scholarly journals The complex relationship between estrogen and migraines: a scoping review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Nihaal Reddy ◽  
Miraj N. Desai ◽  
Anna Schoenbrunner ◽  
Steven Schneeberger ◽  
Jeffrey E. Janis
Keyword(s):  
Scoping Review ◽  
Extended Period ◽  
Estrogen Withdrawal ◽  
History Of ◽  
Migraine Pathogenesis ◽  
Increased Sensitivity ◽  
Menstruating Women ◽  
Migraine Onset ◽  
Estradiol Levels ◽  
Shed Light

Abstract Background Migraines are a chronic disease for millions worldwide and have been hypothesized to be hormonally mediated due to their higher prevalence in females and menstrual associations. Estrogen has been commonly implicated in migraine pathogenesis, yet its exact role in the pathophysiology of migraines has yet to be fully understood. Method We conducted a scoping review of the literature regarding estrogen’s role in migraine pathogenesis and included 19 studies out of an initial 202 in the final review. Two independent reviewers screened and extracted data from included studies based on predetermined inclusions and exclusion criteria. Results The estrogen withdrawal hypothesis, discussed by 12 of the reviewed studies, is the most discussed theory about estrogen’s role in migraine physiology and describes the association of migraine onset with natural declines in estrogen levels, particularly when estrogen levels fall below 45–50 pg/mL after an extended period of priming. Additional findings suggest that women with a history of migraine have an increased sensitivity to physiologic fluctuations in estradiol levels. Several studies suggest that migraines are associated with menstruation. Conclusion It appears that estrogen is very likely to play a key role in migraine pathogenesis, but seems to affect patients in different ways depending on their past medical history, age, and use of hormonal therapy. Further research is warranted to isolate the effects of estrogen in each unique patient population, and we believe that studies comparing menstruating women to postmenopausal women could help shed light in this area.

scholarly journals The Complex Relationship between Estrogen and Migraines: A Scoping Review

2021 ◽  
Author(s):  
Nihaal Reddy ◽  
Miraj Desai ◽  
Anna Schoenbrunner ◽  
Steven Schneeberger ◽  
Jeffrey Janis
Keyword(s):  
Scoping Review ◽  
Extended Period ◽  
Estrogen Withdrawal ◽  
History Of ◽  
Migraine Pathogenesis ◽  
Increased Sensitivity ◽  
Menstruating Women ◽  
Migraine Onset ◽  
Estradiol Levels ◽  
Shed Light

Abstract Background: Migraines are a chronic disease for millions worldwide and have been hypothesized to be hormonally mediated due to their higher prevalence in females and menstrual associations. Estrogen has been commonly implicated in migraine pathogenesis yet its exact role in the pathophysiology of migraines has yet to be fully understood.Method: We conducted a scoping review of the literature regarding estrogen’s role in migraine pathogenesis and included 19 studies out of an initial 202 in the final review. Two independent reviewers screened and extracted data from included studies based on predetermined inclusions and exclusion criteria.Results: The estrogen withdrawal hypothesis, discussed by 12 of the reviewed studies, is the most discussed theory about estrogen’s role in migraine physiology and describes the association of migraine onset with natural declines in estrogen levels, particularly when estrogen levels fall below 45-50 pg/mL after an extended period of priming. Additional findings suggest that women with a history of migraine have an increased sensitivity to physiologic fluctuations in estradiol levels. Several studies suggest that migraines are associated with menstruation.Conclusion: It appears that estrogen is very likely to play a key role in migraine pathogenesis, but seems to affect patients in different ways depending on their past medical history, age, and use of hormonal therapy. Further research is warranted to isolate the effects of estrogen in each unique patient population, and we believe that studies comparing menstruating women to postmenopausal women could help shed light in this area.Systematic Review registrations: none

scholarly journals The Complex Relationship between Estrogen and Migraines: A Scoping Review

2020 ◽  
Author(s):  
Nihaal Reddy ◽  
Steven Schneeberger ◽  
Anna Schoenbrunner ◽  
Miraj Desai ◽  
Jeffrey Janis
Keyword(s):  
Scoping Review ◽  
Hormone Replacement ◽  
Definitive Evidence ◽  
Migraine Headaches ◽  
Trigeminal Nociception ◽  
Pain Pathways ◽  
Great Insight ◽  
Estrogen Withdrawal ◽  
Migraine Pathogenesis ◽  
Migraine Onset

Abstract Background:Migraine headaches are a chronic and complex medical issue for millions of patients worldwide. Despite how common migraines are, there is much to be unveiled regarding their pathogenesis due to the numerous factors implicated in the pathophysiology of migraines. Migraines are significantly more common in women and many female migrainers notice menstrual associations of their headaches. Because of this, migraines have popularly been hypothesized to be largely hormonally mediated. Estrogen has been commonly implicated in migraine pathogenesis yet its exact role in the pathophysiology of migraines has yet to be fully understood. Methods: We conducted a scoping review of the literature regarding estrogen’s role in migraine pathogenesis and included 11 studies out of an initial 199 in the final review. Results: The estrogen withdrawal hypothesis is the most discussed theory about estrogen’s role in migraine physiology and describes the association of migraine onset with natural declines in estrogen levels. Estrogen is also implicated in biochemical pain pathways, and specifically effects pain processing, trigeminal nociception, and neural inflammatory peptides. Human studies have been conducted in female populations such as pregnant women and postmenopausal women, and these studies have supported the estrogen withdrawal hypothesis.Conclusions: Hormone replacement therapy remains to treat migraines is promising, yet still lacks definitive evidence in its efficacy. More primary research into estrogen’s mechanisms in migraine pathogenesis is needed, as its specific roles are still unclear. While human-based, clinical trials on the subject are rare, they would provide great insight into migraines and would allow clinicians to better treat patients. Systematic Review registrations: none

Investigating the Dynamics of Suicidal Ideation

Crisis ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Nina Hallensleben ◽  
Lena Spangenberg ◽  
Thomas Forkmann ◽  
Dajana Rath ◽  
Ulrich Hegerl ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Small Sample Size ◽  
Unipolar Depression ◽  
Small Sample ◽  
History Of ◽  
Severity Of Depression ◽  
Ecological Momentary ◽  
Depressive Episodes ◽  
Ema Method ◽  
Shed Light

Abstract. Background: Although the fluctuating nature of suicidal ideation (SI) has been described previously, longitudinal studies investigating the dynamics of SI are scarce. Aim: To demonstrate the fluctuation of SI across 6 days and up to 60 measurement points using smartphone-based ecological momentary assessments (EMA). Method: Twenty inpatients with unipolar depression and current and/or lifetime suicidal ideation rated their momentary SI 10 times per day over a 6-day period. Mean squared successive difference (MSSD) was calculated as a measure of variability. Correlations of MSSD with severity of depression, number of previous depressive episodes, and history of suicidal behavior were examined. Results: Individual trajectories of SI are shown to illustrate fluctuation. MSSD values ranged from 0.2 to 21.7. No significant correlations of MSSD with several clinical parameters were found, but there are hints of associations between fluctuation of SI and severity of depression and suicidality. Limitations: Main limitation of this study is the small sample size leading to low power and probably missing potential effects. Further research with larger samples is necessary to shed light on the dynamics of SI. Conclusion: The results illustrate the dynamic nature and the diversity of trajectories of SI across 6 days in psychiatric inpatients with unipolar depression. Prediction of the fluctuation of SI might be of high clinical relevance. Further research using EMA and sophisticated analyses with larger samples is necessary to shed light on the dynamics of SI.

Editorial Introduction

2020 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Editors of the JIOWS
Keyword(s):  
Nineteenth Century ◽  
Indian Ocean ◽  
Western Indian Ocean ◽  
Late Nineteenth Century ◽  
Fourth Volume ◽  
History Of ◽  
The Indian Ocean ◽  
Complex Relationships ◽  
Indian Ocean World ◽  
Shed Light

The editors are proud to present the first issue of the fourth volume of the Journal of Indian Ocean World Studies. This issue contains three articles, by James Francis Warren (Murdoch University), Kelsey McFaul (University of California, Santa Cruz), and Marek Pawelczak (University of Warsaw), respectively. Warren’s and McFaul’s articles take different approaches to the growing body of work that discusses pirates in the Indian Ocean World, past and present. Warren’s article is historical, exploring the life and times of Julano Taupan in the nineteenth-century Philippines. He invites us to question the meaning of the word ‘pirate’ and the several ways in which Taupan’s life has been interpreted by different European colonists and by anti-colonial movements from the mid-nineteenth century to the present day. McFaul’s article, meanwhile, takes a literary approach to discuss the much more recent phenomenon of Somali Piracy, which reached its apex in the last decade. Its contribution is to analyse the works of authors based in the region, challenging paradigms that have mostly been developed from analysis of works written in the West. Finally, Pawelczak’s article is a legal history of British jurisdiction in mid-late nineteenth-century Zanzibar. It examines one of the facets that underpinned European influence in the western Indian Ocean World before the establishment of colonial rule. In sum, this issue uses two key threads to shed light on the complex relationships between European and other Western powers and the Indian Ocean World.

De splitsing van de Belgische Socialistische Partij. Twee verklarende documenten

2008 ◽  
Vol 67 (2) ◽  
pp. 99-114
Author(s):  
Pieter-Jan Van Bosstraeten
Keyword(s):  
Socialist Party ◽  
French Speaking ◽  
History Of ◽  
Post War ◽  
Shed Light ◽  
Do So

Op 11 oktober 1978 splitste de Belgische Socialistische Partij zich als laatste van de drie unitaire partijen op in twee autonome partijen. Langs Franstalige zijde werd éénzijdig de Parti Socialiste opgericht, twee jaar later volgde de Socialistische Partij. De splitsing vormde het eindpunt van een lange en bewogen geschiedenis van de socialistische eenheidspartij.Ondanks het feit dat heel wat auteurs reeds een licht hebben geworpen op de belangrijkste gebeurtenis uit de na-oorlogse geschiedenis van de BSP, is het antwoord op de vraag naar de oorzaken van de splitsing vrij eenduidig. Overwegend wordt aangenomen dat de splitsing van de BSP het gevolg is van een moeilijke samenwerking in het kader van het communautaire dossier. Andere oorzaken worden amper aangehaald, of onvoldoende verduidelijkt. Tevens wordt slechts het politiek-tactische aspect van het communautaire dossier uitvoerig besproken. In de bestaande literatuur wordt zo goed als nergens dieper ingegaan op de inhoudelijke elementen die binnen de partij problemen teweegbrachten.Onderzoek van twee cruciale documenten heeft de mogelijkheid geboden het verhaal van de splitsing beter te reconstrueren. Daarbij is gebleken dat de splitsing van de partij in een ruimer kader dient te worden geïnterpreteerd dan het communautaire dossier. Aan de splitsing van de partij ging een lang proces van autonomisering en vleugelvorming vooraf. Bovendien werd aangetoond dat de problematiek inzake het Egmont-Stuyvenbergpact niet de enige directe oorzaak vormde voor de splitsing van de partij, in de periode 1977-1978. Enkele andere oorzaken hebben daartoe eveneens bijgedragen.________The division of the Belgian Socialist Party. Two explanatory documentsOn 11 October 1978 the Belgian Socialist Party divided into two autonomous parties, the last of the three unitary parties to do so. First the French speaking section unilaterally founded the ‘Parti Socialiste’, two years later the ‘Socialistische Partij’ followed. The division constituted the termination of the long and eventful history of the socialist unitary party.In spite of the fact that many authors have already shed light on the most important event from the post-war history of the BSP, the answer to the question about the causes for the division are fairly unequivocal. The majority of opinions favour the view that the division of the BSP was the consequence of the difficulty of collaborating within the framework of the community dossier. Other causes are hardly cited, or insufficiently elucidated. Moreover only the politico-tactical aspect of the community dossier is discussed in detail. The existing literature hardly ever carries out a more thorough examination of the intrinsic elements that caused problems within the party.The investigation of the two crucial documents has offered the opportunity to provide a better reconstruction of the division. This showed that the division of the party should be interpreted within a larger framework than the community dossier alone. A long process of autonomisation and the formation of political wings preceded the division of the party. It also demonstrated that the issues concerning the Egmont-Stuyvenberg pact were not the only direct cause for the division of the party, during the period 1977-1978. There were several other causes that also contributed to this division.

Poetics of the Pillory

2019 ◽  
Author(s):  
Thomas Keymer
Keyword(s):  
English Literature ◽  
Extended Period ◽  
Government Control ◽  
History And Criticism ◽  
Romantic Period ◽  
Restoration Measure ◽  
History Of ◽  
The Government ◽  
Argument Proceeds ◽  
Prior Restraint

On the lapse of the Licensing Act in 1695, Thomas Macaulay wrote in his History of England, ‘English literature was emancipated, and emancipated for ever, from the control of the government’. It’s certainly true that the system of prior restraint enshrined in this Restoration measure was now at an end, at least for print. Yet the same cannot be said of government control, which came to operate instead by means of post-publication retribution, not pre-publication licensing, notably for the common-law offence of seditious libel. For many of the authors affected, from Defoe to Cobbett, this new regime was a greater constraint on expression than the old, not least for its alarming unpredictability, and for the spectacular punishment—the pillory—that was sometimes entailed. Yet we may also see the constraint as an energizing force. Throughout the eighteenth century and into the Romantic period, writers developed and refined ingenious techniques for communicating dissident or otherwise contentious meanings while rendering the meanings deniable. As a work of both history and criticism, this book traces the rise and fall of seditious libel prosecution, and with it the theatre of the pillory, while arguing that the period’s characteristic forms of literary complexity—ambiguity, ellipsis, indirection, irony—may be traced to the persistence of censorship in the post-licensing world. The argument proceeds through case studies of major poets and prose writers including Dryden, Defoe, Pope, Fielding, Johnson, and Southey, and also calls attention to numerous little-known satires and libels across the extended period.

Imagining the Woman Reader in the Age of Dante

2018 ◽  
Author(s):  
Elena Lombardi
Keyword(s):  
Material Culture ◽  
Mother Tongue ◽  
The Other ◽  
Women Readers ◽  
Literary Authority ◽  
Woman Reader ◽  
History Of ◽  
Female Literacy ◽  
Female Audience ◽  
Shed Light

The literature of the Italian Due- and Trecento frequently calls into play the figure of a woman reader. From Guittone d’Arezzo’s piercing critic, the ‘villainous woman’, to the mysterious Lady who bids Guido Cavalcanti to write his grand philosophical song, to Dante’s female co-editors in the Vita Nova and his great characters of female readers, such as Francesca and Beatrice in the Comedy, all the way to Boccaccio’s overtly female audience, this particular sort of interlocutor appears to be central to the construct of textuality and the construction of literary authority in these times. The aim of this book is to shed light on this figure by contextualizing her within the history of female literacy, the material culture of the book, and the ways in which writers and poets of earlier traditions (in particular Occitan and French) imagined her. Its argument is that these figures of women readers are not mere veneers between a male author and a ‘real’ male readership, but that, although fictional, they bring several advantages to their vernacular authors, such as orality, the mother tongue, the recollection of the delights of early education, literality, freedom in interpretation, absence of teleology, the beauties of ornamentation and amplification, a reduced preoccupation with the fixity of the text, the pleasure of making mistakes, dialogue with the other, the extension of desire, original simplicity, and new and more flexible forms of authority.

scholarly journals The History of Adversity and Collective Strength of Individuals of Mexican Ancestry in the United States: A Scoping Literature Review and Emerging Conceptual Framework

Genealogy ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 32
Author(s):  
Araceli Orozco-Figueroa
Keyword(s):  
United States ◽  
Scoping Review ◽  
Historical Trauma ◽  
The United States ◽  
People Of Color ◽  
Trauma Narratives ◽  
Treatment And Prevention ◽  
Scoping Literature Review ◽  
History Of ◽  
Baseline Knowledge

Recently, Black, Indigenous, and other People of Color (BIPOC) have encountered an escalation in adverse social conditions and trauma events in the United States. For individuals of Mexican ancestry in the United States (IMA-US), these recent events represent the latest chapter in their history of adversity: a history that can help us understand their social and health disparities. This paper utilized a scoping review to provide a historical and interdisciplinary perspective on discussions of mental health and substance use disorders relevant to IMA-US. The scoping review process yielded 16 peer reviewed sources from various disciplines, published from 1998 through 2018. Major themes included historically traumatic events, inter-generational responses to historical trauma, and vehicles of transmission of trauma narratives. Recommendations for healing from historical and contemporary oppression are discussed. This review expands the clinical baseline knowledge relevant to the diagnosis, treatment, and prevention of contemporary traumatic exposures for IMA-US.

scholarly journals Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Cecilia Rustichelli ◽  
Elisa Bellei ◽  
Stefania Bergamini ◽  
Emanuela Monari ◽  
Flavia Lo Castro ◽  
...  
Keyword(s):  
Exploratory Study ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Pregnenolone Sulfate ◽  
Menstrually Related Migraine ◽  
History Of ◽  
Estradiol Levels

Abstract Background Neurosteroids affect the balance between neuroexcitation and neuroinhibition but have been little studied in migraine. We compared the serum levels of pregnenolone sulfate, pregnanolone and estradiol in women with menstrually-related migraine and controls and analysed if a correlation existed between the levels of the three hormones and history of migraine and age. Methods Thirty women (mean age ± SD: 33.5 ± 7.1) with menstrually-related migraine (MM group) and 30 aged- matched controls (mean age ± SD: 30.9 ± 7.9) participated in the exploratory study. Pregnenolone sulfate and pregnanolone serum levels were analysed by liquid chromatography-tandem mass spectrometry, while estradiol levels by enzyme-linked immunosorbent assay. Results Serum levels of pregnenolone sulfate and pregnanolone were significantly lower in the MM group than in controls (pregnenolone sulfate: P = 0.0328; pregnanolone: P = 0.0271, Student’s t-test), while estradiol levels were similar. In MM group, pregnenolone sulfate serum levels were negatively correlated with history of migraine (R2 = 0.1369; P = 0.0482) and age (R2 = 0.2826, P = 0.0025) while pregnenolone sulfate levels were not age-related in the control group (R2 = 0.04436, P = 0.4337, linear regression analysis). Conclusion Low levels of both pregnanolone, a positive allosteric modulator of the GABAA receptor, and pregnenolone sulfate, a positive allosteric modulator of the NMDA receptor, involved in memory and learning, could contribute either to headache pain or the cognitive dysfunctions reported in migraine patients. Overall, our results agree with the hypothesis that migraine is a disorder associated with a loss of neurohormonal integrity, thus supporting the therapeutic potential of restoring low neurosteroid levels in migraine treatment.

scholarly journals Multilocus phylogeny and historical biogeography of Hypostomus shed light on the processes of fish diversification in La Plata Basin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yamila P. Cardoso ◽  
Luiz Jardim de Queiroz ◽  
Ilham A. Bahechar ◽  
Paula E. Posadas ◽  
Juan I. Montoya-Burgos
Keyword(s):  
Middle Miocene ◽  
Drainage Pattern ◽  
Ecological Diversification ◽  
La Plata ◽  
La Plata Basin ◽  
History Of ◽  
Dispersal Corridors ◽  
Shed Light ◽  
Strong Barrier ◽  
Multilocus Phylogeny

AbstractDistribution history of the widespread Neotropical genus Hypostomus was studied to shed light on the processes that shaped species diversity. We inferred a calibrated phylogeny, ancestral habitat preference, ancestral areas distribution, and the history of dispersal and vicariance events of this genus. The phylogenetic and distribution analyses indicate that Hypostomus species inhabiting La Plata Basin do not form a monophyletic clade, suggesting that several unrelated ancestral species colonized this basin in the Miocene. Dispersal to other rivers of La Plata Basin started about 8 Mya, followed by habitat shifts and an increased rate of cladogenesis. Amazonian Hypostomus species colonized La Plata Basin several times in the Middle Miocene, probably via the Upper Paraná and the Paraguay rivers that acted as dispersal corridors. During the Miocene, La Plata Basin experienced marine incursions, and geomorphological and climatic changes that reconfigured its drainage pattern, driving dispersal and diversification of Hypostomus. The Miocene marine incursion was a strong barrier and its retraction triggered Hypostomus dispersal, increased speciation rate and ecological diversification. The timing of hydrogeological changes in La Plata Basin coincides well with Hypostomus cladogenetic events, indicating that the history of this basin has acted on the diversification of its biota.

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