scholarly journals Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gang Huang ◽  
Junbo Xu ◽  
Tingjie Zhang ◽  
Lin Cai ◽  
Hanxiong Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Metabolic Diseases ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Very Elderly ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Elderly Chinese

Abstract Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community very elderly in Chengdu. In this cross-sectional study, 1056 very elderly in the community were enrolled. Serum uric acid (SUA), fast plasma glucose, triglycerides and high–density lipoprotein cholesterol were measured, and then MetS components were calculated. Logistic regression models were used to explore risk factors for MetS in the very elderly. Finally, 1035 participants were included in analysis whose ages ranged between 80 and 100 with a mean age of 83.6 ± 3.4 years. The mean SUA level was 356.2 ± 95.0 µmol/L. The estimated prevalence of MetS in the very elderly was 25.0% vs. 21.6% (international diabetes federation (IDF) criteria vs. Chinese guideline), which was significantly higher for women (IDF criteria:17.3% in men vs 33.6% in women, p < 0.001). Logistic regression has found that participants with hyperuricemia (SUA level > 416 µmol/L in men and > 357 µmol/L in women) had a higher risk (IDF criteria: odds ratio (OR): 2.136, 95% confidence interval(CI): 1.525–2.993, p < 0.001. Chinese guideline: OR: 1.769, 95%CI: 1.249–2.503, p = 0.001) of MetS in very elderly Chinese. MetS is common in the community of very elderly Chinese in Chengdu. Hyperuricemia is associated with MetS in general very elderly and lifestyle changing should also be considered in the very elderly.

scholarly journals HUBUNGAN PERILAKU SEDENTARI DENGAN SINDROM METABOLIK PADA PEKERJA

2019 ◽  
Vol 13 (2) ◽  
pp. 145
Author(s):  
Lailiyah Yusna Yusfita
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Diseases ◽  
Sedentary Lifestyle ◽  
International Diabetes Federation ◽  
Hdl Cholesterol ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Chi Square Analysis

Sedentary lifestyle has been done by many workers either in the workplace, home, even on transportation. High sedentary lifestyle is a risk factor for metabolic syndrome among workers that cause of metabolic diseases such as Coronary Heart Disease, diabetes mellitus type 2, and Stroke. According to the International Diabetes Federation (IDF) in 2005, the metabolic syndrome is characterized by abdominal obesity plus at least 2 other positive components consisting of hypertriglycerides, low HDL cholesterol, hypertension, and hyperglycemia. This study is a cross sectional study to determine relationship of sedentary lifestyle with metabolic syndrome. 66 workers of 113 workers who performed Medical Check Up (MCU) at Prima Medika Laboratory Surabaya during November - December 2017 became a sample of this study. Sampling method was simple random sampling. The independent variables in this study were age, sex, and sedentary lifestyle. The dependent variable was metabolic syndrome. This study used Chi-square analysis to assess the relationship between independent variable and dependent variable. The results showed the prevalence of metabolic syndrome among workers was 43.9%. Of the 29 workers with metabolic syndrome, 26 workers had a sedentary lifestyle ≥ 6 hours per day with a median was 9.11 hours per day. There was a correlation between sedentary lifestyle ≥ 6 hours per day with metabolic syndrome (p = 0.000), whereas showed no association with metabolic syndrome between age (p = 0.058) and sex (p = 0.168). The conclusions of this study were sedentary ≥ 6 hours per day associated with metabolic syndrome among workers. Workers should reduce sedentary lifestyle by stretching, avoiding sitting too long while working, and increasing physical activity in the workplace.

scholarly journals Prevalence of Metabolic Syndrome and Its Components in Adults with Central Obesity at Janakpur Zone, Nepal

2021 ◽  
Vol 18 (4) ◽  
pp. 681-685
Author(s):  
Birendra Kumar Jha ◽  
Mingma Lhamu Sherpa ◽  
Binod Kumar Dahal ◽  
Jitendra Kumar Singh
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Central Obesity ◽  
International Diabetes Federation ◽  
Cross Sectional Study ◽  
High Density Lipoproteins ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
The Metabolic Syndrome

Background: Urbanization, surplus energy uptake, decreased physical activities are general risk factors of metabolic syndrome However, it’s status, and associated components remain unexplored in the Terai region of Nepal. This study evaluated the prevalence of metabolic syndrome and its components among adults with central obesity of Terai region of Nepal using International Diabetes Federation criteria.Methods: Community based cross-sectional study was conducted in three Terai districts of Janakpur Zone, Nepal. A total of 378 adults having central obesity were selected using cluster sampling by camp approach. Interview, physical and clinical examination, measurement of fasting blood sugar, and lipid profile were conducted for all participants. The prevalence of metabolic syndrome and its components with 95% CI were estimated.Results: The metabolic syndrome prevalence was 74.9% (95% CI:70.2-79.2%), with no significant differences between male (77.7%, 95% CI:71.0-83.5%) and female (72.2%, 95% CI: 65.2-78.3%). The most common factors observed were low high density lipoproteins with highly significant differences between male (77.7%, 95% CI:71.0-83.5%)) and female (90.2%, 95% CI: 85.094.0%-; p=0.001) and hypertriglyceridemia with significant differences between male (57.6%, 95% CI: 50.1-64.5%) and female (46.9%, 95% CI: 39.7-54.2%; p=0.037). Conclusions: Higher prevalence of metabolic syndrome and its risk factors in Janakpur of Nepal likely suggest lack of awareness and health promotion activities for metabolic syndrome and indicate an urgency for a public health program to maintain quality of life. Keywords: Metabolic syndrome; Nepal; prevalence; risk factors; terai

scholarly journals Association of 25(OH)D and PTH with Metabolic Syndrome and Its Traditional and Nontraditional Components

2011 ◽  
Vol 96 (1) ◽  
pp. 168-175 ◽  
Author(s):  
Sheena Kayaniyil ◽  
Reinhold Vieth ◽  
Stewart B. Harris ◽  
Ravi Retnakaran ◽  
Julia A. Knight ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Waist Circumference ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Supplement Use ◽  
The Metabolic Syndrome ◽  
Multivariate Adjustment ◽  
25 Hydroxy Vitamin D

Context: Emerging evidence suggests that 25-hydroxy vitamin D [25(OH)D] and PTH may play a role in the etiology of the metabolic syndrome (MetS). However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components. Objective: The objective of the study was to examine the association of vitamin D and PTH with MetS and its traditional and nontraditional components in a large multiethnic sample. Design, Setting, and Participants: In this cross-sectional study, we examined 654 participants from London and Toronto, Ontario, Canada, aged 30 yr and older with risk factors for type 2 diabetes. Main Outcome Measures: Presence of MetS and its traditional and nontraditional components was measured. Results: Approximately 43% of the study participants were classified as having MetS. Higher 25(OH)D was significantly associated with a reduced presence of MetS after adjustment for age, sex, season, ethnicity, supplement use, physical activity, and PTH (odds ratio 0.76, 95% confidence interval 0.62–0.93). PTH was not associated with the presence of MetS after multivariate adjustment. Multivariate linear regression analyses indicated significant adjusted inverse associations of 25(OH)D with waist circumference, triglyceride level, fasting insulin, and alanine transaminase (P &lt; 0.041). Elevated PTH was positively associated with waist circumference and high-density lipoprotein cholesterol (P &lt; 0.04). Other associations between PTH and MetS components were attenuated after adjustment for adiposity. Conclusions: Serum 25(OH)D, but not PTH, was significantly associated with MetS as well as a number of MetS components after multivariate adjustment. These results suggest that low 25(OH)D may play a role in the etiology of the MetS.

scholarly journals The Study of Relationship between Breastfeeding and Metabolic Syndrome and its Components in Premenopausal Parous Women: From the Korean National Health and Nutrition Examination Survey, 2010-2016

2020 ◽  
Vol 24 (3) ◽  
pp. 154-161
Author(s):  
Minji Kim ◽  
Jusuk Lee ◽  
Taehong Kim
Keyword(s):  
Metabolic Syndrome ◽  
National Health ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Nutrition Examination Survey ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
The Metabolic Syndrome ◽  
Nationally Representative

Purpose: Here we aimed to examine the association of breastfeeding (BF) with the metabolic syndrome (Mets) and its components among premenopausal parous Korean women.Methods: We conducted a cross-sectional study on 7,116 Korean women by using nationally representative data from the Korea National Health and Nutrition Examination Survey, between 2010 and 2016. Multivariate logistic regression analysis was performed for examining the association of BF with Mets and its components.Results: A total 7,116 women were selected for this study. Mets was present in 12.9% of the study participants. The prevalence of Mets in the BF group (12.38%) was lower than that of the non-BF group (14.69 %) (p<0.05). The prevalence of hypertension and hypertriglyceridemia was significantly higher in the non-BF group compared to that of the BF group. For each of Mets components, the total cholestrol level and systolic blood pressure were significantly higher in the non-BF group, compared to those of the BF group (p<0.05). The BF group was associated with a decreased risk of Mets (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.68–0.99). and lower risks of hypo-high-density lipoprotein-cholesterolemia (OR, 0.78; 95% CI, 0.62–0.68), compared to those of the non-BF group.Conclusion: BF is an important factor in reducing the risks of Mets. These results provide fundamental evidence for the establishment of policies for promoting BF.

scholarly journals Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2163 ◽  
Author(s):  
José María Rico-Gomis ◽  
Antonio Palazón-Bru ◽  
Irene Triano-García ◽  
Luis Fabián Mahecha-García ◽  
Ana García-Monsalve ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Regression Models ◽  
Atypical Antipsychotics ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
The Metabolic Syndrome

Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166 patients with these characteristics. In these patients, the association between the polymorphism and the presence of the metabolic syndrome was determined by implementing binary logistic regression models adjusted for variables associated with the metabolic syndrome. We did not confirm previous claims that the C allele of the polymorphism was linked to the metabolic syndrome: the association was in the opposite direction and non-significant. This conclusion held after taking gender and lifestyle variables into account.

scholarly journals Gender and Age-Related Differences in Patients with the Metabolic Syndrome in A Highly Endogamous Population.

2010 ◽  
Vol 10 (3) ◽  
pp. 210-217 ◽  
Author(s):  
Abdulbari Bener ◽  
Abdul-Ghani Mohammad ◽  
Asia N. Ismail ◽  
Mahmoud Zirie ◽  
Waleed K. Abdullatef ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
International Diabetes Federation ◽  
Developed Countries ◽  
Cross Sectional Study ◽  
Age Group ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Age Related ◽  
Gender And Age ◽  
Primary Health Care Centers

The objective of the study was to examine the differences in gender and age prevalences of metabolic syndrome (MetS) among adult Qatari population according to the revised criteria of NCEP ATP III and IDF, assess which component contributed to the higher prevalence of the MetS and identify the characteristics of the subjects with MetS. The study was designed as a cross-sectional study. The survey was carried out in urban and semi-urban primary health care centers. The survey was conducted in the period from January 2007 to July 2008 among Qatari nationals above 20 years of age. Of the 1536 subjects who were approached to particípate in the study, 1222 (79.6%) gave their consent. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. MetS was defined using the National Cholesterol Education Program - Third Adult Treatment Panel (ATP III) as well as the International Diabetes Federation (IDF). The overall prevalence of MetS in studied subjects was 26.7% and 33.9% according to ATPIII and IDF (p<0.001) criteria respectively. The prevalence of MetS by both definitions peaked in the 30-39 years age group among males, and the 40-49 years age group among females. The greatest number of males with MetS were university educated; while the greatest number of females with MetS were either illiterate or had a primary school education. The prevalence of MetS was higher among females. Among the components of MetS, the prevalence of central obesity was significantly higher in studied subjects. The overall prevalence of MetS and its components according to IDF criteria was higher in studied subjects than the estimates given by the ATPIII criteria. Overall, the prevalence of the metabolic syndrome in the State of Qatar is about 10-15% higher than in most developed countries, with generally higher prevalence rates for women. Preventive strategies will require identifying socio-demographic factors and addressing modifiable risk behaviours, including lack of physical activity, and dietary intake.

Influence of 5-HTR2C Polymorphisms on Metabolic Syndromes in Thai Schizophrenia Patients

2017 ◽  
Vol 41 (S1) ◽  
pp. S168-S168
Author(s):  
A. Puangpetch ◽  
C. Na Nakorn ◽  
W. Unaharassamee ◽  
C. Sukasem
Keyword(s):  
Metabolic Syndrome ◽  
International Diabetes Federation ◽  
Cross Sectional Study ◽  
Nucleotide Polymorphisms ◽  
Cross Sectional ◽  
Female Patients ◽  
The Metabolic Syndrome ◽  
Significant Difference ◽  
Male Patients ◽  
Competing Interest

IntroductionMetabolic syndrome is a significant problem in the schizophrenia patients. Previous research demonstrated that single nucleotide polymorphisms in the serotonin 2C receptor (5HTR2C) genes are associated with metabolic syndrome related to schizophrenia patients taking atypical anti-psychotic drugs. This study aimed to investigate whether the effect of 3 SNPs in 5HTR2C gene on the presence of the metabolic syndrome in Thai schizophrenia patients.MethodWe conducted a cross-sectional study and 154 patients were recruited. The schizophrenia patients were identified from a diagnostic and statistical manual of mental disorders, 4th edition, (DSM-IV) and criterion and determined the metabolic syndrome according to the 2005 international diabetes federation (IDF) Asia criteria. Patients were genotyped for the 5HTR2C rs51,8147, rs126,881,02, rs128,367,71 polymorphisms.ResultsThe preliminary analysis from 154 patients showed the metabolic syndrome prevalence was 38.73%, with 46.50% in male and 53.48% in female patients. The results showed that the patients who have heterozygous and homozygous variant on 5HTR2C gene (rs518,147 and rs126,881,02) showed a significant difference in the presence of metabolic syndrome when compare with patients who carry homozygous wild type (P = 0.007), especially in male patients (P = 0.002). The association between 5HTR2C polymorphisms and metabolic syndrome was found in male patients but not found in female patients.ConclusionThese findings suggest that 5HTR2C genotypes are associated with the metabolic syndrome in patients taking atypical anti-psychotics. However, the metabolic syndrome results from the multigenetic effects. The further studies should focus on the other genes, which were involved in metabolic syndrome.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Correlation between hsCRP and Anti-beta2GPI Antibody in Metabolic Syndrome

2011 ◽  
Vol 3 (2) ◽  
pp. 122
Author(s):  
Meiriza Djohari ◽  
Mansyur Arif ◽  
Burhanuddin Bahar
Keyword(s):  
Metabolic Syndrome ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Low Grade ◽  
Related Factors ◽  
Cross Sectional ◽  
Immunological Mechanism ◽  
The Metabolic Syndrome

BACKGROUND: Several researches reported that inflammatory and immunological mechanism such as autoantibody to β2-glycoprotein I (anti β2GPI) appear as related factors in initiation and progress of atherosclerosis lesion in patient with autoimmune disease. Antibody to β2GPI titers are correlated with atherosclerosis and in vitro studies showed that they enhance oxidized low density lipoprotein (ox-LDL) uptake by macrophages. Immunization with auto-antigen β2GPI elicits an immune response to influence lesion progression that mostly happens in autoimmune subjects. The metabolic syndrome (MetS) is combination of several metabolic disorders such as obesity, dyslipidemia, Diabetes Mellitus (DM) and conditions due to inflammation and stress oxidative. The Correlation between inflammatory markers such as High sensitivity C-Reactive Protein (hsCRP) and anti-β2GPI antibody in MetS needs to be further investigated.METHODS: This was an observational study with cross sectional design on subject with MetS as determined by the International Diabetes Federation (IDF) 2005’s criteria.RESULTS:There was a positive and significant correlation between hsCRP and anti-β2GPI antibody in MetS group (r=0.406; p≤0.05) as compared to non-MetS group. We found that there was elevated level of anti-β2GPI antibody in hsCRP of 3-10 mg/L.CONCLUSIONS: Anti-β2GPI antibody may be elevated in subjects with MetS who have low grade of inflammation as shown by hsCRP.KEYWORDS: metabolic syndrome, inflammation, autoantigen, atherosclerosis, obesity

scholarly journals Relationship between Serum Homocysteine and Metabolic Syndrome among Patients with Schizophrenia and Bipolar Disorder: A Cross Sectional Study

2020 ◽  
Author(s):  
Shadi Naderyan Fe'li ◽  
Seyed Mojtaba Yassini Ardekani ◽  
Ali Dehghani
Keyword(s):  
Metabolic Syndrome ◽  
Bipolar Disorder ◽  
Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Multivariable Logistic Regression Model ◽  
Cross Sectional ◽  
Exact Test ◽  
The Metabolic Syndrome ◽  
Significant Difference

Objective: This study aimed to compare the prevalence of metabolic syndrome and hyperhomocysteinemia and to specify predictors of the metabolic syndrome among patients with schizophrenia and bipolar disorder. Method: This cross sectional study was conducted on 100 patients with schizophrenia and 100 patients with bipolar disorder. The participants' metabolic syndrome was determined according to the criteria set by Third Report of the National Cholesterol Education Program–Adult Treatment Panel III. Hyperhomocysteinemia was considered as homocysteine levels higher than 15 µmol/L. Chi-square test, Fisher's exact test, student t test, Mann-Whitney test, and logistic regression were used for data analysis. Results: The prevalence of metabolic syndrome was not significantly different (P = 0.07) between patients with schizophrenia (27%) and bipolar disorder (39%). No statistically significant difference (P = 0.17) was observed between patients with schizophrenia (82%) and bipolar disorder (74%) in the prevalence of hyperhomocysteinemia. The results of multivariable logistic regression model showed a significant association of smoking and BMI with metabolic syndrome in patients with schizophrenia (OR = 3.69, 95% CI: 1.13-12.05, and OR = 1.38, 95% CI: 1.20-1.60, respectively). In patients with bipolar disorder, BMI was a significant predictor of developing metabolic syndrome (OR = 1.29, 95% CI: 1.14-1.47). Metabolic syndrome was more prevalent in women than in men in both diagnostic groups (P < 0.05). No significant difference was observed in hyperhomocysteinemia prevalence between male and female patients with schizophrenia (P = 1.00). However, hyperhomocysteinemia was more prevalent in males than in females among patients with bipolar disorder (P = 0.001). Conclusion: Findings showed a high prevalence of metabolic syndrome and hyperhomocysteinemia among patients with schizophrenia and bipolar disorder. To deal with this problem, regular monitoring and conducting early interventions are recommended to determine the metabolic risk profile and to prevent the cardiovascular diseases.

scholarly journals Association between Hyperuricemia and Metabolic Syndrome: An Epidemiological Study of a Labor Force Population in Taiwan

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Cheng-Yu Wei ◽  
Chia-Cheng Sun ◽  
James Cheng-Chung Wei ◽  
Hsu-Chih Tai ◽  
Chien-An Sun ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multiple Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Multiple Logistic Regression ◽  
Cross Sectional ◽  
The Relationship

The increasing prevalence of metabolic syndrome (MetS) has become an important issue worldwide. Metabolic comorbidities of hypertension, obesity, and hyperlipidemia are shown as important risk factors for incident gout. The purpose of this study was to investigate the relationship between hyperuricemia and MetS. This is a cross-sectional study. The effective sample included 21,544 individuals who received worker health examinations at a local teaching hospital in Changhua County from 2008~2012. We used multiple logistic regression analysis to investigate the influences of hyperuricemia on MetS. The results showed that individuals with MetS had significantly higher blood pressure, fasting plasma glucose, triglycerides, waist circumference, and high-density lipoprotein cholesterol than those without MetS(P<0.001). Multiple logistic regression analysis revealed hyperuricemia to be an important factor of MetS. The risk of developing MetS is higher with high levels of serum uric acid (SUA) and the odds ratio (OR) of having MetS is 4.98 times higher for Tertile 3 than for Tertile 1 (95% CI = 4.16–5.97) and 4 times higher for Quartile 4 than for Quartile 1 (95% CI = 3.59–4.46). In conclusion, males are more likely to develop MetS than females, and the risk of having MetS increases with age and SUA concentration.

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