scholarly journals Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Qianqian Shen ◽  
Qian Xu ◽  
Guoju Li ◽  
Lisheng Ren ◽  
Zhenhong Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Synergistic Effect ◽  
Secondhand Smoke ◽  
Molecular Mechanisms ◽  
Interactive Effect ◽  
Joint Effect ◽  
Directed Acyclic Graphs ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Increased Risk

Abstract Background Vitamin D deficiency (VDD) may increase the risk of hypertension in women of childbearing age, who may be exposed to secondhand smoke (SHS) simultaneously. Till now, few studies have investigated the joint effects of VDD and SHS on hypertension in this population. We evaluated whether exposure to SHS modified the association between VDD and hypertension. Methods Data from National Health and Nutrition Examination Surveys (NHANES) 2007-2014 were analyzed. Our research subjects were 2826 nonsmoking and nonpregnant women of childbearing age (20-44 years old). Hypertension was defined based either on systolic blood pressure (SBP) ≥ 130 mmHg and/or diastolic blood pressure (DBP) ≥ 80 mmHg or on now taking prescribed medicine for hypertension. The directed acyclic graphs (DAG) and the back-door criterion were used to select a minimal sufficient adjustment set of variables (MSAs) that would identify the unconfounded effect of 25(OH)D and hypertension. The interactive effect of VDD and SHS on hypertension was evaluated by using logistic regression models, followed by strata-specific analyses. Results The prevalence of VDD in the hypertension group was significantly higher than that in the non-hypertension group (48.2% vs 41.0%, P = 0.008), as well as the exposure rate of SHS (39.1% vs 33.8%, P = 0.017). VDD was independently associated with nearly 50% increased risk of hypertension [adjusted odds ratio (aOR) = 1.43, 95% confidence interval (CI): 1.01, 2.04], while no significant association was observed between SHS and hypertension. However, SHS showed a significant synergistic effect on VDD with a higher aOR of 1.79 (95% CI: 1.14, 2.80) (Pinteraction = 0.011). This synergistic effect was more obvious when stratified by BMI (in overweight women, aOR, 95% CI =4.74, 1.65-13.60 for interaction vs 2.33, 1.01-5.38 for VDD only) and race (in Non-Hispanic Black women, aOR, 95% CI =5.11, 1.58-16.54 for interaction vs 2.69, 1.10-6.62 for VDD only). Conclusion There exist synergistic effects of SHS and VDD on the prevalence of hypertension in American women of childbearing age, with more significant effects in women who were overweight or Non-Hispanic Black. Further studies are warranted to verify this finding in other populations, and the molecular mechanisms underlying the joint effect of SHS and VDD need to be elucidated.

scholarly journals Joint Effect of 25-hydroxyvitamin D and Secondhand Smoke Exposure on Hypertension in Non-smoking Women of Childbearing Age: NHANES 2007-2014

2021 ◽  
Author(s):  
Qianqian Shen ◽  
Qian Xu ◽  
Guoju Li ◽  
Lisheng Ren ◽  
Zhenhong Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Secondhand Smoke ◽  
Molecular Mechanisms ◽  
Synergistic Effects ◽  
Interactive Effect ◽  
Joint Effect ◽  
Smoke Exposure ◽  
Secondhand Smoke Exposure ◽  
Women Of Childbearing Age ◽  
Childbearing Age

Abstract BackgroundVitamin D deficiency (VDD) may increase the risk for hypertension in women of childbearing age, and they may expose to secondhand smoke exposure (SHS) simultaneously. Till now, few studies have investigated the joint effects of VDD and SHS. We evaluated whether exposure to SHS modified the association between VDD and hypertension.MethodsData from 2007-2014 National Health and Nutrition Examination Surveys (NHANES) were analyzed. Our research subjects were 2802 nonsmoking and nonpregnant women of childbearing age (20-44 years old). Hypertension was defined based either on systolic blood pressure (SBP) ≥ 130 mmHg and/or diastolic blood pressure (DBP) ≥ 80 mmHg or on now taking prescribed medicine for hypertension. The interactive effect of VDD and SHS on hypertension was evaluated by using logistic regression models, followed by strata-specific analyses.ResultsThe prevalence of VDD in the hypertension group was significantly higher than that in the non-hypertension group (48.2% vs 40.7%, P = 0.005), as well as the exposure rate of SHS (35.7% vs 30.5%, P = 0.017). VDD was positively associated with hypertension [adjusted odds ratio (aOR): 1.47, 95% confidence interval (CI): 1.03-2.08]. There was no association between secondhand smoke exposure and hypertension (aOR: 1.10, 95%CI: 0.85-1.43). However, when exposed to SHS and VDD simultaneously, the aOR estimation of the risk of hypertension increased to 1.83 (1.17, 2.87) with a significant interactive effect between SHS and VDD (Padjusted = 0.009). When stratified according to BMI and race, the interactive effect was about twice the effect of VDD on hypertension alone in women who were overweight (for VDD: aOR = 2.37, 95%CI: 1.05-5.47; for interaction: aOR = 4.14, 95%CI: 1.48-11.58), and a similar pattern could also be observed in Non-Hispanic Black (for VDD: aOR = 2.74, 95%CI: 1.11-6.73; for interaction: aOR = 4.60, 95%CI: 1.53-13.80).ConclusionThere exist synergistic effects of SHS and VDD on the prevalence of hypertension in American women of childbearing age, with more significant effects in overweight women and Non-Hispanic Black women. Further studies are warranted to verify in other populations, and the molecular mechanisms underlying the joint effect of SHS and VDD need to be elucidated.

scholarly journals Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155801 ◽  
Author(s):  
Minxue Shen ◽  
Hongzhuan Tan ◽  
Shujin Zhou ◽  
Ravi Retnakaran ◽  
Graeme N. Smith ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chinese Women ◽  
Cross Sectional Study ◽  
Serum Folate ◽  
Inverse Association ◽  
Women Of Childbearing Age ◽  
Sectional Study ◽  
Childbearing Age ◽  
Cross Sectional

scholarly journals Peranan Ultraviolet B Sinar Matahari terhadap Status Vitamin D dan Tekanan Darah pada Wanita Usia Subur

2014 ◽  
pp. 256 ◽  
Author(s):  
Betty Yosephin ◽  
Ali Khomsan ◽  
Dodik Briawan ◽  
Rimbawan Rimbawan
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Ultraviolet B ◽  
P Value ◽  
Vitamin D Status ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Anthropometric Parameter

Sinar ultraviolet B adalah sumber utama vitamin D, tetapi wanita usia subur yang bekerja di dalam ruangan mempunyai vitamin D yang rendah meskipun Indonesia negara tropis. Tujuan penelitian ini untuk mengevaluasi peranan paparan sinar matahari pada wanita usia subur terhadap status vitamin D dan tekanan darah. Desain penelitian yang digunakan adalah eksperimen tanpa kelompok kontrol pada 21 wanita sehat. Penelitian ini membandingkan status vitamin D dan tekanan darah sebelum dan setelah mendapat paparan sinar matahari pada wajah dan lengan tiga kali seminggu selama 12 minggu. Analisis data menggunakan uji t-berpasangan. Paparan sinar matahari dapat meningkatkan vitamin D. Serum 25(OH)D meningkat 15,9% dari 15.7 ng/dL menjadi 18,2 ng/dL. Paparan sinar matahari menurunkan tekanan darah sistolik (nilai p = 0,004) dan diastolik (nilai p = 0,011). Ultraviolet B dari sinar matahari 30 menit tiga kali seminggu selama 12 minggu dapat memperbaiki status vitamin D dan tekanan darah.Ultraviolet B sunlight exposure is a primary source of vitamin D, but women of childbearing age who worked in room every day had low serum vitamin D despite Indonesia is a tropical country. The objective of this study was to evaluate the role of sun exposure in women of childbearing age on vitamin D status, and blood pressure. An intervention before-after study without group control was conducted on 21 healthy women. This study compared vitamin D status, and blood pressure before and after receiving ultraviolet B (UVB) from sun exposure on the face and both arms three times a week for 12 weeks. Anthropometric parameter and blood pressure were measured, were determined at baseline and after 12 weeks of sun exposure. The effect of sun exposure can improve vitamin D. Serum 25 (OH)D increase 15.9% from 15.7 ng/dL to 18.2 ng/dL. Sun exposure significantly reduced systolic blood pressure (p value = 0.004), and diastolic blood pressure (p value = 0.011). Ultraviolet B from sun exposure for 30 minutes, 3 times a week for 12 weeks improves the vitamin D status, and blood pressure.

scholarly journals Mercury Exposure in Munduruku Indigenous Communities from Brazilian Amazon: Methodological Background and an Overview of the Principal Results

2021 ◽  
Vol 18 (17) ◽  
pp. 9222
Author(s):  
Paulo Cesar Basta ◽  
Paulo Victor de Sousa Viana ◽  
Ana Claudia Santiago de Vasconcellos ◽  
André Reynaldo Santos Périssé ◽  
Cristina Barroso Hofer ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Indigenous Communities ◽  
Brazilian Amazon ◽  
Mercury Exposure ◽  
Mercury Determination ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Hair Samples ◽  
Exposure Levels

The Amazonian indigenous peoples depend on natural resources to live, but human activities’ growing impacts threaten their health and livelihoods. Our objectives were to present the principal results of an integrated and multidisciplinary analysis of the health parameters and assess the mercury (Hg) exposure levels in indigenous populations in the Brazilian Amazon. We carried out a cross-sectional study based on a census of three Munduruku indigenous villages (Sawré Muybu, Poxo Muybu, and Sawré Aboy), located in the Sawré Muybu Indigenous Land, between 29 October and 9 November 2019. The investigation included: (i) sociodemographic characterization of the participants; (ii) health assessment; (iii) genetic polymorphism analysis; (iv) hair mercury determination; and (v) fish mercury determination. We used the logistic regression model with conditional Prevalence Ratio (PR), with the respective 95% confidence intervals (CI95%) to explore factors associated with mercury exposure levels ≥6.0 µg/g. A total of 200 participants were interviewed. Mercury levels (197 hair samples) ranged from 1.4 to 23.9 μg/g, with significant differences between the villages (Kruskal–Wallis test: 19.9; p-value < 0.001). On average, the general prevalence of Hg exposure ≥ 6.0 µg/g was 57.9%. For participants ≥12 years old, the Hg exposure ≥6.0 µg/g showed associated with no regular income (PR: 1.3; CI95%: 1.0–1.8), high blood pressure (PR: 1.6; CI95%: 1.3–2.1) and was more prominent in Sawré Aboy village (PR: 1.8; CI95%: 1.3–2.3). For women of childbearing age, the Hg exposure ≥6.0 µg/g was associated with high blood pressure (PR: 1.9; CI95%: 1.2–2.3), with pregnancy (PR: 1.5; CI95%: 1.0–2.1) and was more prominent among residents in Poxo Muybu (PR: 1.9; CI95%: 1.0–3.4) and Sawré Aboy (PR: 2.5; CI95%: 1.4–4.4) villages. Our findings suggest that chronic mercury exposure causes harmful effects to the studied indigenous communities, especially considering vulnerable groups of the population, such as women of childbearing age. Lastly, we propose to stop the illegal mining in these areas and develop a risk management plan that aims to ensure the health, livelihoods, and human rights of the indigenous people from Amazon Basin.

Challenges of Takayasu Arteritis in Pregnancy: A Case Report

2017 ◽  
Vol 51 (4) ◽  
pp. 195-198 ◽  
Author(s):  
Sarah Soo-Hoo ◽  
Jenny Seong ◽  
Brandon R. Porten ◽  
Nedaa Skeik
Keyword(s):  
Heart Failure ◽  
Takayasu Arteritis ◽  
Cardiovascular Complications ◽  
Unknown Etiology ◽  
Optimal Management ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Clinical Challenge ◽  
Increased Risk ◽  
In Pregnancy

Takayasu arteritis is a rare, chronic vasculitis of unknown etiology characterized by inflammation of the aorta and its main branches. Although Takayasu arteritis mostly affects women of childbearing age, there is a paucity in the literature on pregnancy associated with Takayasu arteritis. Pregnant patients are at increased risk of cardiovascular complications, including hypertension and congestive heart failure, which may jeopardize both maternal and fetal outcomes. Furthermore, optimal management has not yet been established for pregnant patients with Takayasu arteritis, posing a clinical challenge. We present a case of a young woman with Takayasu arteritis whose symptoms and disease activity improved during 2 pregnancies. Although her first pregnancy was complicated with preeclampsia, gestational diabetes, and preterm vaginal delivery, her second pregnancy was uneventful. This case provides a rare glimpse of Takayasu arteritis in pregnancy and highlights the challenges of medical management in gravid patients.

scholarly journals Socioeconomic status and vitamin D deficiency among women of childbearing age: a population-based, case–control study in rural northern China

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e042227
Author(s):  
Shiqi Lin ◽  
Lifang Jiang ◽  
Yuan Zhang ◽  
Jian Chai ◽  
Jiajia Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Northern China ◽  
Population Based ◽  
Vitamin D Insufficiency ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Severe Deficiency ◽  
Increased Risk ◽  
Control Study

ObjectiveTo explore the association between socioeconomic status (SES) and vitamin D deficiency/insufficiency of women of childbearing age in rural northern China.DesignA population-based, case–control study was conducted.SettingFour counties of Henan Province, China from 2009 to 2010.Participants1151 non-pregnant healthy women between 18 and 40 years old.Primary and secondary outcome measuresSerum 25-hydroxyvitamin D (25(OH)D) levels were measured using high-performance liquid chromatography-tandem mass spectrometry. Vitamin D insufficiency was defined as serum 25(OH)D ≥20 ng/mL and <30 ng/mL, deficiency as ≥10 ng/mL and <20 ng/mL, and severe deficiency as <10 ng/mL. SES was measured separately by women’s and their husbands’ education level and occupation, household income and expenditure, as well as aggregately by SES index constructed with principal component analysis.ResultsThe median serum 25(OH)D level was 20.90 (13.60–34.60) ng/mL, and the prevalence of vitamin D insufficiency, deficiency and severe deficiency was 20.16%, 31.80% and 15.99%, respectively. After adjustment, household annual income <¥10 000 was associated with increased risk of vitamin D insufficiency (adjusted OR (aOR): 2.10, 95% CI 1.41 to 3.14), deficiency (aOR: 1.58, 95% CI 1.09 to 2.29) and severe deficiency (aOR: 2.79, 95% CI 1.78 to 4.38); inadequate household income for expenditure was associated with elevated risk of vitamin D insufficiency (aOR: 1.66, 95% CI 1.08 to 2.54) and deficiency (aOR: 1.81, 95% CI 1.26 to 2.62); low SES index was associated with elevated risk of vitamin D insufficiency (aOR: 2.40, 95% CI 1.52 to 3.80) and deficiency (aOR: 1.64, 95% CI 1.08 to 2.50); and both middle and low SES index were associated with increased risk of vitamin D severe deficiency (aOR: 1.70, 95% CI 1.02 to 2.84; aOR: 2.45, 95% CI 1.45 to 4.14).ConclusionsLower SES was associated with higher risk of vitamin D deficiency/insufficiency in women of childbearing age in rural northern China. More should be done to explore potential mechanisms and to narrow down SES inequalities in vitamin D status.

scholarly journals The Influence Of Nutrition Counseling On The Knowledge And Intake Of Macro Nutrient Wus Kek In Region Work Puskesmas Sawah Lebar Bengkulu

2019 ◽  
Vol 10 (1) ◽  
pp. 35-45
Author(s):  
Meili Dwi Ananda ◽  
Jumiyati Jumiyati ◽  
Emy Yuliantini
Keyword(s):  
Statistical Analysis ◽  
Health Center ◽  
Post Partum ◽  
Wilcoxon Test ◽  
Nutrition Counseling ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Increased Risk ◽  
Low Birth Weight Babies ◽  
The City

Women of Childbearing Age (WUS) are a population that are of particular interest inthe prevention of nutritional problems, especially in addressing their Lack of Chronic Energy (KEK). KEK in WUS is very likely to result in a difficult childbirth and post partum hemorrhage as well as an increased risk death of the mother and of low birth weight babies. Data WUS SEZ in Indonesia in 2010 (30,9%) increased in 2013 (46,4%). Sixteen provinces with the prevalence of the risk of SEZ above the national province, namely the Bengkulu Province (15%). The purpose of this study is to determine the effect of nutrition counseling on the knowledge and intake of macro nutrient on WUS SEZ in the working area of Health Center of Sawah Lebar the Width of the City of Bengkulu the Year 2018. The results of this study there was significant influence of nutritional counseling (p = 0.000) on the intake of macro nutrient (p = 0.000). On WUS KEK in the working area of Health Center of Sawah Lebar the width of the city of bengkulu the year 2018.The Design of this Research is Pre Experimental Design with design One Group Pretest-Posttest. Nutrition counseling on WUS KEK performed 3 times during 3 weeks. The number of samples as many as 23 people. Statistical analysis using dependent t-test and wilcoxon test

Sign in / Sign up

Export Citation Format

Share Document