scholarly journals EVALUASI PENGGUNAAN KOMBINASI OBAT DIGOKSIN DAN FUROSEMID

2020 ◽  
Vol 6 (2) ◽  
pp. 700-707
Author(s):  
Ine Suharyani
Keyword(s):  
Heart Failure ◽  
Drug Delivery ◽  
Prescription Drug ◽  
Serum Sodium ◽  
Heart Muscle ◽  
The Body ◽  
Clinical Aspects ◽  
Prescription Drug Use ◽  
The Right ◽  
Descriptive Method

Gagal jantung merupakan kondisi ketika otot jantung sangat lemah sehingga tidak bisa memompa cukup darah keseluruh tubuh dengan tekanan yang tepat. Penelitian ini bertujuan untuk mengetahui ketepatan penggunaan kombinasi digoksin dan furosemid berdasarkan aspek klinis serta pengeluaran kalium dalam tubuh. Penelitian ini dilakukan dengan metode retrospektif  yaitu menggunakan data yang telah lalu yang diperoleh dari bagian rekam medik. Data yang diambil adalah  resep penggunaan obat kombinasi digoksin dan furosemid yang ada di poli klinik jantung pada periode Oktober – Desember 2014. Hasil penelitian memperlihatkan bahwa  39 resep kombinasi digoksin dan furosemid yang menunjukkan bahwa terdapat 100 % obat berinteraksi, 100 % durasi pemberian obat sesuai dengan literatur, serta 100% penggunaan dosis sesuai dengan literatur. Hasil pemeriksaan laboratorium kadar elektrolit natrium dalam serum adalah 136 – 145 mEq/l, kadar kalium dalam serum adalah 4,4 – 4,5 mEq/l, serta kadar klorida dalam serum adalah 100 – 110 mEq/l yang menunjukkan hasil pemeriksaan laboratorium kadar elektrolit dalam tubuh keadaan normal.Kata kunci : gagal jantung, skrining, digoksin, furosemid  ABSTRACTHeart failure is a condition when the heart muscle becomes so weak that it can’t pump enough blood throughout the body at the right pressure. The aim of this research to determine the right of combination of digoksin and furosemide seen from clinical aspects as well as the expenditure of potassium in the body. This research is descriptive method. Data  collected used retrospective method used the data in the medical record. Prescription drug use a combination of digoxin and furosemide from October to December 2014. The results are 39 recipes combination of digoxin and furosemide which indicate that the drug interacts are 100%, 100% of the right duration of drug delivery, and 100%  are the right dose. Results of electrolyte level in serum sodium is 136-145 mEq / L, potassium is 4.4 to 4.5 mEq / l and chloride is 100-110 mEq / l which shows the electrolytes level in the body at the normal state.Keywords: Heart failure, screening, digoxin, furosemide          

scholarly journals TARGETING THE TARGET USING NANOPARTICLES - A REVIEW

2017 ◽  
Vol 10 (12) ◽  
pp. 6
Author(s):  
Aravinthrajkumar G ◽  
Gayathri R ◽  
Vishnupriya V
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Intravenous Injection ◽  
Immediate Release ◽  
Dosage Forms ◽  
The Body ◽  
Specific Location ◽  
The Right ◽  
Reproducible Manner

  The challenge of drug delivery is the liberation of drug agents at the right time in a safe and reproducible manner, usually to a specific target site. Conventional dosage forms, such as orally administered pills and subcutaneous or intravenous injection, are the predominant routes for drug administration. However, pills and injections offer limited control over the rate of drug release into the body; usually, they are involved in an immediate release of the drug. This article is about how nanoparticles can be used as an effective drug delivery system to target the drug to a specific location or organ.

scholarly journals Structural Organization of Themagnetic Part of Smart Material Based on Nanoparticles of Iron or Magnetite in Pores of Mcm-41 Mesoporous Silica for Target Drug Delivery

2018 ◽  
Vol 57 (2) ◽  
pp. 175-182
Author(s):  
E.G. Zemtsova ◽  
A.N. Ponomareva ◽  
A.Y. Arbenin ◽  
V.M. Smirnov
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Smart Material ◽  
The Body ◽  
Superparamagnetic Nanoparticles ◽  
Target Drug Delivery ◽  
Target Drug ◽  
The Matrix ◽  
The Right ◽  
Mcm 41

Abstract The important stage of the development of smart material for the target drug delivery is the construction of the magnetic part of this material, including mesoporous silica and magnetic nanoparticles (Fe3O4or Fe0). Such a systemwill allow carry outmagnetic decapsulation (excretion) of drug from smart material using the magnetic field of a given value in the right place of the body. The paper considers the features of synthesis mesoporous silica MCM-41 with various pore diameter (33-51 Å) and synthesis of superparamagnetic nanoparticles of magnetite or metallic iron in the pores of mesoporous silica. The dependence of magnetic properties of nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 from the pore diameters of MCM-41 templates is studied. It was found that the matrix has a decisive influence on the content of iron or magnetite nanoparticles. The saturation magnetization of the material increases with increasing pore size of the mesoporous matrix. Nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 exhibit superparamagnetism, that allows them to be used as a magnetic material for targeted drug delivery.

Pulsatile Drug Delivery Systems: An Overview

2009 ◽  
Vol 2 (3) ◽  
pp. 605-614
Author(s):  
Ramesh D. Parmar ◽  
Rajesh K. Parikh ◽  
G. Vidyasagar ◽  
Dhaval V. Patel ◽  
Chirag J. Patel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Night Time ◽  
Technological Developments ◽  
Pulsatile Drug Delivery ◽  
Formulation Parameters ◽  
The Right

Pulsatile  Drug  Delivery  Systems  are  gaining  a  lot  of  interest  as  they  deliver  the  drug  at  the  right  place  at  the  right  time  and  in  the  right  amount,  thus  providing  spatial  and  temporal  delivery  and  increasing  patient  compliance.  These  systems  are  designed  according  to  the  circadian  rhythm  of  the  body.  The  principle  rationale  for  the  use  of  pulsatile  release  of  the  drugs is where  a  constant  drug  release  is  not  desired.  A  pulse  has  to  be  designed  in  such  a  way  that  a  complete  and  rapid  drug  release  is  achieved  after  the  lag  time.  Various  systems  like  capsular  systems,  osmotic  systems,  single-  and  multiple-unit  systems  based  on  the  use  of  soluble  or  erodible  polymer  coating  and  use  of  rupturable  membranes  have  been  dealt  with  in  the  article.  It  summarizes  the  latest  technological  developments,  formulation  parameters,  and  release  profiles  of  these  systems.  These  systems  are  beneficial  for  the  drugs  having  chronopharmacological  behavior  where  night  time  dosing  is  required,  such  as  anti-arhythmic  and  anti-asthmatic.

scholarly journals TINGKAT PENGETAHUAN SWAMEDIKASI DALAM PENANGANAN DEMAM PADA ANAK OLEH IBU DI RW 5 DUSUN SIDOHARUM SEMPOR KEBUMEN

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
R Rafila ◽  
Chondro Suro Miyarso
Keyword(s):  
High Heat ◽  
First Aid ◽  
The Body ◽  
Observational Research ◽  
Infants And Toddlers ◽  
Self Medication ◽  
Complete Knowledge ◽  
Level Of Knowledge ◽  
The Right ◽  
Descriptive Method

All age levels of humans can experience high heat or fever, it occurs because of various possibilities for the entry of seeds of disease into the body. However, cases of fever in infants and toddlers cannot be ignored. Treatment and handling is much different from adults, if the treatment and handling is wrong, slow and inappropriate will result in disruption of the development and growth of the body in infants and the safety of his soul can also be threatened. Therefore parents must master a complete knowledge of fever in children, so that when their children experience a fever it is not panic that arises but rather the right attitude and immediate action or first aid to prevent worse consequences. This research is an observational research with descriptive method. The purpose of this study was to determine the level of knowledge and factors that encourage fever self-medication by mothers in Hamlet Sidoharum RW 05, Sempor. This study was conducted involving 89 respondents. The results of the study showed that the knowledge of respondents in Sidoharum RW 05 village towards self-medication for fever was in the sufficient category.

PULSATILE DRUG DELIVERY A PROGRAMMED POLYMERIC DEVICE

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (05) ◽  
pp. 5-22
Author(s):  
S Rawat ◽  
◽  
S Bisht ◽  
P Kothiyal
Keyword(s):  
Drug Delivery ◽  
Peptic Ulcer ◽  
Circadian Rhythm ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
The Body ◽  
Latin Literature ◽  
Dose Frequency ◽  
Pulsatile Drug Delivery ◽  
The Right

Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place, at the right time and in the right amount, thus providing spatial, temporal and smart delivery and increasing patient compliance. The use of pulsatile release of the drugs is desirable where constant drug release is not desired. These systems are designed according to the circadian rhythm of the body. According to Latin literature circa means about and Diem means day. This could be advantageous for many drugs or therapies including asthma, peptic ulcer & arthritis etc. To correlate with our biological needs, “precisely timed drug delivery,” which could be accomplished with “programmable dosage forms,” is desirable. Precisely timed drug delivery may maximize therapeutic efficacy, minimize dose frequency, and may reduce toxicity. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical device.

scholarly journals ANALISIS PERBANDINGAN TARIF PAJAK PENGHASILAN PASAL 17 DAN TARIF PAJAKPENGHASILAN PASAL 4 AYAT 2 (STUDY KASUS PADA CV. MELANIA)

2016 ◽  
Vol 11 (3) ◽  
Author(s):  
Marcelino Ransulangi ◽  
Herman Karamoy ◽  
Sonny Pangerapan
Keyword(s):  
Data Collection ◽  
Income Tax ◽  
The Body ◽  
Magnitude Comparison ◽  
Literature Research ◽  
The Government ◽  
Tax Payments ◽  
The Right ◽  
The City ◽  
Descriptive Method

Income tax (VAT) is a tax levied on income earned by a taxpayer or entity. Income tax article 17 and article 4, paragraph 2 is one of the taxes that are used by the taxpayer or the body to calculate the tax to be paid to the government. The purpose of this study was to determine and analyze the process of calculation of Income Tax Article 17 and Article 4 paragraph 2 so that taxpayers can know the magnitude comparison of tax payments by using Tax Article 17 and Income Tax Article 4, paragraph 2 also taxpayers can determine the article where the right to apply in the company. The research was conducted in the city of Manado on the CV. Melania. The method used in this research is descriptive method. Data collection techniques that will be done is by way of literature research, documentation, and interviews. Keywords: Income Tax, Income Tax Article 17, Income Tax Article 4 paragraph 2.

scholarly journals Evaluasi Penggunaan Obat Antihipertensi pada Pasien Gagal Jantung Rawat Jalan di Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat

2020 ◽  
Vol 1 (2) ◽  
pp. 66
Author(s):  
Baiq Leny Nopitasari ◽  
Baiq Nurbaety ◽  
Hafni Zuhroh
Keyword(s):  
Heart Failure ◽  
Antihypertensive Treatment ◽  
Antihypertensive Drugs ◽  
Treatment Success ◽  
Cross Sectional ◽  
Heart Failure Patients ◽  
Provincial Hospital ◽  
Body Tissues ◽  
The Right ◽  
Descriptive Method

ABSTRAKGagal jantung adalah ketidakmampuan jantung memompa darah guna memenuhi kebutuhan oksigen serta memberikan nutrisi jaringan tubuh. Gagal jantung biasanya disebabkan oleh kelainan sekunder dari abnormalitas struktur jantung atau fungsi yang merusak kemampuan ventrikel kiri untuk mengisi atau mengeluarkan darah. Keberhasilan penanganan secara medis tapi juga ditentukan oleh ketepatan dalam penggunaan obat. Penelitian ini bertujuan untuk mengevaluasi ketepatan pengobatan antihipertensi pada pasien gagal jantung di poli jantung RSUD Provinsi NTB pada bulan April-Mei tahun 2019. Penelitian ini menggunakan metode deskriptif dengan pendekatan cross sectional. Penelitian dilakukan terhadap 49 catatan rekam medis pasien yang mendapatkan terapi antihipertensi dengan gagal jantung. Hasilnya menunjukan bahwa ketepatan penggunaan obat antihipertensi pada pasien gagal jantung di RSUD Provinsi NTB tahun 2019 yaitu tepat indikasi sebesar 100%, tepat pasien sebesar 100%, tepat obat sebesar 100%, tepat dosis sebesar 73,54% dan tepat frekuensi sebesar 100%.Kata kunci: Evaluasi Penggunaan Obat; Antihipertensi; Gagal Jantung.ABSTRACTHeart failure is the inability of the heart to pump blood to meet oxygen needs and provide nutrition for body tissues. Heart failure is usually caused by a secondary disorder of abnormal heart structure or function that damages the ability of the left ventricle to fill or bleed. Medical treatment success but also determined by the accuracy in the use of drugs. This study aims to evaluate the accuracy of antihypertensive treatment in heart failure patients in the heart poly of the NTB Provincial Hospital in April-May 2019. This study used a descriptive method with a cross sectional approach. The study was conducted on 49 medical record records of patients receiving antihypertensive therapy with heart failure. The results showed that the accuracy of the use of antihypertensive drugs in heart failure patients in the NTB Provincial Hospital in 2019 was seen based on the exact indication of 100%, the right patient at 100%, the exact drug at 100%, the right dose of 73,54% and the exact frequency of 100%.Keywords: Evaluation of drug use; antihypertensive; heart failure.

A Concise Insight on Pulsatile Drug Delivery System: An Outlook towards its Development

2021 ◽  
Vol 14 (5) ◽  
pp. 5577-5587
Author(s):  
Om M Bagade ◽  
Snehal S Sutar ◽  
Priyanka E Doke
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
The Body ◽  
Multiple Unit ◽  
Pulsatile Drug Delivery ◽  
Pulsatile Delivery ◽  
Time Specific ◽  
The Right

In pharmaceutical science, the pulsatile drug delivery system gains more attraction because of their number of benefits over the other dosage forms. In these systems, the drug is released at right time at the right site of action, and in the right amount, it is the most beneficial and important characteristic of the PDDS system due to that the patient compliance is increased, and the drug release is after a well-defined lag time.  Moreover, this system is designed according to the circadian rhythm of the body. Because the disease has a predictable cyclic rhythm, such as Arthritis, diabetes mellitus, asthma, peptic ulcer, hypertension, cardiovascular disease the PDDS is more effective than other dosage forms.This system is a more time-specific and site-specific drug delivery system. In this system the drug is released as a pulse. The mechanism of PDDS is first diffusion then erosion and then osmosis. For the drug having a high first-pass effect and having a high risk of toxicity and side effects, these systems can be very useful. And to reduce dosing frequency and improve patient compliance this system is very helpful. There are various methods present like, single-unit systems and multiple-unit systems – which included capsular system, pulsatile delivery by osmosis, pulsatile delivery by erosion of membrane, delivery by rupture of membrane, etc.  

THE CRITICALLY ILL CHILD: CARE OF THE INFANT IN CARDIAC FAILURE

PEDIATRICS ◽  
1971 ◽  
Vol 47 (6) ◽  
pp. 1056-1063
Author(s):  
David Goldring ◽  
Antonio Hernandez ◽  
Alexis F. Hartmann
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Blood Flow ◽  
Diastolic Pressure ◽  
Medical Center ◽  
Signs And Symptoms ◽  
The Body ◽  
Compensatory Mechanisms ◽  
The Right ◽  
Salvage Rate

Heart failure may be defined simply as the inability of the heart to pump blood commensurate with the body needs. Although it is possible for the right or left ventricle to fail separately, it is much more common for infants to present with failure of both chambers. When a ventricle fails, the end-diastolic pressure in that chamber rises and the pressure in the atrium, central, and peripheral veins is increased. There is a decrease in blood flow to the kidney which is thought to be responsible for the renal retention of sodium and water which, in turn, increases blood volume. Thus, the elevations in pressures, the disturbances in blood flow, and abnormal distribution of water and electrolytes are homeostatic and compensatory mechanisms which help preserve cardiac output while they are recognized as the signs and symptoms of heart failure. Infants under 1 year of age account for 90% of pediatric patients who develop congestive heart failure. The majority of these have congenital malformations, which are increasingly amenable to corrective surgery. The physician must, therefore, be able to make the diagnosis of heart failure with confidence and institute immediate therapy. The patient, ideally, should be transferred to a medical center with a well-equipped and well-staffed intensive care unit where therapy can be administered under 24-hour monitoring. Such an approach should steadily improve the salvage rate of infants in congestive heart failure.

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