CNS involvement by North American-ATLL (NA-ATLL) is associated with discrete patterns and molecular profile involving XPO1 E571 and KLF2/PI3KCD in selected cases.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 8063-8063
Author(s):  
Nishi Shah ◽  
Riya Jayesh Patel ◽  
Astha Thakkar ◽  
Shafia Rahman ◽  
Ana Acuna-Villaorduna ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
Tertiary Hospital ◽  
Background Information ◽  
Molecular Profile ◽  
Cns Involvement ◽  
Neurological Exam ◽  
First Time ◽  
The Brain ◽  
Cell Malignancy

8063 Background: Information on central nervous system (CNS) involvement with NA-ATLL is limited. In this study, we describe CNS involvement in ATLL patients at a tertiary hospital in New York City. Methods: We considered CNS involvement if one of the following criteria was met 1) cerebrospinal fluid (CSF) cytology or flow cytometry was positive 2) CNS imaging was positive for disease involvement or 3) Physical exam findings were compatible with neurologic involvement. Results: Of 94 NA-ATLL patients, 21 (22.3%) had CNS involvement by ATLL. CSF was involved in 13/21 and 5/21 patients at diagnosis and relapse respectively. At diagnosis, MRI showed CNS involvement in brain and spine in 5/21 (24%) and 3/ 21 (14%) cases respectively. At relapse, imaging revealed brain and spine involvement in 2 patients each. Neurological exam was abnormal in 7 (33%) and 3 (14%) cases at diagnosis and relapse respectively. Next generation exon targeted sequencing was performed in 9 cases. Table shows the mutations (mtn) and functional groups with frequencies. XPO1 E571K mutation was present in 2 patients with extensive CNS disease and refractory to conventional treatment with an overall survival (OS) of 2 months. To our knowledge, this is the first time that XPO1 E571K is reported in a T-Cell malignancy. We also describe here a second set of mutations with CNS involvement (KLF2 and PI3KCD) in 2 patients. Median OS was 8.5 months, Median RFS was 6.5 months in our series. In most cases, the lymphomatous phenotype appeared to have direct mass-like extension (5/21) with several cases of accompanying osteolytic spine or skull lesions, whereas cases with hematogenous involvement tends to spread to the CSF by traversing the brain blood barrier. Conclusions: In this report we describe patterns of CNS involvement in ATLL and the associated mtns. We also describe two unique cases of XPO1E571K mtn in a TCL. [Table: see text]

Introduction

2018 ◽  
pp. 1-14
Author(s):  
Catherine Keyser
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Great Gatsby ◽  
The Great Gatsby ◽  
The World ◽  
First Time ◽  
The City

In The Great Gatsby (1925), Nick Carraway gazes upon the New York City skyline: Over the great bridge, with the sunlight through the girders making a constant flicker upon the moving cars, with the city rising up across the river in white heaps and sugar lumps all built with a wish out of non-olfactory money. The city seen from the Queensboro Bridge is always the city seen for the first time, in its first wild promise of all the mystery and beauty of the world....

Impact of Transit Fare Increase on Ridership and Revenue

2005 ◽  
Vol 1927 (1) ◽  
pp. 239-248 ◽  
Author(s):  
Robert L. Hickey
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Percentage Increase ◽  
Price Changes ◽  
Spreadsheet Model ◽  
Transit Agencies ◽  
Work Done ◽  
First Time

On May 4, 2003, the Metropolitan Transportation Authority's New York City Transit subsidiary (NYCT) raised its subway and bus fares for the first time since discounted and unlimited-ride MetroCards (electronic fare cards) were introduced between July 1997 and January 1999. Before the 2003 fare increase, the agency did not have any experience with either the direct ridership effects of price changes for unlimited-ride passes or the shift of customers when prices of different fare media increased at different rates and customers could shift from one fare medium to another. Partly on the basis of work done by other transit agencies, NYCT developed a spreadsheet model that used direct fare elasticities to estimate absolute ridership loss and used trip diversion rates (similar to cross-elasticities) to estimate the likelihood that passengers would shift from a fare instrument with a larger percentage increase to one with a smaller increase. The actual shift of customers between fare instruments after the fare increase was greater than projected, with the result of a lower than expected systemwide average fare. The negative revenue impact from the lower average fare was mostly offset by a lower than expected ridership decline. The estimated fare elasticities were below the average of historical NYCT fare elasticities and suggest that customers using unlimited-ride passes were less sensitive to fare changes.

Jack Kirby

2018 ◽  
pp. 191-205
Author(s):  
Andrew Alan Smith
Keyword(s):  
New York ◽  
Twentieth Century ◽  
New York City ◽  
Working Class ◽  
Real World ◽  
York City ◽  
Background Information ◽  
East Side ◽  
Alter Ego

Ben “The Thing” Grimm of the Fantastic Four is portrayed as a working-class “guy,” despite the vast amount of money at his disposal as a principal in Fantastic Four, Inc. However, his origins go back further than his first appearance in 1961, to the childhood of his co-creator and original artist, Jack Kirby. Kirby, a working-class Jew from the slums of Lower East Side New York City in the early part of the twentieth century, patterned Grimm after himself. Even after both Kirby and cocreator Stan Lee left Fantastic Four, successive writers and artists would include new pieces of background information about the character cementing the direct correlation between the fictional Thing and his real-world creator and alter ego, Jack Kirby.

Jump Up!

2019 ◽  
Author(s):  
Ray Allen
Keyword(s):  
New York ◽  
New York City ◽  
Urban Studies ◽  
Cultural Context ◽  
Transnational Identities ◽  
Musical Practices ◽  
History Of ◽  
The Caribbean ◽  
First Time ◽  
Comprehensive History

Jump Up! Caribbean Carnival Music in New York City is the first comprehensive history of Trinidadian calypso and steelband music in the diaspora. Carnival, transplanted from Trinidad to Harlem in the 1930s and to Brooklyn in the late 1960s, provides the cultural context for the study. Blending urban studies, oral history, archival research, and ethnography, Jump Up! examines how members of New York’s diverse Anglophile-Caribbean communities forged transnational identities through the self-conscious embrace, transformation, and hybridization of select Carnival music styles and performances. The work fills a significant void in our understanding of how Caribbean Carnival music—specifically calypso, soca (soul/calypso), and steelband—evolved in the second half of the twentieth century as it flowed between its island homeland and its burgeoning New York migrant community. Jump Up! addresses the issues of music, migration, and identity head on, exploring for the first time the complex cycling of musical practices and the back-and-forth movement of singers, musicians, arrangers, producers, and cultural entrepreneurs between New York’s diasporic communities and the Caribbean.

Introduction to the Species Accounts

2018 ◽  
pp. 73-80
Author(s):  
P. A. Buckley
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Long Island ◽  
Quantitative Distribution ◽  
The Core ◽  
First Time ◽  
Extended Discussion ◽  
Winter Population ◽  
Quantitative Assessments

The core of this book, offering qualitative and quantitative assessments of the migratory, breeding, wintering, and resident avifauna of the Northwest Bronx, New York City back to 1872. The present and historical statuses of 301 study area species and another 70 potential species are described in detail for the Bronx, for New York City, for Long Island, and for Westchester and Rockland Cos. for the first time since 1964. Study area winter population changes are amplified by comparison to their numbers on 90 annual Bronx-Westchester Christmas Bird Counts from 1924. Extended discussion of pertinent identification, ecological, taxonomic, and distributional issues complements the quantitative distribution and occurrence data and update all 371 species to 2016.

The Freethinker, the Jews, and the Missionaries: George Houston and the Mystery of Israel Vindicated

AJS Review ◽  
1980 ◽  
Vol 5 ◽  
pp. 101-114 ◽  
Author(s):  
Jonathan D. Sarna
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Minority Groups ◽  
Self Interest ◽  
History Of ◽  
American Society ◽  
First Time ◽  
New Evidence ◽  
New Yorkers

In 1820, a volume entitled Israel Vindicated, written by "An Israelite," was published in New York City. It was the first Jewish polemic composed in response to the founding of a missionary society, the American Society for Meliorating the Condition of the Jews, and it remained influential throughout the nineteenth century. The author of this work, however, has never been identified. Nor has the volume itself received the attention it deserves. This article attempts to fill both of these lacunae.Section one describes and analyzes Israel Vindicated. It places the work within the context of its times, and compares it to other, more traditional anti-Christian polemics. Section two outlines the postpublication history of Israel Vindicated. Soon after it appeared, some New Yorkers attempted to have the work banned, and its author exposed and punished. Later, the work was variously invoked by Jews and Judeophobes alike, though, of course, for different purposes. In section three, the author of Israel Vindicated assumes center stage. A review of old and new evidence leads to the conclusion that the work flowed from the pen of freethinker George Houston, assisted probably by his Jewish printer, Abraham Collins. Finally, section four analyzes the motivations of George Houston and his Jewish supporters. As is shown, this was far from the first time that Jews joined forces temporarily with other, sometimes hostile minority groups in pursuit of self-interest. Adversity makes strange bedfellows.

Beyond the Melting Pot 35 Years Later: On the Relevance of a Sociological Classic for the Immigration Metropolis of Today

2000 ◽  
Vol 34 (1) ◽  
pp. 243-243 ◽  
Author(s):  
Richard Alba
Keyword(s):  
New York ◽  
New York City ◽  
African Americans ◽  
York City ◽  
American City ◽  
Melting Pot ◽  
Sociological Society ◽  
First Time ◽  
New Yorkers ◽  
Accessible Form

The following essays were originally presented at a symposium at the 1998 annual meeting of the Eastern Sociological Society. The charge to the authors was to revisit Beyond the Melting Pot, the classic statement about ethnicity, race, and the American city, first published in 1963, and to assess how well its interpretations apply to the contemporary immigration metropolis. The commentators included two New Yorkers (Nancy Foner and Philip Kasinitz), since New York City was the terrain of the book, and two non-New Yorkers (Elijah Anderson and Alejandro Portes). Their commentaries touch on many points in the immigration landscape of today, from immigration's impacts on African Americans to immigrant transnationalism, and identify a number of continuities and discontinuities between the contemporary metropolis and that of nearly four decades ago. Further, Nathan Glazer's response provides, for the first time in a widely accessible form, his reflections on how well the book's portrait and predictions have held up. I am grateful to the IMR editor, Lydio Tomasi, and the journal's board for the opportunity to present this symposium to readers.

The Impact of Shelter Environment, Parental Communication, and Supervision on Depression Outcomes Among an Urban Sample of Adolescent First-Time Shelter Users in New York City

2018 ◽  
Vol 39 (11) ◽  
pp. 3075-3095 ◽  
Author(s):  
Binta Alleyne-Green ◽  
Alex Kulick ◽  
Hadiza L. Osuji ◽  
Nisha Beharie ◽  
Yvette Sealy
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Parental Communication ◽  
Cross Sectional ◽  
Environment Quality ◽  
Urban Sample ◽  
Using Data ◽  
The Impact ◽  
First Time

Using data from the cross-sectional HIV prevention Outreach for Parents and Early Adolescents (HOPE) study, we explored the impact of shelter environment, quality parenting, as well as the effects of gender and first-time shelter use on depression outcomes among 243 adolescent shelter users in New York City. Results indicate comfort in the shelter environment, and higher rates of monitoring and supervision were associated with lower rates of depression. Girls residing in shelters for the first time reported highest rates of depression. Recommendations for future interventions with this population are discussed.

Queue the Music: Cohan's Yellowface Substitution in Little Johnny Jones

2018 ◽  
Vol 59 (2) ◽  
pp. 190-220
Author(s):  
Brynn Shiovitz
Keyword(s):  
New York ◽  
New York City ◽  
Presidential Election ◽  
Republican Party ◽  
Theodore Roosevelt ◽  
Broadway Musical ◽  
Recent Success ◽  
Political Views ◽  
William Mckinley ◽  
First Time

It is 7 November 1904, 7:55 p.m. New York City theatregoers anxiously await the opening of George M. Cohan's newest production, Little Johnny Jones. The house is just about filled, but the well-dressed ushers hustle a few stragglers to their seats. Some of the theatre's usual patrons have been held up late at work, while others are too consumed by Clifford Berryman's political cartoons in the Washington Star to attend the performance. This particular Monday evening marks an important moment for America: polls for the thirtieth presidential election will be opening in fewer than twelve hours. Theodore Roosevelt represents the Republican Party, and Alton B. Parker heads the Democratic ticket. Although results will not be known for sure until the close of the 8 November election, Roosevelt's recent success in office upon the assassination of William McKinley gives him a political boost. New York City's predominantly Republican values leave little doubt about which name a majority of tonight's audience will be checking off on the ballot come morning; Roosevelt has carried every region but the South in his campaigning efforts thus far. Nonetheless, Broadway occasionally attracts a few guests from the slightly less liberal states of Maryland and Pennsylvania, and this evening's house is no different; the Liberty Theatre is filled with men of opposing political views. A nervous excitement fills the room; a combination of political gossip, predictions about how Cohan's first Broadway musical will compare to his earlier comedic works and vaudeville skits, and occasional gasps and awestruck sighs from spectators who are seeing the inside of the Liberty Theatre for the first time since its very recent grand opening at 234 West 42nd Street. The twenty-thousand-square-foot theatre, with its dramatic stage, extensive balconies, and striking cathedrallike ceilings is the perfect home for the unfolding of Broadway, a theatrical form and style that America will come to call its own. As the house lights dim and the violins hum a piercing A note, other members of the orchestra slowly begin tuning their individual instruments. As the oboists finish adjusting their pitch, the conductor taps his music stand: musicians tilt their gaze to the front of the pit, audience members sink into the velvet of their plush seats and begin to quiet their chatter. Blackout.

scholarly journals There are two solutions to the equations of Feynman’s Quantum Electrodynamics (QED): the newly discovered solution is free of quantum weirdness

2020 ◽  
Vol 18 ◽  
pp. 39-57
Author(s):  
Jeffrey H. Boyd
Keyword(s):  
New York ◽  
New York City ◽  
Los Angeles ◽  
Empirical Data ◽  
Quantum Electrodynamics ◽  
Born Rule ◽  
Neutron Interferometer ◽  
First Time ◽  
The Waves ◽  
Coherent Picture

No one previously noticed there is a second solution to the equations of Richard Feynman’s Quantum Electrodynamics (QED). It makes identical predictions in the lab. The new solution (Reverse-QED) is closer to nature: it is free of quantum weirdness. For example, it eliminates Schrödinger’s cat. This article is the first time the equations of R-QED have been published. The R-QED amplitude is the negative of Feynman’s amplitude. Because of the Born rule, both amplitude and negative amplitude, when squared, produce the same probability to be tested against empirical data. If you were to measure the distance from Los Angeles to New York City with R-QED’s accuracy, it would be exact to the breadth of a human hair. If reality corresponds to the newly discovered R-QED equations, but scientists use the old QED equations, the result would be predictions for the lab that are precisely accurate, but scientists would be unable to construct a coherent picture of the quantum world. R-QED is based on a different picture of how the quantum world is organized. Experiments, including a neutron interferometer experiment we review, show that particles follow waves backward. R-QED integrates in the same direction that the waves travel.

Sign in / Sign up

Export Citation Format

Share Document