Anti-oxidant and anti- bacterial properties of extracts: Terminalia chebula and terminalia bellerica

2017 ◽  
pp. 213-231
Author(s):  
Harsha Patel ◽  
Hemali Padalia ◽  
Mital J. Kaneria ◽  
Yogesh Vaghasiya ◽  
Sumitra Chanda
Keyword(s):  
Terminalia Chebula ◽  
Terminalia Bellerica ◽  
Anti Oxidant

Phytochemical Investigation and Antimutagenic Potential of Ethanolic Extracts of Emblica officinalis, Terminalia chebula and Terminalia bellirica

2020 ◽  
Vol 10 (4) ◽  
pp. 488-494 ◽  
Author(s):  
Venugopal Singamaneni ◽  
Sudheer Kumar Dokuparthi ◽  
Nilanjana Banerjee ◽  
Ashish Kumar ◽  
Tulika Chakrabarti
Keyword(s):  
Ethyl Acetate ◽  
Gallic Acid ◽  
Ellagic Acid ◽  
Antimutagenic Activity ◽  
Dependent Manner ◽  
Terminalia Chebula ◽  
Emblica Officinalis ◽  
Dried Fruits ◽  
Terminalia Bellerica ◽  
The Family

Background: Emblica officinalis Gaertn. which belongs to the family Euphorbiaceae, Terminalia chebula Retz. and Terminalia bellerica Roxb. belong to the family Combretaceae. These are well known medicinal plants with phytochemical reservoir of great medicinal values and possess a vast ethnomedical history. Objective: The aim of the present study is to isolation of major compounds and to evaluate antimutagenic potential of the ethanol extracts of these plants. Methods: The dried fruits of E. officinalis, T. bellirica and T. chebula were powdered and extracted with 95% ethanol. The ethyl acetate portions were chromatographed over silica gel to isolate major compounds. Antimutagenic activity was determined by Ames test using TA98 and TA100 strains of Salmonella typhimurium. Results: Two major known compounds, gallic acid and ellagic acid were isolated from the dried fruits of Emblica officinalis, Terminalia chebula and T. bellirica. All the three extracts counteracted the mutagenicity induced by different genotoxic compounds in a dose dependent manner. Conclusion: This study showed that ethyl acetate portion of three extracts contain two major compounds, gallic acid and ellagic acid which might be responsible for potent antimutagenic activity of these extracts.

scholarly journals TERMINALIA CHEBULA: SUCCESS FROM BOTANY TO ALLOPATHIC AND AYURVEDIC PHARMACY

2016 ◽  
Vol 9 (5) ◽  
pp. 21
Author(s):  
Varun Garg ◽  
Barinder Kaur ◽  
Sachin Kumar Singh ◽  
Bimlesh Kumar
Keyword(s):  
Chemical Constituents ◽  
Present Review ◽  
Terminalia Chebula ◽  
Pharmacological Activities ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Inflammatory

ABSTRACTTerminalia chebula (TC) is a unique herb having various therapeutic potentials as anti-inflammatory, antioxidant, anticancer, and digestant. It belongsto family Combretaceae. In the present review, an attempt has been made to decipher classification, chemical constituents, therapeutic uses, andpatents that have been reported for TC. Various pharmacological activities of TC that make it as potential medicine and its Ayurvedic formulationsare highlighted.Keywords: Terminalia chebula, Anti-oxidant, Anti-cancer, Ayurvedic formulations, Anti-oxidant.

scholarly journals Protective Effect of Terminalia catappa Leaves and Terminalia chebula Fruits on the Enzymatic and Non-enzymatic Anti-oxidant Levels in the Doxorubicin Induced Toxicity Rats

2019 ◽  
Vol 11 (2) ◽  
pp. 346-349
Author(s):  
Panneerselvam Punniyakotti ◽  
Rengasamy Lakshminarayanan Rengarajan ◽  
Shanmugam Velayuthaprabhu ◽  
Kalaiyarasan Vijayakumar ◽  
Ramasamy Manikandan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Terminalia Chebula ◽  
Terminalia Catappa ◽  
Anti Oxidant

scholarly journals Researches done on Extra pharmacopoeial drugs (Anukta Dravyas) belonging to Terminalia Genus – A systematic review and Meta-analysis.

1970 ◽  
Vol 7 (4) ◽  
Author(s):  
Neha Gaonkar
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Research Work ◽  
Therapeutic Agents ◽  
Indian Species ◽  
Terminalia Chebula ◽  
Anticancer Activities ◽  
Medicinal Uses ◽  
Anti Oxidant ◽  
Medicinal Properties

The aim of this work was to systematically review and Meta-analyze the researches done on extra pharmacopoeial drugs (anukta dravyas) belonging to Terminalia genus. Terminalia is the second largest genus of family Combrataceae. Plants of the genus Terminalia are amongst the most widely used plants for traditional medicinal purposes worldwide. Many species are used for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, anti oxidant, anti inflammatory and anticancer activities. Indeed, the Indian species Terminalia chebula is known as the king of plants in Ayurveda due to its broad range of medicinal uses. However, apart from the reported ethnopharmacological uses of many Terminalia species, surprisingly few studies have rigorously examined this important genus for their medical properties/mechanisms. The last decade has seen a large increase in the number of studies into the use of Terminalia species as therapeutic agents. Data collected till 2018, showed around 120 different databases, articles and researches done on medicinal properties of plants belonging to Terminalia species. It was observed that out of the 250 species of Terminalia genus, research work of 80 plants was done which claimed their potential as medicines.

scholarly journals ANTIBACTERIAL AND SYNERGISTIC ACTIVITY OF TERMINALIA CHEBULA AND TERMINALIA BELLERICA FRUIT EXTRACTS AGAINST ESBL PRODUCERS

2017 ◽  
Vol 9 (6) ◽  
pp. 8
Author(s):  
Bharani Thirunavukkarasu ◽  
Nirmala Purushothaman
Keyword(s):  
Bacterial Infections ◽  
Antibiotic Use ◽  
Point Of View ◽  
Synergistic Activity ◽  
Terminalia Chebula ◽  
Terminalia Bellerica ◽  
Fruit Extracts ◽  
Medicinal Plant Extracts ◽  
Ethanolic Extracts ◽  
Alternative Choice

Objective: Bacterial infections and the resistance related to indiscriminate antibiotic use have led to an alarming situation in the clinics. The rapid spread of Extended Spectrum Beta Lactamases (ESBLs) and carbapenemase producing Gram negative bacteria has initiated the need for development of a new drug or an alternative choice by using the combination of drugs with medicinal plant extracts. This study was aimed at examining the antibacterial potential and synergistic activity of ethanolic extracts of Terminalia chebula and Terminalia bellerica fruits against clinically important reference bacterial strains.Methods: The crude ethanolic extracts of T. chebula and T. bellerica fruits were prepared and reconstituted with 5% dimethylsulfoxide (DMSO). The fruit extracts (~25 mg/well) were added into the wells in the plates inoculated with various ESBL and AmpC producers and they were incubated at 37 °C for 24 h. The antibiotics ceftazidime (30 µg) and cefotaxime (30 µg) were added to the wells alone and in combination with the fruit extracts to determine their own antibacterial and synergistic activity respectively.Results: The ethanolic fruit extracts combination improved the activity of ceftazidime and cefotaxime against the tested ESBL and AmpC producers. Though both the extracts showed activity, T. chebula was found to show better synergistic antibacterial activity.Conclusion: The synergistic activity of these fruit extracts with ceftazidime and cefotaxime against the ESBL and AmpC producers shows the efficiency of the combination therapy, which can be considered in therapeutic point of view to prevent the misuse of antibiotics and minimise the increasing resistance in bacteria.

scholarly journals ROLE OF SHILAJIT AND TRIPHALA KWATH IN HYPOTHYROIDISM: A REVIEW

2020 ◽  
Vol 11 (6) ◽  
pp. 64-68
Author(s):  
Gayatri Devi ◽  
Vipin Kumar ◽  
Sheetal Verma
Keyword(s):  
Fulvic Acid ◽  
Iron Status ◽  
Signs And Symptoms ◽  
Primary Hypothyroidism ◽  
Muscle Stiffness ◽  
Terminalia Chebula ◽  
Chronic Autoimmune Thyroiditis ◽  
Terminalia Bellerica ◽  
Wide Range ◽  
Current Scenario

Hypothyroidism is one of the burning issues in the current scenario and is affecting the lives of many people on various levels. Autoimmunity is responsible for over 90% of non-iatrogenic hypothyroidism in iodine-sufficient area. In iodine-sufficient areas, the most common cause of hypothyroidism is chronic autoimmune thyroiditis (also known as Hashimoto’s disease). Subclinical hypothyroidism is a mild form of primary hypothyroidism. Signs and symptoms of hypothyroidism are weight gain, cold intolerance, fatigue, somnolence, dry skin, dry hair, menorrhagia are more common constipation, hoarseness of voice, aches and pains, muscle stiffness, deafness, depression, infertility is less common. As per Ayurveda (science of life), it is caused due to vitiation of Agni. Shilajit an exudate, contains mainly fulvic acid, humic acid, and trace element (iron, selenium) which includes anti-inflammatory, immune-stimulant, properties. Anaemia as a symptom is associated with Hypothyroidism. The constituent present in Shilajit that is Fulvic acid enhances the absorption of iron so that serum iron status increases and can be helpful in the management of hypothyroidism. Triphala is an Ayurvedic herbal formulation of dried fruits of Terminalia chebula, Terminalia bellerica and Phyllantus emblica. The major phytoconstituent of Terminalia bellerica, Terminalia chebula and Phyllantus emblica fruits is gallic acid, which is known to have a wide range of therapeutic activity, e.g. anti-atherosclerotic, cardioprotective. In this review paper, it is being established that all these characteristics of Shilajit with Triphala kwath may be the probable reason for its effect on the management of hypothyroidism.

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