Baseline and change from baseline in tumor burden compared with patient outcomes

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e17530-e17530
Author(s):  
L. Kaiser ◽  
J. Fridlyand ◽  
G. Fyfe
Keyword(s):  
Patient Outcomes ◽  
Positive Relationship ◽  
Objective Response ◽  
Tumor Burden ◽  
Cox Models ◽  
Strong Positive Relationship ◽  
Oncology Clinical Trials ◽  
The Impact ◽  
The Relationship ◽  
Negative Predictor

e17530 Background: The impact of baseline tumor burden (bTB) and percentage reduction in tumor burden (dTB) on patient outcome has not been systematically studied in oncology clinical trials. We assess the relationship between both bTB and dTB and objective response (OR), progression free and overall survival (PFS and OS) in bevacizumab (B) and trastuzumab (T) trials. Methods: We analyzed 3 B and 1 T Ph 3 mBC and mCRC trials of > 1800 patients total. We used correlations and Cox models for the relationships between pairs of variables and multivariate Cox models to evaluate TB and PFS as independent predictors of OS. Here, we present the minimum dTB value until progression. Results: bTB is not related to dTB, OR rate or PFS time; it is negatively related to OS. dTB shows a strong positive relationship with PFS and OS. TB and PFS are independent predictors of OS, with PFS the better predictor. Results at earlier dTB assessments and within treatment arms are similar. Conclusions: Patients with high bTB are equally likely to respond to treatment and to have prolonged PFS as those with lower bTB, but high bTB is a negative predictor for OS. In contrast, greater percentage reductions in TB are strongly associated with better PFS and OS outcomes. Tumor burden and PFS are independent predictors of OS. Owing to these relationships, assessing bTB and dTB, as well as OR, PFS and OS, may improve the interpretation of phase II data. [Table: see text] [Table: see text]

scholarly journals Intraday Relationship Between Market Activity And Public Announcements

2011 ◽  
Vol 27 (3) ◽  
pp. 55
Author(s):  
Alexis Cellier ◽  
Waël Louhichi
Keyword(s):  
Stock Returns ◽  
Information Flow ◽  
Trading Volume ◽  
Positive Relationship ◽  
Public Information ◽  
Positive Relation ◽  
Market Activity ◽  
Strong Positive Relationship ◽  
The Impact ◽  
The Relationship

<span>This paper aims to study the relationship between public information arrival and Euronext Paris intraday activity. The information flow is measured as the number of news items recorded by Reuters and conditional volatility is modeled by an EGARCH process. Our results reveal a strong positive relationship between public information flow and trading volume and a moderate positive relation between stock returns volatility and the information flow. These results are available for the CAC40 Index as well as for individual stocks and are robust even after controlling for the impact of the intraday patterns.</span>

scholarly journals The impact of the entrepreneurial orientation on SMES performance: Evidence from Mexican agribusiness

2017 ◽  
Vol 7 (4) ◽  
pp. 6-13
Author(s):  
María del Carmen Martínez Serna ◽  
Javier Eduardo Vega Martínez ◽  
Neftalí Párga Párga Montoya
Keyword(s):  
Entrepreneurial Orientation ◽  
Business Performance ◽  
Positive Relationship ◽  
Structural Equations ◽  
Strong Positive Relationship ◽  
Evolution Of Technology ◽  
The Subject ◽  
The Impact ◽  
The Relationship

The issue of agribusiness represents at the present a challenge for management due to the evolution of technology, the market and particularly the changing needs of consumers. Entrepreneurial orientation is a strategy that positively influences the performance of business, however in the study of this relationship, the results are still inconsistent since a group of scholars in the subject noted that the strength of the relationship changes according to the context is empirically evaluated. The study contributes to evaluate the strength of the relation of entrepreneurial orientation and business performance in the context of 81 small and medium agribusinesses of Aguascalientes, México. The data are analyzed by structural equations and the results indicate that entrepreneurial orientation has a strong positive relationship in the performance of agribusiness.

scholarly journals The Relationship between Personality Five Factor Theory and the Career Success of Executive Workers in Apparel Sector Organizations in Sabaragamuwa Province Sri Lanka

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
SH Dias ◽  
P Jayasekara
Keyword(s):  
Sri Lanka ◽  
Career Success ◽  
Positive Relationship ◽  
Negative Relationship ◽  
Process Models ◽  
Future Research ◽  
Work Related ◽  
Strong Positive Relationship ◽  
The Impact ◽  
The Relationship

Area of the Study As a significant determinant of career success of employee, this study is discussing the relationship between Personality Five Factor theory and the Career Success of executive workers in the apparel sector organizations in Sabaragamuwa province Sri Lanka.Problem of the Study There is an empirical knowledge gap in the context of the impact of personality five factor theory on the career success of employees in Sri Lanka. therefore, the problem of the study is: Does Five Factor Theory of personality affect to the career success of executives in the apparel sector organization in Sabaragamuwa province.Method of the study The data were collected from a selected sample of 122 executives in the apparel industry in Sabaragamuwa province Sri Lanka by administrating a structured questionnaire, which consisted of 63 questions/ statements with 5 points scale. The data analyses included the univariate and bivariate analyses.Findings of the Study The authors found that some of the factors have strong positive relationship and some have negative relationship and some haven’t any relationship with career success of executives in apparel sector organizations in Sabaragamuwa province, Sri Lanka. Extraversion and Conscientiousness have strong positive relationship with career success of the executives and Agreeableness and Neuroticism have negative relationship with the executives of the apparel sector organizations. However, there is no any relationship in Openness to experience with career success of the executives.Conclusion of the Study Future research based on the current theoretical model can investigate the relationship of personality with other work related behaviors and outcomes. The empirical confirmation of this conceptual model is another area of future research. Future research should attempt to replicate these results and develop process models that may explain why conscientiousness and Extraversion have such apparently enduring associations with career success.Keywords: Personality Five Factors, Career Success, Executives, Apparel Sector Organizations

INTERCONNECTION OF SUSTAINABLE DEVELOPMENT COMPONENTS FOR THE INDIGENOUS PEOPLES OF THE NORTH

2020 ◽  
Vol 2 (8) ◽  
pp. 101-110
Author(s):  
N. N. ILYSHEVA ◽  
◽  
E. V. KARANINA ◽  
G. P. LEDKOV ◽  
E. V. BALDESKU ◽  
...  
Keyword(s):  
Climate Change ◽  
Sustainable Development ◽  
Economic Development ◽  
Indigenous Peoples ◽  
Ecological Footprint ◽  
Positive Relationship ◽  
The North ◽  
Strong Positive Relationship ◽  
The Face ◽  
The Relationship

The article deals with the problem of achieving sustainable development. The purpose of this study is to reveal the relationship between the components of sustainable development, taking into account the involvement of indigenous peoples in nature conservation. Climate change makes achieving sustainable development more difficult. Indigenous peoples are the first to feel the effects of climate change and play an important role in the environmental monitoring of their places of residence. The natural environment is the basis of life for indigenous peoples, and biological resources are the main source of food security. In the future, the importance of bioresources will increase, which is why economic development cannot be considered independently. It is assumed that the components of resilience are interrelated and influence each other. To identify this relationship, a model for the correlation of sustainable development components was developed. The model is based on the methods of correlation analysis and allows to determine the tightness of the relationship between economic development and its ecological footprint in the face of climate change. The correlation model was tested on the statistical materials of state reports on the environmental situation in the Khanty-Mansiysk Autonomous Okrug – Yugra. The approbation revealed a strong positive relationship between two components of sustainable development of the region: economy and ecology.

Career Plateau and Turnover Intention in Chinese Employees: Career Anchor as Moderator

2015 ◽  
Vol 43 (5) ◽  
pp. 757-766 ◽  
Author(s):  
Yueran Wen ◽  
Liu Liu
Keyword(s):  
Turnover Intention ◽  
Positive Relationship ◽  
Management Practices ◽  
Career Anchor ◽  
Career Plateau ◽  
Strong Positive Relationship ◽  
High Level ◽  
The Relationship ◽  
Moderating Role

Based on a survey of 147 Chinese employees, we examined the relationship between perceived career plateau and turnover intention, and the moderating role of career anchor in challenge in this process. We hypothesized that perceived career plateau would be positively related to turnover intention, and that this relationship would be stronger in employees with a higher level of career anchor in challenge than in those with a lower level. The results showed that perceived career plateau had a strong positive relationship with turnover intention, especially in employees with a high level of career anchor in challenge. These findings have implications for research in career development and turnover intention, as well as in management practices.

scholarly journals HUBUNGAN DISPOSISI MATEMATIS DAN SELF-EFFICACY MAHASISWA

2021 ◽  
Vol 10 (1) ◽  
pp. 117
Author(s):  
Wanda Tri Utami ◽  
Ali Mustadi ◽  
Marsigit Marsigit ◽  
Ibrahim Ibrahim
Keyword(s):  
Data Analysis ◽  
Self Efficacy ◽  
Positive Relationship ◽  
Questionnaire Data ◽  
Public And Private ◽  
Spearman's Rho ◽  
Strong Positive Relationship ◽  
Spearman’S Rho ◽  
Quantitative Descriptive ◽  
The Relationship

The writing of this article is a survey research with the aim of knowing the relationship between mathematical disposition and self-efficacy of PGSD/ PGMI students in universities throughout Indonesia. This study used a total of 37 public and private universities with 357 students using questionnaire data collection techniques. The data obtained were analyzed using quantitative descriptive. In addition, data analysis used Spearman's Rho. The results explained that the mathematical disposition with self-efficacy of PGSD / PGMI students in Indonesia based on the average questionnaire filling reached a correlation coefficient of 0.612 which was included in the very strong category. Sig. Value (2-tailed) obtained 0,000 which is smaller than 0.01 which means that there is a significant relationship between mathematical disposition variables and self-efficacy. This caused a strong positive relationship between mathematical disposition and student self-efficacy. AbstrakPenulisan artikel ini merupakan penelitian survei dengan tujuan mengetahui hubungan disposisi matematis dan self-efficacy mahasiswa PGSD/PGMI yang berada di Universitas se-Indonesia. Penelitian ini menggunakan subjek yang berjumlah 37 universitas negeri dan swasta dengan 357 mahasiswa dengan tekhnik pengumpulan data penyebaran angket. Data yang diperoleh dianalisis menggunakan deskriptif kuantitatif. Selain itu, analisis data menggunakan Spearman’s Rho. Hasil penelitian menjelaskan bahwa disposisi matematis dengan self-efficacy mahasiswa PGSD/PGMI yang berada di Indonesia berdasarkan rata-rata pengisian angket mencapai koefisien korelasi 0.612 yang termasuk dalam kategori sangat kuat. Nilai Sig. (2-tailed) didapat 0.000 yang lebih kecil dari 0.01 yang memiliki makna bahwa terdapat hubungan signifikan antara variabel disposisi matematis dengan self-efficacy. Hal tersebut menyebabkan hubungan positif yang kuat antara disposisi matematis dengan self-efficacy mahasiswa. 

scholarly journals The Impact of Organizational Learning Capability on Product Innovation Performance: Evidence from the Turkish Manufacturing Sector

2016 ◽  
Vol 6 (1) ◽  
pp. 70-84 ◽  
Author(s):  
Özlem Yaşar Uğurlu ◽  
Mustafa Kurt
Keyword(s):  
Organizational Learning ◽  
Empirical Data ◽  
Product Innovation ◽  
Positive Relationship ◽  
Manufacturing Sector ◽  
Innovation Performance ◽  
Learning Capability ◽  
The Impact ◽  
The Relationship

This study aims to examine the effect of organizational learning capability on product innovation performance in the manufacturing sector using empirical data. A survey was conducted with 120 firms that were on the list of Top 1000 Firms of Turkey and registered with the Istanbul Chamber of Industry, to examine the relationship between the dimensions of organizational learning capability and the dimensions of product innovation performance. The findings of the study indicate a positive relationship between organizational learning capability and product innovation performance.

Abstract P274: Relationship Between Stroke Quality Metrics and Patient Outcomes: A Systematic Review

2011 ◽  
Vol 4 (suppl_2) ◽  
Author(s):  
Carol J Parker ◽  
Mathew J Reeves
Keyword(s):  
Systematic Review ◽  
Acute Care ◽  
Patient Outcomes ◽  
Stroke Care ◽  
Evidence Base ◽  
Quality Metrics ◽  
Care Quality ◽  
Stroke Recurrence ◽  
The Impact ◽  
The Relationship

Background: Stroke quality metrics play an increasingly important role in quality improvement efforts and policies, but the relationship between quality metrics and patient-orientated outcomes are not well described. We conducted a systematic review of observational hospital-based studies examining this relationship. Methods: We searched MEDLINE and EMBASE for studies published before December 31, 2010 that examined the relationship between 2 or more stroke quality metrics and patient-oriented outcomes in acute stroke admissions. Outcomes included mortality, length of stay, discharge to home, functional status, and stroke recurrence. Results: A total of 470 hits were identified. After screening the titles and abstracts, 27 studies underwent full review, and 14 were deemed eligible. Given the variation in study characteristics, quality metrics, and outcomes utilized, it was not possible to generate summary estimates describing the relationship between quality metric compliance and patient-oriented outcomes. Evidence of a positive relationship between quality metrics and improved patient outcomes was limited by the lack of high quality studies. Four of the 14 studies found a statistically significant relationship between increased compliance with acute care quality metrics and improved patient-oriented outcomes. Two studies failed to find an association between acute care measures and improved outcomes, but did find statistically significant positive relationships between compliance with post-acute rehabilitation measures and improved patient outcomes. Five other studies reported mixed findings, while the remaining three found no relationships. Conclusions: We found a limited evidence-base addressing the impact of compliance on stroke quality metrics and patient-oriented outcomes. Generation of data clarifying the relationship between compliance with stroke quality metrics and stroke-related outcomes should be prioritized so that the current investments undertaken to improve stroke care can be sustained.

Emotional brand attachment: a factor in customer-bank relationships

2016 ◽  
Vol 34 (2) ◽  
pp. 136-150 ◽  
Author(s):  
Shalom Levy ◽  
Hayiel Hino
Keyword(s):  
Factor Analysis ◽  
Conceptual Framework ◽  
Structural Equation ◽  
Positive Relationship ◽  
Service Providers ◽  
Equation Modeling ◽  
Emotional Attachment ◽  
Content Type ◽  
The Impact ◽  
The Relationship

Purpose – The purpose of this paper is to evaluate the relationship between customers’ emotional attachment toward bank service providers and bank loyalty. In particular, the study examines the impact of the emotional attachment factor while treating established effecting variables by employing a new conceptual framework that integrates these variables. Design/methodology/approach – The study employs data collected from a survey involving 436 participants. The study employs Exploratory Factor Analysis and Confirmatory Factor Analysis methods following a path analysis method and structural equation modeling for testing research hypotheses. Findings – The empirical results support the claim that the conceptual framework applied in this study better explains the relationship between customers’ emotional attachment toward bank service providers and bank loyalty. Specifically, the findings show a significant, direct and positive relationship between the customer’s emotional attachment and bank loyalty; an indirect positive relationship also exists through the connection of customer satisfaction. The study distinguishes between two integrated pathways consumers possibly follow when making decisions about services: the conscious decision-making process path and the emotional process path. Practical implications – The paper provides managerial and planning implications to bank service providers who seek to achieve excellent performance and a positive brand personality, thus maintaining long-lasting relationships with their customers. Originality/value – The study is among the few empirical works to specifically examine the impact of customers’ emotional attachment on bank loyalty and contributes to the available literature in that it suggests a systematic conceptual framework that evaluates the impact of key factors on bank loyalty.

Who Takes the Floor and Why

2011 ◽  
Vol 56 (4) ◽  
pp. 622-641 ◽  
Author(s):  
Victoria L. Brescoll
Keyword(s):  
Positive Relationship ◽  
Past Research ◽  
Data Sets ◽  
Negative Consequences ◽  
Experimental Setting ◽  
Mediation Analyses ◽  
Strong Positive Relationship ◽  
And Gender ◽  
The Relationship ◽  
Positive Effect

Although past research has noted the importance of both power and gender for understanding volubility—the total amount of time spent talking—in organizations, to date, identifying the unique contributions of power and gender to volubility has been somewhat elusive. Using both naturalistic data sets and experiments, the present studies indicate that while power has a strong, positive effect on volubility for men, no such effect exists for women. Study 1 uses archival data to examine the relationship between the relative power of United States senators and their talking behavior on the Senate floor. Results indicate a strong positive relationship between power and volubility for male senators, but a non-significant relationship for female senators. Study 2 replicates this effect in an experimental setting by priming the concept of power and shows that though men primed with power talk more, women show no effect of power on volubility. Mediation analyses indicate that this difference is explained by women’s concern that being highly voluble will result in negative consequences (i.e., backlash). Study 3 shows that powerful women are in fact correct in assuming that they will incur backlash as a result of talking more than others—an effect that is observed among both male and female perceivers. Implications for the literatures on volubility, power, and previous studies of backlash are discussed.

Sign in / Sign up

Export Citation Format

Share Document