scholarly journals Blood lipid profile changes in type 2 diabetic rats after tail suspension and reloading

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Shoji Tanaka ◽  
Sachiko Madokoro ◽  
Pleiades Tiharu Inaoka ◽  
Toshiaki Yamazaki
Keyword(s):  
Lipid Profile ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Tail Suspension ◽  
Blood Lipid Profile ◽  
Cholesterol Levels ◽  
Intramuscular Lipid ◽  
Muscle Catabolism ◽  
Activity Dependent

Abstract Purpose The effects of the tail suspension and reloading on the protein and lipid metabolism in muscle and blood in type 2 diabetes mellitus (T2DM) are unclear. This study evaluated the hypothesis that skeletal muscle catabolism is greater in T2DM than in non-diabetes mellitus (non-DM) rats and that the activity-dependent changes in the intramuscular lipid accumulation and blood lipid profile are poorer in T2DM than in non-DM rats. Methods T2DM and non-DM rats were suspended for two weeks followed by reloading for two weeks. The muscle and blood were then examined. Results In contrast to our hypothesis, there was no marked difference between the T2DM and non-DM groups in terms of the skeletal muscle catabolism and activity-dependent changes in intramuscular lipid accumulation. However, the blood lipid profile increased in the T2DM group compared to the non-DM group. One interesting finding in this study was the decrease in non-high-density lipoprotein (non-HDL) cholesterol levels after one week of reloading followed by a significant increase in the non-HDL cholesterol levels after two weeks of reloading in the T2DM group. Conclusion These results suggest that a dramatic increase in activity after a period of inactivity may rapidly improve the blood lipid profile in T2DM rats.

732-P: Effect of Serum 25-Hydroxyvitamin D on Blood Lipid Profile in Type 2 Diabetics

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 732-P
Author(s):  
NAN LI ◽  
YANRU WANG ◽  
BING ZHU ◽  
HANG SUN ◽  
PENG YANG ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Blood Lipid ◽  
Blood Lipid Profile ◽  
Hydroxyvitamin D ◽  
Type 2 Diabetics ◽  
25 Hydroxyvitamin D

scholarly journals Effect of Basil Seed and Chia SeedExtracts on Blood Lipid Profile

2021 ◽  
Vol 15 (6) ◽  
pp. 1368-1371
Author(s):  
S. Munir ◽  
S. Khurshid ◽  
Q. J. Iqbal ◽  
N. Iqbal ◽  
Z. Masood
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Plasma Lipid ◽  
Blood Lipid ◽  
Histopathological Analysis ◽  
Omega 3 ◽  
Blood Lipid Profile ◽  
Cholesterol Levels ◽  
Maintain Body Weight

Background: Basil and Chia seeds contain higher nutritive values like vitamin, carbohydrates, Omega-3 oil and other dietary fibers. With all these rich dietary benefits these seeds regulate necessary health conditions and maintain body weight. Ocimumbasilicum (Basil) plant have been known to contain properties of weight loss, better digestion and other health benefits. Aim: To check the Basil seed against hyperlipidemia in mice with Chia seeds. Methodology: In this research, the effect of both seeds extract on body weight and plasma lipid profile were estimated in Albino mice after raising their cholesterol levels by high fatty diet. The experiments were performed in different groups like normal control, standard control, hyperlipidemia group and four groups of diet supplemented chia or basil seeds with two different doses. Results: The biochemical analysis revealed that the supplementation of Basil seeds (400mg/kg/day) significantly lowered the levels of total plasma cholesterol, lipoproteins and triacylglycerol. Moreover, histopathological analysis of vital organs like kidneys, heart reported no toxicity. Conclusion: Extracts of Chia and Basil seeds have shown controlling effects over the given parameters in the blood and weights of the animals and these may have potential to control high fat diet-induced hyperlipidemia when taken as dietary supplements. Keywords: Cholesterol, Hyperlipidemia, Ocimumbasilicum, Salvia hispanica

Krill oil to improve blood lipids status in advanced cancer patient with cachexia.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19634-e19634
Author(s):  
Roberto Serpe ◽  
Clelia Madeddu ◽  
Filomena Panzone ◽  
Giorgia Antoni ◽  
Maria Chiara Cau ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cancer Cachexia ◽  
Blood Lipid ◽  
Blood Levels ◽  
Krill Oil ◽  
Omega 3 ◽  
Blood Lipid Profile ◽  
Cholesterol Levels

e19634 Background: Cancer patients with cachexia symptoms often show a lipid profile disorder, consisting in severe hypertriglyceridemia due to increased circulating free fatty acids and variable total cholesterol levels, decreased activity of lipoprotein lipase and increased lipolysis, which is correlated with proinflammatory cytokines levels, particularly IL-6 and TNFα. Recent evidence further confirms impairment of adipose tissue metabolism in inflammatory condition like cancer cachexia. The aim of this study was to assess the effect of nutritional supplementation with Omega 3 fatty acids (EPA and DHA) in the form of Krill Oil, on main parameters of blood lipid profile and on IL-6 and TNFα blood levels. Methods: In 2011, 34 IV stage cachectic patients (M/F 20/14; age range 55-85 y) with cancer at different sites were enrolled. 21 healthy subjects were studied as controls. All patients had high blood tryglicerides, low total cholesterol levels , high levels of blood IL-6 and TNFα compared to controls. Patients received 3 capsules (3 g/day) of krill oil (Superba™ Krill Oil, Aker Biomarine, Norway), which is an oil extract from the crustacean krill (Euphausia Superba) which contains Omega-3 series unsaturated fatty acids in phospholipidic form, of which 98 % are EPA and DHA mainly in phospholipid form. Treatment duration was 2 months. Results: A significant reduction of tryglicerides blood levels (148.23 ± 88.06 vs 114 ± 55.8 mg/dl) and a significant improvement of HDL cholesterol (42.5 ± 15.6 vs 60.9 ± 12.3 mg/dl) and Total Cholesterol (135.6 ± 46.3 vs 159 ± 41.1 mg/dl) was observed after treatment. Cytokines Il-6 and TNFα blood levels did not change significantly after treatment Conclusions: Nutritional supplementation with krill oil showed a positive activity in the regulation of blood lipid profile, involving different metabolic and inflammatory pathways, probably mainly affecting hormone-sensitive lipase activity. Our data suggest that krill oil could be useful in multi-targeted combined pharmaco-nutritional approaches to treat cancer-cachexia. Additional phase III clinical studies are warranted.

scholarly journals Egg consumption and blood lipid parameters according to the presence of chronic metabolic disorders: The EVIDENT II Study

2021 ◽  
Author(s):  
Arthur Eumann Mesas ◽  
Miriam Garrido-Miguel ◽  
Rubén Fernández-Rodríguez ◽  
Sofía Fernández Franco ◽  
Cristina Lugones-Sánchez ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Metabolic Disorders ◽  
Metabolic Diseases ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Linear Regression Models ◽  
Blood Lipid Profile ◽  
Cross Sectional ◽  
Egg Consumption ◽  
Lipid Parameters

Abstract Context Egg consumption is one of the main dietary sources of cholesterol, but whether individuals who eat more eggs have a worse blood lipid profile remains controversial. Objective We examined the relationship between egg consumption and lipid parameters and explored whether this relationship changes according to the presence of chronic metabolic disorders. Methods A multicenter cross-sectional study was conducted with adult participants in the EVIDENT II trial. Adjusted linear regression models were stratified by the main chronic metabolic disorders. Results Among the 728 participants (61.9% women, mean age 52.1±11.9 years), the mean egg consumption was equivalent to 5-to-6 eggs per week for a 70 kg individual. In the fully-adjusted analysis, no association was found of egg consumption with total and HDL cholesterol, and triglyceride levels. Furthermore, compared to the first quartile of consumption, the fourth quartile was associated with lower LDL-c levels (coefficient: -7.01; 95%CI: -13.39, -0.62) and a lower LDL-c/HDL-c ratio (coefficient: -0.24, 95%CI: -0.41, -0.06). In the analyses stratified by chronic metabolic diseases, higher egg consumption was not associated with lipid profile in those with obesity, hypertension, type 2 diabetes, dyslipidemia, or treated with hypolipidemic drugs, and was associated with a better lipid profile in participants without these conditions. Conclusions Higher egg consumption was not associated with blood lipids in individuals with chronic metabolic disorders. In individuals without such conditions, the lipid profile was better among those who consumed more eggs. Our findings support current guidelines recommending eggs as part of a healthy diet.

scholarly journals Content of n-3 LC-PUFA in Breast Milk Four Months Postpartum is Associated with Infancy Blood Pressure in Boys and Infancy Blood Lipid Profile in Girls

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 235 ◽  
Author(s):  
Signe Bruun ◽  
Lenie van Rossem ◽  
Lotte Lauritzen ◽  
Steffen Husby ◽  
Lotte Neergaard Jacobsen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Breast Milk ◽  
Lipid Profile ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Blood Lipid Profile ◽  
Long Term Effect ◽  
Maternal Educational Level ◽  
Changes Over Time

Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = −20.0 (95% CI = −33.4, −6.7), p = 0.004 and β = −10.2 (95% CI = −19.8, −0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = −0.7 (95% CI = −1.1, −0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.

scholarly journals Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM)

2015 ◽  
Vol 22 (1) ◽  
pp. 86-91
Author(s):  
M. V. Kim ◽  
S. A. Skoryukova ◽  
A. A. Bystrova ◽  
E. I. Baranova ◽  
S. N. Pchelina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Blood Lipid ◽  
Blood Lipid Profile ◽  
Study Objective ◽  
Therapy Effect ◽  
Atorvastatin Therapy

Study objective: to estimate efficiency of atorvastatin therapy in patients with type 2 diabetes mellitus (T2DM), who are the carrier of various genotypes Q192R paraoxonase gene 1 (PON1). 386 T2DM patients, who have not received statin therapy before, and 187 healthy people were examined. All those examined were exposed to blood lipid profile testing and molecular genetic research. The atorvastatin treatment group included 164 T2DM patients with abnormality of lipids, their blood lipid profile values were assessed before and after 3 months of the therapy. Blood lipid profile values did not differ in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism. Atorvastatin therapy decreased atherogenic lipoprotein levels in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism, but reduction degree in the carriers of different Q192R genotypes differed - in Q192Q bearers it was greater than in the bearers of Q192R genotype of gene PON1 (р = 0,031). Atorvastatin 3-months therapy revealed greater reduction of total cholesterol in the carriers of Q192Q genotype of gene 1 (PON1) than in the carriers of Q192R genotype of gene 1 (PON1).

scholarly journals Comparative Studies of the Effects of Egg Yolk, Oats, Apple, and Wheat Bran on Serum Lipid Profile of Wistar Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
J. O. Omole ◽  
O. M. Ighodaro
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Wheat Bran ◽  
Serum Lipid ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Egg Yolk ◽  
Blood Lipid Profile

Excess consumption of egg especially its yolk has been implicated in hyperlipidaemia (high level of cholesterol and triglyceride in the blood). Conversely, soluble dietary fibers, probably due to their ability to bind free lipid molecules, appear to play an important role in protecting against hyperlipidaemia. This study sought to evaluate the comparative effects of selected sources of fibers: apple, oats, and wheat bran, on serum lipid profile in physiologically normal Wistar rats. Twenty rats were used for the study and were randomized into four groups, with each containing five animals (). A group which serves as control was fed with egg yolk while the other three groups were fed with apple, oats, and wheat bran, respectively. After two weeks of feeding, the animals were fasted overnight and blood samples from the retro-orbital sinus of the eye were collected for analyses of lipid profile. The results obtained showed that the group fed with oats had the lowest level of total cholesterol ( mg), low density lipoprotein (LDL) cholesterol ( mg), and triglycerides (TG) ( mg), as well as the highest level of HDL cholesterol ( mg). On the contrary, the group fed with egg yolk showed the highest level of total cholesterol ( mg), LDL cholesterol ( mg), and triacylglyceride ( mg), as well as the lowest level of HDL cholesterol ( mg). There was no significant difference () between oats and apple in their effects on blood lipid profile of Wistar rats. Wheat bran, being an insoluble dietary fibre, had less significant () effect on the blood lipid profile when compared to oats and apple. Findings from this study may assist physicians and dieticians in recommending appropriate diet for individuals desiring to normalize their blood lipids levels.

scholarly journals HUBUNGAN ASUPAN SERAT DENGAN STATUS GIZI DAN PROFIL LIPID DARAH PADA ORANG DEWASA DISLIPIDEMIA

2014 ◽  
Vol 8 (3) ◽  
pp. 195
Author(s):  
Lilik Kustiyah ◽  
Maya Utami Widhianti ◽  
Mira Dewi
Keyword(s):  
Nutritional Status ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Cross Sectional Survey ◽  
Blood Lipid Profile ◽  
Cross Sectional

The objective of this study was to analyze the association of fiber consumption with nutritional status and blood lipid profile in dyslipidemic adults. The design study was cross sectional survey involving 79 subjects. The results showed that there were significant correlations between energy intake with High Density Lipoprotein (HDL) cholesterol and total cholesterol, fat intake with BMI (Body Mass Index), and BMI with Low Density Lipoprotein (LDL) cholesterol and total cholesterol (p&lt;0.05). There was no significant correlation between consumption of fiber with nutritional status and blood lipid profile (p&gt;0.05). In conclusion, most of the dyslipidemia subjects were obese. Dyslipidemia subjects should keep their intake of energy and fat in recommended ranges in order not to be obese and keep the BMI in normal range to avoid abnormalities of blood lipid profile.<br /><br />

scholarly journals Two Blends of Refined Rice Bran, Flaxseed, and Sesame Seed Oils Affect the Blood Lipid Profile of Chinese Adults with Borderline Hypercholesterolemia to a Similar Extent as Refined Olive Oil

2020 ◽  
Vol 150 (12) ◽  
pp. 3141-3151
Author(s):  
Sumanto Haldar ◽  
Long Hui Wong ◽  
Shia Lyn Tay ◽  
Jörg J Jacoby ◽  
Pengfei He ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Olive Oil ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Chinese Adults ◽  
Similar Extent ◽  
Blood Lipid Profile ◽  
Refined Olive Oil ◽  
Oil Blends ◽  
Time Treatment

ABSTRACT Background Individual vegetable oils have a characteristic fatty acids (FA) composition and unique phytonutrient profiles, enabling formulation of oil blends that may have health-promoting effects. Objective The primary objective of this study was to investigate effects of 2 oil blends made with refined rice bran, flaxseed, and sesame oils, with distinct monounsaturated to saturated FA, polyunsaturated to saturated FA, and omega-3 (n–3) to omega-6 FA ratios and different phytonutrient concentrations on blood lipid profile, compared with refined olive oil as a control. The secondary outcomes were other markers of cardiometabolic health. Methods A parallel-design, randomized controlled trial compared consumption of 30 g of allocated intervention oil per day for a period of 8 wk. The study recruited 143 borderline hypercholesterolemic (LDL cholesterol: 3.06–4.51 mmol/L) Chinese volunteers between 50 and 70 y old and with a BMI (kg/m2) ≤27.5. All outcomes were measured every 2 wk, and the time × treatment interactions and the main effects of treatment and time were analyzed using an intention-to-treat approach. Results Compared with baseline (week 0), there were significant reductions during the post-intervention time points in serum total cholesterol (−3.47%; P &lt; 0.0001), LDL cholesterol (−4.16%; P &lt; 0.0001), triglycerides (−10.3%; P &lt; 0.0001), apoB (−3.93%; P &lt; 0.0001), total to HDL-cholesterol (−3.44%; P &lt; 0.0001) and apoB to apoA1 (−3.99%; P &lt; 0.0001) ratios, systolic and diastolic blood pressures (−3.32% and −3.16%, respectively; both P &lt; 0.0001), and serum glucose (−1.51%; P &lt; 0.05) and a small but significant increase in body weight (+0.7%; P &lt; 0.001) for all 3 intervention oils but no effects of intervention on HDL-cholesterol or apoA1 concentration. No significant effects of treatment or time × treatment interactions were found. Conclusions Using blended vegetable oils that are extensively consumed in Asia, this study found that specific oil blends can improve blood lipid profile and other cardiometabolic parameters, to a similar extent as refined olive oil, in Chinese adults with borderline hypercholesterolemia. This trial is registered at www.clinicaltrials.gov as NCT03964857.

scholarly journals Reliability of Friedewald formula in patients with type 2 diabetes mellitus and its relation to lipid profile in diabetes regulation

2021 ◽  
Vol 29 (2) ◽  
pp. 179-187
Author(s):  
Didem Barlak Keti ◽  
Sabahattin Muhtaroglu
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Direct Measurement ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Cholesterol Ratio ◽  
Cholesterol Levels ◽  
Type 2 Dm ◽  
Friedewald Formula

Abstract Introduction: Many laboratories utilize Friedewald formula (FF) to analyze LDL cholesterol levels of patients including diabetes mellitus (DM). Therefore, it is essential to consider the coherence of results acquired by FF and direct measurement. The number of studies that investigated the effect of lipid parameters, especially TG/HDL cholesterol ratio, on the difference between the two methods is limited. The study was designed to compare LDL cholesterol values obtained by using FF with direct measurement, and to evaluate the relationship between diabetes regulation and lipid profile. Material and Methods: In the cross-sectional study, 529 type 2 DM patients and 1703 non-DM subjects were divided into four groups regarding TG concentrations. Unlike other studies, the study focuses on direct LDL (DLDL) cholesterol levels obtained with the help of different DLDL cholesterol kits (n=20). The correlations were implemented between HbA1c and lipid profiles. Results: It was determined that the bias% was over 10% in 24% of patients with 100-199 mg/dL TG levels. The parameter revealed that the most significant difference and the strongest correlation with HbA1c was TG/HDL cholesterol ratio in patients with type 2 DM. Conclusions: In patients with type 2 DM, even if it was TG <200 mg/dL, LDL calculated with FF should be evaluated together with the TG/HDL cholesterol ratio. Otherwise, direct measurement can be recommended. This ratio is related to diabetes regulation and may be used to monitor patients..

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