scholarly journals Circulating inflammatory markers may mediate the relationship between low carbohydrate diet and circadian rhythm in overweight and obese women

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Atefeh Tavakoli ◽  
Atieh Mirzababaei ◽  
Forough Sajadi ◽  
Khadijeh Mirzaei
Keyword(s):  
Circadian Rhythm ◽  
Inflammatory Markers ◽  
Transforming Growth Factor ◽  
Overweight And Obesity ◽  
Obese Women ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Galectin 3 ◽  
Morning Type

Abstract Background Low carbohydrate diet (LCD) can improve inflammation and obesity and also circadian rhythm disorders can lead to increased inflammation in obese individuals. The purpose of this study is to evaluate the association between adherence of LCD and circadian rhythm mediated by inflammatory markers including transforming growth factor-β (TGF-β), interleukin-1β (IL-1β) and Galectin-3 in overweight and obese women. Methods 304 women affected by overweight and obesity were enrolled. We evaluated LCD scores by Semi-quantitative food frequency questionnaire (FFQ) of 147 items. The morning-evening questionnaire (MEQ) was applied to evaluate the circadian rhythm. Biochemical parameters such as inflammatory markers and anthropometric components were assessed. Results There was a negative significant correlation between adherence of LCD and circadian rhythm status. In other words, as the LCD scores increased, the odds of circadian rhythm disturbance in intermediate group and morning type persons decreased compared to evening type. It was showed that, IL-1β and Galectin-3 in intermediate and morning type groups, destroyed the significance of this relationship and may be considered as mediating markers. Conclusion Adherence of LCD can improve the circadian rhythm by reducing levels of inflammatory markers and may be considered as a treatment for obesity.

scholarly journals The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257275
Author(s):  
Leila Setayesh ◽  
Reyhane Ebrahimi ◽  
Sara Pooyan ◽  
Habib Yarizadeh ◽  
Elaheh Rashidbeygi ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Transforming Growth Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Significant Difference ◽  
Low Carbohydrate ◽  
Galectin 3 ◽  
Pai 1

Background Previous studies showed the possible association between obesity, dietary pattern, and depressive symptoms. Due to the lack of enough data to confirm the association of obesity and depression in the Middle East, here, we aimed to explore the possible mediatory role of adipokines Galectin-3, transforming growth factor-beta (TGF-β), and endothelial plasminogen activator inhibitor (PAI-1) in the association between low carbohydrate diet (LCD) and depressive symptoms. Methods A total of 256 women aged 17–56 years old were grouped based on their LCD score. Depression anxiety stress scales-21 (DASS-21) self-administered questionnaire was used to evaluate the three negative emotional states of stress, depressive symptoms, and anxiety. Body composition and dietary intake were assessed. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Galectin-3, TGF-β, and PAI-1. Results No significant difference was observed regarding Galectin-3, TGF-β, and PAI-1 levels between the groups with dissimilar adherence to LCD or the groups with different levels of depressive symptoms (P>0.05). However, there was a negative association between LCD score as a covariant and depressive symptoms as an independent variable (P = 0.02) and remarkably, a regression model linear analysis using Galectin-3, TGF-β, and PAI-1 as confounding variables indicated the mediatory role of these adipokines in this association (P>0.05). In other words, adipokines eliminated the significance of the relationship between adherence to LCD and depressive symptoms. Conclusion It seems that higher adherence to LCD is probably associated with a lower prevalence of depressive symptoms in obese adults through the mediatory role of adipokines.

scholarly journals Adherence to a Low Carbohydrate Diet may Modify Resting Metabolic Rate among Overweight and Obese Women

2020 ◽  
Author(s):  
Seyedeh Forough Sajjadi ◽  
Atieh Mirzababaei ◽  
nasim Ghodoosi ◽  
Sara Pooyan ◽  
Hana Arghavani ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Fat Free Mass ◽  
Obese Women ◽  
Carbohydrate Diet ◽  
Cross Sectional ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Carb Diet ◽  
Adjusted Model

Abstract Objective Resting metabolic rate (RMR) accounts for most of the daily energy expenditure. The low-carb diet attenuates decreases in RMR. This study aims to investigate the relationship between a low-carb diet and resting metabolic rate status. Methods We enrolled 304 overweight and obese women in this cross-sectional study. BMI, fat mass, fat-free mass, visceral fat, insulin level were assessed. RMR was measured using indirect calorimetry. A low carbohydrate diet score was measured using a validated semi-quantitative food frequency questionnaire (FFQ). Results Our results showed no relationship between LCDS and DNR even after adjust for confounders (Inc. RMR: OR: 0.97; 95% CI: 0.92–1.01, P = 0.20; Dec. RMR: OR: 0.97; 95% CI: 0.94-1.00, P = 0.14). Some components of LCDS had significant differences with DNR, such as carbohydrate and Dec. RMR in adjusted model (OR: 1.62; 95% CI: 0.98–1.37, P = 0.08), MUFA and Dec. RMR in adjusted model (OR: 0.48; 95% CI: 0.21–1.10, P = 0.08) and refined grain and Inc. RMR in crude model (OR: 0.87; 95% CI: 0.77–0.99, P = 0.04). Conclusion Our study showed that there is no association between a low-carb diet and RMR status but carbohydrate, MUFA, and refined grain had a significant relationship.

scholarly journals The Relationship between Low Carbohydrate Diet Score and Mental Health in Overweight and Obese Women

2020 ◽  
Vol 14 (2) ◽  
pp. 47-54
Author(s):  
Habib Yarizadeh ◽  
Leila Setayesh ◽  
Moein Askarpour ◽  
Seyed Ali Keshavarz ◽  
Khadijeh Mirzaei ◽  
...  
Keyword(s):  
Mental Health ◽  
Obese Women ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
The Relationship ◽  
Diet Score

Psychological benefits of a high-protein, low-carbohydrate diet in obese women with polycystic ovary syndrome—A pilot study

Appetite ◽  
2007 ◽  
Vol 49 (3) ◽  
pp. 590-593 ◽  
Author(s):  
Cherrie Galletly ◽  
Lisa Moran ◽  
Manny Noakes ◽  
Peter Clifton ◽  
Lisa Tomlinson ◽  
...  
Keyword(s):  
Pilot Study ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
High Protein ◽  
Obese Women ◽  
Psychological Benefits ◽  
Ovary Syndrome ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

scholarly journals Consumption of a Low Carbohydrate Diet in Overweight or Obese Pregnant Women Is Associated with Longer Gestation of Pregnancy

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3511
Author(s):  
Helen Tanner ◽  
Helen L. Barrett ◽  
Leonie K. Callaway ◽  
Shelley A. Wilkinson ◽  
Marloes Dekker Nitert
Keyword(s):  
Gestational Age ◽  
Linear Regression Analysis ◽  
Carbohydrate Intake ◽  
Obstetric Outcomes ◽  
Absolute Amount ◽  
Obese Women ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Gestational Age At Delivery

Studies of obstetric outcomes in women consuming low-carbohydrate diets have reported conflicting results. Most studies have defined low-carbohydrate diets by the percentage that carbohydrates contribute to overall energy intake, rather than by an absolute amount in grams per day (g/d). We hypothesised that a low absolute carbohydrate diet affects obstetric outcomes differently than a low percentage carbohydrate diet. Dietary data were collected from overweight or obese women in the Study of Probiotic IN Gestational diabetes at 16- and 28-weeks’ gestation. Obstetric outcomes were compared between women whose carbohydrate intake was in the lowest quintile vs quintiles 2–5. Mean gestation was increased in women whose absolute carbohydrate intake was in the lowest quintile at 16 and at both 16- and 28-weeks’ gestation compared with all other women (16: 39.7 vs. 39.1 weeks, p = 0.008; 16 and 28: 39.8 vs. 39.1, p = 0.005). In linear regression analysis, a low absolute carbohydrate intake at 16 and at 28 weeks’ gestation was associated with increased gestation at delivery (16: p = 0.04, adjusted R2 = 0.15, 28: p = 0.04, adjusted R2 = 0.17). The coefficient of beta at 16 weeks’ gestation was 0.50 (95% CI 0.03–0.98) and at 28 weeks’ gestation was 0.51 (95%CI 0.03–0.99) meaning that consumption of a low absolute carbohydrate diet accounted for an extra 3.5 days in gestational age. This finding was not seen in women whose percentage carbohydrate intake was in the lowest quintile. Low-carbohydrate consumption in pregnancy is associated with increased gestational age at delivery.

Adipokines: The possible association between low carbohydrate diet score and depression

2020 ◽  
Author(s):  
Leila Setayesh ◽  
Sara Pooyan ◽  
Reyhane Ebrahimi ◽  
Habib Yarizadeh ◽  
Elaheh Rashidbeygi ◽  
...  
Keyword(s):  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Plasminogen Activator Inhibitor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Independent Variable ◽  
Pai 1

Abstract Background Due to lack of enough date to confirm the association of obesity and depression in middle east, We aimed to explore the possible mediatory role of adipokines such as galactin1, transforming growth factor beta (TGF-beta), and endothelial plasminogen activator inhibitor (PAI-1) in the association between obesity and depression.Methods A total of 256 women ranged between 18-48 years old were grouped based on their low carbohydrate diet (LCD) score. Body composition and dietary intake were assessed. Enzyme-linked immunosorbent assay was used to measure serum adipokines levels.Results There was a negative association between LCD score as a covariant and depression as an independent variable (P= 0.02) (beta ±SE= -0.143±0.031) (CI= -0.129 to -0.08). A regression model linear analysis using galactin1, TGF-β, and PAI 1 as a covariant indicated the mediatory effects of these adipokines (P > 0.05). The higher adherence to LCD was associated with a decrease of anthropometric components (p < 0.05).Conclusion We indicated that a higher adherence to LCD would probably ameliorate depression through the mediatory role of the study adipokines. The higher adherence of LCD in depressive obese individuals due to possible improvement effects on mental health.

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