Association between Serum Leptin Concentrations and Bone Mineral Density, and Biochemical Markers of Bone Turnover in Adult Men

Leptin, the product of the ob gene, has been shown to inhibit bone formation in mice. We addressed whether leptin has any role in the regulation of bone mineral density (BMD) in humans. Subjects were 221 adult men with a mean (±sd) age and body mass index of 52.1 ± 8.7 yr and 23.6 ± 2.8 kg/m2. Serum leptin, carboxyterminal propeptide of type 1 procollagen (PICP; a marker of bone formation), and cross-linked carboxyterminal teleopeptide of type 1 collagen (a marker of bone resorption) were measured by RIA. BMD was assessed by single photon absorptiometry, and total fat mass was determined by bioimpedance analysis. BMD was inversely associated with serum leptin concentrations and total fat mass after adjustment for body weight. PICP, but not cross-linked carboxyterminal teleopeptide of type 1 collagen, was inversely correlated with serum leptin. These results may suggest that an increase in serum leptin reduces bone formation and decreases BMD in adult men. Leptin may be a regulator of BMD in humans.

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Bone mineral density and body composition in adolescents with failure to thrive

Einstein (São Paulo) ◽

10.1590/s1679-45082010ao1361 ◽

2010 ◽

Vol 8 (2) ◽

pp. 168-174

Author(s):

Thiago Sacchetto de Andrade ◽

Luiz Anderson Lopes ◽

Marcelo de Medeiros Pinheiro ◽

Vera Lucia Szejnfeld ◽

José Augusto de Aguiar Carrazedo Taddei

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Bone Mass ◽

Bone Mineral ◽

Fat Mass ◽

Failure To Thrive ◽

Fat Free Mass ◽

Z Score ◽

Mineral Density ◽

Total Fat

ABSTRACT Objective To evaluate bone mineral mass in adolescents with failure to thrive in relation to body composition. Methods A case control study involving 126 adolescents (15 to 19 years), in final puberty maturation being 76 eutrophic and 50 with failure to thrive (genetic or constitutional delay of growth), of matching ages, gender and pubertal maturation. The weight, height and calculated Z score for height/age and body mass index; bone mineral content, bone mineral density and adjusted bone mineral density were established for total body, lower back and femur; total fat-free mass and height-adjusted fat-free mass index, total fat mass and height-adjusted. The statistical analyses were performed using the Student's t-test (weight, height and body composition); Mann-Whitney test (bone mass) and multiple linear regression (bone mass determinants). Results weight, height and height/age Z-score were significantly higher among eutrophic subjects. Both groups did not show statistically significant differences for fat mass, percentage of fat mass, total fat mass height adjusted and fat-free mass index height sadjusted. However, total free fat maass was smaller for the failure to thrive group. Conclusions There was no statistically significant difference for bone mass measurements among adolescents with failure to thrive; however, the factors that determine bone mass formation should be better studied due to the positive correlation with free fat mass detected in these individuals.

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Bone Mineral Density in Adults With Cerebral Palsy

Frontiers in Neurology ◽

10.3389/fneur.2021.733322 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jun Hee Won ◽

Se Hee Jung

Keyword(s):

Bone Mineral Density ◽

Cerebral Palsy ◽

Lumbar Spine ◽

Femoral Neck ◽

Motor Function ◽

Bone Mineral ◽

Fat Mass ◽

Mineral Density ◽

Male Sex ◽

Total Fat

Low bone mineral density (BMD) is an emerging health issue in adults with cerebral palsy (CP). This cross-sectional study aimed to describe the characteristics of BMD in adults with CP, and to elucidate the risk factors for low BMD in this population. People aged ≥20 years and diagnosed with CP were recruited from February 2014 to November 2014. We assessed BMD using dual-energy X-ray absorptiometry (DXA) for the lumbar spine, femoral neck, and total femur. Moreover, the body composition was assessed using DXA. We included a total of 87 adults with CP (mean age 42.01 years; 52 men). The prevalence of low BMD was 25.3%. Male sex and age were associated with lower BMD. BMD was significantly lower in the non-ambulatory group than that in the ambulatory group for both lumbar spine and femoral neck. The total fat mass demonstrated a positive correlation with the Z-score and BMD for the femur neck and total femur. Body mass index (BMI) and total fat mass were positively correlated with BMD in the lumbar spine, femoral neck, and total femur. However, the Gross Motor Function Classification Scale levels were negatively correlated with BMD at the aforementioned three sites. In conclusion, adults with CP revealed decreased BMD, which was associated with male sex, age, decreased gross motor function, loss of ambulatory function, low BMI, decreased total fat mass, and decreased total fat-free mass.

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Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Bone ◽

10.1016/s8756-3282(01)00487-2 ◽

2001 ◽

Vol 29 (2) ◽

pp. 114-120 ◽

Cited By ~ 188

Author(s):

T Thomas ◽

B Burguera ◽

L.J Melton ◽

E.J Atkinson ◽

W.M O’Fallon ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Fat Mass ◽

Mineral Density ◽

Serum Leptin ◽

The Relationship

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A Novel Peptide, CK2.3, Improved Bone Formation in Ovariectomized Sprague Dawley Rats

International Journal of Molecular Sciences ◽

10.3390/ijms21144874 ◽

2020 ◽

Vol 21 (14) ◽

pp. 4874 ◽

Cited By ~ 1

Author(s):

Linda Sequeira ◽

John Nguyen ◽

Liyun Wang ◽

Anja Nohe

Keyword(s):

Bone Mineral Density ◽

Bone Formation ◽

Bone Mineral ◽

Single Photon ◽

Femoral Shaft ◽

Ovariectomized Rats ◽

Sprague Dawley ◽

Micro Computed Tomography ◽

Mineral Density

Osteoporosis is a bone disease that has no definite cure. Current treatments for osteoporosis are divided into two categories: anti-resorptive and anabolic. However, these treatments are not perfect and have considerable risks. In addition, bone quality often declines over time with these treatments. We designed a peptide, CK2.3, that has both anabolic and anti-resorptive effects on bone. We reported that CK2.3 induced osteoblastic mineralization, promoted bone formation, and suppressed osteoclastogenesis in vivo. The effect of CK2.3 to rescue an osteoporosis phenotype model has never been shown. In this study, we demonstrated the effect of CK2.3 in ovariectomized rats, a standard model of osteoporosis. We systemically injected CK2.3 at 2.3 µg/kg each day for five consecutive days. Micro-computed tomography indicated that CK2.3 increased bone mineral density, (bone volume/tissue volume) BV/TV and (trabecular number) TbN, and decreased (trabecular space) TbSp in the femoral head. Similarly, single photon absorptiometry showed that treatment with CK2.3 increased bone mineral density in the lumbar spine and the pelvis. Additionally, we observed increased femoral shaft stiffness with ovariectomized rats treated with CK2.3. We also detected no significant changes in the weight of organs such as the heart, lung, liver, kidney, and spleen. An advantage of CK2.3 over current treatments was that it not only promoted bone formation but also improved fracture resistance. In conclusion, we demonstrated CK2.3 as a new anabolic treatment for osteoporosis.

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Leptin and Bone Mineral Density: A Cross-Sectional Study in Obese and Nonobese Men

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2003-030496 ◽

2003 ◽

Vol 88 (12) ◽

pp. 5795-5800 ◽

Cited By ~ 45

Author(s):

Cathrine M. Morberg ◽

Inge Tetens ◽

Eva Black ◽

Soeren Toubro ◽

Thorkild I. A. Soerensen ◽

...

Keyword(s):

Bone Mineral Density ◽

Body Mass Index ◽

Lean Body Mass ◽

Body Mass ◽

Bone Mineral ◽

Fat Mass ◽

Control Group ◽

Mineral Density ◽

Cross Sectional ◽

Serum Leptin

Abstract Leptin has been suggested to decrease bone mineral density (BMD). This observational analysis explored the relationship between serum leptin and BMD in 327 nonobese men (controls) (body mass index 26.1 ± 3.7 kg/m2, age 49.9 ± 6.0 yr) and 285 juvenile obese men (body mass index 35.9 ± 5.9 kg/m2, age 47.5 ± 5.1 yr). Whole-body dual-energy x-ray absorptiometry scan measured BMD, fat mass, and lean mass. Fasting serum leptin (nanograms per milliliter) was strongly associated with fat mass (kilograms) in both controls (r = 0.876; P < 0.01) and juvenile obese (r = 0.838; P < 0.001). An inverse relation between BMD adjusted for body weight and serum leptin emerged in both the control group (r = −0.186; P < 0.01) and the juvenile obese group (r = −0.135; P < 0.05). In a multiple linear regression, fat mass, lean body mass, and occupational physical activity were positively associated with BMD in the control group, whereas in the juvenile obese, only lean body mass was positively associated with BMD and smoking negatively associated with BMD. Our study supports that leptin is inversely associated with BMD and may play a direct role in the bone metabolism in nonobese and obese Danish males, but it also stresses the fact that the strong covariation between the examined variables is a shortcoming of the cross-sectional design.

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