Rate of depressive episode in Peruvian oncologic outpatients.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e12043-e12043
Author(s):  
Luis Furuya ◽  
Erick Infanzon ◽  
Diego Venegas
Keyword(s):  
Breast Cancer ◽  
Depressive Episode ◽  
Financial Status ◽  
The Poor ◽  
Epidemiological Features ◽  
Two Factors ◽  
Icd 10 ◽  
The Mean ◽  
The Relationship ◽  
Transversal Study

e12043 Background: Depression in Lima, Peru has a prevalence rate of 6.7% and lifetime prevalence of 19%. The relationship between depression and cancer has been widely studied, affects approximately 15% to 25% of cancer patients. However, there is little research in latin population. We report the results of evaluate the frequency of depressive disorder in Peruvian oncologic outpatients and describe clinical and epidemiological features Methods: A descriptive transversal study was performed to 70 patients that attended to oncology clinic at the Hospital Nacional Cayetano Heredia. Data was collected through a survey that included a clinical demographic record and the spanish version – ICD 10 of the Mini International Neuropsychiatric Interview for the diagnosis of depressive episode. Results: The 52% of the participants were females. The mean age was 57 years (18- 83 y) Breast cancer (21%) and lymphoma non Hodgkin (21%) were the most common types of cancer. The mean period from diagnosis was 5 month. The frequency of depressive episode was 21.4%. The 33.3% of women with breast cancer had depression, while patients with NHL had only 13.3% of frequency. We founded two factors with statistically significant association: poor financial status (p =0.041) and advance clinical stages (III and IV) (p = 0.026; OR: 6.8) Conclusions: The frequency of depressive episode was similar to other reports in the literature, the poor financial status and advanced stage are most associated with depression in our population

The role of MRI in predicting Ki-67 in breast cancer: preliminary results from a prospective study

2018 ◽  
Vol 104 (6) ◽  
pp. 438-443 ◽  
Author(s):  
Corrado Caiazzo ◽  
Rosa Di Micco ◽  
Emanuela Esposito ◽  
Viviana Sollazzo ◽  
Maria Cervotti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Mri ◽  
Cancer Prognosis ◽  
Time Signal ◽  
Local Health ◽  
Ki 67 ◽  
Contrast Enhanced ◽  
Response To Chemotherapy ◽  
The Mean ◽  
The Relationship

Purpose: In the last decade contrast-enhanced magnetic resonance imaging (MRI) has gained a growing role as a complementary tool for breast cancer diagnosis. Currently the relationship between the kinetic features of a breast lesion and pathologic prognostic factors has become a popular field of research. Our aim is to verify whether breast MRI could be considered a useful tool to predict Ki-67 score, thus resulting as a breast cancer prognosis indicator. Methods: From June to December 2014, we enrolled patients with breast cancer who underwent preoperative dynamic contrast-enhanced MRI at the local health agency. We analyzed the time-signal intensity curves calculating the mean values of the following parameters: the basal enhancement (Ebase), the enhancement ratio (ENHratio), the maximum enhancement (Emax), and the steepest slope of the contrast enhancement curve (Smax). Scatterplots and Pearson correlation test were used to investigate the eventual associations among these parameters. Results: A total of 27 patients underwent breast MRI during the study period. The mean ± SD Ki-67 percentage was 27.03 ± 16.8; the mean Emax, Smax, Ebase, and ENHratio were 433.9 ± 120.2, 267.3 ± 96.8, 165.5 ± 77.1, and 187.1 ± 94.8, respectively. Scatterplots suggest a positive correlation between Ki-67 and both Emax and Smax. The correlation tests between Ki-67 and Emax, Ki-67 and Smax showed statistical significance. Conclusions: Our preliminary data suggest that enhancement pattern is closely linked to breast cancer proliferation, thus proving the relationship between more proliferating tumors and more rapidly enhanced lesions. This is hypothesis-generating for further studies aimed at promoting breast MRI in the early estimation of cancer prognosis and tumor in vivo response to chemotherapy.

316 Comorbidities among medically diagnosed insomnia patients: A MarketScan database study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A127-A127
Author(s):  
Wenjun Zhong ◽  
Xinyue Liu ◽  
Katrina Mott ◽  
Zaina Qureshi
Keyword(s):  
Claims Data ◽  
Skin Diseases ◽  
Database Analysis ◽  
High Frequencies ◽  
Diagnosis Codes ◽  
Icd 10 ◽  
Physical Disorders ◽  
The Common ◽  
The Mean ◽  
The Relationship

Abstract Introduction A large proportion of patients with insomnia frequently suffer from comorbid medical conditions. Literature on the relationship between insomnia and associated comorbidities is severely limited due to challenges of generalizability, focus on a specific comorbidity and concerns of information biases. We conducted a comprehensive secondary database analysis to describe comorbidities among medically diagnosed insomnia patients. Methods All patients in the MarketScan database in 2018 with a full year of enrollment were included. Insomnia patients were identified using ICD-10-CM diagnosis codes (at least 2 outpatient claims or 1 inpatient claim of insomnia in 2018), along with their comorbidities recorded in that year. The frequencies of comorbidities among patients with insomnia were estimated. For comorbidities with prevalence > 1%, we further grouped them when appropriate to reduce the number of comorbidities. Results Among 20,209,292 enrollees, 259,035 (1.3%) had insomnia in 2018. Patients with insomnia had a median of 2 (IQR: 1–3) insomnia claims. The mean age of these insomnia patients was 49.3 years (std: 15.7), most of them were female (62.5%). About 172 comorbidities with >1% were found in this patient population, and 35 comorbidities had a frequency greater than 10%. The common comorbidities among these insomnia patients included 1): common physical disorders among middle aged and older adults: hyperlipidemia (39%), hypertension (39%), skin diseases (37%), back pain 35%; 2):common mental health disorders such as anxiety disorder (41%), depression (28%); and 3): other diseases such as GERD and thyroid diseases also had high frequencies among insomnia patients (18% and 18.7%, respectively). Conclusion Using claims data, we provided a quantitative assessment of comorbidities among patients with medically diagnosed insomnia. These results could help clinicians become aware of the most frequently occurring comorbidities and assist in integrating management of the insomnia. Support (if any):

The relationship between hormone receptor content and the effect of adjuvant tamoxifen in operable breast cancer.

1989 ◽  
Vol 7 (10) ◽  
pp. 1474-1484 ◽  
Author(s):  
L E Rutqvist ◽  
B Cedermark ◽  
T Fornander ◽  
U Glas ◽  
H Johansson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Postoperative Radiotherapy ◽  
Adjuvant Tamoxifen ◽  
Free Survival ◽  
Survival Difference ◽  
Er Positive ◽  
The Mean ◽  
The Relationship

The relationship between hormone receptor status and the effect of adjuvant tamoxifen in early breast cancer remains controversial. This article presents the results of a randomized trial of adjuvant tamoxifen (40 mg daily for 2 years) versus no adjuvant endocrine therapy in postmenopausal patients. During 1976 to 1984, 1,407 patients were included in the study. Of these, 427 (30%) had high-risk tumors (pN + or pT greater than 30 mm) and were included in a concurrent randomized comparison of postoperative radiotherapy versus adjuvant polychemotherapy. The mean follow-up time was 61/2 years. Tamoxifen improved the recurrence-free survival (RFS) (P less than .01), but the overall survival difference in favor of the tamoxifen-allocated patients was not significant. Data on estrogen (ER) and progesterone receptor (PgR) content were available in 750 patients. Their mean follow-up time was 41/2 years. The effect of tamoxifen was significantly related to ER level (P less than .01). No benefit with tamoxifen was observed among ER-negative patients. The relation to PgR level was of borderline significance (P = .06). Multivariate analysis indicated that most of the interaction between treatment and receptor content was explained by the interaction with ER (P less than .01). The PgR status appeared to modify the effect of tamoxifen among the ER-positive patients and the greatest effect was observed among patients who were positive for both receptors. However, the additional predictive information provided by the PgR assay did not help to identify an unresponsive subgroup of patients.

scholarly journals Prevalence of Comorbidity and Impact On Survival in Women with Lung, Breast and Cervical Cancer

2021 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Breast Cancer ◽  
Cervical Cancer ◽  
Cox Regression ◽  
The Elderly ◽  
Breast And Cervical Cancer ◽  
Incidence And Mortality ◽  
Impact On Survival ◽  
Icd 10 ◽  
Comorbidity Index ◽  
The Relationship

Background: The relationship between cancer incidence and mortality, and the resulting comorbidities of the elderly reflects current demographics trends Objective: The study aimed to investigate the prevalence of comorbidities and their impact on survival of women diagnosed with: NSCLC, breast and cervical cancer, at the National Institute of Oncology and Radiobiology in Havana, Cuba. Methods: Data were collected retrospectively from patients' clinical charts. The study involved 138 NSCLC, 1 598 breast cancer and 631 cervical cancer registered during 2007-2011. Comorbidity was classified according to the ICD-10 diagnosis code and was measured using Charlson Comorbidity Index. Associations between comorbidities and mortality by all causes were analyzed in Cox regression models. Results: The highest prevalence of comorbidities was in NSCLC (68.8%). The 3-year OS for NSCLC were 44.5% (95%CI: 29.3–59.7) and 23.3% (95%CI: 13.2–33.4) in patients without and with comorbidity, respectively (p=.01). The 5-year OS for breast cancer in the no comorbidity group was 91.4% (95%CI: 89.6–91.6) compared with 37.2% (95%CI: 32.7-59.9) in the comorbodity group (p=.00). The 5-year OS for cervical cancer in patients without diseases was (55.8% [95%CI: 50.7 – 59.9]), in women with comorbidity (27.7% [95%CI: 15.9–29.5]) (p =.00). Comorbidity was an independent predictor for overall survival: NSCL (HR Adjusted: 2.28 [95%CI: 1.43 - 3.65], p=.000), breast cancer (HR Adjusted: 3.16 [95%CI: 2.69–3.71], p=.000), cervical cancer (HR Adjusted: 1.38 [95%CI: 1.10–1.86], p=.032) Conclusions: Comorbidity is an important prognostic factor for women diagnosed with lung, breast and cervical cancer

scholarly journals The Relationship Between Hope and Received Information About Cancer Among Women with Breast Cancer: A Descriptive-Correlational Study

2021 ◽  
Vol 14 (8) ◽  
Author(s):  
Maryam Ehsani ◽  
Mansoureh Ashghali Farahani ◽  
Shima Haghani ◽  
Fateme Negari
Keyword(s):  
Breast Cancer ◽  
Educational Level ◽  
Healthcare Providers ◽  
European Organization ◽  
Eastern Culture ◽  
Care Plans ◽  
The Mean ◽  
The Individual ◽  
Eortc Qlq ◽  
The Relationship

Background: In Western culture, information about different aspects of cancer is directly provided to the individual, but in Eastern culture, health professionals and families do not prefer to inform the patient from diagnosis, treatment, test results, causes of the disease, and the effect of treatment on sexual intercourse in front of patients in order to maintain their hope. Objectives: This study aimed at investigating the relationship between hope and received information about cancer (RIAC) among patients with breast cancer. Methods: Using a descriptive-correlational design, this study was conducted from July to December 2019 on 200. Patients with breast cancer were consecutively recruited from 2 hospitals affiliated with the Iran University of Medical Sciences, Tehran, Iran. The participants completed a demographic and clinical characteristics questionnaire, the European Organization of Research and Treatment of Cancer Quality of Life Information module (EORTC QLQ-INFO25), and the Herth hope index. Results: The response rate was 100% and participants’ mean age was 49.0 ± 10.33. The mean scores of participants’ RIAC and hope were 40.17 ± 11.52 (in the possible range of 0 - 100) and 36.77 ± 4.61 (in the possible range of 12 - 48), respectively. The mean score of hope had significant positive relationships with the mean score of RIAC (r = 0.305; P < 0.001), and educational level (P = 0.004). Moreover, the mean score of RIAC had a significant positive relationship with educational level (0.049). Conclusions: Greater RIAC is associated with greater hope among patients with breast cancer. Therefore, healthcare providers need to establish effective communication with these patients and provide them with necessary education and information in order to promote their engagement in care plans, improve their self-efficacy, and boost their hope.

scholarly journals Factors affecting the voluntary intake of food by cows

1966 ◽  
Vol 20 (2) ◽  
pp. 229-244 ◽  
Author(s):  
R. C. Campling ◽  
M. Freer
Keyword(s):  
Dry Matter ◽  
Alimentary Tract ◽  
Crude Fibre ◽  
Factors Affecting ◽  
The Poor ◽  
Food Digestibility ◽  
Oat Straw ◽  
The Mean ◽  
Voluntary Intake ◽  
The Relationship

1. Two experiments were conducted to examine the effect of grinding and pelleting roughages on the voluntary intake of food, digestibility, time of retention of food in the digestive tract, amounts of digesta in the recitulo-rumen and eating and ruminating behaviour of adult, non-lactating, non-pregnant cows. The first experiment was with artificially dried grass and the second with oat straw; also, with a diet of ground, pelleted oat straw the effect was studied of giving a daily intraruminal infusion of 150 g urea. The size of the particles of the ground roughages are given. 2. The mean voluntary intakes of long and ground dried grass were similar, the voluntary intake of ground, pelleted oat straw was 26% greater than that of long straw and the daily infusion of urea increased the voluntary intake of ground, pelleted oat straw by 53%. 3. The digestibility of the ground roughages was lower than that of the long roughages, the lower digestibility of the ground roughages was due mainly to the poor digestibility of crude fibre in the reticulo-rumen. The rate of disappearance of cotton thread placed in the ventral sac of the rumen was slower with ground than with long roughages. 4. The mean times of retention of ground roughages were shorter than those of long roughages when equal and restricted amounts of each food were given; with food offered ad lib. there was little difference between the mean times of retention of long and ground roughages in the alimentary tract. 5. On average, the mean amounts of digesta dry matter in the reticulo-rumen immediately after a meal were about the same with long and ground dried grass, with long and ground oat straw the amounts of dry matter were similar, but when the intraruminal infusion of urea was given the amount of dry matter increased by 49%. 6. The rate of eating (min/kg food) ground, pelleted roughages was much faster than that with long roughages; when the cows received ground roughage rumination did not occur but during short periods triple reticular contractions were seen. 7. The relationship between the voluntary intake of food, the amount of digesta in the reticulo-rumen and the rate of disappearance of digesta from the alimentary tract is discussed.

scholarly journals Hubungan Kadar Cancer Antigen 15-3 Serum dengan Metastasis Kanker Payudara

2021 ◽  
Vol 1 (3) ◽  
pp. 371-378
Author(s):  
Fakhriyyatur Rahmi M ◽  
Rikarni Rikarni ◽  
Nora Harminarti
Keyword(s):  
Breast Cancer ◽  
Distant Metastasis ◽  
Sampling Technique ◽  
Total Sample ◽  
Test Results ◽  
Cross Sectional ◽  
Over Expression ◽  
The Mean ◽  
Cross Sectional Design ◽  
The Relationship

Background: CA 15-3 serum is one of the tumor marker that has been recommended by American Soviety of Clinical Oncology to show the response of the therapy, prognosis and metastasis of the breast cancer.  CA 15-3 serum is a mucin that will be expressed by breast cancer cell. The over expression of CA 15-3 serum can be occurred if the cell progressivity is increase. Several studies have shown that CA 15-3 serum is increasing in metastasis breast cancer. Objective: This study aimed to determine the relationship between the CA 15-3 serum with metastasis breast cancer. Methods: This study used a cross sectional design in breast cancer patient at Dr. M Djamil Hospital. Sampling using consequtive sampling technique with a total sample of 46 people. Data was analyzed by using Mann-Whitney test. Results: Distant metastasis of Breast cancer was more common in age group of 40-60 years (65,21%) and  86,96% had shown a lymphatic metastasis. The mean of CA 15-3 serum was higher in the group with distant metastasis 385,0439 U/mL compared to group without distant metastasis. Distant metastasis was more common in single state metastasis (69,6%) with the mean 472,24 U/mL. Common targeting organ of  the distant metastasis was lung (69,9%). The highest mean of CA 15-3 serum was in pleura 557,2 U/mL. Conclusion: There was a statistically significant relationship between the mean of CA 15-3 serum with metastasis breast cancer (p=0.000).

Multi-Center Calibration of the Second Reference Material for Thromboplastin, Rabbit, Plain, Coded CRM 149R

1991 ◽  
Vol 65 (03) ◽  
pp. 263-267 ◽  
Author(s):  
A M H P van den Besselaar ◽  
R M Bertina
Keyword(s):  
Reference Material ◽  
Standard Error ◽  
Standard Errors ◽  
Sensitivity Index ◽  
Long Term Stability ◽  
Significant Bias ◽  
The Mean ◽  
The Relationship ◽  
International Sensitivity Index

SummaryIn a collaborative trial of eleven laboratories which was performed mainly within the framework of the European Community Bureau of Reference (BCR), a second reference material for thromboplastin, rabbit, plain, was calibrated against its predecessor RBT/79. This second reference material (coded CRM 149R) has a mean International Sensitivity Index (ISI) of 1.343 with a standard error of the mean of 0.035. The standard error of the ISI was determined by combination of the standard errors of the ISI of RBT/79 and the slope of the calibration line in this trial.The BCR reference material for thromboplastin, human, plain (coded BCT/099) was also included in this trial for assessment of the long-term stability of the relationship with RBT/79. The results indicated that this relationship has not changed over a period of 8 years. The interlaboratory variation of the slope of the relationship between CRM 149R and RBT/79 was significantly lower than the variation of the slope of the relationship between BCT/099 and RBT/79. In addition to the manual technique, a semi-automatic coagulometer according to Schnitger & Gross was used to determine prothrombin times with CRM 149R. The mean ISI of CRM 149R was not affected by replacement of the manual technique by this particular coagulometer.Two lyophilized plasmas were included in this trial. The mean slope of relationship between RBT/79 and CRM 149R based on the two lyophilized plasmas was the same as the corresponding slope based on fresh plasmas. Tlowever, the mean slope of relationship between RBT/79 and BCT/099 based on the two lyophilized plasmas was 4.9% higher than the mean slope based on fresh plasmas. Thus, the use of these lyophilized plasmas induced a small but significant bias in the slope of relationship between these thromboplastins of different species.

Harmonic scalpel versus traditional ligation in axillary dissection for breast cancer: a retrospective multivariate analysis

2020 ◽  
Vol 99 (11) ◽  
Keyword(s):  
Breast Cancer ◽  
Axillary Dissection ◽  
Harmonic Scalpel ◽  
Breast Conserving Surgery ◽  
Seroma Formation ◽  
Nodal Involvement ◽  
Single Centre ◽  
Absorbable Material ◽  
Drain Removal ◽  
The Mean

Introduction: The aim of this pilot retrospective study is to evaluate the complication rate in patients after axillary dissection comparing preparation with harmonic scalpel vs traditional ligation technique, and to analyse risk factors for complications occurrence. Methods: 144 patients with 148 axillary dissections operated in a single centre between January 2014 and 2019 were included into the study. Axillary dissection was performed using harmonic scalpel in 73 and absorbable ligations in 70 cases. Results: Seroma formation was observed in 41 patients (56.2%) in the harmonic scalpel group and in 21 patients (30.0%) in the ligations group (p=0.003). The mean period from the surgery to drain removal was 4.0 days in the harmonic scalpel group and 3.0 days in the ligations group (p<0.001). The mean amount of the drained fluid after mastectomy was 300.9 ml in the harmonic scalpel group and 168.7 ml in the ligations group (p=0.005); after breast conserving surgery, it was 241.9 ml and 107.4 ml, respectively (p =0.023). Conclusion: In comparison with traditional ligations with absorbable material, axillary dissection using harmonic scalpel significantly increases the risk of postoperative seroma formation, prolongs the time from the surgery to drain removal, and increases the amount of drained fluid.ut any suspicion of nodal involvement, hemithyroidectomy is considered to be a sufficient procedure or the method of choice, respectively.

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