Explore a novel function of human condensins in cellular senescence

AbstractThere are two kinds of condensins in human cells, known as condensin I and condensin II. The canonical roles of condensins are participated in chromosome dynamics, including chromosome condensation and segregation during cell division. Recently, a novel function of human condensins has been found with increasing evidences that they play important roles in cellular senescence. This paper reviewed the research progress of human condensins involved in different types of cellular senescence, mainly oncogene-induced senescence (OIS) and replicative senescence (RS). The future perspectives of human condensins involved in cellular senescence are also discussed.

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Faculty Opinions recommendation of Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718246824.793504350 ◽

2015 ◽

Author(s):

Laura Trinkle-Mulcahy

Keyword(s):

Cell Division ◽

Human Cells ◽

Nuclear Domain

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Asteroid and Comet Surveys

Symposium - International Astronomical Union ◽

10.1017/s0074180900047720 ◽

1994 ◽

Vol 161 ◽

pp. 385-400

Author(s):

B.G. Marsden

Keyword(s):

Logical Sequence ◽

Different Types ◽

The Future ◽

Ecliptic Latitude ◽

Similarities And Differences

Past surveys are described in the logical sequence of (1) comets visually, (2) asteroids visually, (3) asteroids photographically and (4) comets photographically. Plots show the evolution of asteroid surveys in terms of visual discovery magnitude and ecliptic latitude, and similarities and differences between surveys for the different types of body are discussed. The paper ends with a brief discussion of more recent discovery methods and some thoughts on the future.

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A review on the properties, reinforcing effects, and commercialization of nanomaterials for cement-based materials

Nanotechnology Reviews ◽

10.1515/ntrev-2020-0023 ◽

2020 ◽

Vol 9 (1) ◽

pp. 303-322 ◽

Cited By ~ 3

Author(s):

Zhifang Zhao ◽

Tianqi Qi ◽

Wei Zhou ◽

David Hui ◽

Cong Xiao ◽

...

Keyword(s):

Cement Hydration ◽

State Of The Art ◽

Research Progress ◽

Market Survey ◽

Future Perspectives ◽

Nano Silica ◽

Physical Processes ◽

Existing Problems ◽

Cement Based Materials ◽

The Cost

AbstractThe behavior of cement-based materials is manipulated by chemical and physical processes at the nanolevel. Therefore, the application of nanomaterials in civil engineering to develop nano-modified cement-based materials is a promising research. In recent decades, a large number of researchers have tried to improve the properties of cement-based materials by employing various nanomaterials and to characterize the mechanism of nano-strengthening. In this study, the state of the art progress of nano-modified cement-based materials is systematically reviewed and summarized. First, this study reviews the basic properties and dispersion methods of nanomaterials commonly used in cement-based materials, including carbon nanotubes, carbon nanofibers, graphene, graphene oxide, nano-silica, nano-calcium carbonate, nano-calcium silicate hydrate, etc. Then the research progress on nano-engineered cementitious composites is reviewed from the view of accelerating cement hydration, reinforcing mechanical properties, and improving durability. In addition, the market and applications of nanomaterials for cement-based materials are briefly discussed, and the cost is creatively summarized through market survey. Finally, this study also summarizes the existing problems in current research and provides future perspectives accordingly.

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Abattoir-Based Measures to Assess Swine Welfare: Analysis of the Methods Adopted in European Slaughterhouses

Animals ◽

10.3390/ani11010226 ◽

2021 ◽

Vol 11 (1) ◽

pp. 226

Author(s):

Silvio De Luca ◽

Emanuela Zanardi ◽

Giovanni Loris Alborali ◽

Adriana Ianieri ◽

Sergio Ghidini

Keyword(s):

Welfare Analysis ◽

The Body ◽

Present Review ◽

Post Mortem ◽

Gastric Lesions ◽

Future Perspectives ◽

The Future ◽

On Farm ◽

Benchmarking System

The assessment of swine welfare requires feasible, reliable, and reasonable indicators. On-farm evaluation of pig welfare can provide valuable information to veterinarians and farmers. However, such protocols can result expensive and time-consuming. With this regard, an interest in the appraisal of swine welfare at abattoir has grown over the recent years. In particular, the use of certain lesions collected directly from slaughtered animals to determine the welfare status of pigs has been evaluated by several authors. In the present review, the different methods developed to score lesions collected directly from the body and the viscera of animals slaughtered in European abattoirs (“abattoir-based measures”) are presented. The text specifically focuses on the methods currently available in the literature for the scoring of body, pluck and gastric lesions during post-mortem activities. Moreover, the strengths and weaknesses of abattoir-based measures schemes are discussed. To conclude, the future perspectives of the assessment of pig welfare at the slaughterhouse are described, appealing for a benchmarking system that can be systematically used by veterinarians and other professional figures involved in the process.

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Interfacing cells with organic transistors: a review of in vitro and in vivo applications

Lab on a Chip ◽

10.1039/d0lc01007c ◽

2021 ◽

Vol 21 (5) ◽

pp. 795-820

Author(s):

Andrea Spanu ◽

Laura Martines ◽

Annalisa Bonfiglio

Keyword(s):

Organic Transistors ◽

Future Perspectives ◽

The Past ◽

The Future

This review focuses on the applications of organic transistors in cellular interfacing. It offers a comprehensive retrospective of the past, an overview of the latest innovations, and a glance on the future perspectives of this fast-evolving field.

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Report on CLEF 2019

ACM SIGIR Forum ◽

10.1145/3458553.3458571 ◽

2019 ◽

Vol 53 (2) ◽

pp. 108-118

Author(s):

Martin Braschler ◽

Linda Cappellato ◽

Fabio Crestani ◽

Nicola Ferro ◽

Gundula Heinatz Bürki ◽

...

Keyword(s):

Standard Test ◽

Future Perspectives ◽

Research Papers ◽

Test Collections ◽

Lessons Learnt ◽

Wide Range ◽

The Future ◽

20Th Anniversary

This is a report on the tenth edition of the Conference and Labs of the Evaluation Forum (CLEF 2019), held from September 9--12, 2019, in Lugano, Switzerland. CLEF was a four day event combining a Conference and an Evaluation Forum. The Conference featured keynotes by Bruce Croft, Yair Neuman, and Miguel Martínez, and presentation of peer reviewed research papers covering a wide range of topics in addition to many posters. The Evaluation Forum consisted to nine Labs: CENTRE, CheckThat, eHealth, eRisk, ImageCLEF, LifeCLEF, PAN, PIR-CLEF, and ProtestNews, addressing a wide range of tasks, media, languages, and ways to go beyond standard test collections. CLEF 2019 marked the 20th anniversary of CLEF, which was celebrated with a dedicated session and a book on the lessons learnt in twenty years of evaluation activities and the future perspectives for CLEF. CLEF 2019 also introduced the Industry Days to further extend the reach and impact of CLEF.

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Project Narratives That Potentially Perform and Change the Future

Project Management Journal ◽

10.1177/8756972821995340 ◽

2021 ◽

pp. 875697282199534

Author(s):

Natalya Sergeeva ◽

Graham M. Winch

Keyword(s):

Life Cycle ◽

Value Creation ◽

Future Research ◽

Future Research Agenda ◽

Project Life Cycle ◽

Different Types ◽

The Future ◽

Organizational Narrative ◽

Project Life ◽

Future Project

This article develops a framework for applying organizational narrative theory to understand project narratives that potentially perform and change the future. Project narratives are temporal but often get repeated throughout the project life cycle to stabilize meaning, and could be about project mission, vision, identity, value creation, and so forth. Project narratives have important implications for organizational identity and image crafting. This article differentiates among different types of project narratives in relation to a project life cycle, providing case studies of project narratives on three major UK rail projects. We then set out the future research agenda into project narrative work.

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Regulating for Content on the Internet: Meeting Cultural and Social Objectives for Broadband

Media International Australia ◽

10.1177/1329878x0110100105 ◽

2001 ◽

Vol 101 (1) ◽

pp. 19-31 ◽

Cited By ~ 3

Author(s):

Gerard Goggin ◽

Catherine Griff

Keyword(s):

The Internet ◽

Final Report ◽

Media Convergence ◽

Different Types ◽

The Future ◽

Broadcasting Regulation ◽

Productivity Commission ◽

Specific Regulation ◽

Film And Video ◽

Do So

Much of the present debate about content on the internet revolves around how to control the distribution of different sorts of harmful or undesirable material. Yet there are considerable issues about whether sufficient sorts of desired cultural content will be available, such as ‘national’, ‘Australian’ content. In traditional broadcasting, regulation has been devised to encourage or mandate different types of content, where it is believed that the market will not do so by itself. At present, such regulatory arrangements are under threat in television, as the Productivity Commission Broadcasting Inquiry final report has noted. But what of the future for certain types of content on the internet? Do we need specific regulation and policy to promote the availability of content on the internet? Or is such a project simply irrelevant in the context of gradual but inexorable media convergence? Is regulating for content just as quixotic and fraught with peril as regulating of content from a censorship perspective often appears to be? In this article, we consider the case of Australian content for broadband technologies, especially in relation to film and video, and make some preliminary observations on the promotion and regulation of internet content.

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