scholarly journals Birth dimensions and risk of depression in adulthood: cohort study of Danish men born in 1953

2005 ◽  
Vol 186 (5) ◽  
pp. 400-403 ◽  
Author(s):  
Merete Osler ◽  
Merete Nordentoft ◽  
Anne-Marie Nybo Andersen

BackgroundTwo British cohort studies have reported birth weight to be associated with self-reported depression in adulthood, even after adjustment for socio-economic factors.AimsTo examine the relationship between birth dimensions and discharge from a psychiatric ward with a depression diagnosis in adulthood.MethodA cohort of 10 753 male singletons born in Copenhagen, Denmark in 1953 and for whom birth certificates had been traced in 1965 were followed from 1969 until 2002, with record linkage for date of first admission to a psychiatric ward that led to a discharge diagnosis of depression.ResultsA total of 190 men, corresponding to 1.8% of the cohort, had a discharge diagnosis of depression. The Cox's regression analyses failed to show any association between birth dimensions (birth weight and ponderal index) and risk of psychiatric ward diagnosis of depression in adult life, before or after adjustment for social indicators at birth.ConclusionsThis study does not support the existence of a relation between birth dimensions and psychiatric ward admission for depression in adult men.

2015 ◽  
Vol 6 (6) ◽  
pp. 512-519 ◽  
Author(s):  
O. O. Akindele ◽  
O. T. Kunle-Alabi ◽  
U. A. Udofia ◽  
T. T. Ahmed ◽  
Y. Raji

The critical period during which maternal hyperglycemia predisposes offspring to develop reproductive disorders in adult life is not known. The relationship between maternal hyperglycemia at different stages and reproductive functions of male offspring was investigated. A single intraperitoneal injection of alloxan (90 mg/kg body weight) was administered at gestation days (GD) 1, 8 and 15. Animals were subsequently given 10% glucose solution daily as drinking water until parturition. All male pups were sacrificed on the 63rd day of postnatal life. Birth weight, anogenital distance index (AGDi), testes descent day, preputial separation day, sperm profile, serum testosterone, luteinizing hormone and follicle-stimulating hormone levels and the histology of the testis were assessed. Data significance test was based on 95% confidence interval. GD1 pups showed a significant increase in mean birth weight, whereas GD8 pups and GD15 pups had significantly reduced birth weight as compared with control. AGDi was significantly increased in GD8 and GD15 pups. Testes descent and preputial separation in all the experimental groups were significantly earlier. There was a significant reduction in sperm count and viability in GD8 offspring. Sperm motility was reduced in all test groups. Testosterone level was reduced in all test groups. Histology of the testis showed varying degrees of pathologies. It was deduced from this study that maternal hyperglycemia caused alterations in reproductive functions in male offspring of Wistar rats irrespective of the period of gestation involved, although GD8 pups were most severely affected.


2019 ◽  
Author(s):  
Terese Sara Høj Jørgensen ◽  
Gunhild Tidemann Christensen ◽  
Kaare Christensen ◽  
Thorkild IA Sørensen ◽  
Merete Osler

ABSTRACTThis study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7,388 twin brothers born 1939-1959 and examined at the conscript board were followed in Danish nationwide registers (1969-2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95%CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The within-brother analyses revealed a smaller estimate for dementia diagnosis the cohort analyses of brothers. The twin analysis showed similar, though less clear associations, which were not statistically significant.


1970 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
S Jahan ◽  
TR Das ◽  
KB Biswas

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)


Author(s):  
Tatiani De Azevedo Lobo ◽  
Marli M. Moraes Da Costa

Resumo: O presente ensaio busca apresentar e fomentar algumas questões pertinentes ao debate contemporâneo sobre a pobreza, demonstrando a importância do tema no cenário mundial. Para tanto, inicialmente discorre-se sobre a construção histórico-social da pobreza e suas características contemporâneas. Com efeito, aponta-se a limitação dos fatores tradicionalmente apresentados como causadores da pobreza, como cultura, genética, geografia etc. Além disso, apresentam-se as formas atuais de monitorar o fenômeno, como o coeficiente de Gini e o IDH. Posteriormente, aborda-se a distribuição mundial da pobreza. Nesse ponto, colaciona-se que a pobreza é um problema mundial. No entanto, é perceptível que o Sul ainda concentra maior número de indivíduos pobres do que o Norte. Na esteira dos últimos dados da pesquisa realizada pelas Nações Unidas, houve uma nítida ascensão do Sul, especialmente nos indicadores sociais ligados à educação. A seguir, trata-se do capital social e da Teoria das Capacidades, apresentando-se novas abordagens da pobreza. Assim, o capital social trata de uma ideia utilizada para verificar a rede de relacionamento dos indivíduos. Já a Teoria das Capacidades está ligada com a ideia de oportunidade da liberdade. Por fim, estuda-se as políticas públicas, bem como seu aspecto fragmentário. Conclui-se, assim, sobre a necessidade de implementação de políticas públicas elaboradas sob a égide de novos paradigmas, a fim de possibilitar o tratamento específico do fenômeno da pobreza, conforme as peculiaridades de cada local. Para tanto foi utilizado neste trabalho o método de abordagem hipotético-dedutivo, o método de procedimento monográfico e a técnica de pesquisa, operacionalizados por meio do emprego de vasta pesquisa bibliográfica. Abstract: This essay seeks to provide and foster some relevant to the contemporary debate on poverty issues, demonstrating the importance of the issue on the world stage. For this purpose, initially spoke about the historical and social construction of poverty and its contemporary features. Indeed, he pointed out the limitation of the factors traditionally presented as the cause of poverty, as a culture, genetics, geography, etc. Furthermore, we presented the current ways of monitoring the phenomenon, such as the Gini coefficient and the HDI. Subsequently addressed the global distribution of poverty. At this point, if collated that poverty is a worldwide problem. However, it is apparent that the South still more concentrated than the poor North individuals. In the wake of recent data from research conducted by the United Nations, there was a sharp rise in the South, especially in social indicators related to education. Next, we treated the capital and the Theory of Capabilities, presenting new approaches to poverty. Thus, social capital is an idea used to verify the relationship network of individuals. Already Capabilities Theory is linked with the idea of freedom of opportunity. Finally, we studied public policy, as well as its fragmentary appearance. Thus, it is concluded on the need to implement public policies prepared under the aegis of new paradigms to enable specific treatment of the phenomenon of poverty, according to the peculiarities of each site. For that was used in this work the method of hypothetical-deductive approach, the method of procedure and the monographic research technique, operationalized through the use of extensive academic research.


2021 ◽  
Vol 12 (2) ◽  
pp. 204380872110199
Author(s):  
Si-Sheng Huang ◽  
Cheng-Chen Chang

Impaired insight in patients with schizophrenia results in less satisfactory clinical outcomes. This study was conducted to investigate the relationship between insight and individual psychopathological dimensions in inpatients with schizophrenia using a self-report questionnaire. In this study, 90 patients with schizophrenia aged 18–75 years admitted in the acute psychiatric ward of a medical center in Taiwan were enrolled. Patient insight was measured using the Self-Appraisal of Illness Questionnaire (SAIQ), and psychopathological dimensions were measured using the Positive and Negative Syndrome Scale (PANSS) and its five-factor structure model. A higher SAIQ score indicates greater insight. In bivariate correlation analyses, statistically significant correlations were observed between age, single marital status, educational level, and positive, excited, and depressed symptom factor of the PANSS and SAIQ score. In regression analyses, age and excited and depressed symptom factors were significantly associated with SAIQ score. No significant association was observed between insight and neurocognitive functions. Considering demographic characteristics, psychopathology, and neurocognition, in the acute phase of schizophrenia, younger patients with less severe excited symptoms and more severe depressive symptoms had greater insight.


2020 ◽  
Vol 149 ◽  
pp. 105154 ◽  
Author(s):  
Elaine Luiza Santos Soares de Mendonça ◽  
Mateus de Lima Macêna ◽  
Nassib Bezerra Bueno ◽  
Alane Cabral Menezes de Oliveira ◽  
Carolina Santos Mello

1991 ◽  
Vol 21 (1) ◽  
pp. 177-184 ◽  
Author(s):  
Sjoerd Sytema

SYNOPSISEnvironmental as well as individual socio-demographic and illness characteristics are related to the risk of admission. This paper addresses the problem of the interrelationships of these factors to admission rates. Using the Groningen Psychiatric Case Register, admission rates (during 1986 and 1987) from 34 administrative areas were calculated. Logit models were fitted in order to test the relationship between the relative risk of being admitted and sex, age, marital status, diagnosis, urbanization and distance from facilities. The effect of urbanization remains under the control of the other independent variables. The concept of ‘need for care’, related to ‘true’ and ‘treated’ incidence, is discussed.


PEDIATRICS ◽  
1982 ◽  
Vol 69 (5) ◽  
pp. 537-543
Author(s):  
Marie C. McCormick ◽  
Sam Shapiro ◽  
Barbara Starfield

A mother's expectations about the development of her infant have been found to be a strong determinant of child development, but little is known about the factors that may affect maternal assessment of development. In this study, the relationship of the mother's opinion of the development of her infant with several sociodemographic, antenatal, intrapartum, and infant health variables was examined for a large sample of 1-year-old infants for whom gross motor observations were also obtained at the time of the interview. Among those observed to be developing at an appropriate rate, 4.0% were perceived by their mothers as developing more slowly than the mothers considered normal; among infants developing more slowly, 28.6% were considered to be developing slowly by their mothers. In both groups, the major determinants of maternal opinion of slow development concerned the infant's health: low birth weight, congenital anomalies regardless of severity, hospitalization during the first year of life, and high ambulatory care use. These results indicate that maternal perception of infant development may not reflect the infant's level, but past or present illness, and raise questions about the influence of infant health on maternal-infant interactions and the effect of such interactions on subsequent development in the child.


PEDIATRICS ◽  
1987 ◽  
Vol 79 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Mary Ellen Avery ◽  
William H. Tooley ◽  
Jacob B. Keller ◽  
Suzanne S. Hurd ◽  
M. Heather Bryan ◽  
...  

Chronic lung disease in prematurely born infants, defined as the need for increased inspired oxygen at 28 days of age, was thought to be more common in some institutions than in others. To test this hypothesis, we surveyed the experience in the intensive care nurseries at Columbia and Vanderbilt Universities, the Universities of Texas at Dallas, Washington at Seattle, and California at San Francisco, the Brigham and Women's Hospital in Boston, Texas Children's Hospital in Houston, and Mt Sinai Hospital in Toronto. The survey included 1,625 infants with birth weights of 700 to 1,500 g. We confirmed the relationship of risk to low birth weight, white race, and male sex. Significant differences in the incidence of chronic lung disease were found between institutions even when birth weight, race, and sex were taken into consideration through a multivariate logistic regression analysis. Columbia had one of the best outcomes for low birth weight infants and the lowest incidence of chronic lung disease.


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