scholarly journals Myiasis absent Wohlfahrtiimonas chitiniclastica bacteremia in a lung cancer patient: a case report

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Peter Dovjak ◽  
Michael Kroißenbrunner ◽  
Bernhard Iglseder
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Lung Cancer Patient ◽  
Chronic Wounds ◽  
Lung Tumor ◽  
Personal Hygiene ◽  
Immunocompromised Patients ◽  
Human Pathogen ◽  
Case Presentation ◽  
First Case

Abstract Background A gruesome infection was found in a woman with advanced lung tumor and associated malnutrition. Worldwide, bacteremia with Wohlfahrtiimonas chitiniclastica was only found in 13 cases yet. Case presentation This is the first case in Austria and the first case without infestation of maggots. Conclusions This germ is an emerging human pathogen not only in patients with poor personal hygiene, difficult social circumstances, alcohol dependence or chronic wounds. It must be included in the differential diagnosis of immunocompromised patients with pneumonia.

Myiasis Absent Wohlfahrtiimonas Chitiniclastica Bacteremia in a Lung Cancer Patient – A Case Report

2021 ◽  
Author(s):  
Peter Dovjak ◽  
Michael Kroissenbrunner ◽  
Bernhard Iglseder
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Cancer Patient ◽  
Lung Cancer Patient ◽  
Chronic Wounds ◽  
Lung Tumor ◽  
Personal Hygiene ◽  
Human Pathogen ◽  
Case Presentation ◽  
First Case

Abstract Background: A gruesome infection was found in a woman with advanced lung tumor and associated malnutrition. Worldwide, bacteremia with Wohlfartiimonas chitiniclastica was only found in 13 cases yet.Case presentation: This is the first case in Austria and the first case without infestation of maggots.Conclusions: This germ may be considered as an emerging human pathogen not only in patients with poor personal hygiene, difficult social circumstances, alcohol dependence or chronic wounds.AbstraktEine grauenhafte Infektion wurde bei einer Patientin mit fortgeschrittenem Lungentumor und Malnutrition gefunden. Bisher wurden weltweit erst 13 Fälle mit einer Wohlfahrtiimonas chitiniclastica - Bakteriämie beschrieben. Dieser erste Fall in Österreich manifestierte sich ohne eine Infestation mit Maden. Dieses Bakterium kann als neuer Krankheitserreger betrachtet werden, der nicht nur bei Patienten unter mangelnder Hygienebedingungen, schwierigen sozialen Verhältnissen, Alkoholabhängigkeit oder chronischen Wunden auftreten kann.

scholarly journals Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring theNSD3-NUTFusion Gene: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Shiho Kuroda ◽  
Shioto Suzuki ◽  
Akira Kurita ◽  
Mari Muraki ◽  
Yoichiro Aoshima ◽  
...  
Keyword(s):  
Case Report ◽  
Nuclear Protein ◽  
Lung Tumor ◽  
Nut Midline Carcinoma ◽  
Case Presentation ◽  
First Case ◽  
Cytological Features ◽  
Pearl Formation ◽  
Mitotic Figures ◽  
First Time

Background. Nuclear protein in testis (NUT) midline carcinoma (NMC) is a very rare and aggressive malignancy. In more than two-thirds of these NMC cases, a fusion betweenNUTandBRD4orBRD3has been documented; other variants are rare. The cytology of NMC itself has been sparsely documented and that of variant NMC has never been reported.Case Presentation. A 36-year-old woman was admitted because of a rapidly progressing lung tumor with metastases to the breast and bone. We recently reported this patient as the first case of a variant NMC of the lung harboring anNSD3-NUTfusion, based on immunohistochemical and genetic analyses. Cytological material was available for the present review. A highly cellular smear contained a predominantly noncohesive pattern of monomorphic cells with diameters 2–2.5 times greater than those of small lymphocytes, with a round-to-oval nucleus, slightly irregular nuclear contours, variably prominent nucleoli, scant cytoplasm, and identifiable mitotic figures. Foci of stratification and overt pearl formation, including a dyskeratocyte, were occasionally observed. The necrotic background contained naked nuclei, karyorrhectic debris, apoptotic cells, and macrophages phagocytizing karyorrhectic debris; nuclear crushing was noted.Conclusion. The cytological features of a variant NMC of the lung are described for the first time.

scholarly journals From suspicion of angioedema to the diagnosis of lung cancer

Oncoreview ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 108-112
Author(s):  
Łukasz Moos ◽  
Wojciech Żurek ◽  
Katarzyna Kapeluszna ◽  
Zenon Brzoza
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Superior Vena Cava Syndrome ◽  
Superior Vena ◽  
Vena Cava ◽  
Small Cell ◽  
Case Presentation ◽  
Facial Swelling ◽  
Vena Cava Syndrome ◽  
Diagnosis Of Lung Cancer

Angioedema is a localized and self-limiting oedema of the subcutaneous and submucosal tissue. Case presentation: 73-year-old man was admitted to the Division of Allergology with the diagnosis of angioedema. Detailed physical examination led to the suspicion of superior vena cava syndrome with secondary face swelling. Biopsy revealed metastasis of small cell carcinoma in superclavicular lymph nodes. Conclusions: Facial swelling, especially recurrent and non-inflammatory, is often, but not always caused by angioedema. Insightful differential diagnosis is crucial before making the final one.

scholarly journals First case report of dermatitis associated with Leporacarus gibbus in cat

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Mirabela Oana Dumitrache ◽  
Adriana Györke ◽  
Gianluca D’Amico ◽  
Viorica Mircean
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Clinical Case ◽  
Clinical Signs ◽  
Zoonotic Potential ◽  
Case Presentation ◽  
First Case ◽  
Skin Conditions ◽  
Pruritic Skin ◽  
Microscopy Examination

Abstract Background Leporacarus gibbus is a highly specific acarian parasitizing in rabbits, with a proven zoonotic potential. While the majority of cases of L. gibbus infestation are asymptomatic, several cases of pruritic cutaneous condition in both laboratory and pet rabbits were reported. Up to date, L. gibbus has not been linked with clinical signs in any other species than rabbits and humans. Case presentation This case report described the clinical case of a 14-month-old cat with a dermatitis linked to L. gibbus. Mites specimens were collected by brushing, followed by light microscopy examination and species identification. To the best of our knowledge, this is the first report of L. gibbus-related dermatitis in cat. Conclusions L. gibbus infestation should be considered as a possible differential diagnosis of pruritic skin conditions in cat.

scholarly journals Pulmonary nocardiosis in a patient with pemphigus foliaceus: case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ning Luo ◽  
Shifan Tan ◽  
Xiaocai Li ◽  
Si Liu ◽  
Shivank Singh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Infectious Disease ◽  
Interesting Case ◽  
Nocardia Asteroides ◽  
Pemphigus Foliaceus ◽  
Immunocompromised Patients ◽  
Case Presentation ◽  
Pulmonary Nocardiosis ◽  
First Case ◽  
Possible Cause

Abstract Background Nocardiosis is an uncommon opportunistic infection seen in immunocompromised patients or those with a dysfunctional immune system. Nocardia asteroides infection in patients with Pemphigus foliaceus (PF) has never been reported. Case presentation We report an interesting case of nocardiosis-characterized by pulmonary intra-cavitary infection, in a 54-year-old man with PF and diabetes mellitus. The man finally recovered from the infection. Conclusions This is the first case reporting pulmonary nocardiosis in a patient with PF. We recommend that physicians be aware of nocardiosis in patients with pemphigus as a possible cause of underlying infectious disease to avoid misdiagnoses and mismanagement.

scholarly journals Sarcoidosis and Lung Cancer

2010 ◽  
Vol 53 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Naohiro Kobayashi ◽  
Ryota Nakamura ◽  
Koichi Kurishima ◽  
Yukio Sato ◽  
Hiroaki Satoh
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Cancer Patients ◽  
Epithelioid Cell ◽  
Lung Cancers ◽  
Lung Cancer Patients ◽  
Sarcoid Reaction ◽  
The Third ◽  
First Case ◽  
Systemic Sarcoidosis

Background: Although sarcoidosis as well as lung cancer are frequently encountered common diseases, their metachronous or synchronous occurrence in the same patient is very rare. Methods: The charts of lung cancer patients, diagnosed between 1980 and 2007 in our hospital, were reviewed. Results: We found 3 cases with sarcoidosis and lung cancer. The first case had lung cancer 16 years after the diagnosis of sarcoidosis. The second case had two different metachronous lung cancers 18 and 10 years after the diagnosis of sarcoidosis. The third case detected these two diseases simultaneously. In simultaneously detected cases, it is difficult to determine whether noncaseating epithelioid cell granulomas coexisting with lung cancer represent sarcoid reaction or genuine systemic sarcoidosis. Conclusions: Either causality or coincidence, lung cancer, a condition that can be observed in patients with sarcoidosis, should be considered in the differential diagnosis when suspicious findings of it are discovered.

scholarly journals Neuroinfection as a Mask of Lung Cancer: A Case Series

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Beata Kuklińska ◽  
Anna Moniuszko-Malinowska ◽  
Robert Mróz ◽  
Sławomir Pancewicz ◽  
Joanna Zajkowska
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Case Series ◽  
Initial Diagnosis ◽  
Neurological Symptoms ◽  
Case Presentation ◽  
Proper Diagnosis ◽  
Diagnosis Of Lung Cancer ◽  
Heavy Smokers

Introduction. The diagnosis of lung cancer may still be difficult due to the fact that the first symptoms very often mimic symptoms of other diseases.Case Presentation. In this paper we present two cases, in which initial diagnosis of neuroinfection delayed proper diagnosis.Conclusion. Based on our experience we concluded that neurological symptoms in the area endemic for tick-borne diseases suggesting neuroinfection require careful differential diagnosis. Moreover, neurological symptoms in heavy smokers may be associated with metastases of lung cancer.

scholarly journals Prenatal findings of cataract and arthrogryposis: recurrence of cerebro-oculo-facio-skeletal syndrome and review of differential diagnosis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Fabio Sirchia ◽  
Ilaria Fantasia ◽  
Agnese Feresin ◽  
Elisa Giorgio ◽  
Flavio Faletra ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Growth Failure ◽  
Recurrence Risk ◽  
Flow Chart ◽  
Molecular Testing ◽  
Compound Heterozygous ◽  
Genetic Investigation ◽  
Diagnostic Features ◽  
Case Presentation ◽  
First Case

Abstract Background Cerebro-oculo-facio-skeletal syndrome (COFS) is a severe and progressive neurologic condition characterized by prenatal onset of arthrogryposis, cataract, microcephaly and growth failure. The aim of this study was to present a case of recurrence of the COFS syndrome and to propose a differential diagnosis flow-chart in case of prenatal findings of arthrogryposis and cataract. Case presentation We report a case of recurrence of COFS3 syndrome within the same family, with similar diagnostic features. In the first case the COFS syndrome remained undiagnosed, while in the second case, due to prenatal findings of arthrogryposis and cataract, genetic investigation focusing on responsible genes of COFS (ERCC5, ERCC6 and FKTN genes) was carried out. The fetus was found to be compound heterozygous for two different ERCC5 mutations, confirming the clinical suspect of COFS syndrome. A review of the literature on possible causative genes of prenatal cataract and arthrogryposis was performed and we present a flow-chart to guide differential diagnosis and possible genetic testing in case of these findings. Conclusion COFS syndrome is a rare autosomic recessive condition. However, it can be suspected and diagnosed prenatally. The flow-chart illustrates a pathway to guide differential diagnosis according to the prenatal findings. Main syndromes, key testing and specific genes are included. Targeted molecular testing should be offered to the couple in order to reach a diagnosis and assess the recurrence risk for future pregnancies.

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

2020 ◽  
Vol 21 (11) ◽  
pp. 902-909
Author(s):  
Jingxin Zhang ◽  
Weiyue Shi ◽  
Gangqiang Xue ◽  
Qiang Ma ◽  
Haixin Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Lung Tumor ◽  
A549 Cells ◽  
Delivery Systems ◽  
Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

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