scholarly journals Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Deeba Nazir ◽  
Zaid Ahmad Wani ◽  
Fahd Bukhari ◽  
Shabir Ahmad Dar ◽  
Yuman Kawoosa
Keyword(s):  
Side Effect ◽  
North India ◽  
Side Effect Profile ◽  
Treatment Resistant ◽  
Nuclear Families ◽  
Wide Range ◽  
The Family ◽  
The World ◽  
The Mean ◽  
Higher Doses

Abstract Background Clozapine is an atypical second-generation antipsychotic belonging to the family of dibenzodiazepines. There is lack of literature on clozapine from this part of the world. So, our aim was to study the socio demographic, clinical and side effect profile of patients on clozapine in Kashmir. Results The mean age of the study group was 32.6 ± 8.9 years with majority being males (78.4%), unmarried (78.4%), unemployed (77.2%), and belonging to nuclear families (77.2%). Almost half of them resided in urban localities (51.1%) and studied upto middle school (55.7%). Around three- fourth (75%) of the patients had diagnosis of treatment-resistant schizophrenia. The mean dose of clozapine was 338.92 ± 158.11 mgs. Sedation (76.1%), hypersalivation (69.5%), constipation (46.6%), and weight gain (34.1%) were most common side effects noted in patients. 4.5% cases developed seizures while on clozapine. 2.3% patients developed agranulocytosis while 4.5% patients developed neutropenia on clozapine. The neutropenia was more pronounced in patients of schizophrenia with suicidal tendencies with doses of more than 400 mg. Conclusions We have used clozapine in a wide range of indications. Our patients seem to tolerate and respond to higher doses of clozapine and the prevalence of blood dyscrasias in our study sample was much higher than the rest of India.

Hidradenitis suppurativa: Wie die Partner von Betroffenen psychosozial beeinträchtigt werden

2021 ◽  
pp. 1-3
Author(s):  
Uwe Gieler
Keyword(s):  
Disease Severity ◽  
Social Life ◽  
Hidradenitis Suppurativa ◽  
Life Quality ◽  
Psychosocial Burden ◽  
Wide Range ◽  
The Family ◽  
The Mean ◽  
Moderate Effect

<b>Background</b>: Hidradenitis suppurativa is a debilitating disease related to a great psychosocial burden in affected patients and subsequently also people around them. Patients’ partners as caregivers may indirectly experience wide range of devastating effects of the disease on their emotional and social life. <b>Objective:</b> The purpose of this study was to determine the QoL impairment in HS patients’ partners and to identify its aspects that are affected the most. Correlation between QoL burden and disease severity, duration, sex, age and smoking was also assessed. <b>Methods:</b> A total of 50 HS sufferers were assessed according to disease severity and their partners’ QoL was determined using the Family Dermatology Life Quality Index questionnaire. <b>Results:</b> The mean FDLQI for patients’ partners was 8.7 ± 6.8 points, indicating generally a moderate effect of HS on their life. Quality of partners’ life correlated significantly with disease severity but no correlation was found according to other factors. <b>Conclusion:</b> Hidradenitis suppurativa is a highly psychologically devastating disease not only for patients but also for their partners. It occurred to diminish partners’ QoL mostly by increasing daily expenditure but also other problems were often reported. Clinicians should be aware of these psychosocial implications, in order to provide optimal therapy of HS affected families by a multidisciplinary specialized management addressing both, patients and their cohabitants simultaneously.

Ceftriaxone Associated Biliary Sludge in Children - A Study in Bangabandhu Sheikh Mujib Medical University

2014 ◽  
Vol 37 (3) ◽  
pp. 142-145 ◽  
Author(s):  
M Kabir Alam ◽  
ASM Baslul Karim ◽  
Mosha Hafsa Kabir ◽  
Syed Saimul Huque ◽  
M Samsuzzaman
Keyword(s):  
Child Health ◽  
Side Effect ◽  
Normal Group ◽  
Older Children ◽  
Sludge Formation ◽  
Biliary Sludge ◽  
Paediatric Department ◽  
The Mean ◽  
Medical University ◽  
Higher Doses

Background: Ceftriaxone is known to induce reversible precipitations, called billiary sludge or pseudolithiasis in the gall bladder.Objective: The aim of this study was to investigate the frequency of biliary sludge and factors that contribute to this side effect in children. Methodology: This study was conducted on 50 consecutive children who were admitted at paediatric department of Bangabandhu Sheikh Mujib Medical University (BSMMU) for different illness and who received ceftriaxone in different dosage and duration. Ultraso-nography of hepatobiliary system was done before and at the end of therapy. Children who developed biliary sludge, a third ultrasonography was done after one month. Results: Biliary sludge was found in 4 (08%) of 50 children which resolved within 30 days of cessation of therapy. The mean dose and duration of ceftriaxone in these four children were 92.5±9.6 mg/kg/day and 8.0±2.0 days respectively while it was 78.5±5.2 mg/kg/day and 6.1±1.2 days respectively rest 46 children who did not develop biliary sludge (p<0.05). The mean age of children in sludge formation group was 8.3±2.1 years while it was 5.6±1.6 years in the normal group (p<0.05). Conclusion: Biliary sludge was found in older children who got higher doses of ceftriaxone for a longer period and it was reversible in all the studied children. DOI: http://dx.doi.org/10.3329/bjch.v37i3.18617 Bangladesh J Child Health 2013; Vol.37(3): 142-145

Safety and Efficacy Results of a Randomized Trial Comparing Adjuvant Toremifene and Tamoxifen in Postmenopausal Patients With Node-Positive Breast Cancer

2000 ◽  
Vol 18 (20) ◽  
pp. 3487-3494 ◽  
Author(s):  
Kaija Holli ◽  
Ritva Valavaara ◽  
Guillermo Blanco ◽  
Vesa Kataja ◽  
Päivi Hietanen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effect ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Side Effect Profile ◽  
Treatment Groups ◽  
Node Positive ◽  
Er Positive ◽  
The Mean

PURPOSE: In this multicenter trial, toremifene 40 mg/d was compared with tamoxifen 20 mg/d, both given orally for 3 years to postmenopausal, axillary node–positive women after breast surgery. PATIENTS AND METHODS: The first 899 patients (toremifene, n = 459; tamoxifen, n = 440) of the total of 1,480 patients accrued to the trial were included in this scheduled safety analysis. The mean follow-up time was 3.4 years. RESULTS: The two treatment groups were well balanced with respect to patient and disease characteristics. The subjective side-effect profile was similar in both treatment groups. Slightly more vascular complications (deep vein thromboses, cerebrovascular events, and pulmonary embolisms) were seen among tamoxifen-treated patients (5.9%) as compared with toremifene-treated patients (3.5%) (P = .11), whereas bone fractures (P = .09) and vaginal leukorrhea (P = .05) were more common in the toremifene group. The number of subsequent second cancers was similar. The breast cancer recurrence rate was 23.1% (n = 106) in the toremifene group and 26.1% (n = 115) in the tamoxifen group (P = .31). When only patients with estrogen receptor (ER)–positive cancer were considered (n = 556), the risk for breast cancer recurrence was nonsignificantly lower among the toremifene-treated women, with a hazards ratio of 0.74 (90% confidence interval, 0.52 to 1.04; P = .14). The mean time to breast cancer recurrence and overall survival were similar in both groups. CONCLUSION: The side-effect profile of toremifene resembles that of tamoxifen. The efficacy of toremifene seems to be no less than that of tamoxifen. The trend for fewer breast cancer recurrences in the ER-positive subgroup is encouraging, but a longer follow-up is needed to confirm this.

Comparative study of the side-effect profile between clozapine and non-clozapine patients

2016 ◽  
Vol 33 (S1) ◽  
pp. s261-s261
Author(s):  
S. Ramos Perdigues ◽  
A. Mane Santacana ◽  
P. Salgado Serrano ◽  
E. Jove Badia ◽  
X. Valiente Torrelles ◽  
...  
Keyword(s):  
Heart Rate ◽  
Side Effects ◽  
Side Effect ◽  
Care Facility ◽  
Good Evidence ◽  
Side Effect Profile ◽  
Continuous Variables ◽  
Wide Range ◽  
Competing Interest ◽  
Main Barrier

IntroductionFor resistant schizophrenia, the only approved treatment is clozapine. However, clozapine is underused, mainly due to its wide range of side-effects. Secondary effects differ amongst antipsychotics (Leucht et al., 2009). Despite that there is no good evidence that combined antipsychotics offer any advantage over the use of a single antipsychotic, combination increases the frequency of adverse events (Maudsley guidelines).ObjectivesTo compare the side-effect profile between clozapine and non-clozapinepatients.AimsTo provide evidence that clozapine patients do not show a worse side-effects profile.MethodsWe cross-sectionally analysed all patients from a Spanish long-term mental care facility (n = 139). Schizophrenic/schizoaffective patients were selected (n = 118) and their treatment was assessed, 31 patients used clozapine. We paired clozapine and non-clozapine patients by sex and age and assessed antipsychotic side effects and possible confounder variables.ResultsOur sample was 27 clozapine patients and 29 non-clozapine patients. 67,9% were male with a mean age of 51.3 (SD 9.6) years. For continuous variables: age, BMI, waist/hip, cholesterol, TG, glucose, prolactin, heart-rate, blood pressure, sleeping hours, the only statistical differences found were lower heart-rate (P = 0.001) in clozapine group and higher salivation subscale of SAS (P = 0.002) in clozapine group. For discrete variables: monotherapy, obesity, overweight, metabolic syndrome or possible confounders as propranolol, laxative, diet, antiglycemiant or insulin, fibrates or statins, antihypertensive or anticholinergic, no statistical differences were found.ConclusionsWe did not find differences in cardiometabolic parameters, which are the main barrier to prescribing clozapine, probably due to the concomitant use of other drugs in both groups.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Studies on Beetles of the Family Ptinidae

1952 ◽  
Vol 43 (1) ◽  
pp. 153-186 ◽  
Author(s):  
R. W. Howe ◽  
H. D. Burges
Keyword(s):  
Developmental Stages ◽  
Adult Life ◽  
Developmental Period ◽  
Animal Origin ◽  
Stored Products ◽  
Larval Instars ◽  
Physical Conditions ◽  
Wide Range ◽  
The Family ◽  
The Mean

The biology of N. hololeucus, T. globulus, G. psylloides, S. squamosum and E. hilleri has been studied to estimate their potentialities as pests of stored products.They are widely distributed and feed on a very wide range of foodstuffs of both plant and animal origin.Adult life is usually longer than the development period. Oviposition extends over most of the adult life. In warehouses all stages of development are present together.At 70 per cent. R.H. the developmental period (egg laid to emergence of adult from its cocoon) comprises: 12 to 21 per cent. as the egg stage, 52 to 70 per cent. as larva, 12 to 16 per cent. as pupa and 6 to 19 per centg. as adult in cocoon.The mean lengths of the various developmental stages, including the larval instars, have been found under several sets of physical conditions.

scholarly journals THE SPECIFIC CHARACTER OF THE ARCHETYPE OF HOME IN THE NOVEL “HOUSE OF DOCTOR DEE” BY P. ACKROYD

2019 ◽  
Vol 3 (93) ◽  
pp. 16-28
Author(s):  
Н.Ю Бондар
Keyword(s):  
Social Protection ◽  
The Novel ◽  
Specific Character ◽  
Family Ties ◽  
Wide Range ◽  
The Family ◽  
The World ◽  
Family Generation ◽  
External Corrosion

The article deals with the specific character of the archetype of home in the novel “The House of Doctor Dee” by P. Ackroyd. The novel of the English writer tells the story of the fate of the famous alchemist and scientist of the 16th century, Doctor John Dee and modern researcher Matthew Palmer. The purpose of the article is to determine the specific character of the archetype of home in the novel “The House of Doctor Dee” by P. Ackroyd in an individually-authored interpretation. The classical understanding of home is a connection with the family, generation, protection and support, shelter and spiritual comfort. In the second half of the 20th century the archetype of home is significantly problematic. “Home” ceases to be perceived as an exclusively “private” locus, even if it has absorbed all the wealth of the souls of its inhabitants, additional inclusions appear, most often of an existential universal plan. The literature of the postmodern era with its “sensitivity” to the world around it, i.e. with the desire to outline the problems of a wide range (philosophical, historical and others), continues to include “home” in the complex context of life. In this regard, P. Ackroyd’s novel “The House of Doctor Dee”, in which mysticism and reality are intertwined together, is of particular interest. The house of Doctor Dee seems to Matthew full of mystical phenomena and becomes a centre, including different time layers. The house in the novel “The House of Doctor Dee” by P. Ackroyd loses archetypal characteristics at all levels (despite the fact that Matthew is changing his attitude to his adoptive mother), from psychological (strong family ties, attention, understanding) to physical and social (protection, stability). All the fundamental mythological motifs of stability, which usually characterize the archetype of the house – the symbolic constancy of the place, the important role of higher female and male creatures (parents, teachers) as a kind of “good guardians” and mentors, the presence of children as a bastion of eternal renewal – are subjected to internal and external corrosion, destruction, and make the idea of returning home impossible. In addition, the house itself acquires the features of the homunculus, it disintegrates and reborn, but in each century in its own way.

The limits of acceptable family size in Western Nigeria

1975 ◽  
Vol 7 (3) ◽  
pp. 273-296 ◽  
Author(s):  
Helen Ware
Keyword(s):  
Family Size ◽  
Ideal Family Size ◽  
Men And Women ◽  
Probability Sample ◽  
Ideal Family ◽  
Value Of Children ◽  
Wide Range ◽  
The Family ◽  
The World ◽  
June July

SummaryThe data in this paper are drawn from interviews with a stratified probability sample of 2996 Yoruba men and women aged 17 or above living in Lagos and Western States in June–July 1973. Although drawing upon other material from the 1 ½-hour interviews the discussion concentrates upon the family size ideals of these individuals. In addition to the customary measures of ideal family size, new measures of the limits of acceptable family size are described, together with the reactions of the whole sample to a wide range of statements relating to family size and the value of children. It is shown that the smallest family which would be acceptable to any appreciable proportion of the population is four children, which would be acceptable to 18% of all respondents. Comparative data from elsewhere in the developing world are presented to show that African family size ideals are amongst the highest in the world. Age, educational and occupational differentials in perceptions of different family sizes are also discussed.

Brazilian natural dietary components (annatto, propolis and mushrooms) protecting against mutation and cancer

2006 ◽  
Vol 25 (5) ◽  
pp. 267-272 ◽  
Author(s):  
L R Ribeiro ◽  
M S Mantovani ◽  
D A Ribeiro ◽  
D MF Salvadori
Keyword(s):  
Side Effect ◽  
Side Effect Profile ◽  
Prevention Strategies ◽  
Preneoplastic Lesions ◽  
Promising Alternative ◽  
Carcinogenic Potential ◽  
The World ◽  
Huge Impact ◽  
Dietary Components ◽  
Favorable Side Effect Profile

Considering the high number of new cancer cases in Brazil (approximately 470 000 cases in 2005) and the remarkable differences in the incidence of this disease around the world, the development of chemopreventive strategies using foods widely consumed would have a huge impact, both medically and economically. This review summarizes some of our studies conducted to verify the anti-mutagenic and anti-carcinogenic potential of some Brazilian natural dietary constituents (annatto, mushrooms, and propolis). Overall data have shown a clear role for these compounds in preventing mutation and specific preneoplastic lesions. Taken together, these agents indicate a favorable side-effect profile and may prove to be a promising alternative for cancer prevention strategies, although more investigation is needed to fully explore this issue.

Antidiabetic Potential of Naturally Occurring Sesquiterpenes: A Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Anupam Maurya ◽  
Sweta Mohan ◽  
Subash C. Verma
Keyword(s):  
Herbal Medicine ◽  
Side Effect ◽  
Biological Activities ◽  
Blood Stream ◽  
Synthetic Drugs ◽  
Wide Range ◽  
The World ◽  
Suitable Treatment ◽  
Underlying Mechanisms ◽  
The Many

: Diabetes Mellitus (DM) is endocrine disease, which causes 3rd leading death in human; additionally, it’s one of the major key concerns over the globe. The high levels of the glucose in blood stream is as well characterized hyperglycemia, which lead to serious damage to heart, blood vessels kidney, eyes, and nerve. The best treatment of the DM is still not available; many scientists all over the world are trying hard to seek out suitable treatment of DM. Though, numerous synthetic drugs are developed for the treatment of diabetes, but their utility has been hampered because of several side effect and poor efficacy. Among the various approaches for the treatment of DM, an herbal medicine, enriched extracts and natural derived molecules are most effective. The herbal medicine and plants contain many bioactive phytochemicals such as terpenoids, alkaloids, flavonoids & phenolics etc. The plant derived molecules and their suitable structure modification have given many leads or drugs to the world which are used in the treatment of many diseases e.g. sesquiterpene; artemisinin and their derivatives artemether & artesunate as an antimalarial drug. Sesquiterpenes are available in human diet, and largely taken as components of the many folk medicines and dietary supplements. Sesquiterpenes have wide range of biological activities such as anti-cancer, anti-inflammatory, anti-nociceptive, immunomodulatory, antidiabetic and antimicrobial which make them potential targets for development of new therapeutics and their usage for medical purposes. The natural products have attracted attention of world due to their large number biological activities, high safety and less side effect. The review mainly focuses on sesquiterpenes such as β-Caryophyllene, dysidine, farnesol & eremanthin etc., a class of terpenoids that may play important role in treatment or prevention of this morbid disorder diabetes, including their underlying mechanisms for the blood glucose-lowering property.

EDUCATION

PEDIATRICS ◽  
1959 ◽  
Vol 23 (4) ◽  
pp. 759-760
Author(s):  
Dorothy Barclay
Keyword(s):  
Common Sense ◽  
Community Schools ◽  
Neighborhood Conditions ◽  
Factors Affecting ◽  
Wide Range ◽  
The Family ◽  
The World ◽  
The Individual ◽  
The Right

AS WE OBSERVED the family scene over the year just past, it seemed to us that public talk about the family, about what it is and what it should be, was taking a definite turn for the wiser. By this we mean that discussions of this sort seemed to become more logical and realistic—more "common-sense," if you will. In 1958 we saw a general easing up on parents, a tapering off of the blame-them-beat-them type of criticism that had flourished in recent years. The experts—and we include under this heading speechmakers from a wide range of fields who make pronouncements on "the right way" to live—continue to recognize parents as the single greatest influence on children's lives. But they recognize that there are other influences at work, too. Some are totally beyond parental control. They include hereditary or constitutional factors affecting the individual child, neighborhood conditions, the quality of community schools and services and, indeed, the whole state of the world.

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