Chapter Delivering the Bullet to the Right Intracellular Target: A Cellular Perspective on Drug Delivery

2010 ◽  
pp. 235-270
Keyword(s):  
Drug Delivery ◽  
Intracellular Target ◽  
The Right

Transferrin-Conjugated Nanocarriers as Active-Targeted Drug Delivery Platforms for Cancer Therapy

2017 ◽  
Vol 23 (3) ◽  
pp. 454-466 ◽  
Author(s):  
Daniele R. Nogueira-Librelotto ◽  
Cristiane F. Codevilla ◽  
Ammad Farooqi ◽  
Clarice M. B. Rolim
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Therapeutic Benefit ◽  
Active Targeting ◽  
Future Research ◽  
Passive Targeting ◽  
The Right ◽  
Review Current ◽  
Target Effects

A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking advantage of the overexpression of transferrin receptors on the surface of tumor cells, transferrin-conjugated nanodevices have been designed, in hope that the biomarker grafting would help to maximize the therapeutic benefit and to minimize the side effects. Notably, active targeting nanoparticles have shown improved therapeutic performances in different tumor models as compared to their passive targeting counterparts. In this review, current development of nano-based devices conjugated with transferrin for active tumor-targeting drug delivery are highlighted and discussed. The main objective of this review is to provide a summary of the vast types of nanomaterials that have been used to deliver different chemotherapeutics into tumor cells, and to ultimately evaluate the progression on the strategies for cancer therapy in view of the future research.

scholarly journals TARGETING THE TARGET USING NANOPARTICLES - A REVIEW

2017 ◽  
Vol 10 (12) ◽  
pp. 6
Author(s):  
Aravinthrajkumar G ◽  
Gayathri R ◽  
Vishnupriya V
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Intravenous Injection ◽  
Immediate Release ◽  
Dosage Forms ◽  
The Body ◽  
Specific Location ◽  
The Right ◽  
Reproducible Manner

  The challenge of drug delivery is the liberation of drug agents at the right time in a safe and reproducible manner, usually to a specific target site. Conventional dosage forms, such as orally administered pills and subcutaneous or intravenous injection, are the predominant routes for drug administration. However, pills and injections offer limited control over the rate of drug release into the body; usually, they are involved in an immediate release of the drug. This article is about how nanoparticles can be used as an effective drug delivery system to target the drug to a specific location or organ.

scholarly journals Structural Organization of Themagnetic Part of Smart Material Based on Nanoparticles of Iron or Magnetite in Pores of Mcm-41 Mesoporous Silica for Target Drug Delivery

2018 ◽  
Vol 57 (2) ◽  
pp. 175-182
Author(s):  
E.G. Zemtsova ◽  
A.N. Ponomareva ◽  
A.Y. Arbenin ◽  
V.M. Smirnov
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Smart Material ◽  
The Body ◽  
Superparamagnetic Nanoparticles ◽  
Target Drug Delivery ◽  
Target Drug ◽  
The Matrix ◽  
The Right ◽  
Mcm 41

Abstract The important stage of the development of smart material for the target drug delivery is the construction of the magnetic part of this material, including mesoporous silica and magnetic nanoparticles (Fe3O4or Fe0). Such a systemwill allow carry outmagnetic decapsulation (excretion) of drug from smart material using the magnetic field of a given value in the right place of the body. The paper considers the features of synthesis mesoporous silica MCM-41 with various pore diameter (33-51 Å) and synthesis of superparamagnetic nanoparticles of magnetite or metallic iron in the pores of mesoporous silica. The dependence of magnetic properties of nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 from the pore diameters of MCM-41 templates is studied. It was found that the matrix has a decisive influence on the content of iron or magnetite nanoparticles. The saturation magnetization of the material increases with increasing pore size of the mesoporous matrix. Nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 exhibit superparamagnetism, that allows them to be used as a magnetic material for targeted drug delivery.

scholarly journals PORPHYSOMES-A PARADIGM SHIFT IN TARGETED DRUG DELIVERY

2018 ◽  
Vol 10 (2) ◽  
pp. 1 ◽  
Author(s):  
Revathy B. Menon ◽  
Lakshmi V. S. ◽  
Aiswarya M. U. ◽  
Keerthana Raju ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Optimum Dose ◽  
Advantages And Disadvantages ◽  
The Right ◽  
Aqueous Core

A novel drug delivery system is the one that ensures optimum dose at the right time, at the right location. Porphysomes are among those drug delivery systems. Porphysomes are a means of vesicular drug delivery systems. They are liposome-like structures composed completely of porphyrin lipid. The porphysomes encapsulates the active medicament in vesicular structure. They are having an aqueous core which can be loaded with the medicament. They have the capacity to destroy the disease tissues. They absorb the heat in the near infrared region and release this heat to destroy the diseased tissues. Porphysomes are having immense applications in the field of positron-electron therapy (PET), photoacoustic imaging, photothermal therapy etc. This review article discusses regarding the Porphysome-the drug delivery system, its advantages and disadvantages, composition, method of preparation, applications and various aspects related to the porphysomal drug delivery.

Implantable device for drug delivery and blood sampling in the rat

1985 ◽  
Vol 59 (5) ◽  
pp. 1665-1666
Author(s):  
J. F. Chester ◽  
S. A. Weitzman ◽  
R. A. Malt
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Chloride ◽  
Implantable Device ◽  
Blood Sampling ◽  
Venous Sampling ◽  
Intravenous Catheter ◽  
Right Colon ◽  
Sampling Device ◽  
The Right

An implantable drug-delivery and venous sampling device is described that is constructed from a polyvinyl chloride catheter and a rubber intravenous catheter plug coated with Silastic. The implant was used for repeated venous sampling and for both administration of parenteral solutions and injections into the right colon of the rat for periods to 1 mo.

Controlling drug delivery from coronary stents: are we aiming for the right targets?

2015 ◽  
Vol 6 (6) ◽  
pp. 705-720 ◽  
Author(s):  
Anne Seidlitz ◽  
Monika Wentzlaff ◽  
Werner Weitschies
Keyword(s):  
Drug Delivery ◽  
Coronary Stents ◽  
The Right

Pulsatile Drug Delivery Systems: An Overview

2009 ◽  
Vol 2 (3) ◽  
pp. 605-614
Author(s):  
Ramesh D. Parmar ◽  
Rajesh K. Parikh ◽  
G. Vidyasagar ◽  
Dhaval V. Patel ◽  
Chirag J. Patel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Night Time ◽  
Technological Developments ◽  
Pulsatile Drug Delivery ◽  
Formulation Parameters ◽  
The Right

Pulsatile  Drug  Delivery  Systems  are  gaining  a  lot  of  interest  as  they  deliver  the  drug  at  the  right  place  at  the  right  time  and  in  the  right  amount,  thus  providing  spatial  and  temporal  delivery  and  increasing  patient  compliance.  These  systems  are  designed  according  to  the  circadian  rhythm  of  the  body.  The  principle  rationale  for  the  use  of  pulsatile  release  of  the  drugs is where  a  constant  drug  release  is  not  desired.  A  pulse  has  to  be  designed  in  such  a  way  that  a  complete  and  rapid  drug  release  is  achieved  after  the  lag  time.  Various  systems  like  capsular  systems,  osmotic  systems,  single-  and  multiple-unit  systems  based  on  the  use  of  soluble  or  erodible  polymer  coating  and  use  of  rupturable  membranes  have  been  dealt  with  in  the  article.  It  summarizes  the  latest  technological  developments,  formulation  parameters,  and  release  profiles  of  these  systems.  These  systems  are  beneficial  for  the  drugs  having  chronopharmacological  behavior  where  night  time  dosing  is  required,  such  as  anti-arhythmic  and  anti-asthmatic.

scholarly journals In situ drug release measuring in α-TCP cement by electrochemical impedance spectroscopy

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Júnio Augusto Rodrigues Pasqual ◽  
Lucas C. Freisleben ◽  
Júlio Cesar Colpo ◽  
Jose Ramón Jurado Egea ◽  
Luis Alberto Loureiro dos Santos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Electrochemical Impedance Spectroscopy ◽  
Impedance Spectroscopy ◽  
Electrochemical Impedance ◽  
Drug Application ◽  
Chemical Mechanism ◽  
Before And After ◽  
Good Technique ◽  
The Right ◽  
Non Destructive

AbstractThe use of drug delivery systems is a good technique to leave the right quantity of medicine in the patient’s body in a suitable dose, because the drug application is delivered directly to the affected region. The current techniques such as HPLC and UV–Vis for the drug delivery calculation has some disadvantages, as the accuracy and the loss of the sample after characterization. With the aim of reducing the amount of material used during the characterization and have a non-destructive test with instantaneous results, the present paper shows the possibility of using electrochemical impedance spectroscopy (EIS) to have a drug delivery measurement during the release phenomena for a calcium phosphate cement (CFC) delivery system with gentamicin sulfate (GS) and lidocaine hydrochloride (LH), at a ratio of 1% and 2%, respectively. The equivalent circuit and the chemical mechanism involved during the measurements have been proposed as a tool to determine the drug delivery profile. The method has been compared with the UV–Vis technique. XRD was realized to verify conditions, before and after release. It was possible to verify the potential for using EIS as an instant technique to quantify drug delivery.

scholarly journals EVALUASI PENGGUNAAN KOMBINASI OBAT DIGOKSIN DAN FUROSEMID

2020 ◽  
Vol 6 (2) ◽  
pp. 700-707
Author(s):  
Ine Suharyani
Keyword(s):  
Heart Failure ◽  
Drug Delivery ◽  
Prescription Drug ◽  
Serum Sodium ◽  
Heart Muscle ◽  
The Body ◽  
Clinical Aspects ◽  
Prescription Drug Use ◽  
The Right ◽  
Descriptive Method

Gagal jantung merupakan kondisi ketika otot jantung sangat lemah sehingga tidak bisa memompa cukup darah keseluruh tubuh dengan tekanan yang tepat. Penelitian ini bertujuan untuk mengetahui ketepatan penggunaan kombinasi digoksin dan furosemid berdasarkan aspek klinis serta pengeluaran kalium dalam tubuh. Penelitian ini dilakukan dengan metode retrospektif  yaitu menggunakan data yang telah lalu yang diperoleh dari bagian rekam medik. Data yang diambil adalah  resep penggunaan obat kombinasi digoksin dan furosemid yang ada di poli klinik jantung pada periode Oktober – Desember 2014. Hasil penelitian memperlihatkan bahwa  39 resep kombinasi digoksin dan furosemid yang menunjukkan bahwa terdapat 100 % obat berinteraksi, 100 % durasi pemberian obat sesuai dengan literatur, serta 100% penggunaan dosis sesuai dengan literatur. Hasil pemeriksaan laboratorium kadar elektrolit natrium dalam serum adalah 136 – 145 mEq/l, kadar kalium dalam serum adalah 4,4 – 4,5 mEq/l, serta kadar klorida dalam serum adalah 100 – 110 mEq/l yang menunjukkan hasil pemeriksaan laboratorium kadar elektrolit dalam tubuh keadaan normal.Kata kunci : gagal jantung, skrining, digoksin, furosemid  ABSTRACTHeart failure is a condition when the heart muscle becomes so weak that it can’t pump enough blood throughout the body at the right pressure. The aim of this research to determine the right of combination of digoksin and furosemide seen from clinical aspects as well as the expenditure of potassium in the body. This research is descriptive method. Data  collected used retrospective method used the data in the medical record. Prescription drug use a combination of digoxin and furosemide from October to December 2014. The results are 39 recipes combination of digoxin and furosemide which indicate that the drug interacts are 100%, 100% of the right duration of drug delivery, and 100%  are the right dose. Results of electrolyte level in serum sodium is 136-145 mEq / L, potassium is 4.4 to 4.5 mEq / l and chloride is 100-110 mEq / l which shows the electrolytes level in the body at the normal state.Keywords: Heart failure, screening, digoxin, furosemide          

Sign in / Sign up

Export Citation Format

Share Document