scholarly journals Association of 25(OH)D and PTH with Metabolic Syndrome and Its Traditional and Nontraditional Components

2011 ◽  
Vol 96 (1) ◽  
pp. 168-175 ◽  
Author(s):  
Sheena Kayaniyil ◽  
Reinhold Vieth ◽  
Stewart B. Harris ◽  
Ravi Retnakaran ◽  
Julia A. Knight ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Waist Circumference ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Supplement Use ◽  
The Metabolic Syndrome ◽  
Multivariate Adjustment ◽  
25 Hydroxy Vitamin D

Context: Emerging evidence suggests that 25-hydroxy vitamin D [25(OH)D] and PTH may play a role in the etiology of the metabolic syndrome (MetS). However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components. Objective: The objective of the study was to examine the association of vitamin D and PTH with MetS and its traditional and nontraditional components in a large multiethnic sample. Design, Setting, and Participants: In this cross-sectional study, we examined 654 participants from London and Toronto, Ontario, Canada, aged 30 yr and older with risk factors for type 2 diabetes. Main Outcome Measures: Presence of MetS and its traditional and nontraditional components was measured. Results: Approximately 43% of the study participants were classified as having MetS. Higher 25(OH)D was significantly associated with a reduced presence of MetS after adjustment for age, sex, season, ethnicity, supplement use, physical activity, and PTH (odds ratio 0.76, 95% confidence interval 0.62–0.93). PTH was not associated with the presence of MetS after multivariate adjustment. Multivariate linear regression analyses indicated significant adjusted inverse associations of 25(OH)D with waist circumference, triglyceride level, fasting insulin, and alanine transaminase (P < 0.041). Elevated PTH was positively associated with waist circumference and high-density lipoprotein cholesterol (P < 0.04). Other associations between PTH and MetS components were attenuated after adjustment for adiposity. Conclusions: Serum 25(OH)D, but not PTH, was significantly associated with MetS as well as a number of MetS components after multivariate adjustment. These results suggest that low 25(OH)D may play a role in the etiology of the MetS.

scholarly journals Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gang Huang ◽  
Junbo Xu ◽  
Tingjie Zhang ◽  
Lin Cai ◽  
Hanxiong Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Metabolic Diseases ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Very Elderly ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Elderly Chinese

Abstract Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community very elderly in Chengdu. In this cross-sectional study, 1056 very elderly in the community were enrolled. Serum uric acid (SUA), fast plasma glucose, triglycerides and high–density lipoprotein cholesterol were measured, and then MetS components were calculated. Logistic regression models were used to explore risk factors for MetS in the very elderly. Finally, 1035 participants were included in analysis whose ages ranged between 80 and 100 with a mean age of 83.6 ± 3.4 years. The mean SUA level was 356.2 ± 95.0 µmol/L. The estimated prevalence of MetS in the very elderly was 25.0% vs. 21.6% (international diabetes federation (IDF) criteria vs. Chinese guideline), which was significantly higher for women (IDF criteria:17.3% in men vs 33.6% in women, p < 0.001). Logistic regression has found that participants with hyperuricemia (SUA level > 416 µmol/L in men and > 357 µmol/L in women) had a higher risk (IDF criteria: odds ratio (OR): 2.136, 95% confidence interval(CI): 1.525–2.993, p < 0.001. Chinese guideline: OR: 1.769, 95%CI: 1.249–2.503, p = 0.001) of MetS in very elderly Chinese. MetS is common in the community of very elderly Chinese in Chengdu. Hyperuricemia is associated with MetS in general very elderly and lifestyle changing should also be considered in the very elderly.

scholarly journals The Study of Relationship between Breastfeeding and Metabolic Syndrome and its Components in Premenopausal Parous Women: From the Korean National Health and Nutrition Examination Survey, 2010-2016

2020 ◽  
Vol 24 (3) ◽  
pp. 154-161
Author(s):  
Minji Kim ◽  
Jusuk Lee ◽  
Taehong Kim
Keyword(s):  
Metabolic Syndrome ◽  
National Health ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Nutrition Examination Survey ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
The Metabolic Syndrome ◽  
Nationally Representative

Purpose: Here we aimed to examine the association of breastfeeding (BF) with the metabolic syndrome (Mets) and its components among premenopausal parous Korean women.Methods: We conducted a cross-sectional study on 7,116 Korean women by using nationally representative data from the Korea National Health and Nutrition Examination Survey, between 2010 and 2016. Multivariate logistic regression analysis was performed for examining the association of BF with Mets and its components.Results: A total 7,116 women were selected for this study. Mets was present in 12.9% of the study participants. The prevalence of Mets in the BF group (12.38%) was lower than that of the non-BF group (14.69 %) (p<0.05). The prevalence of hypertension and hypertriglyceridemia was significantly higher in the non-BF group compared to that of the BF group. For each of Mets components, the total cholestrol level and systolic blood pressure were significantly higher in the non-BF group, compared to those of the BF group (p<0.05). The BF group was associated with a decreased risk of Mets (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.68–0.99). and lower risks of hypo-high-density lipoprotein-cholesterolemia (OR, 0.78; 95% CI, 0.62–0.68), compared to those of the non-BF group.Conclusion: BF is an important factor in reducing the risks of Mets. These results provide fundamental evidence for the establishment of policies for promoting BF.

scholarly journals Metabolic syndrome in haemodialysis patients: Prevalence, determinants and association to cardiovascular outcomes

2020 ◽  
Author(s):  
Arnaud Delautre ◽  
François Chantrel ◽  
Yves Dimitrov ◽  
Alexandre Klein ◽  
Olivier Imhoff ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Visceral Obesity ◽  
Density Lipoprotein ◽  
Roc Curves ◽  
Major Adverse Cardiovascular Events ◽  
Operating Characteristics ◽  
Clinical Predictors ◽  
Cross Sectional ◽  
The Metabolic Syndrome

Abstract Background In the general population, the metabolic syndrome (MetS) has been identified as predictive of major adverse cardiovascular events (MACE). Waist circumference (WC), a component of the MetS criteria, is linked to visceral obesity, which in turn is correlated with MACE. However, in haemodialysis (HD) patients, the association between MetS, WC and MACE is unclear.Methods In a cross-sectional study of 1000 HD patients, we evaluated the prevalence and characterised the clinical predictors of MetS. The relationship between MetS and its components, alone or in combination, and MACE, as defined by comorbidity among coronary diseases, peripheral arteriopathy, stroke or cardiac failure, was further studied using receiver operating characteristics (ROC) curves and logistic regression.Results A total of 753 patients were included between October 2011 and April 2013. The prevalence of MetS was 68.5%. Waist circumference (> 88 cm in women, 102 cm in men) was the best predictor of MetS (sensitivity 80.2; specificity 82.3; AUC 0.80; p < 0.05). In multivariate analysis, MetS was associated with MACE (OR: 1.85; 95CI 1.24-2.75; p < 0.01), but not WC alone. There was a stronger association between the combination of abdominal obesity, hypertriglyceridaemia and low high-density lipoprotein cholesterol with MACE after exclusion of impaired fasting glucose and hypertension.ConclusionsMetS is frequent and associated with MACE in HD patients in our region and probably in other European dialysis populations. In HD patients, a new simplified definition could be proposed, in keeping with the concept of hypertriglyceridaemic waist.

scholarly journals Evaluation of Metabolic Syndrome among Locomotive Drivers

2020 ◽  
Author(s):  
M Saraei ◽  
A Najafi ◽  
E Heidarbagi ◽  
A Rahimi-Golkhandan
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
High Waist Circumference ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Train Drivers

Introduction: Screening of risk factors for metabolic syndrome among commercial and train drivers that are considered safety sensitive jobs, is an important issue in safety of transportation system. Metabolic syndrome is consisted of disturbed lipid profile, high blood pressure, and high waist circumference. It can lead to decrease the quality of life and higher health associated costs for these patients. This study aimed to assess risk factors for metabolic syndrome among train drivers. Methods: This cross-sectional study was conducted on 281 train drivers referred to their annual health examinations to Occupational Medicine Clinic of Baharloo Hospital, Tehran University of Medical Sciences. Demographic characteristics of participants were recorded. Blood pressure, body mass index and waist circumference of drivers were measured. Participants’ blood sample for fasting blood sugar, triglyceride, high and low density lipoproteins were collected. Metabolic syndrome was defined according to the NCEP ATP III criteria. Results: All of the participants were males.  Their mean age and BMI was 43±10 year and 26.60±3.67 Kg/m2, respectively. Fifty three (21%) of the participants were diagnosed with metabolic syndrome. The more frequent risk factor for metabolic syndrome was triglyceride more than 150mg/dl. Conclusion: Findings of the present study revealed high prevalence of metabolic syndrome among train drivers. Further studies are needed for screening the metabolic syndrome in this occupational group as it is a sensitive occupation.

scholarly journals Comparison of Formulas for Low-Density Lipoprotein (LDL) Calculation for Predicting the Risk of Metabolic Syndrome

2020 ◽  
Vol 9 ◽  
pp. 1607
Author(s):  
Babak Pezeshki ◽  
Mojtaba Golrazeghi ◽  
Sayed Reza Hojati ◽  
Fatemeh Rostamian ◽  
Hadi Raeisi Shahraki ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Clinical Laboratory ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Target Population ◽  
Cross Sectional Study ◽  
Low Density ◽  
Cross Sectional ◽  
Predictive Values ◽  
The Metabolic Syndrome

Background: The correlation between serum cholesterol level and the risk of developing atherosclerosis and metabolic syndrome has been well established in previous studies. Serum low-density lipoprotein (LDL-C) measurement is conducted using different methods which are generally divided into two groups, namely direct and indirect. Using indirect methods or calculations such as the Friedewald or Iranian formula for measuring LDL, particularly in developing countries, is quite common. The present study has stepped in to compare the robustness of the extant formulas in prognosticating and determining the incidence of metabolic syndrome. Materials and Methods: In this cross-sectional study, the target population was the community of Fasa cohort study. According to the views of the statistical advisor, 9530 people were included in the study and clinical laboratory examinations were done for each person. Their serum LDL level was measured using the existing formulas. Then, the results of the serum LDL level that was computed with different formulas, were compared with both the status of metabolic syndrome and laboratory tests of individuals. Results: The Iranian formula has the highest area under curve, the sensitivity of 0.73, and specificity of 0.77, higher positive and negative predictive values among other formulas. In Friedewald formula, for example, sensitivity and specificity equal 0.28 and 0.80, respectively. After further analysis, two new models proposed for predicting metabolic syndrome. The results revealed that these two models even outperform the Iranian formula. Conclusion: The Iranian formula for plasma LDL calculation has higher precision and application for predicting and measuring the metabolic syndrome in the Iranian population due to its considerable features. It is required to develop a new formula for each population and even for each sex, if possible. [GMJ.2020;9:e1607]

scholarly journals Comparison of metabolic syndrome criteria in obese and overweight children

2010 ◽  
Vol 50 (5) ◽  
pp. 295 ◽  
Author(s):  
Astrid Anastasia Malonda ◽  
Helena Anneke Tangkilisan
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Overweight Child ◽  
Test Results ◽  
Overweight Children ◽  
Obese Children ◽  
Cross Sectional

Background Metabolic syndrome (MS) is a group of disorders which occur in relation to increasing body weight. Only a few studies have reported the differences in the fulfillment of MS criteria between obese and overweight children, and none were from Indonesia.Objective To detennine the differences in metabolic syndrome disorders between obese and overweight children.Methods A cross-sectional study was conducted in Manado from May to August 2010. The diagnosis of MS is established by fulfilling three of five criteria: waist circumference  ≥90th percentile, blood pressure ≥ 90th  percentile, fasting blood sugar (FBS) ≥ 100 mg/dL, triglycerides  ≥110 mg/dL and high density lipoprotein (HDL) ≤40 mg/dL. Obesity was defined as body mass index (BMI) of> 3 SD and overweight as BMI of 2-3 SD. Results Results ere analyzed by x2 and t-test. Results Thirty obese and 30 overweight children aged 10-14years were examined for the disorders of MS. Twenty􀁄three obese and 4 overweight children had waist circumferences  ≥90th percentile. Seventeen obese and 3 overweight children had blood pressure  ≥90th percentile. No significant differences in FBS, HDL, and triglycerides were observed between the two groups. Thirteen obese children met the MS inclusion criteria, while only 1 overweight child did so (P<0.001).Conclusions High blood pressure (≥90th percentile) and waist circumference (≥90th  percentile) occurred were observed at higher frequency in obese children than in overweight children. The occurrence of MS in obese children was significantly higher than in overweight children.

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