scholarly journals Differences in Free Estradiol and Sex Hormone-Binding Globulin in Women with and without Premenstrual Dysphoric Disorder

2008 ◽  
Vol 93 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Susan Thys-Jacobs ◽  
Don McMahon ◽  
John P. Bilezikian
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Luteal Phase ◽  
Premenstrual Dysphoric Disorder ◽  
Sex Hormone Binding Globulin ◽  
Self Assessment ◽  
Ovarian Steroid ◽  
Cross Sectional ◽  
Symptom Screening ◽  
Hormonal Evaluation

Abstract Context: Over the years, different hypotheses involving the ovarian steroid hormones have been proposed to explain the luteal phase occurrence of severe premenstrual syndrome symptoms. Although it had been strongly suspected that differences in the concentrations of the ovarian steroids may underlie the mood and psychological imbalance of this disorder, the evidence for this hypothesis has been inconsistent and remains controversial. Objective: Our objective was to measure the ovarian steroid hormones across the menstrual cycle in women with and without luteal phase symptoms consistent with premenstrual dysphoric disorder (PMDD). Design: We measured estradiol (E2), progesterone, and SHBG in women with and without PMDD using a cross-sectional and prospective experimental design. Participating women underwent 2-month self-assessment symptom screening and 1-month hormonal evaluation. Results: Overall means for LH, progesterone, E2, peak E2, and free E2 were not different between groups. Across the menstrual cycle, overall percent free E2 was significantly lower and SHBG significantly greater in the PMDD group compared with controls (1.39 ± 0.26 vs. 1.50 ± 0.28, P = 0.03; 61.4 ± 25.1 vs. 52.4 ± 21.3 nmol/liter, P = 0.046, respectively). During the luteal phase, free E2 was significantly lower in the PMDD group compared with controls (PMDD 7.6 ± 7.0 vs. controls 8.9 ± 8.4 pmol/liter; P = 0.032). For both follicular and luteal phases, SHBG was significantly higher in the PMDD group (follicular phase 60.5 ± 31.7 vs. 51.4 ± 38.2 nmol/liter, P = 0.047; luteal phase 65.1 ± 32.3 vs. 55.1 ± 38.9 nmol/liter, P =0.03). In both groups, SHBG significantly increased from the follicular to luteal phase. Conclusion: Luteal phase concentrations of free E2, percent free E2, and SHBG differ significantly between women with and without PMDD.

scholarly journals Dream Recall and Content versus the Menstrual Cycle: A Cross-Sectional Study in Healthy Women

2019 ◽  
Vol 7 (7) ◽  
pp. 81
Author(s):  
Ioannis Ilias ◽  
Nicholas-Tiberio Economou ◽  
Anastasia Lekkou ◽  
Andrea Romigi ◽  
Eftychia Koukkou
Keyword(s):  
Menstrual Cycle ◽  
Young Women ◽  
Luteal Phase ◽  
Cross Sectional Study ◽  
Dream Content ◽  
Dream Recall ◽  
Sectional Study ◽  
Cross Sectional ◽  
Large Sample ◽  
Hormonal Milieu

The association between sleep and the menstrual cycle has been scarcely studied. This study aimed to investigate the association between dream recall and content and the menstrual cycle among a large sample of young women. To this aim, 944 women were asked about their day of menstrual cycle, whether they remembered the previous night’s dreams and if they did so to describe the dream content as pleasant or unpleasant. A total of 378 women recalled the previous nights’ dreams, with 199 reporting pleasant dream affect/content and 179 reporting unpleasant dream content. In women who recalled their dreams, there was an association of pleasant dream content with the luteal phase (p = 0.038). In conclusion, in women, the hormonal milieu of the luteal phase may influence dream content.

Brain activation during emotion regulation in women with premenstrual dysphoric disorder

2017 ◽  
Vol 48 (11) ◽  
pp. 1795-1802 ◽  
Author(s):  
Nicole Petersen ◽  
Dara G. Ghahremani ◽  
Andrea J. Rapkin ◽  
Steven M. Berman ◽  
Letty Liang ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Region Of Interest ◽  
Premenstrual Dysphoric Disorder ◽  
Follicular Phase ◽  
Precentral Gyrus ◽  
Affective Symptoms ◽  
Dorsolateral Prefrontal ◽  
The Right

AbstractBackgroundDifficulties in regulating emotions are linked to the core symptoms of premenstrual dysphoric disorder (PMDD). We therefore investigated the neural substrates of emotion-regulation problems in women with PMDD.MethodsOn the basis of self-evaluations over 2 months on the Daily Record of Severity of Problems, eligible participants were assigned to two groups: PMDD and control (18 per group). Functional magnetic resonance imaging (fMRI) and a well-validated task were used to assess brain function during emotion regulation. Participants were tested twice, once during the follicular (asymptomatic) and once in the late luteal (symptomatic) phase of the menstrual cycle.ResultsWomen with PMDD gave higher ratings of negative affect in the luteal phase than in the follicular phase, and compared with healthy control participants during the luteal phase. A region-of-interest fMRI analysis indicated that during the late luteal phase, women with PMDD had hypoactivation in right dorsolateral prefrontal cortex (dlPFC) during all conditions of the emotion-regulation task, not only in the contrast that isolated emotion regulation. An exploratory whole-brain, voxel-wise analysis showed that women with PMDD had less activation in the precentral gyrus during the luteal phase than the follicular phase, and less activation in the postcentral gyrus compared with control participants.ConclusionsDuring the luteal phase of the menstrual cycle, women with PMDD experience difficulty regulating emotions. Hypoactivation in the right dlPFC may contribute to this problem, but may be related more generally to other affective symptoms of PMDD. Hypofunction in the right pre- and postcentral gyri warrants additional study.

scholarly journals Pulsatile secretory characteristics of allopregnanolone, a neuroactive steroid, during the menstrual cycle and in amenorrheic subjects

2002 ◽  
pp. 347-356 ◽  
Author(s):  
AD Genazzani ◽  
M Luisi ◽  
B Malavasi ◽  
C Strucchi ◽  
S Luisi ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Pulse Amplitude ◽  
Follicular Phase ◽  
Neuroactive Steroid ◽  
Hypothalamic Amenorrhea ◽  
Temporal Coupling ◽  
Serum Gonadotropin ◽  
Hormonal Evaluation ◽  
Neuroendocrine Functions

OBJECTIVE: To investigate whether allopregnanolone, a neuroactive steroid involved in modulating behavioural and neuroendocrine functions, shows episodic secretion in eumenorrheic women, during the follicular and luteal phases of the menstrual cycle, and in women with stress-induced amenorrhea. PATIENTS: Six eumenorrheic women and 14 women with hypothalamic amenorrhea were enrolled for the present study. METHODS: All subjects underwent hormonal evaluation in baseline conditions and a pulsatility study to determine LH, cortisol and allopregnanolone episodic release. Eumenorrheic subjects were investigated twice, in the follicular phase (days 3-7) and in the luteal phase (days 18-22) of the menstrual cycle. LH, FSH, prolactin, estradiol, phosphate, DHEA, allopregnanolone and cortisol levels were evaluated in each case. RESULTS: In healthy women, serum gonadotropin and gonadal steroid levels were significantly lower (P<0.01 and P<0.05 respectively) than those in amenorrheic subjects. Allopregnanolone was higher in amenorrheic subjects and during the luteal phase, compared with the follicular phase, of eumenorrheic subjects (P<0.01). Pulse analysis revealed a significant episodic discharge of allopregnanolone in all subjects (follicular phase 6.5+/-0.3 peaks/6 h and luteal phase 5.5+/-0.4 peaks/6 h, hypothalamic amenorrhea 7.0+/-0.7 peaks/6 h) with higher pulse amplitude in amenorrheic subjects and during the luteal phase compared with the follicular phase of the eumenorrheic subjects (P<0.05). Moreover, the specific concordance index demonstrated that allopregnanolone is coupled with LH only during the luteal phase of the cycle and with cortisol during both phases. Allopregnanolone-cortisol coupling was also observed in amenorrheic subjects. CONCLUSIONS: Allopregnanolone is secreted episodically. Both the ovary and adrenal glands release this steroid hormone and it shows temporal coupling with LH only during the luteal phase, with cortisol during both the studied phases of the menstrual cycle in eumenorrheic women and again with cortisol in hypothalamic amenorrheic patients.

Hubungan Antara Status Gizi Dan Tingkat Stres Dengan Kejadian Pre-Menstrual Syndrome Pada Remaja Putri Di Pondok Pesantren Lirboyo Kota Kediri Tahun 2016

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Miftakhul Mualimah ◽  
Ana Wildani
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Simple Random Sampling ◽  
Physical Symptoms ◽  
Nutrition Status ◽  
P Value ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
Stress Levels ◽  
Current Cycle

ABSTRAK Pre-Menstrual Syndrome adalah kumpulan gejala fisik, psikologis dan emosi yang terkait dengan siklus menstruasi wanita dan secara konsisten terjadi selama fase luteal dari siklus menstruasi akibat perubahan hormonal yang berhubungan dengan siklus saat ovulasi dan menstruasi. Salah satu faktor penyebab pre-menstrual syndrome adalah status gizi dan tingkat stres.Desain penelitian yang digunakan adalah penelitian analitik korelasional dengan menggunakan pendekatan cross sectional. Populasi yang diteliti adalah semua remaja putri usia 12-21 tahun di Pondok Pesantren Lirboyo pada Tahun 2016 sejumlah 127 orang dengan teknik simple random sampling analisa dengan menggunakan spearman rank.Hasil analisis diperoleh nilai p value = 0,000 sehingga  p value  α  maka H0 ditolak dan H1 diterima dengan nilai r =- 0,533. Sedangkan variabel tingkat stres dengan kejadian pre-menstrual syndrome, dengan hasil p value = 0,000 sehingga  p value  α  maka H0 ditolak dan H1 diterima dengan nilai r = 0,650. Berdasarkan hasil penelitian diharapkan angka kejadian pre-menstrual syndrome dapat berkurang dengan cara mengenali dini gejala terjadinya pre-menstrual syndrome dan memberikan penyuluhan kepada santri cara mencegah pre-menstrual syndrome. Kata kunci : status gizi, tingkat stres dan pre-menstrual syndrome.   ABSTRACT Pre-Menstrual Syndrome is collection of physical symptoms, psychological and emotion associated with a woman’s menstrual cycle and consistently occur during the luteal phase of the menstrual cycle due to hormonal changes associated with the current cycle of ovulation and menstruation. One of couses factor pre-menstrual syndromeis nutrition status and stress levels. The research design used an analytic corelation research by using the cross sectional approach. The population of this research were young women aged 12-21 years at Pondok Pesantren Lirboyo in 2016 amount 127 peoples with probability sampling type analyse by spearman rank.The analysis result showed that between nutrition status with pre-menstrual syndrome that p value = 0.000, p value α so H0 was rejected and H1 was accepted by r =-0,533.Futhermore, the result showed that between stress levels with pre-menstrual syndrome, get p value = 0.000 so p value α, H0was rejected and H1 was acceptedby r = 0,650. Based on this result was expected that the incident of pre-menstrual syndromecan be decrease by recognize the symptomps of pre-menstrual syndrome and provide counseling to students how to prevent pre-menstrual syndrome. Keywords : nutrition status, stress levels and pre-menstrual syndrome

scholarly journals Insomnia, Inattention and Fatigue Symptoms of Women with Premenstrual Dysphoric Disorder

2021 ◽  
Vol 18 (12) ◽  
pp. 6192
Author(s):  
Pai-Cheng Lin ◽  
Chih-Hung Ko ◽  
Yen-Ju Lin ◽  
Ju-Yu Yen
Keyword(s):  
Menstrual Cycle ◽  
Functional Impairment ◽  
Repeated Measures ◽  
Luteal Phase ◽  
Rating Scale ◽  
Sleep Problems ◽  
Premenstrual Dysphoric Disorder ◽  
Assessment Scale ◽  
Control Group ◽  
Late Luteal Phase

Aim: Premenstrual dysphoric disorder (PMDD) has predictable, cyclic, psychological, and somatic symptoms, such as sleep problems. They result in functional impairment, are aggravated in the late luteal phase of the menstrual cycle, and are resolved by menstruation. The present study evaluated the insomnia, inattention, and fatigue symptoms of PMDD and their fluctuations during the menstrual cycle. Methods: A total of 100 women were diagnosed as having PMDD based on psychiatric interviews and a prospective investigation of three menstrual cycles. A total of 96 individuals without PMDD were recruited as controls. Their symptoms, namely insomnia, inattention, and fatigue as well as functional impairment were assessed by using the premenstrual symptoms screening tool, the Pittsburgh insomnia rating scale, the attention and performance self-assessment scale, and the fatigue-assessment scale during both premenstrual and follicular phases. Results: In both the premenstrual and follicular phases, women with PMDD experienced more severe insomnia, inattentiveness, and fatigue than did women in the control group. A paired t-test demonstrated that women with PMDD had more severe severity insomnia, inattentiveness, and fatigue in the luteal phase than in the follicular phase. A repeated-measures analysis of variance demonstrated that the interaction period of PMDD and a menstrual cycle was significantly associated with insomnia, inattentiveness, and fatigue. A further correlation analysis demonstrated that all three symptoms were positively associated with self-reported functional impairment due to PMDD. Conclusions: Our results demonstrated that women with PMDD experienced an exacerbation of insomnia, memory problems, difficulty maintaining focus, and fatigue in the premenstrual phase. These symptoms are correlated with PMDD symptoms severity and functional impairment, and as such, they should be evaluated, and interventions should be employed in the late luteal phase of women with PMDD.

scholarly journals HUBUNGAN ANTARA HIPERTENSI DENGAN PREMENSTRUAL SYNDROME PADA WANITA USIA REPRODUKTIF

Biomedika ◽  
2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Azhim Rahmawati ◽  
Retno Siryaningsih ◽  
Safari Wahyu Jatmiko
Keyword(s):  
Risk Factor ◽  
Menstrual Cycle ◽  
Medical Care ◽  
Premenstrual Syndrome ◽  
Luteal Phase ◽  
Reproductive Age ◽  
Physical Disturbance ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

Premenstrual syndrome (PMS) is a cycle disorder which is commonly occured during the luteal phase of the menstrual cycle and will dissapear at the time of menstruation. Ninety percent of women on reproductive ages experience symptomps of PMS and 10% of them experience severe premenstrual symptomps that cuse physical disturbance, medical care necessity, even worst death. Hypertension is a risk factor for a PMS. The aim of this research is to find out a conection between PMS and hypertension. This research was designated using analytic observational with cross sectional approach. We used purposive sampling to get sample. Based on sample formula, we got 104 respondents which is consist of 52 women with hypertension and 52 women normotensive. To obtain data, we used shortened premenstrual syndrome assesment form (SPAF). Data collected were analyzed by chi square test. The result showed that the value of p = 0.00 (p<0.005). This result indicated that there is a conection between hypertension and PMS occurence in reproductive age. The probability of hypertension women to get PMS is 6.75.Keywords: Hypertension, Premenstrual Syndrome, reproductive age

scholarly journals Modulation of Platelet Functions Assessment during Menstruation and Ovulatory Phases

2019 ◽  
Vol 12 (3) ◽  
pp. 296-300
Author(s):  
Faisal Alzahrani ◽  
◽  
◽  
Fathelrahman Hassan ◽  
Keyword(s):  
Menstrual Cycle ◽  
Platelet Function ◽  
Luteal Phase ◽  
Thrombus Formation ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Platelet Activity ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Platelet Functions

During menstruation, endometrial hemostasis is achieved by platelet aggregation, fibrin deposition, and thrombus formation that interact with local endocrine and immunological factors which cause termination of menstrual bleeding. Interactions between steroidal sex hormones and platelet functions are not well understood. The aim of this study was to evaluate the effect of platelet function during the menstrual cycle and luteal phase in women of reproductive age. The cross-sectional study on women of reproductive age included 44 healthy women. Platelet function was assessed by PFA-100TM analyzer with collagen/epinephrine and collagen/ADP cartridges during the menstrual cycle and luteal phase. There were no significant differences in platelet function between menstruation and ovulatory phase. Platelet activity in Arab collagen/epinephrine cartridge increased during menstruation compared to non-Arab ethnic subjects and no significant differences in platelet function were found when using collagen/ADP cartridge. This study suggested modulation in platelet functions during menstruation and luteal phase in women of reproductive age. Further studies, including a large number of subjects, platelet genetic and progesterone factors change in platelet clotting associated to menstrual cycle should be conducted.

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