An unmatched case-control study evaluating the relationship between cancer diagnosis and drinking water source on the lower Eastern Shore of Maryland.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e22514-e22514
Author(s):  
Angela Marie DeRidder ◽  
Adeel Masood
Keyword(s):  
Cancer Diagnosis ◽  
Tap Water ◽  
Water Source ◽  
Water Filtration ◽  
Well Water ◽  
Eastern Shore ◽  
Cancer History ◽  
Municipal Water ◽  
Filtration System ◽  
The Relationship

e22514 Background: The lower Eastern Shore of Maryland is an agricultural and rural region with high cancer rates. Prior research has suggested that cancer patients on the lower Eastern Shore of Maryland rely on residential private well water more than municipal water, and that cancer patients rely on residential private well water more than individuals in the general county population. The purpose of this unmatched case-control study was to further clarify the relationship between cancer diagnosis and residential private well water use. Methods: A water consumption survey was provided to new hematology/oncology clinic patients seen at a regional hospital on the lower Eastern Shore from October 2020 through February 2021. Participants were asked their age, county of residence, residential water source, daily tap water consumption, presence of a water filtration system, and current or prior cancer history. A case was defined as an individual using residential private well water, and a control was defined as an individual using municipal water. Fisher’s exact test and binominal logistic regression were used to evaluate the relationship between residential water source and cancer history. Results: 334 patients were surveyed and 270 were included in analysis, with 133 cases and 137 controls. Median age of cases was 64 years (SD ± 16.6) and median age of controls was 62 years (SD ± 16.87). Our study found that compared to individuals utilizing municipal water, individuals utilizing residential private well water were more likely to live in their homes for > 5 years (61% vs. 46%, p = 0.015), drink tap water (61% vs. 41%, p = 0.015), and utilize a water filtration system (31% vs. 16%, p = 0.006). Controlling for age, subjects who reported drinking at least two glasses of unfiltered private well water per day were more likely to have a current or prior cancer diagnosis compared to individuals relying on municipal water (OR = 2.57; 95% CI: 1.07-6.12, p = 0.03). Among subjects who drank less than 2 glasses of tap water per day or utilized a water filtration system, there was no difference in cancer history between individuals utilizing private well water versus municipal water. There were no relationships between county of residency, length of home residency, and cancer diagnosis. Conclusions: Individuals on the lower Eastern Shore of Maryland who consume at least 2 glasses of private well water without a water filtration system were more likely to indicate a current or prior cancer history compared to individuals consuming at least 2 glasses of municipal water. Interpretation is limited by small sample size and lack of causality, however, the results signal a need for additional studies evaluating well water use and cancer risk in this region.

A retrospective chart review evaluating the relationship between cancer diagnosis and drinking water source on the Lower Eastern Shore of Maryland.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13587-e13587
Author(s):  
Angela Marie DeRidder ◽  
Sowjanya Kalluri ◽  
Veera Holdai
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Water Use ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Water Source ◽  
Well Water ◽  
Eastern Shore ◽  
Cancer History ◽  
County Population

e13587 Background: The lower Eastern Shore of Maryland is an agricultural and rural region with high cancer rates. The purpose of this retrospective study was to determine if cancer patients on the lower Eastern Shore utilize higher rates of well water compared to individuals in the general county population. Methods: A retrospective chart review of all cases of colon, lung, melanoma and breast cancer diagnosed at Peninsula Regional Medical Center in 2017 was completed. Demographic and clinical information including family, smoking and prior cancer history, as well as residential water source were recorded. Individuals with residential addresses outside of Wicomico, Worcester and Somerset counties were excluded. Overall well water use for each county was determined using U.S. 2010 census data. Fisher’s exact test was used to compare well water utilization rates in cancer patients and the overall county population. Results: 631 patient cases were reviewed and 384 patients were identified for data analysis. The majority of patients were white (81%), diagnosed with breast cancer (41%), and used well water (52%, n = 209). Cancer patients in the three counties combined were significantly more likely to use well water than individuals in the general county population (OR = 2.5, 95% CI 2.11, 3.16). In Wicomico county, 61% of cancer patients used well water (n = 140). Wicomico cancer patients were more likely to use well water than individuals in the general Wicomico county population (OR = 4.4, 95% CI 3.41, 5.78). No significant findings were observed for patients living in Worcester and Somerset counties. No differences in family, smoking or prior cancer history in patients using well water versus municipal water were identified. Conclusions: Cancer patients on the lower Eastern Shore of Maryland used well water more than municipal water. Cancer patients also utilized higher rates of well water compared to individuals in the general county population. Interpretation is limited by small sample size and lack of causality, however the results signal a need for additional studies evaluating well water use and cancer risk in this region.

scholarly journals Factors determining vulnerability to diarrhoea during and after severe floods in Bangladesh

2008 ◽  
Vol 6 (3) ◽  
pp. 323-332 ◽  
Author(s):  
Masahiro Hashizume ◽  
Yukiko Wagatsuma ◽  
Abu S. G. Faruque ◽  
Taiichi Hayashi ◽  
Paul R. Hunter ◽  
...  
Keyword(s):  
Linear Models ◽  
Drinking Tube ◽  
Tap Water ◽  
Economic Status ◽  
Water Source ◽  
Well Water ◽  
Normal Numbers ◽  
Modifying Factors ◽  
Flood Period ◽  
Tube Well

This paper identifies groups vulnerable to the effect of flooding on hospital visits due to diarrhoea during and after a flood event in 1998 in Dhaka, Bangladesh. The number of observed cases of cholera and non-cholera diarrhoea per week was compared to expected normal numbers during the flood and post-flood periods, obtained as the season-specific average over the two preceding and subsequent years using Poisson generalised linear models. The expected number of diarrhoea cases was estimated in separate models for each category of potential modifying factors: sex, age, socio-economic status and hygiene and sanitation practices. During the flood, the number of cholera and non-cholera diarrhoea cases was almost six and two times higher than expected, respectively. In the post-flood period, the risk of non-cholera diarrhoea was significantly higher for those with lower educational level, living in a household with a non-concrete roof, drinking tube-well water (vs. tap water), using a distant water source and unsanitary toilets. The risk for cholera was significantly higher for those drinking tube-well water and those using unsanitary toilets. This study confirms that low socio-economic groups and poor hygiene and sanitation groups were most vulnerable to flood-related diarrhoea.

scholarly journals A Retrospective Chart Review Evaluating the Relationship between Cancer Diagnosis and Residential Water Source on the Lower Eastern Shore of Maryland, USA

2020 ◽  
Vol 18 (1) ◽  
pp. 145
Author(s):  
Angela DeRidder ◽  
Sowjanya Kalluri ◽  
Veera Holdai
Keyword(s):  
Cancer Patients ◽  
Water Use ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Water Source ◽  
Well Water ◽  
Eastern Shore ◽  
Water Utilization ◽  
Regional Population ◽  
Residential Water

Well water contamination in heavily agricultural regions has previously been linked with increased cancer incidence and mortality. The lower Eastern shore of Maryland is a rural, agricultural region with some of the highest rates of cancer in Maryland and the United States. Our study sought to characterize residential private well water use among cancer patients on the lower Eastern shore of Maryland, and to compare private well water utilization between cancer patients and the general regional population. Retrospective chart review was conducted to identify patients diagnosed with colon, lung, melanoma or breast cancer at a regional hospital from 1 January 2017 through 31 December 2018. Residential water source was determined using residential address and municipal water records. Fisher’s exact test was used to compare residential private well water utilization between our study population and the baseline regional population. The majority of cancer patients (57%) lived in homes supplied by private well water (428/746). Cancer patients were more likely to live in homes supplied by private well water compared to individuals in the general regional population (57% vs. 32%, p < 0.001). In conclusion, cancer patients on the lower Eastern shore of Maryland were more likely to live in homes supplied by residential private well water than the regional population. Additional studies are needed to evaluate well water use and cancer risk in this vulnerable region.

Perchlorate, chlorate and bromate in water samples from the South-West coast of India

2012 ◽  
Vol 12 (5) ◽  
pp. 595-603 ◽  
Author(s):  
V. N. Anupama ◽  
K. Kannan ◽  
P. V. G. Prajeesh ◽  
S. Rugmini ◽  
B. Krishnakumar
Keyword(s):  
Surface Water ◽  
Water Samples ◽  
High Performance ◽  
Sea Water ◽  
Tap Water ◽  
Water Source ◽  
Well Water ◽  
The South ◽  
South West ◽  
South West Coast

Occurrence of perchlorate (ClO4−), chlorate (ClO3−) and bromate (BrO3−) in public drinking, open well and surface water sources at 20 locations in the South-West coastal state of Kerala (India) is reported. The analysis was performed by high performance liquid chromatography interfaced with tandem mass spectrometry (HPLC–MS/MS). Irrespective of water source (public tap water, open well water and surface water) all the analyzed samples contained high levels of ClO4−, indicating its contamination throughout the region. The highest ClO4− level found was 91.4 μg/L, which is 3.7 times higher than US EPA recommendations. ClO3− and BrO3− were also detected in the samples, with highest concentrations of 177 and 5.34 μg/L respectively in tap water samples. Regression analysis showed moderate positive correlation between ClO4− and bromide (Br−) in tap water (r2=0.659) and open well water (r2=0.485) samples, respectively. Similar correlation was also observed between ClO4− and Cl− (r2=0.591) concentrations in well water samples, indicating sea water could be one of the probable sources in addition to ClO4− manufacturing in the area. This is the first report of high levels of ClO4− and ClO3− and detectable BrO3− in water samples from anywhere in India.

IDENTIFIKASI SERTA HUBUNGAN KONSTRUKSI SUMUR GALI TERHADAP KANDUNGAN COLIFORM PADA AIR SUMUR GALI DI DUSUN JIKEN KABUPATEN LOMBOK TIMUR

2019 ◽  
Vol 7 (2) ◽  
pp. 115
Author(s):  
Dini Yuliansari
Keyword(s):  
Cross Sectional Study ◽  
Coliform Bacteria ◽  
Well Water ◽  
Chi Square ◽  
Cross Sectional ◽  
Content Variable ◽  
Chi Square Test ◽  
Dug Wells ◽  
Dug Well ◽  
The Relationship

The well is one of the source water used for bathing, washing, and drinking by the citizens in Jiken Hamlet, Rarang Village, Terara Sub-District. Poor dug well construction conditions can affect the amount of coliform bacteria contained in the dug well water. The purpose of this study is to identify the construction of dug wells and the content of coliform bacteria in dug well water and determine the relationship between dug well construction and the content of coliform bacteria. This research is analytic with a cross sectional study design. The results were obtained from 11 samples of dug wells which were observed in construction and the coliform content was known that all samples did not requirements as good dug well construction. Coliform content test results showed that as many as 5 dug well water samples did not pass the clean water quality standards. The results of data analysis with the chi-square test variable construction of dug wells with coliform content variable  showed 0,172 > 0,05, then the concluded is the dug well not suitable to use by people in that area as a source of water for daily needs.

scholarly journals Effect of prior cancer on survival outcomes for patients with advanced prostate cancer

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yechen Wu ◽  
Xi Chen ◽  
Duocheng Qian ◽  
Wei Wang ◽  
Yiping Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Outcomes ◽  
Cancer Diagnosis ◽  
Advanced Prostate Cancer ◽  
Lymphocytic Leukemia ◽  
Cancer History ◽  
Non Hodgkin Lymphoma ◽  
Kaplan Meier ◽  
History Of ◽  
The Impact

Abstract Background A history of prior cancer commonly results in exclusion from cancer clinical trials. However, whether a prior cancer history has an adversely impact on clinical outcomes for patients with advanced prostate cancer (APC) remains largely unknown. We therefore aimed to investigate the impact of prior cancer history on these patients. Methods We identified patients with advanced prostate cancer diagnosed from 2004 to 2010 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance baseline characteristics. Kaplan–Meier method and the Cox proportional hazard model were utilized for survival analysis. Results A total of 19,772 eligible APC patients were included, of whom 887 (4.5 %) had a history of prior cancer. Urinary bladder (19 %), colon and cecum (16 %), melanoma of the skin (9 %) malignancies, and non-hodgkin lymphoma (9 %) were the most common types of prior cancer. Patients with a history of prior cancer had slightly inferior overall survival (OS) (AHR = 1.13; 95 % CI [1.02–1.26]; P = 0.017) as compared with that of patients without a prior cancer diagnosis. Subgroup analysis further indicated that a history of prior cancer didn’t adversely impact patients’ clinical outcomes, except in patients with a prior cancer diagnosed within 2 years, at advanced stage, or originating from specific sites, including bladder, colon and cecum, or lung and bronchus, or prior chronic lymphocytic leukemia. Conclusions A large proportion of APC patients with a prior cancer history had non-inferior survival to that of patients without a prior cancer diagnosis. These patients may be candidates for relevant cancer trials.

scholarly journals CHARACTERISTICS AND ADSORPTION PERFORMANCE OF FORMULATED TRIKOTAC FILTER AIDS

2019 ◽  
Vol 81 (3) ◽  
Author(s):  
N. Masdiana ◽  
M. Rashid ◽  
S. Hajar ◽  
M. R. Ammar
Keyword(s):  
Particle Size ◽  
Activated Carbon ◽  
Particle Density ◽  
Adsorption Properties ◽  
The Other ◽  
Bet Surface Area ◽  
Adsorption Performance ◽  
Filtration System ◽  
Filter Aids ◽  
The Relationship

TrikotAC filter aids is a combination of a pre-coating material PreKot™ with two adsorbents; activated carbon and lime and their characteristics were investigated in this study. TrikotAC was formulated into three different weight ratios of 5:1:94, 10:1:89 and 10:5:85, respectively. The relationship between adsorption properties and characteristics of the formulated materials particle size distribution, particle density, bulk density, and BET surface area were investigated. The results showed that the adsorption capacity for TrikotAC 10:5:85 (11.88 mg/g) was higher than for the other formulated filter aids samples, and the formulated filter aids material TrikotAC showed promising characteristic as a filter aids and adsorbent for organic compound in fabric filtration system.

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