A randomized controlled pilot of home-based exercise (HBEX) versus standard care (SC) among breast (BC) and prostate cancer (PC) patients receiving radiation therapy (RTH)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 8504-8504 ◽  
Author(s):  
K. M. Mustian ◽  
G. R. Morrow ◽  
J. Yates ◽  
L. Gillies ◽  
C. Boles
Keyword(s):  
Aerobic Exercise ◽  
Aerobic Capacity ◽  
Exercise Intervention ◽  
Treatment Compliance ◽  
Positive Influence ◽  
Phase Iii ◽  
Post Intervention ◽  
Change Scores ◽  
Randomized Controlled ◽  
Home Based

8504 Background: Cancer-related fatigue (CRF) is reported in up to 97% of cancer patients during RTH. 60% rate it as moderate to severe. Fatigue can significantly reduce functional capacity (FC), treatment compliance, and QOL. Although there is no standard treatment for CRF, aerobic exercise has demonstrated a positive influence on CRF and FC during RTH, but the influence of combined resistance and aerobic exercise is not clear. We explored the efficacy of a low to moderate home-based exercise intervention, including resistance and aerobic training, to SC on CRF and domains of FC (aerobic capacity and strength), in a sample of BC and PC patients during RTH. Methods: BC and PC patients (N=38; ξ age=56; 71% BC), beginning at least 28 sessions of RTH were randomized to a 4wk HBEX (7 days/wk) or SC condition, with CRF (FACT subscale), aerobic capacity (6-min. walk), and strength (handgrip dynamometry) assessments pre and post-intervention. Results: Change scores indicated improvements in the HBEX group (N=19) in CRF (ξ=3.6, SE=2.1) and aerobic capacity (ξ=43.6, SE=52.3), while the SC group declined in CRF (ξ=-1.1, SE=1.1) and aerobic capacity (ξ=-28.5 SE=71.6). Change scores revealed declines in strength among both groups, however the HBEX group showed smaller declines in strength (ξ=-.05, SE=0.7) compared to the SC group (ξ=-.80, SE=.91). T-tests using intent-to-treat indicated statistically significant between group differences on changes in CRF (ES=.63; p=.05) from pre to post-intervention, as well as significantly higher aerobic capacity (ES=1.3; p<.001) with a statistical trend toward lower CRF (ES=.51; p=.09) between groups post-intervention. Conclusions: HBEX improved CRF and aerobic capacity, while SC resulted in declines. HBEX reduced declines in strength compared to SC. Future phase III randomized controlled trials are needed with larger samples to fully investigate the influence of this HBEX intervention on CRF, aerobic capacity and strength. Funded by NCI grant 1R25CA102618. No significant financial relationships to disclose.

scholarly journals The Effects of Exercise Duration and Intensity on Breast Cancer-Related DNA Methylation: A Randomized Controlled Trial

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4128
Author(s):  
Arielle S. Gillman ◽  
Timothy Helmuth ◽  
Claire E. Koljack ◽  
Kent E. Hutchison ◽  
Wendy M. Kohrt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Randomized Controlled Trial ◽  
Aerobic Exercise ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Post Intervention ◽  
Randomized Controlled ◽  
Supervised Exercise

Emerging research suggests that one mechanism through which physical activity may decrease cancer risk is through its influence on the methylation of genes associated with cancer. The purpose of the current study was to prospectively test, using a rigorous experimental design, whether aerobic exercise affects DNA methylation in genes associated with breast cancer, as well as whether quantity of exercise completed affects change in DNA methylation in a dose–response manner. 276 women (M age = 37.25, SD = 4.64) were recruited from the Denver metro area for a randomized controlled trial in which participants were assigned to a supervised aerobic exercise program varying in a fully crossed design by intensity (55–65% versus 75–85% of VO2max) and duration (40 versus 20 min per session). DNA methylation was assessed via blood samples provided at baseline, after completing a 16-week supervised exercise intervention, and six months after the intervention. 137 participants completed the intervention, and 81 had viable pre-post methylation data. Contrary to our hypotheses, total exercise volume completed in kcal/kg/week was not associated with methylation from baseline to post-intervention for any of the genes of interest. An increase in VO2max over the course of the intervention, however, was associated with decreased post-intervention methylation of BRCA1, p = 0.01. Higher levels of self-reported exercise during the follow-up period were associated with lower levels of GALNT9 methylation at the six-month follow-up. This study provides hypothesis-generating evidence that increased exercise behavior and or increased fitness might affect methylation of some genes associated with breast cancer to reduce risk.

scholarly journals Adherence to a Lifestyle Exercise and Nutrition Intervention in University Employees during the COVID-19 Pandemic: A Randomized Controlled Trial

2021 ◽  
Vol 18 (14) ◽  
pp. 7510
Author(s):  
Guillermo García Pérez de Sevilla ◽  
Olga Barceló Guido ◽  
María de la Paz De la Cruz ◽  
Ascensión Blanco Fernández ◽  
Lidia B. Alejo ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Effect Size ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Nutrition Intervention ◽  
Sitting Time ◽  
Post Intervention ◽  
University Employees ◽  
Randomized Controlled

Healthy lifestyles should be encouraged in the workplace through the occupational health teams of the companies. The objective of the present study was to evaluate the adherence to a lifestyle intervention carried out in university employees during the COVID-19 pandemic and its impact on health-related quality of life (HrQoL). A randomized controlled trial following the CONSORT guidelines was performed, consisting of three supervised interventions lasting for 18 weeks: an educational intervention on healthy habits, a nutritional intervention, and a telematic aerobic and strength exercise intervention. Lifestyle and HrQoL were analyzed six months post-intervention to assess adherence. Twenty-three middle-aged participants completed the study. The intervention group significantly improved their lifestyle according to the Health Promoting Lifestyle Profile II questionnaire, especially in the categories of Health Responsibility, Physical Activity, and Nutrition, with a large effect size. Sitting time was reduced by 2.5 h per day, with a moderate effect size. Regarding HrQoL, the intervention group showed a clinically significant improvement in the Physical Component Summary. Despite the lockdown and the mobility restrictions caused by the COVID-19 pandemic, this intervention performed on university employees achieved adherence to a healthier lifestyle and improved their HrQoL, which is of great clinical relevance.

scholarly journals Supervised and home-based physical exercise in patients newly diagnosed with multiple myeloma—a randomized controlled feasibility study

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Rikke Faebo Larsen ◽  
Mary Jarden ◽  
Lisbeth Rosenbek Minet ◽  
Ulf Christian Frølund ◽  
Niels Abildgaard
Keyword(s):  
Multiple Myeloma ◽  
Bone Disease ◽  
Exercise Intervention ◽  
Newly Diagnosed ◽  
Test Procedures ◽  
Physical Test ◽  
Randomized Controlled ◽  
Supervised Exercise ◽  
Home Based ◽  
Physical Tests

Abstract Background The study evaluated the feasibility and safety of the exercise intervention and physical test procedures of our ongoing randomized controlled trial, examining the effect of physical exercise in newly diagnosed patients with multiple myeloma. Methods Patients are randomized 1:1 to a control group (usual care) or an intervention group (usual care and exercise) by block randomization with stratification of planned treatment, WHO performance status, and study site. The exercise intervention consists of eight supervised exercise sessions combined with home-based exercise over a 10-week period. Bone disease is systematically evaluated to determine limitations regarding physical testing and/or exercise. Feasibility outcome measures were study eligibility, acceptance, and attrition, and furthermore attendance, adherence, tolerability, and safety to the exercise intervention. Additionally, test completion, pain, and adverse events during the physical test procedures were evaluated. Outcome assessors were blinded to allocation. Results Of 49 patients screened, 30 were included. The median age was 69 years, range 38–90, 77% were males, and 67% had bone disease. Study eligibility was 82%, acceptance 75%, and attrition 20%. Attendance at supervised exercise sessions was 92%, and adherence to supervised exercise sessions and home-based exercise sessions was 99% and 89%, respectively. No serious adverse events attributed to exercise or physical tests were reported. All patients completed the physical tests, except for two patients, where physical test procedures were modified due to bone disease. Discussion The exercise intervention and physical test procedures were feasible and safe in patients with multiple myeloma, even in older patients with multiple myeloma and in patients with myeloma bone disease. Trial registration ClinicalTrials.gov. ID NCT02439112. Registered on May 7, 2015.

Aerobic exercise intervention improves aerobic capacity and movement initiation in Parkinson's disease patients

2002 ◽  
Vol 17 (2) ◽  
pp. 161-168 ◽  
Author(s):  
John L. Bergen ◽  
Tonya Toole ◽  
Robert G. Elliott III ◽  
Brian Wallace ◽  
Keith Robinson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Aerobic Exercise ◽  
Aerobic Capacity ◽  
Exercise Intervention ◽  
Movement Initiation

Effect of exercise on sleep and bi-directional associations with accelerometer-assessed physical activity in men with obesity

2020 ◽  
Author(s):  
Tatiana Plekhanova ◽  
Alex V. Rowlands ◽  
Melanie Davies ◽  
Charlotte L. Edwardson ◽  
Andrew Hall ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sleep Quality ◽  
Aerobic Exercise ◽  
Sleep Duration ◽  
Exercise Intervention ◽  
Vigorous Physical Activity ◽  
Sleep Onset ◽  
Onset Time ◽  
Post Intervention

This study examined the effect of exercise training on sleep duration and quality and bidirectional day-to-day relationships between physical activity (PA) and sleep. Fourteen inactive men with obesity (49.2±7.9 years, BMI 34.9±2.8 kg/m²) completed a baseline visit, eight-week aerobic exercise intervention, and one-month post-intervention follow-up. PA and sleep were assessed continuously throughout the study duration using wrist-worn accelerometry. Generalised estimating equations (GEE) were used to examine associations between PA and sleep. Sleep duration increased from 5.2h at baseline to 6.6h during the intervention period and 6.5h at one-month post-intervention follow-up (p<0.001). Bi-directional associations showed that higher overall activity volume and moderate-to-vigorous physical activity (MVPA) were associated with earlier sleep onset time (p<0.05). Later timing of sleep onset was associated with lower overall volume of activity, most active continuous 30 minutes (M30CONT), and MVPA (p<0.05). Higher overall activity volume, M30CONT, and MVPA predicted more wake after sleep onset (WASO) (p<0.001), whereas greater WASO was associated with higher overall volume of activity, M30CONT, and MVPA (p<0.001). An aerobic exercise intervention increased usual sleep duration. Day-to-day, more PA predicted earlier sleep onset, but worse sleep quality and vice versa. Novelty: • Greater levels of physical activity in the day were associated with an earlier sleep onset time that night, whereas a later timing of sleep onset was associated with lower physical activity the next day in men with obesity • Higher physical activity levels were associated with worse sleep quality, and vice versa

scholarly journals Sex Moderates the Effect of Aerobic Exercise on Some Aspects of Cognition in Cognitively Intact Younger and Middle-Age Adults

2019 ◽  
Vol 8 (6) ◽  
pp. 886 ◽  
Author(s):  
Yaakov Stern ◽  
Seonjoo Lee ◽  
David Predovan ◽  
Richard P. Sloan
Keyword(s):  
Aerobic Exercise ◽  
Aerobic Capacity ◽  
Processing Speed ◽  
Exercise Intervention ◽  
Parallel Group ◽  
Normal Individuals ◽  
Exercise Effect ◽  
Underlying Mechanisms ◽  
Age Range ◽  
The Impact

We recently reported the results of a randomized, parallel-group, observer-masked, community-based clinical trial of 132 cognitively normal individuals aged 20–67 with below median aerobic capacity who were randomly assigned to one of two 6-month, four-times-weekly conditions: aerobic exercise and stretching/toning. We now assessed potential sex moderation on exercise-related changes in aerobic capacity, BMI and cognitive function. There was no sex moderation of the effect of aerobic exercise on aerobic capacity or BMI. We had previously reported an effect of aerobic exercise on executive function that was moderated by age. We found additional moderation by sex, such that in any age range men improved more than women. Processing speed showed significant sex moderation but not significant age moderation. In men, processing speed significantly improved by week 12 (b = 0.35, p = 0.0051), but the effect was diminished relative to week 12 at week 24 (b = 0.24, p = 0.0578). In women, there was no exercise effect at either time point (week 12: b = −0.06, p = 0.4156; week 24: b = −0.11, p = 0.1841). Men benefited cognitively more than women from aerobic exercise. This study highlights the importance of using sex-disaggregated analyses when assessing the impact of physical exercise intervention, and the need to ascertain the underlying mechanisms for differential cognitive benefit by sex.

An Innovative Home-based Aerobic Exercise Intervention Improves Endothelial Function in Overweight West Virginia Children

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S571
Author(s):  
Emily C. Murphy ◽  
David Donley ◽  
Linda Carson ◽  
Irma Ullrich ◽  
Justine Vosolo ◽  
...  
Keyword(s):  
West Virginia ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Exercise Intervention ◽  
Home Based

The effect of a home‐based exercise intervention on postnatal depression and fatigue: A randomized controlled trial

2014 ◽  
Vol 21 (5) ◽  
pp. 478-485 ◽  
Author(s):  
Fatemeh Mohammadi ◽  
Jamileh Malakooti ◽  
Jalil Babapoor ◽  
Sakineh Mohammad‐Alizadeh‐Charandabi
Keyword(s):  
Randomized Controlled Trial ◽  
Postnatal Depression ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Home Based

The Effects of Unsupervised Home-based Exercise Upon Functional Capacity After 6 Months of Discharge From Cardiac Rehabilitation: A Retrospective Observational Study

2016 ◽  
Vol 13 (11) ◽  
pp. 1230-1235 ◽  
Author(s):  
Juliana Pereira Borges ◽  
Mauro Felippe Felix Mediano ◽  
Paulo Farinatti ◽  
Marina Pereira Coelho ◽  
Pablo Marino Correa Nascimento ◽  
...  
Keyword(s):  
Observational Study ◽  
Cardiac Rehabilitation ◽  
Body Mass ◽  
Aerobic Capacity ◽  
Exercise Intervention ◽  
Retrospective Observational Study ◽  
Anthropometric Data ◽  
Maximal Aerobic Capacity ◽  
Home Based

Background:It remains unclear whether self-regulated exercise is sufficient to maintain the benefits acquired during formal cardiac rehabilitation (CR). This retrospective observational study investigated the effects of a home-based exercise intervention after discharge from CR upon anthropometric and aerobic capacity markers in clinically stable patients.Methods:Fifty patients with cardiovascular disease were discharged after 6 months of CR and encouraged to maintain aerobic exercise without supervision. Subsequent to 6 months of follow-up, patients were assigned to compliant (n = 34) or noncompliant (n = 16) groups according to their compliance to the home-based program. Maximal aerobic capacity (VO2peak) and anthropometric data were assessed before CR, at discharge, and after 6 months of follow-up.Results:No statistical differences between compliant and noncompliant groups were observed at baseline and at discharge from CR. At the end of the follow-up, statistical differences across groups were not found for body mass or body mass index, but increases in VO2peak (+3.6 vs. –0.6 ml/kg·min, P = 0.004) and oxygen pulse (+1.5 vs. +0.2 ml/bpm, P = .03) were greater in compliant than noncompliant group.Conclusions:Self-regulated exercising following CR discharge seems to be effective to maintain gains in exercise capacity acquired during supervised center-based programs.

scholarly journals PATHway-I: Feasibility, acceptability and clinical effectiveness of a technology enabled cardiac rehabilitation platform. A randomized controlled trial. (Preprint)

2019 ◽  
Author(s):  
Jomme Claes ◽  
Véronique Cornelissen ◽  
Clare McDermott ◽  
Niall Moyna ◽  
Nele Pattyn ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cardiac Rehabilitation ◽  
Clinical Effectiveness ◽  
Phase Iii ◽  
Convenience Sample ◽  
Randomized Controlled ◽  
Bonferroni Adjustment ◽  
Home Based ◽  
System Usability ◽  
Over Time

BACKGROUND Cardiac rehabilitation (CR) is highly effective as secondary prevention for cardiovascular diseases (CVD). Uptake of CR remains suboptimal (30% of eligible patients) and long-term adherence to a physically active (PA) lifestyle is even lower. Innovative strategies are needed to counteract this phenomenon. OBJECTIVE We developed the PATHway system (Physical Activity Towards Health) to provide a comprehensive, remotely monitored home-based CR program for CVD patients. The PATHway-I study aimed to investigate its feasibility and clinical efficacy during phase III CR. METHODS Participants were randomized on a 1:1 basis to the PATHway intervention group (PW) or usual care control group (UC) in a Single-blind, multicenter, randomized controlled pilot trial. Outcomes were assessed at completion of phase II CR and six months follow-up. The primary outcome was PA (Actigraph GT9X link). Secondary outcomes included measures of physical fitness, modifiable cardiovascular risk factors, endothelial function, intima-media thickness of the common carotid artery and quality of life. System usability and patients' experiences were evaluated only in PW. A mixed-model ANOVA with Bonferroni adjustment was used to analyze between-group effects over time. Missing values were handled by means of an intention-to-treat analysis. Statistical significance was set at a two-sided alpha level of 0.05. Data are reported as mean ± SD. RESULTS A convenience sample of 120 CVD patients (61.4 ± 13.5 years, 22 women) was included. The PATHway system was deployed in the homes of 60 participants. System use decreased over time and system usability was average with a score of 65.7 ± 19.7 (range 5-100). Moderate to vigorous intensity PA increased in PW (PW: 127 ± 58 min to 141 ± 69 min, UC: 146 ± 66 min to 143 ± 71 min; p-interaction=0.039), while diastolic blood pressure (PW: 79 ± 11 to 79 ± 10 mmHg, UC: 78 ± 9 to 83 ± 10 mmHg; p-interaction=0.004) and cardiovascular risk score remained constant, but deteriorated in UC (PW: 15.9 ± 10.4 to 15.5 ± 10.5%, UC: 14.5 ± 9.7 to 15.7 ± 10.9%; p-interaction=0.004). CONCLUSIONS This pilot study demonstrated the feasibility and acceptability of a technology-enabled, remotely monitored, home-based CR program. Although clinical effectiveness was demonstrated, several challenges were identified that could influence adoption of PATHway. CLINICALTRIAL This trial was registered at www.clinicaltrials.gov: NCT02717806

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