Skin-compatible lecithin drug delivery systems for fluconazole: effect of phosphatidylethanolamine and oleic acid on skin permeation

: Atopic dermatitis is a chronic inflammatory disease of the skin, which is characterized by itching, erythema and eczematous lacerations. It affects about 10 % of adults and approximately 15-20 % of children in the worldwide. As a result of genetic, immunologic and environmental factors, the disease manifests itself with impaired stratum corneum barrier and then immunological responses. Topical administration of corticosteroids and calcineurin inhibitors are currently used as the first strategy in the management of disease. However, they have low skin bioavailability and some side effects. The nano-carriers as novel drug delivery systems could overcome limitations of conventional dosage forms, owing to increment of poorly soluble drug' solubility, then its thermodynamic activity and consequently its skin permeation. Also, side effects of the drug substances on the skin could be reduced by the nano sized drug delivery systems, due to encapsulation of the drug in the nano-carriers and targeted drug delivery of drug substances to the inflammated skin areas. Thereby, there have been available a numerous of research studies and patents regarding use of the nano-carriers in the management of atopic dermatitis. This review focuses on the mechanism of disease and, developments on the nano-carrier based on novel drug release systems of in the management of atopic dermatitis.

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Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview

Current Drug Therapy ◽

10.2174/1574885514666190212113754 ◽

2019 ◽

Vol 14 (3) ◽

pp. 192-209 ◽

Cited By ~ 1

Author(s):

Balamurugan Manickam ◽

Rajesh Sreedharan ◽

Kumarappan Chidambaram

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery Systems ◽

Skin Permeation ◽

Barrier Properties ◽

Systemic Circulation ◽

Delivery Systems ◽

Drug Molecules ◽

Number Of Factors ◽

Transdermal Drug Delivery Systems

:Transdermal drug delivery systems (TDDS) are one of the fascinating unconventional drug delivery systems offering plentiful advantages of which patient compliance is of paramount importance. However, as a matter of fact, the transdermal delivery of drug molecules is absolutely a tedious job which is precisely influenced by a number of factors including penetration barrier properties of the skin, drug characteristics formulation allied issues, etc. Over the years, innumerable tremendous efforts have been made in transporting the drugs through the skin into the systemic circulation by noteworthy tactics. This paper discusses such revolutionary formulation based techniques that have been endeavored in achieving the enhanced skin permeation of drugs, controlled release, and safety.

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New Approach for Administration of Doxazosin Mesylate: Comparative Study between Liquid and Solid Self-nanoemulsifying Drug Delivery Systems

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v12i2.4638 ◽

2021 ◽

Vol 12 (2) ◽

pp. 1095-1101

Author(s):

Al Zahraa G. Al Ashmawy ◽

Noura G. Eissa ◽

Gehan F. Balata ◽

Hanan M. El Nahas

Keyword(s):

Drug Delivery ◽

Oleic Acid ◽

Drug Delivery Systems ◽

Water Solubility ◽

Tween 80 ◽

Delivery Systems ◽

Water Soluble ◽

Dissolution Enhancement ◽

Surfactant Mixture ◽

Doxazosin Mesylate

Self-nanoemulsifying drug delivery systems (SNEDDS) in both liquid and solid forms were suggested to improve water solubility of Doxazosin mesylate (DOX) a poorly water- soluble antihypertensive drug. Oleic acid: Smix (1:9 w/w) and Tween 80: co-surfactant mixture (Ethanol and PEG 400) (1:1, 2:1, 3:1 and 4:1) were chosen to prepare a liquid and solid forms of SNEDDS according to their solubility. TEM images revealed change in the crystalline nature of DOX into uniform particles with smooth surface. Characterization studies revealed droplet size ranges from 79.80±14.39 to 273.10±4.17 nm, zeta potential ranges from -5.57±0.10 to -21.13±0.46 mV and dissolution enhancement of more than two folds with more favorable properties for the solid forms. FTIR demonstrated significant physical changes in DOX crystalline structure. In conclusion, the solid SNEDDS containing oleic acid: Smix (1:9 w/w) and Tween 80: co-surfactant mixture (3:1 w/w) and adsorbent mixture of Avicel 101 and Aerosil 200 (40:1 w/w) might be a promising formula for better management of hypertension with expected shelf stability.

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Amphiphilic Janus nanoparticles for imaging-guided synergistic chemo-photothermal hepatocellular carcinoma therapy in the second near-infrared window

Nanoscale ◽

10.1039/d0nr09017d ◽

2021 ◽

Vol 13 (7) ◽

pp. 3974-3982

Author(s):

Xiangjun Chen ◽

Xiuping Zhang ◽

Lingyu Zhang ◽

Yuzhou Gao ◽

Changrong Wang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Drug Delivery ◽

Oleic Acid ◽

Drug Delivery Systems ◽

Near Infrared ◽

Delivery Systems ◽

Janus Nanoparticles ◽

Novel Strategy ◽

Dual Drug ◽

Infrared Window

The unique amphiphilic oleic acid-NaYF4:Yb,Er/polydopamine Au nanoflower Janus NPs with the discrete multi compartment nanostructures as dual-drug delivery systems are fabricated, which exhibit a novel strategy for efficiently combating HCC.

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Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

Current Pharmaceutical Design ◽

10.2174/1381612826666200614175236 ◽

2020 ◽

Vol 26 (36) ◽

pp. 4569-4579 ◽

Cited By ~ 5

Author(s):

Tejashree Waghule ◽

Vamshi Krishna Rapalli ◽

Srividya Gorantla ◽

Ranendra Narayan Saha ◽

Sunil Kumar Dubey ◽

...

Keyword(s):

Drug Delivery ◽

Bacterial Infections ◽

Drug Delivery Systems ◽

Skin Diseases ◽

Skin Permeation ◽

Clinical Status ◽

Age Groups ◽

Delivery Systems ◽

Nanostructured Lipid Carriers ◽

Skin Disorders

Background: Skin diseases affect all the age groups of people and have an impact on patients’ physical, mental, and emotional status. Conventional topical preparation is limited with its efficacy due to low permeation, frequent application, and poor adherence to the therapy for prolong time. Objective: The objective of this review article is to address the emerging trends of nanotechnology derived lipidic carrier systems for an effective treatment for skin disorders. Methodology: Various research and review articles from reputed international journals were referred and compiled. Results and Discussion: opical drug delivery systems were found to be more effective than oral and parenteral drug delivery systems for treating skin diseases due to targeted localized applications with reduced side effects. Lipid-based nanoparticles have been found to have the potential in treating skin diseases due to the biocompatibility and the versatility of the lipids. Nanostructured lipid carriers (NLCs) have gained much attention in treating skin diseases due to improved stability of the drugs, enhanced skin permeation, retention, and better therapeutic efficacy. The review summarizes the NLCs characteristics and their application for topical delivery of various therapeutics in skin disorders. NLCs have shown great potential in effective drug delivery for the treatment of psoriasis, dermatitis, bacterial infections, and skin cancer. Its cosmetic application has opened a new area for skincare. Furthermore, safety and clinical status revealed its future commercial acceptability. Conclusion: NLCs have been found as effective lipid nanocarriers for the delivery of topical therapeutics.

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A Review on Film Forming Drug Delivery Systems

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00972 ◽

2021 ◽

pp. 5579-5588

Author(s):

Hayder Yahya Mansoor Al-Jarsha ◽

Mowafaq M. Ghareeb ◽

Ahmed A. Hussein

Keyword(s):

Drug Delivery ◽

Patient Compliance ◽

Drug Delivery Systems ◽

Skin Permeation ◽

Dosage Forms ◽

Delivery Systems ◽

Mechanism Of Formation ◽

Film Forming ◽

Supersaturated State ◽

Recent Advancement

Conventional dosage forms for topical and transdermal drug delivery have several disadvantages related mainly to its poor skin permeation and patient compliance. Many approaches have been developed to improve these dosage forms. Film forming drug delivery systems represents a recent advancement in this field. It provides improved patient compliance with enhanced skin permeation of drugs. In its simplest form, these consist of a polymeric solution, usually in a supersaturated state, in a suitable solvent. A plasticizer is usually added to improve the flexibility and enhance the tensile strength to the film. It is also possible to control and sustain the drug release from the films by controlling the polymeric content, concentration of plasticizer, or formulation with other additives. In this review, we are summarizing the mechanism of formation of these films as well as its types and possible applications. The main ingredients, properties, and evaluation of the various film forming delivery systems are also discussed.

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Exploring Therapeutic Potential Of Invasomes, Transfersomes, Transethosomes, Oleic Acid Vesicles, And Cubosomes Adopting Topical/Transdermal Route

Micro and Nanosystems ◽

10.2174/1876402913666210406163452 ◽

2021 ◽

Vol 13 ◽

Author(s):

Shivani Verma ◽

Puneet Utreja

Keyword(s):

Drug Delivery ◽

Oleic Acid ◽

Transdermal Drug Delivery ◽

Therapeutic Potential ◽

Skin Permeation ◽

Delivery Systems ◽

Literature Survey ◽

Sustain Release ◽

Extensive Degradation

Background: Transdermal drug delivery is considered as a better alternative to oral administration of drugs like proteins or peptides that are susceptible to extensive degradation via first pass metabolism. This delivery route also shows high patient compliance due to no use of painful injections. Conventional delivery systems like creams and gel show poor skin permeation and high dosing frequency. Objective: The objective of this work was to investigate the role of highly advanced micro and nanocarrier systems like invasomes, transfersomes, transethosomes, oleic acid vesicles, and cubosomes for transdermal drug delivery exploring literature survey. Methods: Literature survey for these advanced micro and nanocarrier systems was carried out using search engines like Pubmed and Google scholar. Results: Results of literature investigations revealed that advanced micro and nanocarrier systems discussed earlier have the caliber to enhance skin permeation of various bioactives, show sustain release, and target particular areas of skin better compared to old nanocarriers like liposomes. Conclusion: Present review concludes that advanced micro and nanocarrier systems like invasomes, transfersomes, transethosomes, oleic acid vesicles, and cubosomes are better alternatives for transdermal delivery of therapeutic agents compared to old nanocarriers like liposomes and conventional delivery systems like creams and gels.

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Skin Delivery of Kojic Acid-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging

BioMed Research International ◽

10.1155/2013/271276 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 20

Author(s):

M. L. Gonçalez ◽

M. A. Corrêa ◽

M. Chorilli

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Liquid Crystalline ◽

Kojic Acid ◽

Skin Permeation ◽

Polarized Light ◽

Skin Aging ◽

Delivery Systems ◽

Skin Delivery

The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can modulate drug permeation through the skin and improve the drug activity. This study is aimed at structurally developing and characterizing a kojic acid-loaded LCS, consists of water (W), cetostearyl isononanoate (oil—O) and PPG-5-CETETH-20 (surfactant-S) and evaluating itsin vitroskin permeation and retention. Three regions of the diagram were selected for characterization: A (35% O, 50% S, 15% W), B (30% O, 50% S, 20% W) and C (20% O, 50% S, 30% W), to which 2% KA was added. The formulations were subjected to polarized light microscopy, which indicated the presence of a hexagonal mesophase. Texture and bioadhesion assay showed that formulation B is suitable for topical application. According to the results from thein vitropermeation and retention of KA, the formulations developed can modulate the permeation of KA in the skin. Thein vitrocytotoxic assays showed that KA-unloaded LCS and KA-loaded LCS didn't present cytotoxicity. PPG-5-CETETH-20-based systems may be a promising platform for KA skin delivery.

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