scholarly journals Clinicopathological features and EBV infection status of lymphoma in children and adolescents in South China: a retrospective study of 662 cases

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Changfei Qin ◽  
Yuhua Huang ◽  
Yanfen Feng ◽  
Min Li ◽  
Na Guo ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Children And Adolescents ◽  
South China ◽  
Clinicopathological Features ◽  
Infection Status ◽  
Ebv Infection

scholarly journals Extranodal NK/T-cell lymphoma in Tunisia: clinicopathological features, immunophenotype and EBV infection

2019 ◽  
Vol 31 (1) ◽  
Author(s):  
Nabiha Missaoui ◽  
Sarra Mestiri ◽  
Aida Bouriga ◽  
Nihed Abdessayed ◽  
Mouna Belakhdher ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
T Cell ◽  
Granzyme B ◽  
Clinicopathological Features ◽  
Histopathological Diagnosis ◽  
Ebv Infection ◽  
Nk T Cell ◽  
Epstein Barr ◽  
Hodgkin's Lymphomas

Abstract Background Extranodal NK/T-cell lymphomas (ENKTL) are rare non-Hodgkin’s lymphomas with aggressive clinical behavior. ENKTL are frequently associated with the Epstein-Barr virus (EBV). Data on ENKTL in Africa and Arab world are extremely limited. The study investigated the clinicopathological characteristics, EBV infection, and immunophenotype of ENKTL in Tunisia. We conducted a retrospective study of ENKTL. Main clinicopathological features were reported. The expression of CD3, CD4, CD5, CD8, CD20, CD56, CD57, and Granzyme B were analyzed by immunohistochemistry. EBV infection was detected by IHC (LMP-1) and Epstein-Barr encoding region (EBER1/2) in situ hybridization. Results A total of nine ENKTL were identified (mean age of 48 years and male-to-female ratio of 8:1). There were five nasal ENKTL, and the remaining four cases had extranasal involvement (palate, sub-mandibular gland, skin, and soft tissues of the ankle). The histopathology showed a lymphoid and pleomorphic proliferation characterized by images of angiocentrism. Strong and diffuse CD3 expression was observed in all cases. Tumor cells exhibited an expression of CD5 (two cases), CD8 (three cases), CD56 (six cases), CD57 (three cases), and Granzyme B (eight cases). All ENKTL cases were EBV-associated. Overall 5-year survival rate was 57%. Although six ENKTL were diagnosed at early clinical stages, the prognosis was unfavorable and associated with patient death in three cases. Conclusions ENKTL are exceptional in Tunisia with unfavorable outcome. Histopathological diagnosis remains challenging in clinical practice. However, a careful histopathological examination combined with a correct interpretation of immunohistochemistry and in situ hybridization results refines the ENKTL diagnosis.

scholarly journals Subtle changes of the crystalline lens after cycloplegia: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Cheng Dai ◽  
Meng Liu ◽  
Xiaodong Lv ◽  
Binzhong Li
Keyword(s):  
Retrospective Study ◽  
Children And Adolescents ◽  
Population Change ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Crystalline Lens ◽  
Equivalent Diameter ◽  
Crystalline Morphology ◽  
Significant Difference ◽  
Before And After

Abstract Background The purpose of this study was to evaluate the shape of the crystalline lens in terms of biometry and diopters before and after cycloplegia using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment. Methods This was a retrospective study. Children and adolescents (26 males and 29 females, aged 4–21 years) with simple ametropia were selected for optometry and CASIA2 imaging at 2 separate visits before and after cycloplegia. Diopter values were derived from the spherical power (S) obtained by optometry. Biometric parameters of the crystalline lens, including the anterior chamber depth (ACD), anterior and posterior curvature of the lens (ACL and PCL), lens thickness (LTH), lens decentration (LD), lens tilt (LT), and equivalent diameter of the lens (LED), were measured by the CASIA2 system. The differences in these parameters after compared with before cycloplegia were determined, and their relationships were analyzed. Results Fifty-five participants (106 eyes) were initially enrolled. There was a significant difference (P < 0.05) in the S (t=-7.026, P < 0.001), ACD (t=-8.796, P < 0.001), ACL (t=-13.263, P < 0.001) and LTH (t = 7.363, P < 0.001) after compared with before cycloplegia. The change in the PCL (t = 1.557, P = 0.122), LD (t = 0.876, P = 0.383), LT (t = 0.440, P = 0.661) and LED (t=-0.351, P = 0.726) was not statistically significant (P > 0.05). There was a significant (P < 0.05) correlation of the change in the S with that in the ACL (r = 0.466, P < 0.001), LTH (r=-0.592, P < 0.001), and LED (r = 0.223, P = 0.021) but not the PCL (r = 0.19, P = 0.051), LD (r=-0.048, P = 0.0628) or LT (r=-0.022, P = 0.822). Furthermore, the change in the ACD was closely related to the change in crystalline morphology. However, in children and adolescents, we found that the change in crystalline morphology was unrelated to age. Conclusions Changes in lens morphology after compared with before cycloplegia are mainly related to the ACL and LTH, but there is no difference in the PCL, LD, LT, or LED. In the adolescent population, change in the S is related to change in the ACL, LED and LTH. However, age is unrelated to the shape and tendency of the crystalline lens. Further research is required to determine whether the same conclusion applies to different age groups and different refractive states (myopia, hyperopia, emmetropia) .

scholarly journals Treatment of children and adolescents with hemangioma using propranolol: preliminary results from a retrospective study

2014 ◽  
Vol 132 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Juliana Costa Albuquerque ◽  
Rosane Aline Magalhaes ◽  
Jamille Araujo Felix ◽  
Maria Vilani Rodrigues Bastos ◽  
Juvenia Bezerra Fontenele ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Children And Adolescents ◽  
Previous Treatment ◽  
Capillary Hemangioma ◽  
Response To Treatment ◽  
Vascular Tumors ◽  
Lesion Volume ◽  
Chi Square ◽  
One Year ◽  
Almost All

CONTEXT AND OBJECTIVE: Hemangiomas are the commonest vascular tumors during childhood. In 2008, the effect of propranolol for treating capillary hemangiomas was demonstrated. Other similar results followed, showing that it rapidly reduces lesion volume. The objective here was to evaluate children and adolescents with hemangiomas that were treated with propranolol. DESIGN AND SETTING: Retrospective study, conducted in a children's hospital. METHODS : Patients aged 0-19 years with or without previous treatment, who were treated between January 2009 and December 2010, were included. The response was assessed by comparing the lesion appearance between the start of treatment and the last consultation. We considered partial or complete responses as the response to treatment. RESULTS : Sixty-nine patients with a median follow-up of 11 months (mean age: 31 months) were included. Of these, 58 patients were recently diagnosed and 11 had had previous treatment. A response (partial or complete) was seen in 60 patients (87%). Among the capillary hemangioma cases, responses were seen in 50 out of 53 (94%), while in other lesion types, it was 10 out of 16 (63%) (P = 0.3; chi-square). Responses in patients less than one year of age were seen in 37 out of 38 (97%), whereas in those over one year of age, in 23 out of 31 (74%) (P = 0.4; chi-square). Side effects were uncommon and mild. CONCLUSIONS: Propranolol seemed to be effective for treatment of hemangiomas in children and adolescents, and not just in the proliferative stage, with responses in almost all the patients.

scholarly journals Screening of epileptic seizures in children and adolescents with hydrocephalus and ventriculoperitoneal shunt

2009 ◽  
Vol 15 (3) ◽  
pp. 106-109 ◽  
Author(s):  
Raimundo Francisco de Amorim Júnior ◽  
Suerda Emiliana Cavalcanti Dantas ◽  
Rodrigo de Holanda Mendonça ◽  
Abdiel de Lira Rolim ◽  
Maria Luiza de Carvalho Jales ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Data Analysis ◽  
Prospective Study ◽  
Children And Adolescents ◽  
Ventriculoperitoneal Shunt ◽  
Epileptic Seizures ◽  
Significant Difference ◽  
A Prospective Study ◽  
Larger Sample ◽  
Diagnosis Age

OBJECTIVES: To assess the occurrence of epileptic seizures (ES) in children and adolescents with hydrocephalus and their relationship with ventriculoperitoneal shunt (VPS) treatment. METHODS: Retrospective study of 45 patients from both genders, aged 0 to 18 years, with hydrocephalus and presenting with ES or not. The following variables were analyzed: gender, hydrocephalus etiology, age at diagnosis, age at initial VPS treatment, age at first ES and types of ES. RESULTS: Data analysis showed the following: 20 (44.4%) presented with ES, 13 (65%) of the girls and seven (35%) of the boys. There was a predominance of ES in the girls, but with no statistically significant difference. In total, 13 (65%) patients used VPS. Of the 13 patients with VPS and ES, it was observed that the onset of ES was after VPS in 10 (76.9%) individuals, whereas it occurred before VPS in two (15.4%). CONCLUSIONS: The results showed no association between VPS treatment and ES (ρ=0.832); however, most of the patients presented with their first ES episode after VPS, suggesting a possible relationship between this treatment and the occurrence of ES. A larger sample and a prospective study might answer this question.

scholarly journals Perfil das notificações de violência contra crianças e adolescentes

2020 ◽  
Vol 14 ◽  
Author(s):  
Samylla Bruna De Jesus Silva ◽  
Hayla Nunes Conceição ◽  
Joseneide Teixeira Câmara ◽  
Rytchelle Silva Machado ◽  
Tharliane Silva Chaves ◽  
...  
Keyword(s):  
Domestic Violence ◽  
Information System ◽  
Retrospective Study ◽  
Elementary Education ◽  
Children And Adolescents ◽  
Common Type ◽  
Descriptive Statistics ◽  
Violencia Domestica ◽  
Quantitative Descriptive ◽  
Educación Primaria

Objetivo: analisar o perfil das notificações de violência perpetrada contra crianças e adolescentes. Método: trata-se de um estudo quantitativo, descritivo, exploratório, retrospectivo, de 2014 a 2015, com 85 casos de violência perpetrada contra crianças e adolescentes. Utilizaram-se os dados provenientes do Sistema de Informação de Agravos de Notificação. Obteve-se a análise dos perfis epidemiológicos por meio da estatística descritiva. Resultados: verificou-se que a violência foi prevalente em crianças com idades entre dez a 14 anos (36,47%), pardas (90,59%), do sexo feminino (83,53%), com Ensino Fundamental (60,60%) e que 98,82% não possuíam alguma deficiência ou transtorno. Revela-se que o tipo de violência mais comum foi a psicológica/moral (43,66%) e o meio de agressão prevalente foi a ameaça (51,92%) praticada na residência (75,29%) da vítima por amigos/conhecidos (47,06%) do sexo masculino (91,76%). Conclusão: evidenciou-se, um aumento no número de casos de violência contra as crianças e adolescentes pardas, do sexo feminino e com Ensino Fundamental, sendo que o tipo de violência mais comum foi a violência psicológica/moral por meio de ameaças praticadas por amigos/conhecidos na residência da vítima. Descritores: Adolescente; Criança; Violência Doméstica; Maus-Tratos Infantis; Agressão; Enfermagem.AbstractObjective: to analyze the profile of notifications of violence perpetrated against children and adolescents. Method: this is a quantitative, descriptive, exploratory, retrospective study, from 2014 to 2015, with 85 cases of violence perpetrated against children and adolescents. Data from the Notifiable Diseases Information System was used. Epidemiological profiles were analyzed using descriptive statistics. Results: it was found that violence was prevalent in children aged ten to 14 years (36.47%), brown (90.59%), female (83.53%), with elementary school (60, 60%) and that 98.82% did not have any disability or disorder. It turns out that the most common type of violence was psychological / moral (43.66%) and the prevalent means of aggression was the threat (51.92%) practiced in the residence (75.29%) of the victim by friends / (47.06%) were male (91.76%). Conclusion: there was an increase in the number of cases of violence against brown children and adolescents, female and with elementary education, and the most common type of violence was psychological / moral violence through threats practiced by friends/ acquaintances at the victim's residence. Descriptors: Adolescent; Child; Domestic Violence; Child Abuse; Aggression; Nursing.ResumenObjetivo: analizar el perfil de las notificaciones de violencia perpetrada contra niños y adolescentes. Método: es un estudio cuantitativo, descriptivo, exploratorio, retrospectivo, de 2014 a 2015, con 85 casos de violencia perpetrados contra niños y adolescentes. Se utilizaron datos del Sistema de Información de Agravios de Notificación. Los perfiles epidemiológicos se analizaron mediante estadística descriptiva. Resultados: se encontró que la violencia prevalecía en niños de 10 a 14 años (36.47%), marrones (90.59%), mujeres (83.53%), con educación primaria (60, 60%) y ese 98.82% no tenía ninguna discapacidad o trastorno. Resulta que el tipo de violencia más común fue psicológica / moral (43.66%) y el medio de agresión predominante fue la amenaza (51.92%) practicada en la residencia (75.29%) de la víctima por amigos /conocidos (47.06%) eran hombres (91.76%). Conclusión: hubo un aumento en el número de casos de violencia contra niños y adolescentes marrones, mujeres y con educación primaria, y el tipo más común de violencia fue la violencia psicológica / moral a través de amenazas practicadas por amigos. / conocidos en la residencia de la víctima. Descriptores: Adolescente; Criança; Violencia Doméstica; Maltrato a los Niños; Agresión; Enfermería.

Sign in / Sign up

Export Citation Format

Share Document