scholarly journals High DHEAS Is Associated With Earlier Pubertal Events in Girls But Not in Boys

2017 ◽  
Vol 1 (7) ◽  
pp. 800-808 ◽  
Author(s):  
Ana Pereira ◽  
German Iñiguez ◽  
Camila Corvalan ◽  
Verónica Mericq
Keyword(s):  
Ovarian Function ◽  
Pubertal Development ◽  
Sex Characteristics ◽  
Premature Thelarche ◽  
Logistic Regression Models ◽  
Tanner Staging ◽  
Secondary Sex Characteristics ◽  
Premature Adrenarche ◽  
The Relationship

Context: Premature adrenarche (PA) has been associated with increased metabolic risk. Objective: To describe the risk of precocious thelarche (PT; <8 years), pubarche (PP; girls <8 years, boys <9 years), and gonadarche (PG; <9 years) in children with high dehydroepiandrosterone sulphate (DHEAS [HD]) vs those with normal DHEAS (ND). Setting and Intervention: Longitudinal Chilean cohort (n = 1052, 49.9% girls). Annual clinical examination including secondary sex characteristics by Tanner staging. Logistic regression models were adjusted by age and BMI. Main Outcome: Assess the relationship between DHEAS and premature thelarche, gonadarche, and pubarche in both sexes. Results: At age of DHEAS determination, overweight/obesity was present in 44.3% of boys and 42.9% of girls. Incidences of any precocious event were observed in 17.2% of boys and in 25.4% of girls, presented as 8.7% of PG and 8.5% of PP in boys and as 21.3% of PT and 4.1% of PP in girls. In crude and adjusted models in boys, HD did not increase the risk of earlier pubertal events. Conversely, girls with HD had a 2.6 times greater risk of early thelarche and a three times greater risk of early pubarche compared with girls with ND concentrations. Conclusion: In Chilean adolescents, precocious events of pubertal development were in line with the worldwide secular trend of earlier sexual maturation. HD was only associated with PT and PP in girls. Continuous follow-up of this cohort is a unique opportunity to prospectively address and analyze the interrelationships among HD, early growth, and adiposity as determinants of gonadarche, pubertal rate/sequence progression, and ovarian function.

Plasma kisspeptin and ghrelin levels in puberty variant cases

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Erdal Kurnaz ◽  
Yaşar Şen ◽  
Süleyman Aydın
Keyword(s):  
Serum Levels ◽  
Control Group ◽  
Control Groups ◽  
Premature Thelarche ◽  
Premature Adrenarche ◽  
Significant Difference ◽  
And Gender ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.

scholarly journals Human Resistance to Plasmodium falciparum Increases during Puberty and Is Predicted by Dehydroepiandrosterone Sulfate Levels

2001 ◽  
Vol 69 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Jonathan D. Kurtis ◽  
Ramadhan Mtalib ◽  
Frederick K. Onyango ◽  
Patrick E. Duffy
Keyword(s):  
Plasmodium Falciparum ◽  
Parasite Density ◽  
Pubertal Development ◽  
Dehydroepiandrosterone Sulfate ◽  
Young Males ◽  
Tanner Staging ◽  
Age Related ◽  
Blood Smears ◽  
Full Immunity ◽  
The Relationship

ABSTRACT Immunity to Plasmodium falciparum develops slowly in areas of endemicity, and this is often ascribed to poorly immunogenic or highly variant parasite antigens. However, among populations newly exposed to malaria, adults acquire immunity more rapidly than children. We examined the relationship between pubertal development and resistance to P. falciparum. During two transmission seasons in western Kenya, we treated the same cohort of young males to eradicate P. falciparum and then obtained blood smears each week for 4 months. We determined pubertal development by Tanner staging and by levels of dehydroepiandrosterone sulfate (DHEAS) and testosterone in plasma. In multivariate and age-stratified analyses, we examined the effect of pubertal development on resistance to malaria. In both seasons (n = 248 and 144 volunteers, respectively), older males were less susceptible than younger males. Age-related decreases in the frequency and density of parasitemia were greatest during puberty (15- to 20-year-olds). DHEAS and testosterone were significant independent predictors of resistance to P. falciparum parasitemia, even after accounting for the effect of age. Fifteen- to 20-year-old males with high DHEAS levels had a 72% lower mean parasite density (P < 0.01) than individuals with low DHEAS levels. Similarly, 21- to 35-year-old males with high DHEAS levels had a 92% lower mean parasite density (P < 0.001) and 48% lower frequency of parasitemia (P < 0.05) than individuals with low DHEAS levels. These data suggest that the long period needed to attain full immunity could be explained as a consequence of host development rather than as the requirement to recognize variant or poorly immunogenic parasite antigens.

scholarly journals Low blood pressure and risk of depression in the elderly

2000 ◽  
Vol 176 (5) ◽  
pp. 464-467 ◽  
Author(s):  
Sabrina Paterniti ◽  
Marie-Hélène Verdier-Taillefer ◽  
Catherine Geneste ◽  
Jean-Claude Bisserbe ◽  
Annick Alpérovitch
Keyword(s):  
Blood Pressure ◽  
Regression Models ◽  
Depressive Symptomatology ◽  
The Elderly ◽  
Epidemiological Studies ◽  
Logistic Regression Models ◽  
Drinking Habits ◽  
Low Blood Pressure ◽  
The Relationship

BackgroundThe relationship between depression and low blood pressure is unclear.AimsTo examine the temporal relation between low blood pressure and depression in a two-year follow-up.MethodThe study group consisted of 1389 subjects aged 59–71 years; 1272 (92%) were examined after two years. Subjects completed the Center for Epidemiological Studies–Depression (CES–D) and the Spielberger inventory scales to assess depressive and anxiety symptoms respectively. Data were collected on socio-demographic characteristics, smoking and drinking habits, medical history, drug use and blood pressure measures.ResultsAmong 1112 subjects who were considered as non-depressed at baseline, logistic regression models showed that low diastolic blood pressure (DBP) and decrease of blood pressure were predictors of high depressive symptomatology at follow-up. Baseline high CES–D scores did not predict low blood pressure two years after.ConclusionsIn our study, low blood pressure was a risk factor for, but not a consequence of, high depressive symptomatology.

scholarly journals Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251598
Author(s):  
Mandy Goldberg ◽  
Anna J. Ciesielski Jones ◽  
John A. McGrath ◽  
Christie Barker-Cummings ◽  
Deborah S. Cousins ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Pubertal Development ◽  
Tanner Stage ◽  
Pubic Hair ◽  
Health Study ◽  
Final Visit ◽  
Tanner Staging ◽  
Non Invasive ◽  
Stage 1

Background Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development. Objective Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage. Methods Thirty-five girls and 42 boys aged 7 to 15 years were enrolled in the Growth and Puberty (GAP) study, a longitudinal pilot study conducted from 2007–2009 involving children of women enrolled in the Agricultural Health Study (AHS) in Iowa. We collected saliva and urine samples and assessed pubertal development by self-rated Tanner staging (pubic hair, breast development (girls), genital development (boys)) at three visits over six months. We measured dehydroepiandrosterone (DHEA) in saliva and creatinine-adjusted luteinizing hormone (LH), testosterone, follicle stimulating hormone (FSH), estrone 3-glucuronide (E13G) and pregnanediol 3-glucuronide (Pd3G) concentrations in first morning urine. We evaluated the relationships over time between Tanner stage and each biomarker using repeated measures analysis. Results Among girls still reporting Tanner breast stage 1 at the final visit, FSH levels increased over the 6-month follow-up period and were no longer lower than higher stage girls at the end of follow-up. We observed a similar pattern for testosterone in boys. By visit 3, boys still reporting Tanner genital stage 1 or pubic hair stage 1 had attained DHEA levels that were comparable to those among boys reporting Tanner stages 2 or 3. Conclusions Increasing concentrations of FSH in girls and DHEA and testosterone in boys over a 6-month period revealed the start of the pubertal process prior to changes in self-rated Tanner stage. Repeated, non-invasive endocrine measures may complement the more subjective assessment of physical markers in studies determining pubertal onset.

scholarly journals Primary Amenorrhoea with Transverse Vaginal Septum Presented with Infected Pyometra of 24 Weeks Size

2018 ◽  
Vol 12 (1) ◽  
pp. 66-68
Author(s):  
Rekha Paudel ◽  
Ganesh Dangal ◽  
Aruna Karki ◽  
Hema Pradhan ◽  
Ranjana Shrestha ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Abdominal Mass ◽  
Lower Abdominal Pain ◽  
Sex Characteristics ◽  
Vaginal Septum ◽  
Primary Amenorrhoea ◽  
Tanner Staging ◽  
Secondary Sex Characteristics ◽  
Transverse Vaginal Septum ◽  
Female Genital

Transverse vaginal septum is a congenital anomaly of the female genital outflow tract. It mostly remains unrecognized till adolescence and manifests as primary amenorrhoea with cyclic lower abdominal pain in background of appropriate Tanner staging secondary sex characterstics. Diagnosis is done by clinical examination and imaging, usually Magnetic Resonance Imaging. Early surgical management by vaginal or abdominal approaches improves the outcome. A 16 years, adolescent with appropriate Tanner staging secondary sex characteristics presented to gynecology (OPD) of Kathmandu Model Hospital with complaints of primary amenorrhoea and palpable abdominal mass of 24 weeks size with cyclic lower abdominal pain. Ultrasound showed features suggestive of hematometra. Under spinal anaesthesia, drainage and excision of the transverse vaginal septum was done followed by placement of vaginal mould post-operatively. We present here a case of primary amenorrhoea with pyometra secondary to transverse vaginal septum.

Influence of Gender in Patients Attended in Emergency Rooms for Suicidal Tendencies

2017 ◽  
Vol 41 (S1) ◽  
pp. S95-S95
Author(s):  
B. Mata Saenz ◽  
E. Segura Escobar ◽  
E. Lopez Lavela ◽  
L.-M. Asensio Aguerri ◽  
L. Nuevo Fernandez ◽  
...  
Keyword(s):  
Personality Traits ◽  
Statistical Correlation ◽  
Toxic Substances ◽  
Emergency Rooms ◽  
Logistic Regression Models ◽  
Competing Interest ◽  
And Gender ◽  
The Relationship ◽  
Repeated Visit

IntroductionThe first time when people attempt suicide first contact is critical. Psychiatrists must decide to hospitalize them or follow-up in mental health units and the bases of a doctor-patient relationship are formed.ObjectivesAn analysis of referrals to psychiatry from the emergency room (ER) was developed. Our objective was to discover if there was a statistical correlation between gender and other variables, especially repeated visits and admissions.MethodsOur sample was composed of patients who visited the ER for suicidal tendencies for 20 months. We carried out an observational retrospective study. The variables collected were: age, gender, cause, repeated visit (visit to the ER in the following two months), previous attempts, previous follow-up, method used, use of toxic substances during the attempt, intentionality, referral from the ER, later follow-up and diagnostic impression at the ER.ResultsA total of 620 patients were sampled. The relationship between gender and repeated visit, previous attempts, dysfunctional personality traits, use of substances and later follow-up was found (Chi2). Although the relationship between admissions and gender were not statistically significant, influence by gender (over all in males) can be observed in logistic regression models. As well as, in patients who visited the ER several times, dysfunctional personality traits seem to be the most common but gender marks significant differences between groups.ConclusionsThe data obtained is consistent with those reported in previous studies. To know who the riskier groups are can allow professionals to plan protocols and unify admission criteria.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium

2018 ◽  
Vol 48 (15) ◽  
pp. 2550-2561 ◽  
Author(s):  
Hsin-Fang Chung ◽  
Nirmala Pandeya ◽  
Annette J. Dobson ◽  
Diana Kuh ◽  
Eric J. Brunner ◽  
...  
Keyword(s):  
Depressed Mood ◽  
Pooled Analysis ◽  
Menopausal Symptoms ◽  
Logistic Regression Models ◽  
Using Data ◽  
Reporting Frequency ◽  
The Relationship ◽  
Sleep Difficulties

AbstractBackgroundMany women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions.MethodsA pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49−51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity). Multivariable logistic regression models were used to examine the bi-directional associations adjusted for within-study correlation.ResultsAt baseline, the prevalence of VMS (40%, range 13–62%) and depressed mood (26%, 8–41%) varied substantially across studies, and a strong dose-dependent association between VMS and likelihood of depressed mood was found. Over 3 years of follow-up, women with often/severe VMS at baseline were more likely to have subsequent depressed mood compared with those without VMS (odds ratios (OR) 1.56, 1.27–1.92). Women with often/severe depressed mood at baseline were also more likely to have subsequent VMS than those without depressed mood (OR 1.89, 1.47–2.44). With further adjustment for the degree of sleep difficulties at baseline, the OR of having a subsequent depressed mood associated with often/severe VMS was attenuated and no longer significant (OR 1.13, 0.90–1.40). Conversely, often/severe depressed mood remained significantly associated with subsequent VMS (OR 1.80, 1.38–2.34).ConclusionsDifficulty in sleeping largely explained the relationship between VMS and subsequent depressed mood, but it had little impact on the relationship between depressed mood and subsequent VMS.

Relationship between inhibin B, puberty, and secondary sex characteristics in childhood cancer survivors.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e22018-e22018
Author(s):  
Emel Cabi Unal ◽  
Gulsum KADIOGLU Simsek ◽  
Nurdan Tacyildiz ◽  
Handan Dincaslan ◽  
Gulsan Yavuz ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Hair Growth ◽  
Pubertal Development ◽  
Childhood Cancer Survivors ◽  
Sex Characteristics ◽  
Adult Type ◽  
Secondary Sex Characteristics ◽  
Gonadal Dysfunction ◽  
Menstrual History ◽  
Gonadal Toxicity

e22018 Background: Prognosis in childhood cancer improved with intensive tx regimens, improved survival,concerns&issues related to QOL become crucial point of interest. Methods: Gonadal functions were studied in 33M,22F survivors of childhood cancers treated w gonadotoxic chemotherapy,with HL,NHL, ALL,Osteosarcoma,Rhabdomyosarcoma. All event-free survivors for > 1year, postpubertal, > 15 years of age at the time of study, 8 pts received abdominal RT,9 pts had prophylactic cranial RT. Patients answered a questionnaire concerning sexual functions,underwent a comprehensive physical examination, clinical evaluation of pubertal development, secondary sex characteristics,menstrual history, measurement of FSH, LH,sex steroids, inhibinB, compared w age-matched controls. Results: All patients had normal pubertal development for age,Females showed no significant differences in secondary sex characteristics, than controls &the progression of puberty, adult-type hair growth in males were significantly late (P:0.002) than controls, low levels of testosterone were found in all.Pubertal development normal in female patients, w elevated FSH than control.(P:0.025)FSH levels in males didn't differ,inhibinB levels were significantly lower than control.(P:0.022).We couldn't demonstrate significant association with age at dx,time elapsed after tx,dx type,gonadotoxic agent.. Conclusions: Our study showed tx of childhood cancer could lead to gonadal toxicity.Our study investigating relationship between puberty,secondary sex characteristics,inhibinB in early postpubertal stage. Findings suggest that, even in the presence of gonadal toxicity, in females, secondary sex characteristics&puberty weren't affected.Inhibin B as a marker for gonadal toxicity is not superior to FSH. In fact that, we found a decrease in InhibinB as the only marker of gonadal dysfunction in males.With normal pubertal development &FSH levels in postpubertal males,low detection of inhibinB can be used as an early,sensitive marker for gonadal toxicity.Late adult-type hair growth with low testosterone demonstrating chemotherapy-induced testicular damage. Clinical trial information: BAP-2734.

Walking and Depression in a Cohort of Older Adults: The Iowa 65+ Rural Health Study

1996 ◽  
Vol 4 (2) ◽  
pp. 119-135 ◽  
Author(s):  
Kenneth E. Mobily ◽  
Linda M. Rubenstein ◽  
Jon H. Lemke ◽  
Michael W. O’Hara ◽  
Robert B. Wallace
Keyword(s):  
Depressive Symptoms ◽  
Rural Health ◽  
Demographic Variables ◽  
Health Study ◽  
Logistic Regression Models ◽  
Age Cohorts ◽  
Cohort Groups ◽  
The Relationship ◽  
Mixed Age

The purpose of the study was to develop an explanatory model of the exercise/depression relationship using a rural-residing population of elderly aged 65 or older. Subjects were selected from the 3,673 persons who participated in the Iowa 65+ Rural Health Study. The 2,084 subjects with complete data, valid information about depressive symptoms, and ability to walk across a small room were divided into two cohort groups at baseline: those with few and those with more depressive symptoms. Logistic regression models using walking status, demographic variables, and chronic health conditions were developed to predict depressive symptoms for this population at a 3-year follow-up. Consistent with previous studies using mixed-age cohorts, physical activity was negatively associated with depressive symptoms. We concluded that the relationship between exercise and depressive symptoms may be manifested in both subjects with more and few depressive symptoms because both groups benefited from daily walking.

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