scholarly journals Characteristics of older adult hospitalized patients with bronchial asthma: a retrospective study

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Yuan Zhang ◽  
Lewei Huang
Keyword(s):  
Asthma Control ◽  
Older Adult ◽  
Bronchial Asthma ◽  
Late Onset ◽  
Hospitalized Patients ◽  
Adult Patients ◽  
Asthma Control Test ◽  
Hospitalization Costs ◽  
Acute Attacks ◽  
Epidemiological Characteristics

Abstract Background Bronchial asthma is a chronic inflammation of the airways. Older adult patients with bronchial asthma are defined as patients older than 65 and with a previous or current clear diagnosis of asthma. The purpose of this study was to determine the characteristics of older adult hospitalized patients with bronchial asthma. Methods We retrospectively analyzed the data from patients with bronchial asthma admitted to the General Hospital of the Northern Theater Command from September 2018 to January 2020. We divided them into the older adult (≥ 65 years) and the younger (< 65 years) groups. We compared the clinical and epidemiological characteristics of the two groups. Results There were 181 inpatients with bronchial asthma, including 41 older adult patients, accounting for 22.7%. There were significant differences in age, sex, smoking, duration of disease, age at diagnosis of asthma, hospital stays, hospitalization costs, number of acute attacks 1 year before admission, number of hospitalizations in our hospital one year before admission, asthma control test score, forced expiratory volume in 1 s (FEV1), FEV1/FVC, the severity of acute attacks, comorbidities, and inhaled corticosteroid dose between the two groups. There were many older adult patients with asthma (mostly late-onset asthma). The hospitalization costs were high. Most patients had many comorbidities, poor asthma control, severe attack, and heavy economic burdens. Conclusion Attention should be focused on achieving asthma control in older adult patients to improve their quality of life and reduce their economic burdens.

scholarly journals Correlation Between the Asthma Control Test Score and FEV1 in Nigerians With Bronchial Asthma

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 146A
Author(s):  
Obianuju B. Ozoh ◽  
Olarenwaju E. Bandele ◽  
Cyril Chukwu ◽  
Njideka Okubadejo
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Test Score ◽  
Control Test ◽  
Asthma Control Test

scholarly journals THE ANALYSIS OF THE ASSOCIATION OF ADRB2 GENE POLYMORPHISM AND EXTERNAL RESPIRATORY FUNCTION IN CHILDREN WITH BRONCHIAL ASTHMA

2021 ◽  
Vol 20 (2) ◽  
pp. 71-76
Author(s):  
E.S. Minina ◽  
◽  
V.I. Novikova ◽  
P.D. Novikov ◽  
A.S. Babenka ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Respiratory Function ◽  
Gene Locus ◽  
Subjective Assessment ◽  
Control Test ◽  
Asthma Control Test ◽  
Individual Program ◽  
Adrb2 Gene

Objectives. To study the role of the ADRB2 gene polymorphism (rs1042713) in the impaired external respiratory function in children with bronchial asthma (BA). Material and methods. The study group included 60 children aged 3-17 years with allergic (n=37) and mixed form of BA (n=23). The genotyping of the investigated gene locus was performed by PCR-RFLP (polymerase chain reaction - restriction fragment length polymorphism), BA control was exercised using the Asthma Control Test (ACT). Results. The analysis of allele frequencies showed an association of allele A with normal spirogram parameters in patients with BA (p=0.042). In children under 12 years, there were statistically significant differences in spirogram indices when comparing patients with genotypes AA and GG (p=0.045). An association of allele A with the absence of pathological changes was revealed when evaluating the results of spirometry (p=0.021). There was a moderate positive correlation (r=0.615, p=0.011) between the assessment of nocturnal symptoms (Asthma Control Test) and the genotype of the ADRB2 gene polymorphism in children aged 12 years and older. Conclusions. An association of the ADRΒ2 gene polymorphism (rs1042713) with the external respiratory function was revealed in an objective study by spirometry and a subjective assessment of this indicator by the patient himself/herself or by his/her parents. This gene locus can be included in the BA target panel in order to determine the likelihood of uncontrolled course development of the disease with impaired external respiratory function and in the future to develop an individual program for dispensary observation of the patient.

scholarly journals Role of a Community Pharmacy Service in Care of Bronchial Asthma Patients in Lithuania

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Arturas Nastaravičius ◽  
Kristina Ramanauskienė
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Pharmacy Service ◽  
Control Test ◽  
Asthma Control Test ◽  
Chronic Respiratory Diseases ◽  
Asthmatic Patients ◽  
Positive Effects ◽  
Community Pharmacy Service ◽  
Asthma Patients

Bronchial asthma is one of the most common chronic respiratory diseases, and its care is often complex. In this research, we tested the proposal that participation of pharmacists in the management of bronchial asthma can improve patient outcomes. A two-stage study was constructed consisting of a training element and a service element, using the Asthma Control Test and a structured questionnaire about the patients’ disease condition (based on the results of a qualitative study). The study was conducted in 21 pharmacies in Lithuania and involved 338 asthmatic patients (age 18–88 years). It was found that before the pharmacy service was provided, the average number of mistakes patients made in administration of asthma medications was 2.03; this number decreased to 1.12 after the service was provided (p<0.05). Disease control paralleled the improvement in number of mistakes: 26.1% of patients who previously exerted no control over the disease symptoms began to exert sufficient control over their asthma symptoms (Asthma Control Test >20) after the service was provided (p<0.05). The reduced number of mistakes probably can be attributed to the positive effects of the provided services. By reducing the number of patient mistakes, pharmacists may improve the outcomes of asthmatic patients.

scholarly journals A comparative study of efficacy and tolerability of doxofylline over other methylxanthenes in mild to moderate persistent bronchial asthma patients in a tertiary care hospital

2018 ◽  
Vol 7 (9) ◽  
pp. 1775
Author(s):  
Satyendra K. Alladi ◽  
Imran Khan
Keyword(s):  
Comparative Study ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Tertiary Care ◽  
Subjective Rating ◽  
Tolerability Profile ◽  
Base Line ◽  
Care Hospital ◽  
Asthma Control Test ◽  
Persistent Bronchial Asthma

Background: Studies have shown that doxofylline is endowed with a remarkable bronchodilator activity with less extra respiratory effects than other methylxanthines. To compare the efficacy and tolerability of doxofylline over other methylxanthines in mild to moderate persistent bronchial Asthma patients.Methods: It is a comparative study conducted in patients of mild to moderate persistent bronchial Asthma in the outpatient department of regional chest hospital. The subjects were randomly assigned into 2 groups, one group treated with oral doxofylline and the other with theophylline oral or Deriphylline. Efficacy was measured objectively using spirometric parameters like FEV1 (Forced Expiratory Volume at the end of 1 second), FVC (Forced Vital Capacity), FEV1/FVC and PEFR (Peak Expiratory flow Rate), Subjectively by the Asthma control test questionnaire, subjective rating of Asthma control and the need for use of rescue medications like β2 agonists in the previous four weeks. Tolerability were done at base line and at the end of study.Results: Doxofylline compared to other methylxanthines groups was statistically better with respect to subjective parameters like Asthma control tests questionnaire, subjective rating of Asthma control. Doxofylline had equal efficacy with spirometric parameters compared to other methylxanthines. Doxofylline was significantly better tolerated with adverse drug reactions noted in 10% compared to 28% in other methylxanthins group.Conclusions: Doxofylline with better tolerability profile and equivalent efficacy seemed to be a good alternative to other methylxanthines in the treatment of bronchial Asthma.

Vitamin D, ventilatory function and asthma control among bronchial asthma patients

2020 ◽  
Vol 7 (3) ◽  
pp. 74-77
Author(s):  
Mohammed H. Saiem Al-Dahr
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Direct Relationship ◽  
Ventilatory Function ◽  
Asthma Control Test ◽  
Group A ◽  
Group B ◽  
Deficiency Group

Background: Asthma is a chronic conducting airway disorder which characterized by reversible airway inflammation and obstruction. However, prevalence of some pulmonary disorders as bronchial asthma is increased with Vitamin D deficiency. Objective: The target of this study is to evaluate the association between status of vitamin D and ventilatory function & asthma control in patients with bronchial asthma in Jeddah area. Material and methods: One hundred Saudi patients with asthma of both sex; their age mean was 35.18±6.27 year were selected on referral to Internal Medicine Department, King Abdulaziz University Teaching Hospital, Saudi Arabia. Asthma was diagnosed by spirometry tests. Criteria for asthma diagnosis were in accordance with the Global Strategy for Asthma Management and Prevention (GINA 2016). Exclusion criteria included patients with renal, cardiac and liver diseases. All participants will be free to withdraw from the study at any time. Following pre-training testing, participants were enrolled in three groups according to 25-OHD levels: vitamin D deficiency group (A) 25-OHD level <20ng/ml, vitamin D deficiency group (B) 25-OHD level=20–30 ng/ml and normal vitamin D group(C) 25-OHD level >30ng/ml. Results: There was significant higher values of FVC, FEV1 and FEV1/FVC in group (C) compared to subgroup (A) and group (B) in addition to lower values of asthma control test in subgroup (C) compared to group (A) and group (B). While there was significant difference between groups. Moreover, the 25-OHD showed a strong direct relationship with FVC, FEV1, FEV1/FVC and asthma control test in the three groups (P<0.05). Conclusion: There is a close direct relationship between level of vitamin D, ventilatory function and asthma control in patients with bronchial asthma.

Older Adult Patients Are at Lower Risk of ARDS Compared to Younger Patients at Risk: Secondary Analysis of a Multicenter Cohort Study

2019 ◽  
Vol 35 (1) ◽  
pp. 42-47
Author(s):  
Daniel Reynolds ◽  
Rahul Kashyap ◽  
Lindsey Wallace ◽  
Ognjen Gajic ◽  
Hemang Yadav
Keyword(s):  
At Risk ◽  
Cohort Study ◽  
Older Adult ◽  
Secondary Analysis ◽  
Severity Of Illness ◽  
Hospitalized Patients ◽  
Adult Patients ◽  
Multicenter Cohort Study ◽  
Younger Patients ◽  
Patients At Risk

Introduction: Older adult individuals often have acute illnesses predisposing them to developing acute respiratory distress syndrome (ARDS). We aimed to identify the relationship between age and the development of ARDS in a cohort of hospitalized patients. Methods: This was a secondary analysis of a prospective multicenter observational cohort study of hospitalized patients at risk of developing ARDS admitted to 22 hospitals from March 2009 to August 2009. Patients were classified as older adults if their age was 80 or greater. A multivariable logistic regression was performed, adjusting for severity of illness via Acute Physiology and Chronic Health Evaluation (APACHE II) and risk of ARDS via Lung Injury Prediction Score. Results: Of 5584 patients, 377 (6.8%) developed ARDS. Twenty-four (3.5%) of 694 patients aged 80 or older developed ARDS, compared to 353 (7.2%) of 4890 patients aged less than 80 ( P < .001). After adjusting for severity of illness and the risk of ARDS development, older adult patients had a lower incidence of ARDS compared to younger individuals (odds ratio: 0.28, 95% confidence interval: 0.18-0.42). Conclusion: Older adult patients aged 80 years or older have a reduced incidence of ARDS compared to younger patients, after adjusting for severity of illness and risk of ARDS development.

scholarly journals Predictors of a Minimal Clinically Important Difference Following Omalizumab Treatment in Adult Patients With Severe Allergic Asthma

2022 ◽  
Vol 8 ◽  
Author(s):  
Wei-Chang Huang ◽  
Pin-Kuei Fu ◽  
Ming-Cheng Chan ◽  
Chun-Shih Chin ◽  
Wen-Nan Huang ◽  
...  
Keyword(s):  
Lung Function ◽  
Allergic Asthma ◽  
Asthma Control ◽  
Minimal Clinically Important Difference ◽  
Adult Patients ◽  
Blood Eosinophil ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Clinically Important Difference ◽  
Severe Allergic Asthma

Several factors have been found to be predictors of a good response following omalizumab treatment in patients with severe allergic asthma (SAA). However, it remains unclear whether clinical characteristics can predict a minimal clinically important difference (MCID) following omalizumab treatment in this population. Therefore, the aim of this study was to investigate the features associated with an MCID following omalizumab treatment in adult patients with SAA. Of the 124 participants enrolled in this retrospective, cross-sectional study, 94, 103, 20 and 53 achieved the MCID following treatment with omalizumab and were considered to be responders of exacerbation reduction (no exacerbation during the 1-year follow-up period or ≧50% reduction in exacerbations from baseline), oral corticosteroid (OCS) sparing (no use of OCS to control asthma during the study period or a reduction of the monthly OCS maintenance dose to &lt;50% of baseline), lung function (an increase of ≧230 ml in the forced expiratory volume in 1 s from baseline) and asthma control (an increase of ≧3 points in the asthma control test score from baseline), respectively. Normal weight [&lt;25 vs. ≧30 kg/m2, odds ratio (OR) = 3.86, p = 0.024] was predictive of a responder of reduction in exacerbations following omalizumab treatment while subjects with a blood eosinophil level of &lt;300 cells/μL (&lt;300 vs. ≧300 cells/μL, OR = 5.81, p = 0.001) were more likely to exhibit an MCID in OCS sparing. No factor was found to be a predictor of lung function or asthma control. When choosing treatment for adult patients with SAA, our findings may help to select those who may benefit the most from omalizumab treatment.

scholarly journals Asthma Control in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia: A Cross-sectional Study

2020 ◽  
Vol 14 (2) ◽  
Author(s):  
Kuan YC ◽  
Tan CH ◽  
Hong CM ◽  
How SH
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Fixed Dose ◽  
Sectional Study ◽  
Act Scores ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Chest Clinic

Introduction: Various initiatives and medications have been introduced to achieve better control of bronchial asthma. However total control according to Global Initiative for Asthma (GINA) remains elusive even at tertiary referral hospitals. Our study is to determine the level of asthma control (according to GINA 2009), Asthma Control Test (ACT) scores and the types of medications used among patients with bronchial asthma in a large tertiary hospital. Methods: A cross-sectional study of all patients with bronchial asthma who attended the Chest Clinic at Hospital Tengku Ampuan Afzan (HTAA) from 2009 to 2011. Patient demographics, self-administered ACT scores, GINA-defined level of asthma control and medications were documented. Results: 208 patients were recruited. There were 23.2%, 46.3% and 30.5% of patients with controlled, partly controlled and uncontrolled asthma respectively. The median ACT scores was 19 [inter quartile range (IQR) 6]. The most frequently used preventer therapy was inhaled long-acting β-agonist/corticosteroids (LABA/ICS) fixed-dose combination (61.7%), and 9.6% were not on preventer therapy. 75% of patients with controlled asthma were on LABA/ICS compared to 58.5% of the partly controlled and uncontrolled groups (p=0.039). Conclusion: The majority of the asthmatic patients attending the Chest Clinic at HTAA did not have GINA-defined controlled asthma. Patients with higher ACT scores had better control of asthma. There were more patients with controlled asthma who were on LABA/ ICS combination.

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