In vitro comparison of high-definition US, CBCT and periapical radiography in the diagnosis of proximal and recurrent caries

2021 ◽  
pp. 20210026
Author(s):  
Oya Şeker ◽  
Kıvanç Kamburoğlu ◽  
Cihan Şahin ◽  
Nejlan Eratam ◽  
Esra Ece Çakmak ◽  
...  
Keyword(s):  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Roc Curves ◽  
High Definition ◽  
Chi Square ◽  
Voxel Size ◽  
Proximal Caries ◽  
Significance Level ◽  
Periapical Radiography

Objective: To assess the in vitro performance of high-definition (HD) US, CBCT and periapical radiography for the visibility of proximal and recurrent caries in teeth with and without restoration. Methods: A total of 240 molar teeth were divided into eight groups each comprised of 30 teeth. Control groups consisted of teeth without caries (Group 1–4; N = 120), whereas diseased groups consisted of teeth with proximal caries (Group 5–8; N = 120 teeth). Finally, a total of four image sets were obtained as follows: i) PSP periapical radiography, ii) CBCT 0.075 mm voxel size, iii) CBCT 0.2 mm voxel size and iv) HD US images. The image sets were viewed separately by four observers by using a 5-point confidence scale. Intraclass correlation coefficients were calculated. The areas under the ROC curves were compared using chi-square tests. Significance level was set at α = 0.05. Results: Intraobserver agreement for both readings for the four observers ranged between 0.848 and 0.988 for CBCT (0.075 mm) images; 0.658 and 0.952 for CBCT (0.2 mm) images; 0.555 and 0.810 for periapical images; 0.427 and 0.676 for US images. Highest AUC values were found for CBCT (0.075 mm) images and lowest for US images. Statistically significant differences were found among CBCT (0.075 mm) images and US images (p < 0.001), CBCT (0.2 mm) images and US images (p < 0.001) and periapical images and US images (p < 0.001) for the detection of proximal caries. Conclusion: Periapical and CBCT images outperformed HD US imaging in the detection of proximal dental caries.

scholarly journals Diagnosis of left ventricular hypertrophy using non-ECG-gated 15O-water PET

2021 ◽  
Author(s):  
Jens Sörensen ◽  
Jonny Nordström ◽  
Tomasz Baron ◽  
Stellan Mörner ◽  
Sven-Olof Granstam ◽  
...  
Keyword(s):  
Method Development ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Roc Curves ◽  
Left Ventricular ◽  
Intraclass Correlation Coefficients ◽  
Concentric Hypertrophy ◽  
2D Echocardiography ◽  
Positron Emission ◽  
Septal Wall Thickness

Abstract Aim To develop a method for diagnosing left ventricular (LV) hypertrophy from cardiac perfusion 15O-water positron emission tomography (PET). Methods We retrospectively pooled data from 139 subjects in four research cohorts. LV remodeling patterns ranged from normal to severe eccentric and concentric hypertrophy. 15O-water PET scans (n = 197) were performed with three different PET devices. A low-end scanner (66 scans) was used for method development, and remaining scans with newer devices for a blinded evaluation. Dynamic data were converted into parametric images of perfusable tissue fraction for semi-automatic delineation of the LV wall and calculation of LV mass (LVM) and septal wall thickness (WT). LVM and WT from PET were compared to cardiac magnetic resonance (CMR, n = 47) and WT to 2D-echocardiography (2DE, n = 36). PET accuracy was tested using linear regression, Bland–Altman plots, and ROC curves. Observer reproducibility were evaluated using intraclass correlation coefficients. Results High correlations were found in the blinded analyses (r ≥ 0.87, P < 0.0001 for all). AUC for detecting increased LVM and WT (> 12 mm and > 15 mm) was ≥ 0.95 (P < 0.0001 for all). Reproducibility was excellent (ICC ≥ 0.93, P < 0.0001). Conclusion 15O-water PET might detect LV hypertrophy with high accuracy and precision.

scholarly journals Measurement properties of the Musculoskeletal Health Questionnaire (MSK-HQ): a between country comparison

2020 ◽  
Author(s):  
David Høyrup Christiansen ◽  
Gareth McCray ◽  
Trine Nøhr Winding ◽  
Johan Hviid Andersen ◽  
Kent Jacob Nielsen ◽  
...  
Keyword(s):  
Measurement Error ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Roc Curves ◽  
Measurement Properties ◽  
Activity Levels ◽  
Health Questionnaire ◽  
Musculoskeletal Health ◽  
Random Measurement Error ◽  
The Uk

Abstract Background: The Musculoskeletal Health Questionnaire (MSK-HQ) has been developed to measure musculoskeletal health status across musculoskeletal conditions and settings. However, the MSK-HQ needs to be further evaluated across settings and different languages.Objective: The objective of the study was to evaluate and compare measurement properties of the MSK-HQ across Danish (DK) and English (UK) cohorts of patients from primary care physiotherapy services with musculoskeletal pain. Methods: MSK-HQ was translated into Danish according to international guidelines. Measurement invariance was assessed by differential item functioning (DIF) analyses. Test-retest reliability, measurement error, responsiveness and minimal clinically important change (MCIC) were evaluated and compared between DK (n=153) and UK (n=166) cohorts. Results: The Danish version demonstrated acceptable face and construct validity. Out of the 14 MSK-HQ items, three items showed DIF for language (pain/stiffness at night, understanding condition and confidence in managing symptoms) and three items showed DIF for pain location (walking, washing/dressing and physical activity levels). Intraclass Correlation Coefficients for test-retest were 0.86 (95% CI 0.81 to 0.91) for DK cohort and 0.77 (95% CI 0.49 to 0.90) for the UK cohort. The systematic measurement error was 1.6 and 3.9 points for the DK and UK cohorts respectively, with random measurement error being 8.6 and 9.9 points. Receiver operating characteristic (ROC) curves of the change scores against patients’ own judgment at 3 months exceeded 0.70 in both cohorts. Absolute and relative MCIC estimates were 8-10 points and 26% for the DK cohort and 6-8 points and 29% for the UK cohort.Conclusions: The measurement properties of MSK-HQ were acceptable across countries, but seem more suited for group than individual level evaluation. Researchers and clinicians should be aware that some discrepancy exits and should take the observed measurement error into account when evaluating change in scores over time.

scholarly journals Assessing the reproducibility of high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging in patients with gliomas

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Woo Hyeon Lim ◽  
Joon Sik Park ◽  
Jaeseok Park ◽  
Seung Hong Choi
Keyword(s):  
Spatial Resolution ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Voxel Size ◽  
Dce Mri ◽  
Intraclass Correlation Coefficients ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Temporal And Spatial ◽  
Arterial Input Functions

AbstractTemporal and spatial resolution of dynamic contrast-enhanced MR imaging (DCE-MRI) is critical to reproducibility, and the reproducibility of high-resolution (HR) DCE-MRI was evaluated. Thirty consecutive patients suspected to have brain tumors were prospectively enrolled with written informed consent. All patients underwent both HR-DCE (voxel size, 1.1 × 1.1 × 1.1 mm3; scan interval, 1.6 s) and conventional DCE (C-DCE; voxel size, 1.25 × 1.25 × 3.0 mm3; scan interval, 4.0 s) MRI. Regions of interests (ROIs) for enhancing lesions were segmented twice in each patient with glioblastoma (n = 7) to calculate DCE parameters (Ktrans, Vp, and Ve). Intraclass correlation coefficients (ICCs) of DCE parameters were obtained. In patients with gliomas (n = 25), arterial input functions (AIFs) and DCE parameters derived from T2 hyperintense lesions were obtained, and DCE parameters were compared according to WHO grades. ICCs of HR-DCE parameters were good to excellent (0.84–0.95), and ICCs of C-DCE parameters were moderate to excellent (0.66–0.96). Maximal signal intensity and wash-in slope of AIFs from HR-DCE MRI were significantly greater than those from C-DCE MRI (31.85 vs. 7.09 and 2.14 vs. 0.63; p < 0.001). Both 95th percentile Ktrans and Ve from HR-DCE and C-DCE MRI could differentiate grade 4 from grade 2 and 3 gliomas (p < 0.05). In conclusion, HR-DCE parameters generally showed better reproducibility than C-DCE parameters, and HR-DCE MRI provided better quality of AIFs.

scholarly journals Influence of intracanal post on apical periodontitis identified by cone-beam computed tomography

2009 ◽  
Vol 20 (5) ◽  
pp. 370-375 ◽  
Author(s):  
Carlos Estrela ◽  
Mike Reis Bueno ◽  
Olavo César Lyra Porto ◽  
Cleomar Donizeth Rodrigues ◽  
Jesus Djalma Pécora
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Apical Periodontitis ◽  
Cone Beam ◽  
Chi Square ◽  
Significance Level ◽  
Anterior Teeth ◽  
Kappa Value ◽  
Chi Square Test ◽  
Periapical Radiography

The determination of the success of endodontic treatment has been often discussed based on outcome obtained by periapical radiography. The aim of this study was to verify the influence of intracanal post on apical periodontitis detected by cone-beam computed tomography (CBCT). A consecutive sample of 1020 images (periapical radiographs and CBCT scans) taken from 619 patients (245 men; mean age, 50.1 years) between February 2008 and September 2009 were used in this study. Presence and intracanal post length (short, medium and long) were associated with apical periodontitis (AP). Chi-square test was used for statistical analyses. Significance level was set at p<0.01. The kappa value was used to assess examiner variability. From a total of 591 intracanal posts, AP was observed in 15.06%, 18.78% and 7.95% using periapical radiographs, into the different lengths, short, medium and long, respectively (p=0.466). Considering the same posts length it was verified AP in 24.20%, 26.40% and 11.84% observed by CBCT scans, respectively (p=0.154). From a total of 1,020 teeth used in this study, AP was detected in 397 (38.92%) by periapical radiography and in 614 (60.19%) by CBCT scans (p<0.001). The distribution of intracanal posts in different dental groups showed higher prevalence in maxillary anterior teeth (54.79%). Intracanal posts lengths did not influenced AP. AP was detected more frequently when CBCT method was used.

scholarly journals Evidence-based practice in primary healthcare from the managerial point of view – a national survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tobias Abelsson ◽  
Helena Morténius ◽  
Ann-Kristin Karlsson ◽  
Stefan Bergman ◽  
Amir Baigi
Keyword(s):  
National Survey ◽  
Primary Healthcare ◽  
Evidence Based Practice ◽  
Statistical Significance ◽  
Correlation Coefficients ◽  
Daily Practice ◽  
Direct Result ◽  
Evidence Based ◽  
Chi Square ◽  
Significance Level

Abstract Background The vast availability of and demand for evidence in modern primary healthcare force clinical decisions to be made based on condensed evidence in the form of policies and guidelines. Primary healthcare managers play a key role in implementing these governing documents. Thus, the aim of this article is to investigate the use and availability of evidence-based practice resources from the perspective of first-line primary healthcare managers. Methods The study is based on a national survey of primary healthcare managers, consisting of 186 respondents, recruited nationally from Sweden. The data was analysed using empirically constructed concepts and validated using factor analysis. A chi-square test was utilized to determine the statistical significance of comparisons. Associations between variables were calculated using Spearman’s correlation coefficients. All tests were two-sided, and the significance level was set to 0.05. Results A majority (97 %) of managers stated that guidelines and policy documents impacted primary healthcare; 84 % of managers observed a direct effect on daily practices. Most of the managers (70 %) stated that some adaptation was needed when new evidence was introduced. The managers emphasized the importance of keeping themselves updated and open to new information about work routines (96 %). Conclusions The study illustrates a nearly unanimous response about the influence of clinical evidence on daily practice. The emphasis on the importance of all staff members keeping their professional knowledge up to date is viewed as a direct result of this effect on daily practice. An information-dense organization such as a primary healthcare organization would have much to gain from increased cooperation with regional information resources such as clinical libraries.

scholarly journals The relationship between the storage methods and the formation of dentinal defects (cracks)

2019 ◽  
Vol 67 ◽  
Author(s):  
Fábio Nakao ARASHIRO ◽  
Michelle Tavares Galotto NANTES ◽  
Pedro Gregol da SILVA ◽  
Key Fabiano Souza PEREIRA ◽  
Muryllo Eduardo Sales dos SANTOS
Keyword(s):  
Storage Period ◽  
Root Apex ◽  
Surgical Instruments ◽  
Distilled Water ◽  
Chi Square ◽  
Significance Level ◽  
Significant Difference ◽  
And Storage ◽  
Group 1

ABSTRACT Objective: This research study aims at conducting an in vitro evaluation of crack formation in freshly extracted teeth after undergoing different storage and decontamination methods. Methods: 60 erupted upper third molars conventionally extracted using forceps # 210h (quinelato surgical instruments, rio claro - sp) and randomly distributed in three groups (n = 30): group 1 - storage in dry environment for 30 days, group 2 - sterilization in autoclave and storage for 30 days in distilled water, and group 3 - 10% formaldehyde decontamination for 14 days and storage in distilled water for additional 30 days. after the storage period, teeth had their roots transversely sectioned at 2, 4 and 6 mm below the root apex using a low rotation diamond disk under constant cooling. the evaluation of fragments was performed using a 30-time magnification microscope. Results: Cracks were seen only in group 1 and the chi-square statistical test with 5% significance level showed a statistically significant difference comparing the dry storage group to the others. Conclusion: The storage of extracted teeth in a dry environment influences the formation of dentinal defects.

scholarly journals Assessment of enamel demineralization using conventional, digital, and digitized radiography

2006 ◽  
Vol 20 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Rívea Inês Ferreira ◽  
Francisco Haiter-Neto ◽  
Cínthia Pereira Machado Tabchoury ◽  
Guilherme Assumpção Neves de Paiva ◽  
Frab Norberto Bóscolo
Keyword(s):  
Roc Analysis ◽  
Operating Characteristic ◽  
Roc Curves ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Enamel Demineralization ◽  
Contrast Enhanced ◽  
Chi Square Test ◽  
Approximal Surfaces

This experimental research aimed at evaluating the accuracy of enamel demineralization detection using conventional, digital, and digitized radiographs, as well as to compare radiographs and logarithmically contrast-enhanced subtraction images. Enamel subsurface demineralization was induced on one of the approximal surfaces of 49 sound third molars. Standardized radiographs of the teeth were taken prior to and after the demineralization phase with three digital systems - CygnusRay MPS®, DenOptix® and DIGORA® - and InSight® film. Three radiologists interpreted the pairs of conventional, digital, and digitized radiographs in two different occasions. Logarithmically contrast-enhanced subtraction images were examined by a fourth radiologist only once. Radiographic diagnosis was validated by cross-sectional microhardness profiling in the test areas of the approximal surfaces. Accuracy was estimated by Receiver Operating Characteristic (ROC) analysis. Chi-square test, at a significance level of 5%, was used to compare the areas under the ROC curves (Az) calculated for the different imaging modalities. Concerning the radiographs, the DenOptix® system (Az = 0.91) and conventional radiographs (Az = 0.90) presented the highest accuracy values compared with the other three radiographic modalities. However, logarithmically contrast-enhanced subtraction images (Az = 0.98) were significantly more accurate than conventional, digital, and digitized radiographs (p = 0.0000). It can be concluded that the DenOptix® system and conventional radiographs provide better performance for diagnosing enamel subsurface demineralization. Logarithmic subtraction significantly improves radiographic detection.

Diagnostic Performance of Different Methods in Detecting Incipient Non-Cavitated Occlusal Caries Lesions in Permanent Teeth

2019 ◽  
Vol 43 (3) ◽  
pp. 173-179
Author(s):  
Murat Ünal ◽  
Arzu Koçkanat ◽  
Seniha Güler ◽  
Esra Gültürk
Keyword(s):  
Intraclass Correlation ◽  
In Vitro Study ◽  
Roc Curves ◽  
Caries Detection ◽  
Permanent Teeth ◽  
Kappa Statistics ◽  
Occlusal Caries ◽  
Diagnodent Pen ◽  
Icdas Ii

Aim: This in vitro study was aimed to investigate the performance of the new caries detection tools on the incipient occlusal caries. Study design: In our study, 100 permanent molar teeth, which were considered to have incipient, enamel caries (D1 and D2 threshold values) according to ICDAS II score. After the visual examination, caries measurements have been applied to all teeth by using DIAGNOdent pen (DP), CarieScan PRO (CP) and SoproLife camera (SC). In addition, in vitro examinations were repeated 2 weeks later. After sectioning and evaluation in stereomicroscope, the lesion depth was determined with histological criteria that are accepted for the gold standard for this research. Sensitivity, specificity, accuracy and area under the ROC curve were calculated at D1 and D2 thresholds. The intra-examiners' reproducibility were analysed using Cohen's kappa statistics and intraclass correlation coefficient (ICC). Results: Intra-examiner repeatability values varied from 0.94 to 0.99 and kappa values ranged from 0.90 to 0.99. While the highest sensitivity and specificity value showed for SC at D1 and D2 thresholds, CP presented the lowest values. The area under ROC curves (Az) varied from 0.70 to 0.99. ICDAS II showed the highest area under ROC curves (Az). Conclusions: ICDAS II, visual diagnostic method by itself is considered to sufficient in order to diagnose incipient occlusal caries. SC may be used as an alternative method for the ICDAS II, since its advantages by displaying caries lesion on the computer monitor, follow-up and motivation of the patients provided.

scholarly journals Comparative Evaluation of Adiposity Indices as Predictors of Hypertension among Brazilian Adults

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Maurílio T. Dutra ◽  
Diego B. V. Reis ◽  
Karla G. Martins ◽  
André B. Gadelha
Keyword(s):  
Roc Curves ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Men And Women ◽  
Significance Level ◽  
Adiposity Index ◽  
Adiposity Indices ◽  
Chi Square Test

Purpose. To compare several anthropometric indices in the prediction of hypertension among adults. Methods. This is a cross-sectional study. Five hundred and eighteen adult men and women (40.9 ± 10.5 years; 1.62 ± .09 m; 72.3 ± 15.6 kg) volunteered to participate and underwent blood pressure and anthropometric measures. Anthropometric assessments were used to calculate body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), body adiposity index (BAI), and conicity index (C). Comparisons between men and women were carried out by independent t-test and chi-square test. Cut-off points for each adiposity index to predict hypertension were obtained using Receiver Operating Characteristic (ROC) curve analyses. The significance level was set at P ≤ .05. Results. All adiposity indices regarding both genders showed significant odds ratios, except BAI (odds ratio: 1.534; CI: 0.916–2.571) for women. In men, WHR and WSR were considered as more balanced indices regarding their sensitivity (AUC: 73.8 and 71.4, respectively) and specificity (AUC: 77.6 and 73.1, respectively). In women, WHR and WSR presented areas under the ROC curves higher than C index (P = .007) and BAI (P = .03), respectively. Conclusion. Indices that consider abdominal adiposity such as WC, WHR, and WSR have a stronger relationship with hypertension compared to others.

scholarly journals Intra-Rater and Inter-Rater Reliability of Pressure Pain Algometry of the Sural and Tibial Nerves in Asymptomatic Elite Youth Footballers

Sports ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 132
Author(s):  
Daniel Richards ◽  
Simon Jones ◽  
Josh Jeffery ◽  
Matthew Lowe ◽  
Mark Godwin ◽  
...  
Keyword(s):  
Measurement Error ◽  
Nervous Tissue ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Neural Tissue ◽  
Ankle Injuries ◽  
Visual Evaluation ◽  
Rater Reliability ◽  
Pressure Algometry ◽  
Significance Level

Ankle injuries are highly prevalent in elite youth footballers and increase the mechanosensitivity of the local neural tissue, which may predispose athletes to re-injury and prolong rehabilitation periods. Increased neural mechanosensitivity presents clinically as altered pain pressure thresholds (PPTs) which are measured with pressure algometry. The purpose of this study was to determine the intra-rater and inter-rater reliability of PPTs of the ankle neural tissue in asymptomatic elite youth football players. Three raters utilised a digital algometer to evaluate the PPTs of the Sural and Tibial nervous tissue at the ankle of elite youth male footballers. Intraclass correlation coefficients (ICCs) with 95% confidence intervals (CI) were calculated to assess intra-rater and inter-rater reliability and Bland–Altman figures were plotted to enable visual evaluation of measurement error with a significance level of p < 0.05. Thirty-four players (16–18 years old) were assessed. Excellent intra-rater (Tibial ICC 0.88 (0.76–0.94); Sural ICC 0.89 (0.79–0.95)) and good inter-rater reliability (Tibial ICC 0.66 (0.40–0.82); Sural 0.71 (0.50–0.85)) was demonstrated. Bland–Altman plots demonstrated low levels of measurement error. Pressure algometry can be utilised clinically to accurately evaluate the PPTs of the Tibial and Sural nervous tissue at the ankle in asymptomatic elite male youth footballers.

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