scholarly journals The effect of intradialytic exercise on inflammatory markers in hemodialysis patients

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Howaida Abdelhameed Elshinnawy ◽  
Mahmoud Mohamed Fayez ◽  
Dina Abou Bakr Farrag ◽  
Moustafa Abd Elnassier AbdElgawad
Keyword(s):  
Physical Performance ◽  
Inflammatory Markers ◽  
Exercise Program ◽  
Hemodialysis Patients ◽  
Exercise Group ◽  
Low Grade ◽  
Number Of Patients ◽  
Increased Risk ◽  
Sedentary Life Style ◽  
Intradialytic Exercise

Abstract Background Chronic low-grade inflammation is a feature of chronic kidney disease associated with increased risk of multiple morbidities and mortalities. Hemodialysis (HD) patients lead a sedentary life style which may aggravate their inflammatory state and practicing exercise may improve this condition. The aim of this work was to study the effect of intradialytic exercise (IDE) on inflammatory markers in HD patients. Results This prospective cohort study included 40 HD patients, divided into 2 groups: exercise group completed IDE for 3 months and non-exercise group matched in age and sex as controls. At baseline, there was no difference between both groups regarding physical performance assessed using short physical performance battery test (SPBT) or inflammatory markers C-reactive protein (CRP) and interleukin 6 (IL-6) P > 0.05. After 3 months, SPBT significantly improved in exercise group (P < 0.001). Also, both serum CRP and IL-6 levels showed significant decrease in exercise group compared to baseline (P < 0.001), while no similar change was noticed in non-exercise group. Conclusions Regular intradialytic aerobic exercise program can improve physical function and inflammation in hemodialysis patients. Further studies on larger number of patients are warranted.

Effect of intradialytic exercise on the inflammatory markers in prevalent hemodialysis patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Howayda Abdelhamid Elshinnawy ◽  
Mahmoud Mohamed Fayez ◽  
Dina Abou-Bakr Farrag ◽  
Mostafa AbdElnassier AbdElgawad
Keyword(s):  
Physical Performance ◽  
Inflammatory Markers ◽  
Hemodialysis Patients ◽  
Exercise Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
Low Grade ◽  
Number Of Patients ◽  
Increased Risk ◽  
Intradialytic Exercise ◽  
Serum Crp

Abstract Background Chronic low-grade inflammation is a feature of chronic kidney disease associated with increased risk of multiple morbidities and mortalities. Dialysis patients lead a sedentary life style which could add to this risk. Aim assessment of the effect of intradialytic exercise IDE on inflammatory markers in prevalent hemodialysis HD patients. Patients and Methods This longitudinal prospective study included 40 adult patients on regular HD, divided equally into 2 groups; Exercise Group (n = 20); received IDE 3 times/week for 3 months and Non-exercise Group (n = 20) matched in age and sex acting as controls. Patients were subjected to full history taking and clinical examination. Physical performance assessment using Short Physical Performance Battery tests (SPBT), Laboratory investigations included; Complete blood picture, C-reactive protein (CRP) and interleukin 6 (IL6) assessed using Enzyme linked immunosorbent assay. All assessments were repeated 3 months after regular IDE. Results At baseline, there was no difference between both groups regarding physical performance or inflammatory markers. After 3 months, SPBT was significantly increased in Exercise group (P &lt; 0.001). Also, both serum CRP and IL-6 levels showed significant decrease in Exercise group compared to baseline (P &lt; 0.001), while no similar change was noticed in non-exercise group. Conclusion The significant decrease in serum CRP and IL-6 levels after 3 months of regular IDE and the improvement in physical performance in exercise group implements that regular IDE exercise training program can improve physical function and inflammation in hemodialysis patients. Further studies on larger number of patients is warranted.

The Effect of a 12-Week Intradialytic Exercise on Patients’ Blood Indices, Physical Performance, and Quality of Life

2020 ◽  
Vol 10 (6) ◽  
pp. 1429-1435
Author(s):  
Ji-Yeon Lee ◽  
Seung-Hui Baek ◽  
Yoon-Mi Lee ◽  
Ji-Hyung Cho ◽  
Jun-Chul Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Performance ◽  
Short Form ◽  
Exercise Program ◽  
Physical Component Score ◽  
Blood Indices ◽  
Sf 36 ◽  
Significant Difference ◽  
Intradialytic Exercise

This study aims to examine the effect of a 12-week intradialytic exercise program on patients’ blood indices, physical performance, and quality of life. Forty-six outpatients who were diagnosed with end-stage renal failure by a nephrologist and received hemodialysis therapy for six months or longer were recruited. The data were analyzed using SPSS and Kruskal-Wallis test was employed to analyze the continuous variables. Among blood indices, Hematocrit decreased significantly after aerobic and complex exercise; hemoglobin dropped only after complex exercise; P and Ca×P increased for a considerable amount only after complex exercise, but the postexamination results show no significant difference. As for physical performance, sit-to-stand (STS)-5 decreased with resistance and complex exercise (p < .01), while there was a significant increase in STS-30 after aerobic, resistance, and complex exercise (p < .01). 6-minute walk test (MWT) grew significantly in all groups (p < .01), but alongside gait speed, and grip strength, it diminished significantly in the non-exercise group (p< .05). When it comes to SF-36, there was a significant rise in the physical component score (PCS) (p< .01) with resistance and complex exercise. In the meantime, mental component summary (MCS) went up significantly after all types of exercises (p < .01). In contrast, Beck depression inventory (BDI) showed a significant decline only with complex exercise (p < .01). To sum up, this study suggests intradialytic complex exercise appears to be effective in enhancing Short Form (SF)-36 and BDI as well as physical performance, which is why we recommend this type of complex exercise program for hemodialysis patients.

Inflammatory Biomarkers after an Exercise Intervention in Acute Lymphoblastic Leukemia Survivors

2021 ◽  
Author(s):  
Tuomas Lähteenmäki ◽  
Liisa Järvelä ◽  
Harri Niinikoski ◽  
Anu Huurre ◽  
Arja Harila-Saari
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Physical Exercise ◽  
Exercise Intervention ◽  
Lymphoblastic Leukemia ◽  
Exercise Program ◽  
Low Grade ◽  
Healthy Controls ◽  
Protein Levels ◽  
Home Based ◽  
Increased Risk

Abstract BackgroundCancer survivors show increased risk for non-communicable diseases and chronic low-grade inflammation characterizes the development of such diseases. We investigated inflammatory plasma protein profiles of survivors of acute lymphoblastic leukemia (ALL) in comparison to healthy controls and after an intervention with a home-based exercise program. ProcedureSurvivors of ALL aged 16-30 years (n=21) with a median time of 15.9 years from diagnosis, and sex- and age-matched healthy controls (n=21), were studied. Stored plasma samples were analyzed with Olink’s 92-protein-wide Inflammation panel in 21 ALL long-term survivors at baseline, after a 16-week home-based exercise intervention (n=17) and in 21 age- and sex-matched controls at baseline. Protein expression levels were compared between the groups. ResultsInflammatory protein levels did not differ between the survivors and controls at baseline. Significantly reduced levels after the intervention were found in 11 proteins related to either vascular inflammation, insulin resistance, or both: TNFSF14, OSM, MCP-1, MCP-2, FGF-21, CCL4, TGF-alpha, TRAIL, ADA, CXCL6, and LAP TGF-beta-1. ConclusionsThe ALL survivors were not significantly more affected by inflammation than controls at baseline. The survivors’ 16-week physical exercise intervention led to significant beneficial change in inflammation protein levels. Physical exercise should be promoted for survivors of cancer.

scholarly journals Possible Sarcopenia and Impact of Dual-Task Exercise on Gait Speed, Handgrip Strength, Falls, and Perceived Health

2021 ◽  
Vol 8 ◽  
Author(s):  
Reshma Aziz Merchant ◽  
Yiong Huak Chan ◽  
Richard Jor Yeong Hui ◽  
Jia Yi Lim ◽  
Sing Cheer Kwek ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Social Isolation ◽  
Physical Performance ◽  
Dual Task ◽  
Gait Speed ◽  
Handgrip Strength ◽  
Exercise Program ◽  
Perceived Health ◽  
Exercise Group ◽  
Community Dwelling

Background: Sarcopenia is defined as a progressive age-related loss in muscle mass and strength affecting physical performance. It is associated with many negative outcomes including falls, disability, cognitive decline, and mortality. Protein enriched diet and resistance training have shown to improve muscle strength and function but there is limited evidence on impact of dual-task exercise in possible sarcopenia.Objective: To evaluate impact of community-based dual-task exercise on muscle strength and physical function in possible sarcopenia defined by either slow gait (SG) or poor handgrip strength (HGS). The secondary aims include effect on cognition, frailty, falls, social isolation, and perceived health.Methods: Community-dwelling older adults ≥60 years old were recruited from screening program intended to identify seniors at risk, and invited to participate in dual-task exercise program called HAPPY (Healthy Aging Promotion Program for You). One hundred and eleven participants with possible sarcopenia completed 3 months follow-up. Questionnaire was administered on demographics, frailty, sarcopenia, falls, perceived health, social network, functional, and cognitive status. Physical performance included assessment of HGS, gait speed, and Short Physical Performance Battery test (SPPB).Results: The mean age of the Exercise group was 75.9 years old and 73.0% were women. The Exercise group had more female (73.0 vs. 47.5%), were older (75.9 vs. 72.5 years old), had higher prevalence of falls (32.4 vs. 15.0%), lower BMI (23.7 vs. 25.8), and education (4.0 vs. 7.2 years). The gait speed of the Exercise group increased significantly with significant reduction in the prevalence of SG and poor HGS. All components of SPPB as well as the total score increased significantly while the prevalence of pre-frailty and falls dropped by half. The risk of social isolation reduced by 25% with significant improvement in perceived health and cognition in the Exercise group. Significant impact on improvement gait speed and SPPB persisted after adjustment for baseline factors.Conclusion: Dual-task exercise program is effective in improving gait speed, SPPB score, and reducing the prevalence of poor HGS with significant improvement in perceived health, cognition, and reduction in falls and frailty. Future prospective randomized control trials are needed to evaluate the effectiveness of dual-task interventions in reversing sarcopenia.

Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism

2016 ◽  
Vol 94 (4) ◽  
pp. 426-432 ◽  
Author(s):  
Amr M. Abbas ◽  
Hussein F. Sakr
Keyword(s):  
Cardiovascular Diseases ◽  
Magnesium Sulfate ◽  
Adhesion Molecule ◽  
Interleukin 6 ◽  
Inflammatory Markers ◽  
Male Rats ◽  
Low Grade ◽  
Inflammatory Status ◽  
Increased Risk ◽  
Tnf Α

Inflammation is a major risk factor for cardiovascular complications. Magnesium sulfate (MgSO4) has anti-inflammatory actions. Therefore we investigated the effects of levothyroxine and MgSO4 on inflammatory markers as C-reactive protein (CRP), interleukin-6, tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in hypothyroid rats. Sixty male rats were divided into 6 groups; normal, normal + MgSO4, hypothyroidism, hypothyroidism + levothyroxine, hypothyroidism + MgSO4, and hypothyroidism + levothyroxine + MgSO4. Thyroxine, triiodothyronine, and thyroid-stimulating hormone (TSH), CRP, interleukin-6, TNF-α, ICAM-1, and VCAM-1 were measured in all rats. Hypothyroidism significantly increased TSH, CRP, interleukin-6, TNF-α, ICAM-1, and VCAM-1 and decreased triiodothronine and thyroxine. Treatment of hypothyroid rats with levothyroxine or MgSO4 significantly decreased CRP, interleukin-6, TNF-α, ICAM-1, and VCAM-1. Combined therapy of hypothyroid rats with levothyroxine and MgSO4 significantly decreased CRP, interleukin-6, TNF-α, ICAM-1, and VCAM-1 compared with hypothyroid rats either untreated or treated with levothyroxine or MgSO4. This study demonstrates that hypothyroid rats have chronic low grade inflammation, which may account for increased risk of cardiovascular diseases. Combined levothyroxine and MgSO4 is better than levothyroxine or MgSO4 alone in alleviating the chronic low grade inflammatory status and therefore reducing the risk of cardiovascular diseases in hypothyroid animals.

The influence of low-grade inflammation on platelets in patients with stable coronary artery disease

2015 ◽  
Vol 114 (09) ◽  
pp. 519-529 ◽  
Author(s):  
Sanne Bøjet Larsen ◽  
Erik Lerkevang Grove ◽  
Morten Würtz ◽  
Søs Neergaard-Petersen ◽  
Anne-Mette Hvas ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Inflammatory Markers ◽  
Cardiovascular Events ◽  
Inflammatory Biomarkers ◽  
Low Grade ◽  
Platelet Production ◽  
Increased Risk ◽  
Artery Disease ◽  
Stable Cad ◽  
Low Grade Inflammation

SummaryInflammation is likely to be involved in all stages of atherosclerosis. Numerous inflammatory biomarkers are currently being studied, and even subtle increases in inflammatory biomarkers have been associated with increased risk of cardiovascular events in patients with coronary artery disease (CAD). Low-grade inflammation may influence both platelet production and platelet activation potentially leading to enhanced platelet aggregation. Thrombopoietin is considered the primary regulator of platelet production, but it likely acts in conjunction with numerous cytokines, of which many have altered levels in CAD. Previous studies have shown that high-sensitive C-reactive protein (CRP) independently predicts increased platelet aggregation in stable CAD patients. Increased levels of CRP, fibrinogen, interleukin-6, stromal cell-derived factor-1, CXC motif ligand 16, macrophage migration inhibitory factor, RANTES, calprotectin, and copeptin have been associated with increased risk of cardiovascular events in CAD patients. Additionally, some of these inflammatory markers have been associated with enhanced platelet activation and aggregation. However, CRP and other inflammatory markers provide only limited additional predictive value to classical risk factors such as smoking, blood pressure, and cholesterol levels. Existing data do not clarify whether inflammation simply accompanies CAD and increased production and aggregation of platelets, or whether a causal relationship exists. In this review, we provide a comprehensive overview of inflammatory markers in stable CAD with particular emphasis on platelet production, activation, and aggregation in CAD patients.

The association between intradialytic exercise and hospital usage among hemodialysis patients

2015 ◽  
Vol 40 (4) ◽  
pp. 371-378 ◽  
Author(s):  
Kristen Parker ◽  
Xin Zhang ◽  
Adriane Lewin ◽  
Jennifer M. MacRae
Keyword(s):  
Cardiac Disease ◽  
Incidence Rate Ratio ◽  
Exercise Program ◽  
Hemodialysis Patients ◽  
Hospitalization Rate ◽  
Program Participation ◽  
End Stage Kidney Disease ◽  
Hospitalization Rates ◽  
End Stage ◽  
Intradialytic Exercise

Hemodialysis (HD) patients have high hospitalization rates. Benefits of intradialytic exercise have been proven in numerous studies yet exercise programs are still rarely used in the treatment of end-stage kidney disease (ESKD). Our objective was to determine if there was an association between a 6-month intradialytic bicycling program and hospitalization rates and length of stay (LOS) in ESKD patients. This was a retrospective cohort study that took place 6 months prior to and 6 months during an intradialtyic exercise program at an outpatient HD unit in Calgary, Alberta, Canada. Participants comprised 102 patients who had commenced HD <6 months (incident) or >6 months (prevalent) prior to starting exercise. The intervention comprised a 6-month intradialytic bicycling program. Main outcome measures were hospitalization rate, cause of hospitalization, and LOS. Patients were predominantly male (67.6%) aged 65.6 ± 13.5 years and median HD vintage 1 year (range: 0–12). Comorbidities included diabetes mellitus (50%) and cardiac disease (38.2%). The hospitalization incidence rate ratio (IRR) was 0.48 (0.23–0.98; P = 0.04) in incident and 0.89 (0.56–1.42; P = 0.64) in prevalent patients. The LOS decreased from 7.8 (95% confidence interval (CI): 7.3–8.4) to 3.1 (95% CI: 2.8–3.4) days and LOS IRR was 0.39 (0.35–0.45; P < 0.001). The main predictors of hospitalization were lower albumin levels (P = 0.007) and lack of intradialytic exercise program participation (P < 0.001). In conclusion, 6 months of intradialytic exercise was associated with decreased LOS in both incident and prevalent HD patients.

scholarly journals Inflammatory Markers and Incidence of Hospitalization With Infection in Chronic Kidney Disease

2019 ◽  
Vol 189 (5) ◽  
pp. 433-444 ◽  
Author(s):  
Junichi Ishigami ◽  
Jonathan Taliercio ◽  
Harold I Feldman ◽  
Anand Srivastava ◽  
Raymond Townsend ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Confidence Interval ◽  
Plasma Levels ◽  
Inflammatory Markers ◽  
Clinical Population ◽  
Low Grade ◽  
Major Infection ◽  
Increased Risk ◽  
Tnf Α

Abstract Persons with chronic kidney disease (CKD) are at high risk of infection. While low-grade inflammation could impair immune response, it is unknown whether inflammatory markers are associated with infection risk in this clinical population. Using 2003–2013 data from the Chronic Renal Insufficiency Cohort Study (3,597 participants with CKD), we assessed the association of baseline plasma levels of 4 inflammatory markers (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1 receptor antagonist (IL-1RA), and transforming growth factor-β (TGF-β)) with incident hospitalization with major infection (pneumonia, urinary tract infection, cellulitis and osteomyelitis, and bacteremia and sepsis). During follow-up (median 7.5 years), 36% (n = 1,290) had incident hospitalization with major infection. In multivariable Cox analyses with each inflammatory marker modeled as a restricted cubic spline, higher levels of IL-6 and TNF-α were monotonically associated with increased risk of hospitalization with major infection (for 95th vs. 5th percentile, hazard ratio = 2.11 (95% confidence interval: 1.68, 2.66) for IL-6 and 1.88 (95% confidence interval: 1.51, 2.33) for TNF-α), while corresponding associations for IL-1RA or TGF-β were nonsignificant. Thus, higher plasma levels of IL-6 and TNF-α, but not IL-1RA or TGF-β, were significantly associated with increased risk of hospitalization with major infection. Future studies should investigate whether inflammatory pathways that involve IL-6 and TNF-α increase susceptibility to infection among individuals with CKD.

scholarly journals Exercise program to enhance physical performance and quality of life of older hemodialysis patients: a feasibility study

2010 ◽  
Vol 42 (4) ◽  
pp. 1125-1130 ◽  
Author(s):  
Mika L. Nonoyama ◽  
Dina Brooks ◽  
Alexandra Ponikvar ◽  
S. Vanita Jassal ◽  
Pia Kontos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Performance ◽  
Feasibility Study ◽  
Exercise Program ◽  
Hemodialysis Patients

scholarly journals Application of Wearables to Facilitate Virtually Supervised Intradialytic Exercise for Reducing Depression Symptoms

Sensors ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 1571
Author(s):  
He Zhou ◽  
Fadwa Al-Ali ◽  
Gu Eon Kang ◽  
Abdullah I. Hamad ◽  
Rania A. Ibrahim ◽  
...  
Keyword(s):  
Weight Bearing ◽  
Wearable Sensors ◽  
Depression Scale ◽  
Exercise Program ◽  
Epidemiologic Studies ◽  
Exercise Group ◽  
Depression Symptoms ◽  
Hemodialysis Treatment ◽  
Supervised Exercise ◽  
Intradialytic Exercise

Regular exercise can reduce depression. However, the uptake of exercise is limited in patients with end-stage renal disease undergoing hemodialysis. To address the gap, we designed a gamified non-weight-bearing intradialytic exercise program (exergame). The intradialytic exergame is virtually supervised based on its interactive feedback via wearable sensors attached on lower extremities. We examined the effectiveness of this program to reduce depression symptoms compared to nurse-supervised intradialytic exercise in 73 hemodialysis patients (age = 64.5 ± 8.7years, BMI = 31.6 ± 7.6kg/m2). Participants were randomized into an exergame group (EG) or a supervised exercise group (SG). Both groups received similar exercise tasks for 4 weeks, with three 30 min sessions per week, during hemodialysis treatment. Depression symptoms were assessed at baseline and the fourth week using the Center for Epidemiologic Studies Depression Scale. Both groups showed a significant reduction in depression score (37%, p < 0.001, Cohen’s effect size d = 0.69 in EG vs. 41%, p < 0.001, d = 0.65 in SG) with no between-group difference for the observed effect (p > 0.050). The EG expressed a positive intradialytic exercise experience including fun, safety, and helpfulness of sensor feedback. Together, results suggested that the virtually supervised low-intensity intradialytic exergame is feasible during routine hemodialysis treatment. It also appears to be as effective as nurse-supervised intradialytic exercise to reduce depression symptoms, while reducing the burden of administrating exercise on dialysis clinics.

Sign in / Sign up

Export Citation Format

Share Document