Conventional and bi-directional genetic evidence on resting heart rate and cardiometabolic traits

2021 ◽  
Author(s):  
Tao Huang ◽  
Wenxiu Wang ◽  
Jingjia Wang ◽  
Jun Lv ◽  
Canqing Yu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Large Scale ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Heat Rate ◽  
Resting Heart Rate ◽  
Causal Inferences ◽  
Reactive Protein ◽  
Cardiometabolic Traits

Abstract Objectives To examine the direction, strength and causality of the associations of resting heart rate (RHR) with cardiometabolic traits. Methods We assessed the strength of associations between measured RHR and cardiometabolic traits in 506,211 and 372,452 participants from China Kadoorie Biobank (CKB) and UK Biobank (UKB). Mendelian randomization (MR) analyses were used to make causal inferences in 99,228 and 371,508 participants from CKB and UKB, respectively. Results We identified significant, directionally-concordant observational associations between RHR and higher total cholesterol, triglycerides (TG), low-density lipoprotein, C-reactive protein (CRP), glucose, body mass index, waist-hip ratio (WHR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) after the Bonferroni correction. MR analyses showed that 10 beat/min higher genetically-predicted RHR were trans-ethnically associated with a higher DBP (beta 2.059 [95%CI 1.544, 2.574] mmHg in CKB; 2.037 [1.845, 2.229] mmHg in UKB), higher CRP (0.180 [0.057, 0.303] log mg/L in CKB; 0.154 [0.134, 0.174] log mg/L in UKB), higher TG (0.052 [-0.009, 0.113] log mmol/L in CKB; 0.020 [0.010, 0.030] log mmol/L in UKB) and higher WHR (0.218 [-0.033, 0.469] % in CKB; 0.225 [0.111, 0.339] % in UKB). In the opposite direction, higher genetically-predicted SBP, TG, glucose, WHR and lower high-density lipoprotein were associated with elevated RHR. Conclusion Our large-scale analyses provide causal evidence between RHR and cardiometabolic traits, highlighting the importance of monitoring heat rate as a means of alleviating the adverse effect of metabolic disorders.

scholarly journals Cardiovascular, anthropometric, metabolic and hormonal profiling of normotensive women with polycystic ovary syndrome with and without biochemical hyperandrogenism

Endocrine ◽  
2021 ◽  
Author(s):  
Małgorzata Kałużna ◽  
Tomasz Krauze ◽  
Katarzyna Ziemnicka ◽  
Katarzyna Wachowiak-Ochmańska ◽  
Jolanta Kaczmarek ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ovary Syndrome ◽  
Reactive Protein ◽  
Healthy Women ◽  
Normal Ranges ◽  
Cardiometabolic Profile

Abstract Purpose Women with polycystic ovary syndrome (PCOS) present with or without biochemical hyperandrogenism (HAPCOS or non-HAPCOS, respectively). Cardiometabolic and hormonal abnormalities have been reported in women with PCOS, particularly those with hypertension. However, no direct comparison between normotensive (blood pressure <140/90 mmHg) patients with HAPCOS and non-HAPCOS has been made. This study compared different cardiovascular (CV), anthropometric, metabolic and hormonal features between normotensive patients with HAPCOS and non-HAPCOS and healthy women. Methods We consecutively recruited 249 normotensive patients with PCOS and 85 healthy eumenorrheic women to a case-control observational study. Based on blood androgen concentration, patients with PCOS were divided into HAPCOS (n = 69) or non-HAPCOS (n = 180) groups. Results Although within normal ranges, patients with HAPCOS had significantly (p < 0.05) higher peripheral and central systolic blood pressure and pulse pressure, C-reactive protein, low-density lipoprotein cholesterol, triglycerides, glucose, and insulin than subjects with non-HAPCOS, and healthy women. They also had lower N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) concentration. In contrast, their body mass index (BMI) was higher of over 4 kg/m2 than patients with non-HAPCOS and nearly 6 kg/m2 than in healthy participants. Except for BMI, statistical differences in the cardiometabolic profile were of little clinical relevance. Conclusions Young normotensive women with HAPCOS have a worse cardiometabolic profile but lower NT-proBNP concentration than patients with non-HAPCOS. Features of this profile in both PCOS groups are within ranges typical for healthy women. Increased BMI is the only clinically relevant feature differentiating hyperandrogenic from non-hyperandrogenic patients with PCOS, and healthy women.

scholarly journals Broad-spectrum physical fitness benefits of recreational football: a systematic review and meta-analysis

2018 ◽  
Vol 53 (15) ◽  
pp. 926-939 ◽  
Author(s):  
Zoran Milanović ◽  
Saša Pantelić ◽  
Nedim Čović ◽  
Goran Sporiš ◽  
Magni Mohr ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Heart Rate ◽  
Physical Fitness ◽  
Passive Control ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Control Group ◽  
Resting Heart Rate ◽  
Muscular Fitness

BackgroundA previous meta-analysis showed that maximal oxygen uptake increased by 3.51 mL/kg/min (95% CI 3.07 to 4.15) during a recreational football programme of 3–6 months in comparison with continuous moderate-intensity running, strength training or a passive control group. In addition, narrative reviews have demonstrated beneficial effects of recreational football on physical fitness and health status.ObjectiveThe purpose of this systematic review and meta-analysis was to evaluate the magnitude of effects of recreational football on blood pressure, body composition, lipid profile and muscular fitness with reference to age, gender and health status.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, PubMed, SPORTDiscus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Google Scholar were searched prior to 1 February 2017. In addition, Google Scholar alerts were set up in January 2012 to identify potential papers with the following key terms: recreational football, recreational soccer, street football and street soccer.Eligibility criteria for selecting studiesRandomised and matched controlled trials with participants allocated to a recreational football group or any other type of exercises or passive control group were included. Training programmes had to last at least 2 weeks to meet the inclusion criteria. The primary outcome measures were blood pressure, resting heart rate, body composition, muscular fitness, and blood lipids and glucose tolerance. A total of 31 papers met the inclusion criteria and were included.ResultsThe effect of recreational football on systolic blood pressure (SBP) versus no-exercise controls was most likely extremely largely beneficial (effect size (ES)=4.20 mm Hg; 95% CI 1.87 to 6.53). In addition, a most likely very large beneficial (ES=3.89 mm Hg; 95% CI 2.33 to 5.44) effect was observed for diastolic blood pressure (DBP), when compared with non-active groups. Furthermore, a most likely extremely large beneficial effect was shown for SBP and DBP in participants with mild hypertension (11 and 7 mm Hg decrease, respectively) and participants with prehypertension (10 and 7 mm Hg decrease, respectively). Meta-analysis of recreational football determined the impact on resting heart rate as most likely extremely largely beneficial (ES=6.03 beats/min; 95% CI 4.43 to 7.64) when compared with non-active groups. The observed recreational football effect on fat mass was most likely largely beneficial (ES=1.72 kg; 95% CI 0.86 to 2.58) and the effect on countermovement jump (CMJ) performance was most likely very largely beneficial (ES=2.27 cm; 95% CI 1.29 to 3.25) when compared with non-active groups. Possibly beneficial decreases were found in low-density lipoprotein levels (ES=0.21 mmol/L; 95% CI 0.06 to 0.36). Possibly largely beneficial effect was observed for DBP in comparison with continuous running training. Small harmful and unclear results were noted for SBP, fat and lean body mass, body mass index, as well as muscular fitness when compared with running and Zumba training.ConclusionThe present meta-analysis demonstrated multiple broad-spectrum benefits of recreational football on health-related physical fitness compared with no-exercise controls, including improvements in blood pressure, resting heart rate, fat mass, low-density lipoprotein cholesterol and CMJ performance. Additionally, recreational football is efficient and effective as Zumba and continuous running exercise regimens with highlighted social, motivational and competitive components.

Relationship between C-reactive protein and intima-media thickness in the carotid and femoral arteries and to antibodies against oxidized low-density lipoprotein in healthy men: the Atherosclerosis and Insulin Resistance (AIR) study

2001 ◽  
Vol 100 (4) ◽  
pp. 371-378 ◽  
Author(s):  
Johannes HULTHE ◽  
John WIKSTRAND ◽  
Björn FAGERBERG
Keyword(s):  
Blood Pressure ◽  
Subclinical Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Oxidized Low Density Lipoprotein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Antibody Titres ◽  
Old Men

Results from several recent reports have linked high serum C-reactive protein (CRP) levels to atherosclerotic disease and its complications. The aims of the present study were to investigate the relationship between CRP levels and subclinical atherosclerosis, as measured by ultrasound in the carotid and femoral arteries; and also to examine whether CRP levels are associated with antibodies to oxidized low-density lipoprotein (Ox-LDL). The study group (n = 391) consisted of clinically healthy 58-year-old men recruited from the general population. CRP and antibody titres to Ox-LDL were measured by ELISA. The results showed an association between CRP and ultrasound-assessed subclinical atherosclerosis in the femoral artery (r = 0.14, P = 0.010), and also between CRP and systolic blood pressure, diastolic blood pressure, heart rate, triglycerides, high-density lipoprotein, body mass index, waist-to-hip ratio (WHR), blood glucose, cigarette-years and antibody titres to ox-LDL (r = 0.19, P < 0.001). In this clinically healthy population of 58-year-old men, CRP levels were associated with both intima-media thickness and plaque occurrence in the femoral artery. The association between CRP and femoral atherosclerosis was not independent of smoking, serum LDL cholesterol, or systolic blood pressure. CRP levels were independently related to abdominal obesity measured as WHR, smoking and antibody titres to Ox-LDL.

scholarly journals Control of Resting Heart Rate and Other Risk Factors Over a Three-year Period in Outpatients with Stable Coronary Artery Disease in Latvia

2014 ◽  
Vol 67 (6) ◽  
pp. 457-465
Author(s):  
Inga Balode ◽  
Sanda Jēgere ◽  
Iveta Bajāre ◽  
Iveta Mintāle ◽  
Inga Narbute ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Density Lipoprotein ◽  
Resting Heart Rate ◽  
Baseline Systolic Blood Pressure ◽  
Artery Disease

Abstract The aim of the study was to evaluate control of heart rate (HR) and other risk factors (RF) over athree-year period in coronary artery disease (CAD) outpatients in Latvia. Patients (n = 120) were examined and questioned at baseline time and annually (four times in total). Increased resting HR (≥70 bpm) when measured by palpation was present in 35.8% of cases at baseline time, 35.6%, 29.8% and 35.1% of cases at Y1, Y2 and Y3, respectively; when measured by electrocardiography: in 33.6% (baseline), 36.8% (Y1), 26.7% (Y2), 33.7% (Y3) of cases. The proportion of patients with increased HR did not significantly change in Y1–Y3 vs baseline. Systolic blood pressure was lower in Y1 and Y3 vs baseline (P = 0.005 and P = 0.003, respectively). The proportion of patients with increased blood pressure (≥140/90 mmHg) was lower in Y1, Y2 and Y3 than at baseline (P = 0.018, P = 0.030 and P = 0.017, respectively). The proportion of patients with a decreased level of high density lipoprotein cholesterol (<1.2 mmol/l for women and <1.0 mmol/l fom men) was lower in Y1–Y3 compared to baseline (P < 0.001). A substantial (about one-third) and stable proportion of patients with increased HR≥70 bpm over the three-year period in the examined sample of treated CAD patients indicates that there is a need for better control of this RF.

scholarly journals The influence of various smoking statuses on the resting heart rate in a physical examination population with high-normal blood pressure

2020 ◽  
Author(s):  
wenyu chen ◽  
Zhixian Fang ◽  
Yufeng Xu
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Physical Examination ◽  
Passive Smoking ◽  
Density Lipoprotein ◽  
Normal Blood ◽  
Resting Heart Rate ◽  
Active Smoking ◽  
Normal Blood Pressure ◽  
Smoking Group

Abstract Background The exact relation between smoking statuses and hypertension in the population with high-normal BP is poorly understood. Objective To investigate the influence of various smoking statuses (active smoking, passive smoking, and non-smoking) on the resting heart rate of the population with high-normal blood pressure. Methods This was a cross-sectional study of patients undergoing physical examination at three Chinese hospitals between January 2018 and December 2019, and who conformed with the criteria of high-normal BP. The subjects were classified into the non-smoking, active smoking and passive smoking groups. The resting heart rate (RHR) and blood pressure (BP) were measured. High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C), triglycerides (TG), total cholesterol (TC), and fasting blood glucose (FBG) were measured. Results TG, TC, and FBG were significantly higher in the active smoking group than in the two other groups (all P<0.05). HDL-C levels were lower in the active smoking group than in the two other groups (P<0.05). There were significant differences in RHR among the three groups (active: 76.0±10.1 vs. passive: 72.6±5.8 vs. non-smoking: 69.4±4.4 bpm, P<0.01). Active smoking (odds ratio (OR)=5.13, P<0.05), SBP (OR=0.70, P<0.05), HDL-C (OR=0.58, P<0.05), and passive smoking (OR=3.57, P<0.05) were independently associated with increased RHR. ConclusionRHR was higher in subjects with high-normal BP and in the passive and active smoking groups. Strengthening smoking cessation education and avoiding exposure secondary smoke could be beneficial to control the population with high-normal BP.

scholarly journals 279GWAS of heart rate in 87,759 Chinese subjects highlighted its genetic correlations with cardiometabolic traits

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Songchun Yang ◽  
Canqing Yu ◽  
Yu Guo ◽  
Zheng Bian ◽  
Robin G. Walters ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Genetic Correlations ◽  
Additive Model ◽  
Density Lipoprotein ◽  
Asian Cohort ◽  
Multiple Chronic Diseases ◽  
Cardiometabolic Traits

Abstract Background Resting heart rate (RHR) has been associated with risks of mortality and multiple chronic diseases. Previous studies, predominantly conducted in Europeans, have reported 91 independent variants associated with RHR and its genetic correlations with several cardiometabolic traits. Studies from East Asians are lacking. Methods We performed a GWAS for RHR in 87,701 participants aged 30-79 years from China Kadoorie Biobank (CKB). A linear mixed model was used under an additive model. Replication was conducted in 37,251 Chinese participants from CKB and UK Biobank. We conducted LD score regression to quantify genetic correlations across RHR and 11 cardiometabolic traits. Results Only 50 previously reported variants were replicated in CKB (=0.025). We identified ten novel loci associated with RHR (P&lt;5 × 10-8), of which 50 candidate genes were prioritized. RHR showed significant genetic correlations with diastolic blood pressure (rg=0.258, P=5.71 × 10−10), mean arterial pressure (rg=0.225, P=3.08 × 10−8), systolic blood pressure (rg=0.170, P=4.92 × 10−5), plasma glucose (rg=0.197, P=0.003), total cholesterol (rg=0.287, P=0.012), and high-density lipoprotein (rg=0.246, P=0.030). Conclusions We identified ten novel loci associated with RHR in a large Asian cohort. The identified genetic correlations of RHR with blood pressure, glucose, and lipids indicate previously reported association of RHR with risk of all-cause death might be mediated via its correlations with cardiometabolic traits. Key messages

scholarly journals Characteristics of Cardiovascular Risk Factors and Their Correlation with the Sex and Age of Patients in the Latvian Population

2009 ◽  
Vol 63 (4-5) ◽  
pp. 125-130
Author(s):  
Inga Stuķēna ◽  
Andrejs Kalvelis ◽  
Guntis Bahs ◽  
Uldis Teibe ◽  
Pēteris Tretjakovs ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Blood Glucose ◽  
Cardiovascular Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Age Group ◽  
Reactive Protein

Characteristics of Cardiovascular Risk Factors and Their Correlation with the Sex and Age of Patients in the Latvian Population Various cardiovascular risk factors (RFs) were determined in 773 out-patients (mean age 55.8 ± 14.5 years). Male individuals had a larger waist circumference (WC) than did female patients (99.1 ± 13.6 cm vs 93.3 ± 15.2 cm), higher diastolic blood pressure (DBP) (83.6 ± 9.6 mmHg vs 81.8 ± 9.6 mmHg), and higher levels of blood glucose (5.73 ± 1.4 mmol/L vs 5.49 ± 1.3 mmol/L) and triglycerides (TG) (1.89 ± 1.3 mmol/L vs 1.60 ± 1.0 mmol/L), but lower levels of total cholesterol (TC) (5.54 ± 1.2 mmol/L vs 5.79 ± 1.2 mmol/L) and high-density lipoprotein cholesterol (HDL-C) (1.21 ± 0.4 mmol/L vs 1.44 ± 0.4 mmol/L). Compared with the younger age group (i.e., males, < 7 years; females, < 65 years), patients in the older age group had a larger WC (98.4 ± 14.2 cm vs 92.8 ± 15.1 cm), higher systolic blood pressure (SBP) (144.2 ± 19.2 mmHg vs 131.6 ± 18.5 mmHg), higher DBP (84.5 ± 8.8 mmHg vs 80.9 ± 9.8 mmHg), higher blood glucose level (5.74 ± 1.3 mmol/L vs 5.46 ± 1.3 mmol/L), and higher low-density lipoprotein cholesterol level (LDL-C) (3.68 ± 1.0 mmol/L vs 3.52 ± 1.0 mmol/L), but lower HDL-C level (1.3 ± 0.4 mmol/L vs 1.41 ± 0.4 mmol/L). Age was significantly correlated with all RFs, with the exception of the level of C-reactive protein. In conclusion, analysis of cardiovascular RFs in different age subgroups of both sexes clearly showed individual peculiarities of risk profile. This conclusion challenges the usual way of risk calculation using "universal" markers like adiposity or dyslipidemia in all population. The new approach requires individual attention depending on sex and age also in management of risk.

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