Progression of vertebral fractures in patients with adrenocortical carcinoma undergoing mitotane therapy

Abstract Context patients with adrenocortical carcinoma (ACC) are frequently on mitotane therapy for a long-time period. The drug exerts an adrenolytic activity requiring glucocorticoid supplementation, which can be potentially detrimental for bone. Objectives to explore whether mitotane plus/minus chemotherapy is associated with an increased proportion of morphometric vertebral fractures (VFs) in ACC patients. Secondary objectives were: proportion of patients with VF progression, or worsening of the spinal deformity index (SDI) during mitotane therapy; predictive factors of VF progression and prognostic role of VF progression. Design and setting multicenter, retrospective cohort study of patients with ACC who received mitotane alone or in association to chemotherapy, recruited from January 2010 to January 2020 in two reference centers in Italy and France. Results a significant increase in the frequency of VFs before and after mitotane therapy was seen both in Italian (28.3% vs 47.8%, p: 0.04) and French (17.8% vs 35.6%, p 0.04) series. VF progression was observed in 39.1%, and 28.9% of patients, respectively. Baseline VFs and increased patient body mass index, but not the dose of cortisol supplementation, showed an independent association with VF progression at multivariate analysis. Among the 72 advanced ACC patients, progression of VFs was associated with a poorer survival. Conclusions the administration of mitotane plus/minus chemotherapy in ACC patients impairs bone health independently from cortisol supplementation. Appropriate preventive measures to decrease the fracture risk should be implemented in these patients.

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Evaluation of a multimarker panel in chronic heart failure: a 10-year follow-up

Biomarkers in Medicine ◽

10.2217/bmm-2020-0722 ◽

2021 ◽

Author(s):

Susanne Bauer ◽

Christina Strack ◽

Ekrem Ücer ◽

Stefan Wallner ◽

Ute Hubauer ◽

...

Keyword(s):

Heart Failure ◽

Prognostic Role ◽

Blood Samples ◽

Kaplan Meier ◽

Risk Of Mortality ◽

Patients With Heart Failure ◽

All Cause Mortality ◽

Long Time

Aim: We assessed the 10-year prognostic role of 11 biomarkers with different pathophysiological backgrounds. Materials & methods/results: Blood samples from 144 patients with heart failure were analyzed. After 10 years of follow-up (median follow-up was 104 months), data regarding all-cause mortality were acquired. Regarding Kaplan–Meier analysis, all markers, except TIMP-1 and GDF-15, were significant predictors for all-cause mortality. We created a multimarker model with nt-proBNP, hsTnT and IGF-BP7 and found that patients in whom all three markers were elevated had a significantly worse long-time-prognosis than patients without elevated markers. Conclusion: In a 10-year follow-up, a combination of three biomarkers (NT-proBNP, hs-TnT, IGF-BP7) identified patients with a high risk of mortality.

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Polyaspartamide Functionalized Catechol-Based Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties

Polymers ◽

10.3390/polym10111188 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1188 ◽

Cited By ~ 3

Author(s):

Milène Tan ◽

Youngjin Choi ◽

Jaeyun Kim ◽

Ji-Heung Kim ◽

Katharina Fromm

Keyword(s):

Antimicrobial Properties ◽

Kinetic Studies ◽

Bactericidal Effect ◽

Release Kinetic ◽

E Coli ◽

Dispersed Particles ◽

Time Period ◽

Long Time ◽

20 Nm

In this study, polyaspartamide-based hydrogels were synthesized by boron-catechol coordination followed by incorporation of AgNPs into the materials. Free catechol moieties were exploited to produce AgNPs. TEM analyses displayed AgNPs of less than 20 nm in diameter and with minimum aggregation, attesting the role of hydrogels to act as an efficient template for the production of dispersed particles. XRD analyses confirmed the mean particle size using the Scherrer equation. Release kinetic studies were performed in DMEM medium, showing a slow release over a long time-period. Finally, the MIC and MBC were determined, demonstrating a bacteriostatic and bactericidal effect against Gram-positive S. aureus and Gram-negative E. coli.

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The changing pattern of UK strikes, 1964-2014

Employee Relations ◽

10.1108/er-05-2015-0084 ◽

2015 ◽

Vol 37 (6) ◽

pp. 733-745 ◽

Cited By ~ 6

Author(s):

Dave Lyddon

Keyword(s):

Design Methodology ◽

Transition Period ◽

Strike Activity ◽

Content Type ◽

The Third ◽

Time Period ◽

Long Time ◽

Legislative Changes ◽

The Uk

Purpose – The purpose of this paper is to provide an overview of the changing strike activity in the UK over the last 50 years. Design/methodology/approach – The paper draws on a wide literature on UK strikes and an extensive trawl of newspaper sources. It is divided into four main sections. The first two summarise, in turn, the changing amount and locus of strike activity between 1964 and 2014. The third discusses the changing relationship and balance between official and unofficial strikes. The last covers the role of the courts and legislation on strikes, highlighting some key moments in this turbulent history. Findings – The period 1964-2014 can be divided into three sub-periods: high-strike activity until 1979; a transition period of “coercive pacification” in the 1980s; and unprecedentedly low-strike activity since the early 1990s. Unions were more combative against the legislative changes of the 1980s than they are normally given credit for. Research limitations/implications – Given its broad scope, this paper cannot claim to be comprehensive. Originality/value – This is a rare study of the changing nature of UK strikes over such a long time period.

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The role of ToM in creating a reminiscence bump for MEAMs from adolescence

Psychology of Music ◽

10.1177/0305735617735374 ◽

2017 ◽

Vol 47 (1) ◽

pp. 51-68 ◽

Cited By ~ 1

Author(s):

Susanne Kristen-Antonow

Keyword(s):

Theory Of Mind ◽

Middle Childhood ◽

Cognitive Theory ◽

Factual Knowledge ◽

Autobiographical Memories ◽

Reminiscence Bump ◽

Time Period ◽

Before And After ◽

Emotional Aspects

To date, studies have yet to consider the role of theory of mind as an important factor in developing music-related autobiographical memories. Further, it remains unclear if one remembers primarily factual knowledge about a song (semantic memory) or if one retrieves the perceptual and emotional aspects of the life situation connected to a song (episodic memory). To close these research gaps, 61 participants with an average age of 20 years listened to 33 songs topping the charts during their early childhood, childhood or youth. Next to a range of control variables (e.g. family size) participants’ state emotions before and after the experiment, as well as their socio-affective and socio-cognitive theory of mind were assessed. The music mainly invoked episodic versus semantic memories. The strongest positive predictor of specific episodic music-related autobiographical memories from later youth was participants’ socio-cognitive theory of mind. Results also revealed that songs released during early and middle childhood were listened to beyond this time period and triggered mainly memories from early youth. The results are discussed in regard to the possible role of socio-cognitive factors in creating a reminiscence bump for music from later youth.

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Vibration of Power Hand Tool and Discomfort Experience among Malaysian Industrial Workers

Advanced Engineering Forum ◽

10.4028/www.scientific.net/aef.10.313 ◽

2013 ◽

Vol 10 ◽

pp. 313-317 ◽

Cited By ~ 1

Author(s):

Rahayu K. Seri ◽

A. Nurulhuda ◽

A. Rohana

Keyword(s):

Industrial Workers ◽

Hand Tools ◽

Industrial Worker ◽

Limit Value ◽

Exposure Limit ◽

Time Period ◽

Hand Tool ◽

Before And After ◽

Long Time ◽

Power Hand Tools

In reality, people who worked with power vibrating tools exposed with the vibrated syndrome that effect their normal life especially who involved for long time period. Hand-arm vibration (HAV) is a widespread hazard in many industries and occupations involving the use of handheld power tools or hand-fed machines. This paper describes a research and observation on the vibrating hand tool. The objective of this study is to measure and compare the grip strength and hand arm vibration before and after using the Ready-Reckoned standard for industrial workers. Continually, an analysis is conducted due to the pain and discomfort experience that face by the workers. This research also do the analysis about the effects of the vibration to the workers hand depend on the duration of handling the power hand tool. Hundred respondent was involved which 50 men and 50 women who had been identified as an industrial worker and working with power hand tools or machinery. The respondents were interviewed and answer Q-Survey that directly conducted at their workplace after doing the test. As the result, worker who works 8 hours per day, the exposure limit value (ELV) is 5m/s, it can cause fatal effects. Most of workers suffered with fingers that gone white on cold exposure and weakness in hand grip.

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Prognostic Role of Minimal Residual Disease before and after Hematopoietic Stem Cell Transplantation in Childhood Acute Lymphoblastic Leukemia

Blood ◽

10.1182/blood.v126.23.1413.1413 ◽

2015 ◽

Vol 126 (23) ◽

pp. 1413-1413

Author(s):

Bartolomeo Rossi ◽

Mimma Campeggio ◽

Elisa Magrin ◽

Marco Zecca ◽

Laura Rubert ◽

...

Keyword(s):

Stem Cell ◽

Poor Prognosis ◽

Residual Disease ◽

Lymphoblastic Leukemia ◽

Good Prognosis ◽

Prognostic Role ◽

Hematopoietic Stem ◽

Before And After ◽

Minimal Residual

Abstract Background and Objectives Currently, more than 80% of children with acute lymphoblastic leukemia (ALL) can be cured through intensive and risk-adapted chemotherapy protocols. Allogeneic hematopoietic stem cell transplantation (HSCT) is considered beneficial for approximately 10% of the patients who are at very-high risk at frontline therapy and for the majority of patients after relapse. In this retrospective study, we aimed to assess the prognostic role of minimal residual disease (MRD) before HSCT and at different time points after transplantation in children with ALL. Patients and Methods We analyzed 64 pediatric ALL patients given HSCT: 22/64 were in first complete remission (1CR) and 42/64 in second complete remission (2CR). Genomic DNA was obtained from bone marrow aspirates collected at diagnosis/relapse, before HSCT (pre-HSCT) and at the first and third trimesters after HSCT (post-HSCT1 and post-HSCT3). MRD was measured by quantitative real-time PCR assays based on patient-specific junctional regions and interpreted according to the EuroMRD guidelines. The association between MRD and survival was assessed by chi-square test. Results All evaluated patients were analyzed for MRD before transplantation (pre-HSCT). MRD was negative in 26/64 patients and positive in 38/64 patients. As for cases with positive MRD, 17/38 showed MRD levels ≥1x10-3 and 21/38 <1x10-3. Any detectable MRD positivity at pre-HSCT was significantly associated with a poor prognosis: 28/38 patients with positive MRD are dead, whereas 22/26 with negative MRD are alive in CR (P < 0.001). Among the 42 patients in 2CR, 14/42 had negative pre-HSCT MRD and 28/42 were MRD positive. The negativity of MRD before transplantation was found to be significantly associated with a good prognosis: 13/14 patients with negative MRD are alive in CR, while 23/28 with positive MRD are dead (p < 0.001). Post-HSCT1 MRD was analyzed in 53 patients: 17/53 were MRD positive and 36/53 were MRD negative. Based on MRD status, the prognosis was significantly different: 26/36 patients with negative post-HSCT1 MRD are alive in CR, whereas 14/17 of patients with positive MRD are dead (P < 0.001). Post-HSCT3 MRD was assessed in 41 patients and 19/41 were found positive. Persistence of MRD was associated with a poor prognosis also at this time-point (P = 0.001). Conclusions These results confirm that MRD assessment has a critical role both before and after transplantation. Negative MRD before transplantation is strongly associated with a good prognosis, particularly in 2CR patients. Since persistence of MRD after HSCT is significantly associated with a worse outcome, these patients could benefit from early discontinuation of immunosuppression, adoptive T-cell therapy and use of new drugs. Disclosures No relevant conflicts of interest to declare.

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Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates

Human Pathology ◽

10.1016/j.humpath.2012.07.025 ◽

2013 ◽

Vol 44 (5) ◽

pp. 822-828 ◽

Cited By ~ 49

Author(s):

Eleonora Duregon ◽

Marco Volante ◽

Jessica Giorcelli ◽

Massimo Terzolo ◽

Enzo Lalli ◽

...

Keyword(s):

Validation Study ◽

Adrenocortical Carcinoma ◽

Prognostic Role ◽

Steroidogenic Factor 1

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Nano Scale Creep and the Role of Defects

MRS Proceedings ◽

10.1557/proc-436-201 ◽

1996 ◽

Vol 436 ◽

Cited By ~ 14

Author(s):

S. A. Syed Asif ◽

J. B. Pethica

Keyword(s):

Room Temperature ◽

Contact Stiffness ◽

Surface Films ◽

Force Method ◽

Before And After ◽

Long Time ◽

Reverse Creep ◽

Temperature Strain ◽

Accurate Observation

AbstractThe modulating force method in nanoindentation gives a direct measure of contact stiffness, and being insensitive to drift, allows the accurate observation of creep in small indents to be carried out over long time periods. We present results for a range of metals at room temperature. Strain rate indices similar to those for macroscopic creep are found. Reverse creep occurs for step unloading greater than about half the starting load. For electropolished tungsten, we find quite different behaviour before and after the sudden pop-in. Afterwards, creep is as in other metals, but beforehand, it is essentially zero. The slight changes of stiffness observed at the very smallest loads are due to diffusion of adsorbed surface films into the contact zone. Our results show that the dislocations nucleated and multiplied at pop-in provide the mechanism of creep.

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