions reported in other jurisdictions. These data provide baseline information on type-specific HPV prevalence in an unvaccinated population and can be useful in evaluating the effectiveness of the HPV immunization program. An added benefit is in the validation of a proof of concept which links a population-based Pap registry to laboratory test results and a risk behaviour survey to assess early and late outcomes of HPV infection. This methodology could be applied to other jurisdictions across Canada where such capacities exist.

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Australian women's needs and preferences for information about human papillomavirus in cervical screening

Journal of Medical Screening ◽

10.1258/0969141054855238 ◽

2005 ◽

Vol 12 (3) ◽

pp. 134-141 ◽

Cited By ~ 59

Author(s):

Kirsten McCaffery ◽

Les Irwig

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Information Needs ◽

Pap Smear ◽

Cervical Screening ◽

Hpv Infection ◽

Sexual Partners ◽

Policy And Practice ◽

Management Options ◽

Multiple Sexual Partners

Objective: The role of human papillomavirus (HPV) in cervical cancer and developments in medical technology to prevent cervical cancer has changed information needs for women participating in cervical screening. Design: Qualitative face-to-face interviews were conducted with 19 women diagnosed with HPV infection on their Pap smear following routine cervical screening. Setting: Family planning clinics, general practice and specialist gynaecologist practices in Sydney and the surrounding area, Australia. Main outcome measures: Women's information needs, preferences and experiences of HPV diagnosis. Results: Women wanted further information on different HPV viral types, transmission, implications for sexual partners, prevalence, latency and regression of HPV, their management options and the implications of infection for cancer risk and fertility. Uncertainty about the key aspects of HPV, the style in which the clinician communicated the result and the mode of delivering the result (letter, telephone or consultation) influenced women's psychological response to the diagnosis of HPV. The delivery of results by letter alone was linked to considerable anxiety among the women interviewed. Women's experience of searching the Internet for further information about HPV was reported as difficult, anxiety provoking and contributing to the stigma of the infection because information was often located in the context of other sexually transmitted infections, with multiple sexual partners highlighted as a risk factor for infection. Conclusion: Women participating in cervical screening need high-quality information about HPV and its role in cervical cancer prior to screening rather than afterwards, when they face an abnormal result. The clinician potentially plays an important role in moderating the effects of diagnosis through the manner and mode in which an HPV diagnosis is delivered. Revision of cervical screening policy and practice in light of the changes in the understanding of HPV is recommended.

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Cytology at the Time of HPV: Some Things to Think about when Discussing HPV

Acta Cytologica ◽

10.1159/000450821 ◽

2016 ◽

Vol 60 (6) ◽

pp. 527-533 ◽

Cited By ~ 1

Author(s):

Kristi Valentine ◽

Davy Vanden Broeck ◽

Ina Benoy ◽

Marie Truyens ◽

Johannes Bogers

Keyword(s):

Cervical Cancer ◽

European Union ◽

Hpv Infection ◽

Population Based ◽

Screening Strategy ◽

The European Union ◽

Member States ◽

Clin Pathol ◽

Eu Member States ◽

The Eu

‘In the current 28 Member States of the European Union (EU), approximately 34,000 new cases of cervical cancer and 13,000 deaths occur' [Ferlay et al.: Eur J Cancer 2014;49:1374-1403]. ‘The current 10-fold gradient in the mortality rates of cervical cancer among the EU Member States largely reflects the persistent absence, or inadequate implementation of cervical cancer screening programmes more than 10 years after organized, population-based screening programmes following European quality assurance guidelines were unanimously recommended by the Health Ministers of the EU' [Council of the European Union: Off J Eur Union 2003;327:34-38]. This article will compare the strengths, weaknesses and risks of the following 4 cervical health screening strategies: HPV as a triage of cytology, cytology as a triage of HPV, cotesting (parallel) or cytology at the time of HPV (HPV-informed guided screening). ‘The optimal screening strategy should identify those cervical cancer precursors likely to progress to invasive cancers (maximizing the benefits of screening) and avoid the detection and unnecessary treatment of transient HPV infection and its associated benign lesions that are not destined to become cancerous (minimizing the potential harms of screening)' [Saslow et al.: Am J Clin Pathol 2012;137:516-542].

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Association between Toll-like Receptor and Tumor Necrosis Factor Immunological Pathways in Uterine Cervical Neoplasms

Tumori Journal ◽

10.5301/tj.5000576 ◽

2016 ◽

Vol 103 (1) ◽

pp. 81-86 ◽

Cited By ~ 13

Author(s):

Lucas G.G. de Matos ◽

Eduardo B. Cândido ◽

Paula V.T. Vidigal ◽

Polyanna H.C. Bordoni ◽

Rivia M. Lamaita ◽

...

Keyword(s):

Cervical Cancer ◽

Tumor Necrosis ◽

Critical Role ◽

Immunological Response ◽

Intraepithelial Neoplasia ◽

Hpv Infection ◽

Membrane Receptors ◽

Premalignant Lesions ◽

Cervical Lesions ◽

Tnf Α

Introduction The immune system plays a critical role in the defense against human papillomavirus (HPV) infection and its persistence. Toll-like receptors (TLRs) are membrane receptors responsible for activation of the innate immune response, and an association between TLR expression and uterine cervical cancer has been shown. Tumor necrosis factors (TNFs) are among the main mediators of skin and mucosa inﬂammation. The aim of this study was to demonstrate the association between TLR and TNF immune expression and cervical cancer and premalignant cervical lesions. Methods A total of 64 embedded tissues were obtained from gynecological procedures, including 35 specimens with cervical intraepithelial neoplasia (CIN) and 10 specimens with cervical squamous cell carcinoma (CSCC) as well as 19 normal cervical samples. The expression of TLR2, TLR3, TLR4, TNF-α and TNF-β was measured by immunohistochemistry and graded into low and high levels of expression. Results There was an association between the expression levels of TLR2 and those of TNF-α and TNF-β (p = 0.01 and p = 0.021, respectively) in the cervical cancer and CIN groups. TLR4 expression was associated with TNF-α and TNF-β expression (p = 0.016 and p = 0.025, respectively) in these 2 groups. By contrast, TLR3 was not statistically associated with TNF-α or TNF-β in any of the groups. Conclusions There might be an association of the TLR2 and TLR4 pathways with the immunological response of TNF-α and TNF-β in cervical cancer. These markers are also expressed at higher levels in cervical cancer and premalignant lesions compared to normal controls.

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Cervical Cancer Awareness Campaign in Qatar: A Population-Based Campaign

Journal of Global Oncology ◽

10.1200/jgo.18.69500 ◽

2018 ◽

Vol 4 (Supplement 2) ◽

pp. 26s-26s ◽

Cited By ~ 2

Author(s):

B. Alemrayat ◽

R. Abu-Abbas ◽

M. Al-Naemi ◽

O. AlTwaisi ◽

W. Saibi ◽

...

Keyword(s):

Cervical Cancer ◽

Early Detection ◽

Signs And Symptoms ◽

Population Based ◽

Detection Methods ◽

Awareness Campaign ◽

Pap Tests ◽

The Public ◽

Prevention And Early Detection ◽

Closing Ceremony

Background: In 2012, it has been estimated that almost 527,600 new patients were diagnosed with cervical cancer causing over 265,000 deaths worldwide. Locally, the disease is affecting a substantial number of women in Qatar, placing it fifth in terms of the most common cancers among females in the country. Unfortunately, most cases are diagnosed at advanced stages, making the treatment more challenging. This is mainly due to the poor knowledge of the disease and the lack of awareness campaigns about cervical cancer. Aim: To raise the awareness about cervical cancer among women in Qatar to promote prevention and early detection. Methods: Qatar Cancer Society (QCS) launched a population-based campaign aimed at raising the public awareness about cervical cancer. In January 2018, health educators from QCS conducted 15 workshops in numerous public and private sectors across Qatar including companies, hotels, hospitals, and healthcare centers to educate the public about the signs and symptoms of the disease, its risk factors, as well as methods of prevention and early detection. In addition, the campaign was advertised in 10 local newspapers, 4 TV programs, 3 radio programs, social media, and 2 Web sites to deliver the educational material to a larger audience as possible. A hotline number was also reserved to answer women's questions and concerns about the disease. To promote the prevention and early detection of cervical cancer, women were encouraged to do Pap tests for free in Al-Ahli and Al-Emadi hospitals. Moreover, QCS organized a closing ceremony at the end of the campaign for all women who did the Pap test and a raffle draw was done to appreciate their participation. Results: A total of 635 women attended the various awareness workshops that were delivered over a month period. Interestingly, 100 women aged 21-65 years visited Al-Ahli and Al-Emadi hospitals to have Pap tests for cervical cancer screening. All of these women reported that they have never done the test before and they became aware of it from QCS campaign. Of note, participants indicated that it was the first time for them to learn about human papilloma virus (HPV) vaccine which prevents 70% of all cervical cancer cases. In addition, about 150 calls were received inquiring about different aspects of the disease. The closing ceremony came to reinforce the awareness messages delivered by QCS where an educational video about cervical cancer was presented, followed by a speech by a cervical cancer survivor who talked about her battle with the disease and her treatment journey. Conclusion: Despite the widespread of cervical cancer among women in Qatar, little was known about its signs and symptoms, prevention, and early detection methods. This population-based awareness campaign was very effective in raising the awareness about cervical cancer, which will help in detecting the disease at earlier stages, and will ultimately result in higher survival rates.

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Interaction of High- and Low-Risk human papillomavirus genotypes is associated with a reduced risk of developing cervical cancer (Preprint)

10.2196/preprints.36017 ◽

2021 ◽

Author(s):

Amir Avan

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

High Risk ◽

Hpv Infection ◽

Population Based ◽

High Risk Group ◽

Low Risk ◽

P Value ◽

Simultaneous Infection ◽

High Risk Hpv

BACKGROUND Cervical cancer is among the most common type of cancers in women and is associated with human papillomavirus (HPV) infection. OBJECTIVE The link between cervical cancer and high-risk HPV infection has been well documented, although the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical malignancy is remained to be unanswered in guideline METHODS We have investigated the association of high and low-risk HPVs (HR or LR) genotype with cervical carcinoma risk, as well as pathological and cytological information in cases recruited from a population-based cohort study of 790 patients. RESULTS The percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15% and 7.10% in class IV and 7.15% and 5.80% in As-CUS smears. Interestingly concurrent infection with HR-HPV and LR-HPV types led to a notable decline in the risk of developing malignancy in comparison with the high-risk group (OR=0.3 (0.098-0.925), p-value=0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within the co-infected and the HR-HPV participants. CONCLUSIONS Our finding demonstrated that simultaneous infection with high- and low-risk HPV reduces the risk of cervical malignancy.

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HPVE6/E7,hTERT, andKi67mRNA RT-qPCR Assay for Detecting High-Grade Cervical Lesion with Microscope Slides

Analytical Cellular Pathology ◽

10.1155/2019/9365654 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7

Author(s):

Geehyuk Kim ◽

Jemberu Taye ◽

Kwangmin Yu ◽

Sunyoung Park ◽

Jungho Kim ◽

...

Keyword(s):

Cervical Cancer ◽

Precancerous Lesion ◽

Hpv Infection ◽

Screening Methods ◽

High Grade ◽

Human Telomerase Reverse Transcriptase ◽

Exfoliated Cells ◽

Hpv Test ◽

Hpv Screening ◽

Microscope Slides

After breast and colon cancer, cervical cancer is the third most common cancer of women worldwide. Since human papillomavirus (HPV) infection is known to be the predominant cause of cervical cancer, molecular HPV screening is currently used along with cytological and histological examination methods for precancer diagnosis. Nevertheless, the sensitivity of the current HPV test is less than 80%; thus, many cervical cancer cases are not able to be diagnosed by HPV screening alone, and likewise, patients with cervical cancer are often determined to be HPV-negative by the current screening methods. Therefore, human telomerase reverse transcriptase (hTERT) andKi67previously identified as cancer markers were attempted. And cervical exfoliated cells of high-grade squamous intraepithelial lesion (HSIL), the most severe precancerous lesion of cancer, were used in the study. However, it takes a long time to collect enough specimens to conduct statistical analysis. Therefore, in the present study, microscope slides, cervical exfoliated cells on glass slides, were attempted. The results of the analysis demonstrated thathTERTandKi67expression levels were useful in distinguishing between cancerous and normal specimens, exhibiting a higher sensitivity and specificity than conventional HPVE6/E7testing. And the study suggests clinical slide cell samples could be effectively used in the context of retrospective studies to identify novel biomarkers.

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Human Papilloma Virus–Associated Lips Verrucous Carcinoma in HIV-Infected Male

Journal of the International Association of Providers of AIDS Care (JIAPAC) ◽

10.1177/2325957417711255 ◽

2017 ◽

Vol 16 (4) ◽

pp. 324-326 ◽

Cited By ~ 3

Author(s):

Giuseppe Vittorio De Socio ◽

Olena Bidovanets ◽

Gian Marco Tomassini ◽

Luca Fanelli ◽

Stefano Simonetti

Keyword(s):

Cervical Cancer ◽

Head And Neck Cancer ◽

Human Papillomavirus ◽

Verrucous Carcinoma ◽

Final Diagnosis ◽

Hpv Infection ◽

Etiologic Factor ◽

Infected Male ◽

Papilloma Virus ◽

Hpv Screening

Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips. The final diagnosis of verrucous carcinoma was delayed. Early detection of HPV lesions in oral mucosa and HPV screening activities could be important in improving the diagnostic sensitivity for the HIV-infected patients with oral cancer.

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A Cervical Cancer Prediction Model Using REPTree Classifier

Journal of Computational and Theoretical Nanoscience ◽

10.1166/jctn.2019.8538 ◽

2019 ◽

Vol 16 (10) ◽

pp. 4438-4442 ◽

Cited By ~ 1

Author(s):

Sharvan Kumar Garg ◽

Manoj Kapil

Keyword(s):

Cervical Cancer ◽

Prediction Model ◽

Sexual Intercourse ◽

Hormonal Contraceptives ◽

Final Point ◽

First Sexual Intercourse ◽

Cancer Prediction ◽

Number Of Sexual Partners ◽

Gynecological Disease ◽

Better Than

Cervical cancer is the foremost gynecological disease globally. In this manuscript, we build up a Cervical Cancer prediction model that can aid medical experts in envisaging Cervical Cancer condition based on the clinical data of patients. At the outset, we choose 32 imperative clinical attributes viz., age, hormonal contraceptives, number of sexual partners, STDs: AIDS, first sexual intercourse (age), STDs: HIV, number of pregnancies, STDs: Hepatitis B, smokes etc., in addition to four classes (Hinselmann, Schiller, Cytology and Biopsy). Secondly, we build up a prediction model by means of REPTree classifier for classifying Cervical Cancer based on these clinical attributes against unpruned, and pruned error pruning approach. As a final point, it is concluded that the precision of unpruned REPTree classifier with Pruned REPTree classifier approach is better than the Pruned REPTree classifier approach. The outcome acquired that which illustrates that age, hormonal contraceptives, first sexual intercourse (age), STDs: genital herpes, number of pregnancies and smokes are the foremost predictive attributes which provides enhanced classification in opposition to the supplementary attributes.

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