Brazilian natural dietary components (annatto, propolis and mushrooms) protecting against mutation and cancer

2006 ◽  
Vol 25 (5) ◽  
pp. 267-272 ◽  
Author(s):  
L R Ribeiro ◽  
M S Mantovani ◽  
D A Ribeiro ◽  
D MF Salvadori
Keyword(s):  
Side Effect ◽  
Side Effect Profile ◽  
Prevention Strategies ◽  
Preneoplastic Lesions ◽  
Promising Alternative ◽  
Carcinogenic Potential ◽  
The World ◽  
Huge Impact ◽  
Dietary Components ◽  
Favorable Side Effect Profile

Considering the high number of new cancer cases in Brazil (approximately 470 000 cases in 2005) and the remarkable differences in the incidence of this disease around the world, the development of chemopreventive strategies using foods widely consumed would have a huge impact, both medically and economically. This review summarizes some of our studies conducted to verify the anti-mutagenic and anti-carcinogenic potential of some Brazilian natural dietary constituents (annatto, mushrooms, and propolis). Overall data have shown a clear role for these compounds in preventing mutation and specific preneoplastic lesions. Taken together, these agents indicate a favorable side-effect profile and may prove to be a promising alternative for cancer prevention strategies, although more investigation is needed to fully explore this issue.

MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile

2017 ◽  
Vol 8 (10) ◽  
pp. 2180-2193 ◽  
Author(s):  
Xin Liu ◽  
Long Zhao ◽  
Yuan Wang ◽  
Jingjing Zhou ◽  
Dan Wang ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Side Effect ◽  
Side Effect Profile ◽  
Favorable Side Effect Profile

scholarly journals Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Deeba Nazir ◽  
Zaid Ahmad Wani ◽  
Fahd Bukhari ◽  
Shabir Ahmad Dar ◽  
Yuman Kawoosa
Keyword(s):  
Side Effect ◽  
North India ◽  
Side Effect Profile ◽  
Treatment Resistant ◽  
Nuclear Families ◽  
Wide Range ◽  
The Family ◽  
The World ◽  
The Mean ◽  
Higher Doses

Abstract Background Clozapine is an atypical second-generation antipsychotic belonging to the family of dibenzodiazepines. There is lack of literature on clozapine from this part of the world. So, our aim was to study the socio demographic, clinical and side effect profile of patients on clozapine in Kashmir. Results The mean age of the study group was 32.6 ± 8.9 years with majority being males (78.4%), unmarried (78.4%), unemployed (77.2%), and belonging to nuclear families (77.2%). Almost half of them resided in urban localities (51.1%) and studied upto middle school (55.7%). Around three- fourth (75%) of the patients had diagnosis of treatment-resistant schizophrenia. The mean dose of clozapine was 338.92 ± 158.11 mgs. Sedation (76.1%), hypersalivation (69.5%), constipation (46.6%), and weight gain (34.1%) were most common side effects noted in patients. 4.5% cases developed seizures while on clozapine. 2.3% patients developed agranulocytosis while 4.5% patients developed neutropenia on clozapine. The neutropenia was more pronounced in patients of schizophrenia with suicidal tendencies with doses of more than 400 mg. Conclusions We have used clozapine in a wide range of indications. Our patients seem to tolerate and respond to higher doses of clozapine and the prevalence of blood dyscrasias in our study sample was much higher than the rest of India.

scholarly journals SAT-278 Vaginal Cabergoline: A Simple Solution to a Challenging Problem

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Munder Abuaisha ◽  
Otto Gibbs ◽  
Rachel Bier
Keyword(s):  
Pituitary Adenoma ◽  
Side Effect ◽  
Gamma Knife Radiosurgery ◽  
Sella Turcica ◽  
Serum Prolactin ◽  
Side Effect Profile ◽  
First Line ◽  
Optic Chiasma ◽  
Persistent Symptoms ◽  
Favorable Side Effect Profile

Abstract Introduction: Prolactinomas is a common endocrine disorder that can be associated with significant morbidity. Generally, prolactinomas are more responsive to pharmacologic treatment than any other types of pituitary adenoma. Dopamine agonists (DA), including cabergoline and bromocriptine, are the first line of treatment in all sizes of prolactinomas and they decrease both the secretion and size of these adenomas. However, treatment remains challenging for patients who are intolerance to those medications. Case: We report a 32-year-old Hispanic woman who presented with secondary amenorrhea, she was found to have hyperprolactinemia of 1496 mcg/L. MRI of the brain showed a pituitary adenoma measuring 2.7 cm with sella turcica invasion and mass effect on the optic chiasma. She failed the lowest doses of oral cabergoline and bromocriptine and underwent TSS and gamma knife radiosurgery. Given her persistent symptoms (marked depression, insomnia, fatigue, short-term memory loss, and lack of concentration along with constipation) and elevation of prolactin, she was started on low dose vaginal cabergoline leading to a marked improvement of her symptoms and a steady decrease in serum prolactin. Discussion: Despite the availability of DA as a first-line treatment of Prolactinoma, treatment remains challenging, given the commonly reported side effects for all DA. Cabergoline is oftentimes the treatment of choice due to efficacy and favorable side-effect profile. However, intolerance to those medications can lead to discontinuation of therapy and increase morbidity. Other strategies, including transsphenoidal surgery (TSS) or radiation therapy, have been considered for the minority of patients whose adenomas are resistant to DA or who cannot tolerate these drugs. Interestingly, tolerance to DA can be improved by administering the drug intravaginally, which can have similar efficacy to the oral route and a more favorable side-effect profile. However, only a few studies assessed the effectiveness and tolerance of vaginal DAs in hyperprolactinemic patients intolerant to oral medications, little evidence supports the use of intravaginal DA to improve drug tolerance, and further studies are necessary to determine the safety and efficacy of vaginal cabergoline.

Evidence-Based Prevention Strategies of Suicide Behavior in the World and Possibilities of their Implementation in Slovenia

Crisis ◽  
2000 ◽  
Vol 21 (4) ◽  
pp. 193-194
Author(s):  
Claire Henderson ◽  
Marija Brecelj ◽  
Paola Dazzan ◽  
Mojca Dernovsek ◽  
Oscar Meehan ◽  
...  
Keyword(s):  
Evidence Based ◽  
Prevention Strategies ◽  
Suicide Behavior ◽  
The World

Valproic Acid:

1999 ◽  
Vol 16 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Sayonara Beatriz Ranciaro Fagundes
Keyword(s):  
Health Care ◽  
Valproic Acid ◽  
Antiepileptic Drug ◽  
Detailed Analysis ◽  
Side Effect ◽  
Side Effect Profile ◽  
Care Givers

Clinical pharmacologists, neurologists, and all health care givers must consider the efficacy, safety, and side effect profile of a given antiepileptic drug when determining which drug is best for a given patient.The purpose of this study was to investigate valproic acid with a detailed analysis of the different reports.

The Paradox of “A High Standard of Public Honesty”

2017 ◽  
Author(s):  
James Kennedy ◽  
Ronald Kroeze
Keyword(s):  
The Netherlands ◽  
Early Modern ◽  
Side Effect ◽  
High Standard ◽  
Dutch Republic ◽  
Liberal Politics ◽  
Patronage Politics ◽  
Starting Point ◽  
The World ◽  
Late Nineteenth

This chapter takes as its starting point the contemporary idea that the Netherlands is one of the least corrupt countries in the world; an idea that it dates back to the late-nineteenth and early-twentieth centuries. In this chapter, the authors explain how corruption was controlled in the Netherlands against the background of the rise and fall of the Dutch Republic, modern statebuilding and liberal politics. However, the Dutch case also presents some complexities: first, the decrease in some forms of corruption was due not to early democratization or bureaucratization, but was rather a side-effect of elite patronage-politics; second, although some early modern forms of corruption disappeared around this period, new forms have emerged in more recent times.

Long-term efficacy and safety of imiquimod 5% and fluorouracil 1% creams in medical monotherapy of complex eyelid basal cell carcinomas

2021 ◽  
pp. 112067212110356
Author(s):  
Manpreet Singh ◽  
Aditi Mehta Grewal ◽  
Himanshi Singh ◽  
Manjula Sharma ◽  
Manpreet Kaur ◽  
...  
Keyword(s):  
Basal Cell ◽  
Side Effect ◽  
The Elderly ◽  
Fixed Dose ◽  
Side Effect Profile ◽  
Efficacy And Safety ◽  
Term Efficacy ◽  
Basal Cell Carcinomas ◽  
Double Blinded

Purpose: To study the long-term efficacy and safety of local application of imiquimod 5% and fluorouracil 1% creams in complex eyelid basal cell carcinomas (BCCs). Methods: A retrospective, non-comparative study in biopsy-proven, complex (involving canthi or >50% of eyelid length) eyelid BCC patients who were medically unfit for surgical procedures. All patients were medically treated with either of the creams using fixed-dose regimens for a minimum of 3 months. All received oral vitamin C 500 mg QID for 3 months as an adjunct for collagen healing. A minimum of “post-treatment” follow-up of 12 months was observed. Results: Of total 30 patients, imiquimod 5% and fluorouracil 1% were used in 16 and 14 patients, respectively. The mean age of our patients was 70.5 years. The co-morbidities included – severe coronary artery disease using blood-thinners ( n = 19), poorly controlled diabetes ( n = 12), poorly controlled hypertension ( n = 6), on nebulization ( n = 3), and tuberculosis with pulmonary fibrosis ( n = 2). Complete clinical tumor resolution was noted in 10 and 8 patients over 12 and 16.5 weeks, respectively, in imiquimod and fluorouracil groups. Periocular skin erythema, chemical conjunctivitis, and skin depigmentation were seen in all the patients of imiquimod group. On the other hand, the local side-effect profile in fluorouracil patients was limited. Conclusion: The medical treatment of complex eyelid BCC is a useful alternative to surgery in the elderly with significant co-morbidities. It provides a promising long-term relief with a tolerable side-effect profile. A prospective, randomized, double-blinded trial would provide stronger evidence for the efficacy of these drugs.

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